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| 1 | 颈椎三维有限元模型的建立及意义显示文摘目的 :建立颈椎 (C4~C7)三维有限元模型 ,以期应用于临床实验研究。方法 :根据正常中年女性CT与CT重建片 ,采用CAD数据处理技术 ,输入相关的材料特性 ,构建C4~C7三维有限元模型。模型包括颈C4~C74个椎体、C4 / 5~C6 / 73个椎间盘以及后部结构与主要的 5条韧带。共 2 178个三维固体 2 0节点有限元结构。在1 8Nm作用力下 ,观察节段运动与力 位移反应。对比国内外的实验结果进行检验。结果 :生物力学实验结果与以往实验模型结果基本相符。结论 :所建立的颈椎三节段有限元模型可以模拟颈椎生物力学实验。 | 陈伯华J 孙鹏J Natarajan N An H Andersson GB | 2002 | 中国脊柱脊髓杂志2002，12，2： | 37 |
| 2 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 3 | Akt inhibitor shows anticancer and radiosensitizing effects in malignant glioma cells by inducing autophagy显示文摘 | Fujiwara K Iwado E Mills GB Sawaya R Kondo S Kondo Y | 2007 | 中国神经肿瘤杂志2007，5，4： | 20 |
| 4 | Gastroesophageal reflux: the features in elderlypatients显示文摘AIM To compare the features ofgastroesophageal reflux disease between elderlyand younger patients.METHODS Twenty-four hour pH-monitoring andendoscopy were P6rformed for the 66 elderlypatients with typical gastroesophageaI refluxsymptoms, and the results were compared with112 symptomatic younger patients.RESULTS The results of 24-h pH-monitoringand endoscopy showed that the elderly patientshad pathological reflux and reflux esophagitismore frequently than the younger patients.P6rcentage time with pH< 4 in elderly patientswith reflux esophagitis was 32.5% in 24 hours,as compared with 12.9% in the younger patientswith reflux esophagitis (P < 0 .05 ). The elderlypatients with reflux esophagitis have longerP6riOds of acid reflux in both upright and Supinepositions than the younger patients. Endoscopyshowed that 20 .8% of elderIy patients had grade Ⅲ / Ⅳ esophagitis, whereas only 3.4% ofyounger patients had grade Ⅲ/ Ⅳ esophagitis(P < 0.002 ). Percentages of grades Ⅰ /Ⅱesophagitis in the two groups were 12.5% and26. 5%, respectiveIy (P< 0. 002 ).CONCLUSION Elderly patients, as comparedwith younger patients, have more severegastroesophageal reflux and esophageal lesions.The incompetence of lower esophageal sphincter and the presence of hiataI hernia may beimportant factors leading to the difference in incidence and severity of reflux esophagitisbetween elderly and younger patients. | Huang X Zhu HM Deng CZ Porro GB Sangaletti O Pace F | 1999 | World Journal of Gastroenterology1999，5，5： | 12 |
| 5 | Telomerase catalytic subunit homologs from fission yeast and human显示文摘 | Nakamura TM Morin GB Chapman KB | | 0，，： | 10 |
| 6 | Fecal markers of inflammation used as surrogate markers for treatment outcome in relapsing inflammatory bowel disease显示文摘AIM: To evaluate fecal calprotectin (FC) as a surrogate marker of treatment outcome of relapse of inflammatory bowel disease (IBD) and, to compare FC with fecal myeloperoxidase (MPO) and fecal eosinophil protein X (EPX). METHODS: Thirty eight patients with IBD, comprising of 27 with ulcerative colitis (UC) and 11 with Crohn’s disease (CD) were investigated before treatment (inclusion), and after 4 and 8 wk of treatment. Treatment outcomes were evaluated by clinical features of disease activity and endoscopy in UC patients, and disease activity in CD patients. In addition, fecal samples were analyzed for FC by enzyme-linked immunosorbent assay (ELISA), and for MPO and EPX with radioimmunoassay (RIA). RESULTS: At inclusion 37 of 38 (97%) patients had elevated FC levels (> 94.7 μg/g). At the end of the study, 31 of 38 (82%) patients fulfilled predefined criteria of a complete response [UC 21/27 (78%); CD 10/11 (91%)]. Overall, a normalised FC level at the end of the study predicted a complete response in 100% patients, whereas elevated FC level predicted incomplete response in 30%. Normalised MPO or EPX levels predicted a complete response in 100% and90% of the patients, respectively. However, elevated MPO or EPX levels predicted incomplete response in 23% and 22%, respectively. CONCLUSION: A normalised FC level has the potential to be used as a surrogate marker for successful treatment outcome in IBD patients. However, patients with persistent elevation of FC levels need further evaluation. FC and MPO provide superior discrimination than EPX in IBD treatment outcome. | Michael Wagner Christer GB Peterson Peter Ridefelt Per Sangfelt Marie Carlson | 2008 | World Journal of Gastroenterology2008，14，36： | 9 |
| 7 | 放疗对头颈癌患者颞骨的作用显示文摘放疗是头颈癌治疗的主要手段之一,长期的副作用正逐渐被认识。该文旨在评估接受放疗后,头颈癌患者颞骨区域的近期和远期改变,包括听力损伤、慢性中耳炎、放射性骨坏死及放射癌。该文同时讨论了放疗剂量与这些并发症的相关性。对放疗后颞骨区域并发症的深入认识,有助于临床医师采用更加科学有效的方法治疗头颈癌患者。 | Lambert EM Gunn GB Gidley PW | 2016 | 中国口腔颌面外科杂志2016，14，5： | 6 |
| 8 | Internal Oxidation of Cu-Al Alloy显示文摘 | Wu, JJ Zhang, Y Shen, YT Li, GB Lei, TQ | 1999 | Journal of Materials Science & Technology1999，15，5： | 5 |
| 9 | 角质细胞与成纤维细胞混合移植修复裸鼠全层皮肤缺损的初步报告显示文摘目的 利用组织工程原理探讨修复全层皮肤缺损的理想方法。方法 以裸鼠为动物模型 ,在皮肤全层缺损区域分别移植纤维蛋白胶 (n =10 ) ,纤维蛋白胶角质细胞悬液 (n =10 ) ,纤维蛋白胶成纤维细胞悬液 (n =10 )以及纤维蛋白胶角质细胞成纤维细胞悬液 (n =10 ) ,术后每天对伤口进行大体观察 ,第 5 ,7,10 ,14,2 1,35d ,分别取材活检行组织学及免疫组织化学检查。结果 移植有角质细胞组 (2和 4组 )的创面愈合快 ,术后 10d组织学提示创面完全上皮化 ,抗人特异性HLA 1型抗原、抗involucrin染色和抗Ⅶ型胶原染色阳性证明新生上皮由移植的人角质细胞形成 ,抗involucrin染色阳性又证明角质细胞分化成熟有角质层形成 ,抗Laminin染色、抗Ⅶ型胶原染色阳性提示早期基底膜形成。组织学检查提示第 4组新生上皮有许多类似皮钉样结构。结论 培养的角质细胞 ,成纤维细胞结合纤维蛋白胶移植到创面上后 ,可以形成复层分化良好。 | 焦向阳 邢新 郭恩覃 Stark GB | 2001 | 中华整形外科杂志2001，17，4： | 4 |
| 10 | Anti-arthritis activity of roots of Hemidesmus indicus R.Br.(Anantmul)in rats显示文摘Objective:To investigate the protective effects of hydroalcoholic and its fractions from roots of Hemidesmus indicus on arthritis in in vitro models of rodents.Methods:Preliminary phytochemical analysis and thin-layer chromoatography were performed to analyze constituents of hydroalcoholic extract and its three fraction namely ethyl acetate fraction,chloroform fraction and residual fraction of mot of Hemidesmus indicus.Arthritis rats models were established by Complete Freund’s Adjuvant.The parameters including paw edema,body weight,arthritic index,erythrocyte sedimentation rate,serum rheumatoid factor,serum C-reactive protein,serum nitrite level,and histopathology of synovial joints were observed.Methotrexate was taken as positive control.Results:Rats treated with hydroalcoholic extract(450 mg/kg,p.o.),ethyl acetate (75 mg/kg,p.o.),chloroform(60 mg/kg,p.o) and residual fractions(270 mg/kg,p.o.),showed significant decrease in physical and biochemical parameters compared with arthritic model rats. Hydroalcoholic extract and its ethyl acetate fraction of Hemidesmus indicus showed significantly higher anti-arthritic activity than chloroform and residual fraction.Histopathological analysis demonstrated that both of hydroalcoholic extract and its ethyl acetate fraction had comparable anti-arthritic activity with methotrexates.Conclusions:The present study suggests that Hemidesmus indicus has protective activity against arthritis and the activity might be attributed to presence of terpenoid in hydroalcoholic extract,as well as in ethyl acetate fraction. | Alka Mehta Neeraj K Sethiya Chetan Mehta GB Shah | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，2： | 4 |
| 11 | Cultured keratinocyte grafting on various biologic matrices显示文摘1IntroductionCulturedkeratinocytesasrelativelydiferenti-atiedsheetgraftshaveimprovedthecareforburnsandotherwounds.Forthelastd... | Stark GB△ Horch RE Voigt M Kopp J Saied S Jiao XY | 1998 | 第二军医大学学报1998，19，S1： | 3 |
| 12 | Twenty-five years of research on the effects of exercise training in breast cancer survivors:A systematic review of the literature显示文摘AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient population.METHODS:Pub Med, Medline Plus, the Cochrane Library, Web of Science, SportD iscus, Embase, Scorpus, and Google Scholar were searched from September to November 2013 to identify exercise training studies that used objective measurements of fitness and/or patient reported outcomes assessed pre and post-exercise training with statistical analyses performed in at least one of the following outcome measurements:Cardiorespiratory function, body composition, muscular strength, fatigue, depression, and overall quality of life. Five reviewers independently identified the studies that met the criteria for the review and discrepancies were resolved by consensus among all authors.RESULTS:Fifty-one studies were included in this review with 5 from the period between 1989-1999, 11 from 2000-2006, and 35 from 2007-2013. The evolution of study designs changed from aerobic only exercise training interventions(1989-1999), to a combination of aerobic and resistance training(2000-2006), to studies including an arm of resistance training or examining the effects of resistance training as the main mode of exercise(2007-2013). Overall, the benefits of exercise showed improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of life.CONCLUSION:Exercise training appears to be safe for most breast cancer patients and improvements in physiological, psychological, and functional parameters can be attained with regular participation in moderate intensity exercise. | Claudio L Battaglini Robert C Mills Brett L Phillips Jordan T Lee Christina E Story Marcelo GB Nascimento Anthony Carl Hackney | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
| 13 | 利用组织工程的方法预制含双面表皮的游离皮瓣显示文摘目的 探讨利用组织扩张器和培养的角质上皮细胞预制含双面表皮的游离皮瓣的可行性。 方法 在 10只大鼠的右下腹腹壁下动静脉皮瓣下各埋置一 10 ml容积的扩张器 ,7天后将体外培养的 10× 10 6同系鼠角质上皮细胞用 1ml纤维蛋白胶 ( fibrin glue)制成悬液后接种到扩张器与包囊之间的间隙 ,大体及组织学观察移植的角质上皮细胞是否能将扩张器外纤维包囊上皮化以形成一含双面表皮的皮瓣。皮瓣预制成功后 ,以腹壁下动静脉连同一段股动静脉为蒂行游离移植覆盖颊部洞穿性缺损。 结果 大体观察及组织学证明培养的角质上皮细胞纤维蛋白胶悬液移植后可以将扩张器的纤维包囊上皮化。 结论 利用组织工程的方法可以预制含双面表皮的皮瓣。 | 焦向阳 邢新 郭恩覃 Tanczos E Stark GB | 1999 | 中华显微外科杂志1999，22，4： | 3 |
| 14 | 《通风与空调工程施工质量验收规范》(GB 50243-2016)抽样检验评定程序解读显示文摘《通风与空调工程施工质量验收规范》(GB 50243-2016)在建筑工程施工质量验收中首次采用基于小总体声称质量水平的抽样检验评定程序。本文介绍了《规范》抽样检验程序的引用背景与依据,阐述了具体抽样检验程序在《规范》中的应用体系,说明了实施《规范》抽样检验程序应注意的问题,并给出了工程实际中应用《规范》抽样检验程序的示例。 | GB 50243-2016编制组 | 2019 | 安装2019，，2： | 2 |
| 15 | 怀俄明州保德河盆地煤田地质显示文摘 | Glass,GB 晓宇 | 1999 | 国外煤田地质1999，，2： | 2 |
| 16 | 贺普丁治疗慢性乙型肝炎的成本-效果分析显示文摘该研究运用中国上海慢性乙型肝炎与肝硬化病人的年总成本和直接医疗成本以及葛兰素史克公司NUCB 30 0 9,NUCB 30 10 ,NUCA 30 10临床研究中的血清转换率与肝硬化转归率 ,分析了贺普丁治疗 1年后的四种成本节约模型。结果显示 :模型Ⅰ采用贺普丁治疗所有慢性乙型肝炎病人一年后 ,每一病人节省的卫生保健成本可抵消 4 6 .3%贺普丁年治疗成本 ;模型Ⅱ采用贺普丁治疗ALT水平高于 2倍正常值的慢性乙型肝炎病人 ,每一病人节省的卫生保健成本可抵消 90 .8%贺普丁年治疗成本 ;模型Ⅲ采用贺普丁治疗ALT水平高于 2倍正常值的慢性乙型肝炎 ,每一病人节省的卫生保健成本可抵消 6 2 .2 %贺普丁年直接医疗成本 ;模型Ⅳ采用贺普丁治疗亚州ALT水平高于 2倍正常值的慢性乙型肝炎病人 ,除可抵消贺普丁年治疗成本外 ,每一病人还可净节省 4 2 6 .9元卫生保健成本。由此可见 ,贺普丁治疗慢性乙型肝炎 | 陈兴宝 Alison Tan Lanrry Lacey Saal GB | 2003 | 中国卫生资源2003，6，5： | 2 |
| 17 | Tissue breakdown and exposure associated with orbital hydroxyapatite implants显示文摘 | Buettner H Bartley GB | 1992 | Am J Ophthalmol1992，113，6： | 2 |
| 18 | Telomerase catalytic subunit homologs from fission yeast and human显示文摘 | Nakamura TM Morin GB Chapman KB | 1997 | Science1997，277，5328： | 2 |
| 19 | SCCT guidelines for the interpretation and reporting of coronary CT angiography: A report of the Society of Cardiovascular Computed Tomography Guidelines Committee显示文摘 | Jonathon Leipsic Suhny Abbara Stephan Achenbach Ricardo Cury James P. Earls GB John Mancini Koen Nieman Gianluca Pontone Gilbert L. Raff | 2014 | Journal of Cardiovascular Computed Tomography2014，，5： | 2 |
| 20 | Adiponectin expression from human adipose tissue: relation to obesity,insulin resistance,and tumor necrosis factor-alpha expression显示文摘 | Kern PA Di Gregorio GB Lu T | 2003 | Diabetes2003，52，7： | 2 |
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