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| 1 | Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals显示文摘ASXL1 变化经常在 hematological 肿瘤被发现,并且 Asxl1 的损失在老鼠支持 myeloid 转变。这里我们在 vivo 在在 Histone H2A (H2AK119ub1 ) 上的 mono-ubiquitylated 离氨酸 119 的 deubiquitylation 为 ASXL1-BAP1 建筑群支持一个角色的现在的数据。Polycomb 组蛋白质在正常开发期间控制 INK4B-ARF-INK4A 地点的表达式,部分地通过催化 H2AK119 的 mono-ubiquitylation。自从地点的激活, INK4B-ARF-INK4A 玩一设有自动保险装置机制免于 tumorigenesis,我们调查了 ASXL1 依赖的 H2A deubiquitylation 是否在它的激活起一个作用。有趣地,我们发现 ASXL1 明确地为 p15 响应 oncogenic 发信号和外来的 anti-proliferative 的 INK4B 发信号。因为我们发现 ASXL1 和 BAP1 两个都在 INK4B 地点被充实,我们的结果建议 INK4B 地点的激活要求 H2AK119ub1 的 ASXL1/BAP1-mediated deubiquitylation。一致地,我们 ASXL1 变化与被联系的结果表演降低 p15 INK4B 和在主要骨头髓房间的造血的祖先的一个 proliferative 优点,和在多重房间线的 ASXL1 的那弄空导致抵抗到生长禁止的信号。一起拿,这研究连接 INK4B 表示的调停 ASXL1 的 H2A deubiquitylation 和 transcriptional 激活到它的肿瘤 suppressor 函数。 | Xudong Wu Ida Holst Bekker-Jensen Jesper Christensen Kasper Dindler Rasmussen Simone Sidoli Yan Qi Yu Kong Xi Wang Yajuan Cui Zhijian Xiao Guogang Xu Kristine Williams Juri Rappsilber Casper Kaae Sonderby Ole Winther Ole N Jensens Kristian Helin | 2015 | Cell Research2015，25，11： | 3 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Field weed population dynamics:a review of model approaches and applications显示文摘 | Holst N Rasmussen I A Bastiaans L | 2007 | Weed Research2007，47，： | 1 |
| 4 | Peripheral markers of brain damage and blood-brain barrier dysfunction 显示文摘 | Marchi N Rasmussen P Kapural M | 2003 | Restor Neurol Neurosci2003，21，34： | 1 |
| 5 | A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies显示文摘 | Jayne D Rasmussen N Andrassy K | 2003 | N Engl J Med2003，349，1： | 1 |
| 6 | A baseline climatology of sounding-derived supercell and tornado forecast pararneters显示文摘 | Rasmussen E N Blanehard D O | 1998 | Weather Forecasing''1998，13，4： | 1 |
| 7 | A vortex particle method for smoke, water and explosions 显示文摘 | SELLE A RASMUSSEN N FEDKIW R | 2005 | ACM Transactions on Graphics (TOG)2005，24，3： | 1 |
| 8 | Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis 显示文摘 | Jayne DR Gaskin G Rasmussen N | 2007 | J Am Soc Nephrol2007，18，7： | 1 |
| 9 | SHRIMP Uranium-lead Dating of Diagenetic Xenotime in Silicialastic Rocks显示文摘 | MCNAUGHTON N J RASMUSSEN B FLETCH- ER I R | 1999 | Science1999，285，： | 1 |
| 10 | Assessment of the Diagnoses of Crohn’s Disease and Ulcerative Colitis in a Danish Hospital Information System显示文摘 | K. Fonager H. Toft S? rensen S. N? rby Rasmussen J. M? ller-petersen M. Vyberg | 1996 | Scandinavian Journal of Gastroenterology1996，，2： | 1 |
| 11 | Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis显示文摘 | Jayne DR Gaskin G Rasmussen N | 2007 | J Am Soc Nephrol2007，18，7： | 1 |
| 12 | Clinical features of obsessive-compulsive disorder显示文摘 | Eisen JL Rasmussen SA | 2000 | Psychiatr Clin North Am2000，23，： | 1 |
| 13 | Field weed population dynamics:a review of model approaches and applications显示文摘 | HOLST N RASMUSSEN IA BASTIAANS L | 2007 | Weed Research2007，47，： | 1 |
| 14 | Trends in the Resistance to Antimicrobial Agents of Streptococcus suis Isolates from Denmark and Sweden显示文摘 | Aarestrup F M Rasmussen Jensen N E | 1998 | Vet Microbiol1998，63，： | 1 |
| 15 | Direct surface thermodynamic observations within the rear-flank downdrafts of non-tornadic and tornadic supercells显示文摘 | Markowski P M Straka J M Rasmussen E N | 2002 | Mon Wea Rev2002，130，7： | 1 |
| 16 | Concrete immersed tunnels-forty years experience显示文摘 | Rasmussen N S | | 0，，01： | 1 |
| 17 | Peripheral markers of brain damage and blood-brain barrier dysfunction显示文摘 | Marchi N Rasmussen P Kapural M | 2003 | Restor Neurol Neurosci2003，21，34： | 1 |
| 18 | Expression of Ror2 mediates invasive phenotypes in renal cell carcinoma 显示文摘 | Rasmussen N R Debebe Z Wright T M | 2014 | PLoS One2014，9，11： | 1 |
| 19 | A safe strategy for addition of vitamins and minerals to foods显示文摘 | RASMUSSEN S E ANDERSEN N L DRAGSTED L O | 2006 | Eur J Nutr2006，45，： | 1 |
| 20 | Mediastinal abscess caused by self - mutilation of the hypopharynx 显示文摘 | Bak NB Rasmussen N | 2010 | Ugeskr Laeger2010，172，21： | 1 |
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