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| 1 | 中耳炎显示文摘中耳炎是儿童的高发病。中耳炎的病因病理是多因素的,包含免疫反应、咽鼓管功能障碍、细菌和病毒的感染、遗传以及环境因素等。早期的观察适用于大多数中耳炎儿童;对于被确诊为急性中耳炎的两岁以内的患儿,建议使用抗生素。手术方法的选择取决于合并症、儿童的生长发育状况以及对自发性渗出液的预期估计。推荐的手术方法有鼓室置管术、腺样体刮除术等。然而,到目前还没有理想的治疗方法,需要探索新的、基于现代中耳炎的病因病理理论的有创意性的治疗方法。 | Rovers MM Schilder AG Zielhuis GA Rosenfeld RM 张江平 杨妙丽 张全安 | 2005 | 国外医学(耳鼻咽喉科学分册)2005，29，3： | 427 |
| 2 | Clinical analysis of propofol deep sedation for 1,104 patients undergoing gastrointestinal endoscopic procedures:A three year prospective study显示文摘瞄准:在经历 gastros 拷贝和结肠镜检查的病人上分析 propofol 的血液动力学、呼吸的效果。方法:在这未来的研究,在三年的一个时期上进行了, 1,104 个病人参考了一一样的天官方补给的内视镜检查法过程被分析。所有病人被给一丸 propofol 大丸药(0.5-1.5 mg/kg ) 。动脉的血压(BP ) 在 3 min 间隔和心搏率被监视,氧饱和(SpO2 ) 被脉搏血氧定量法连续地记录。分析数据获得以前被执行,在期间,并且在过程以后。结果:在吝啬的动脉压的统计上重要的减小被表明(P <
0.001 ) 什么时候与干预前价值,而是严重低血压相比,在 60 毫米汞柱下面定义为收缩血压,在仅仅 5 个病人(0.5%) 被注意。氧饱和从 96.5% ~ 94.4 % 减少了(P <
0.001 ) 。在氧饱和的批评减少(<
90%) 在 27 个病人(2.4%) 被记录。结论:如果小心地滴定,我们的结果证明 propofol 向好镇静提供了优秀疼痛控制,短复原时间和没有重要血液动力学的副作用。所有病人(并且特别 ASA III 组) 要求监视并且一个麻醉学者关心。 | Stojanka Gaparovi Nadan Rustemovi Milorad Opai Marina Premuzi Andelko Korui Jadranka Bozikov Tamara Bates | 2006 | World Journal of Gastroenterology2006，12，2： | 41 |
| 3 | 植物激素与马铃薯块茎形成显示文摘综述了近年来马铃薯块茎形成与植物激素关系的研究进展以及不同激素在块茎形成中的作用,提出块茎形成是多种激素共同调节的,对今后的研究方向进行了讨论。 | 郭得平 应振土 Shah GA | 1991 | 植物生理学通讯1991，27，2： | 35 |
| 4 | Etelcalcetide治疗继发性甲状旁腺功能亢进的随机对照3期临床试验显示文摘矿物质代谢紊乱是终末期肾病(ESRD)患者最具挑战性的临床问题之一。从早期阶段开始,慢性肾脏病(CKD)即开始增加成纤维细胞生长因子23(FGF23)的循环浓度, | Block GA Bushinsky DA Cunningham J 王建中 | 2017 | 中华肾病研究电子杂志2017，6，1： | 33 |
| 5 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 6 | Inhibition of 12-lipoxygenase reduces proliferation and induces apoptosis of hepatocellular carcinoma cells in vitro and in vivo显示文摘BACKGROUND:12-lipoxygenase(12-LOX) has been reported to be an important gene in cancer cell proliferation and survival,and tumor metastasis.However,its role in hepatocellular carcinoma(HCC) cells remains unknown.METHODS:Expression of 12-LOX was assessed in a diethylnitrosamine-induced rat HCC model,and in SMMC-7721,HepG2 and L-02 cells using immunohistochemical staining and reverse transcriptase-polymerase chain reaction(RT-PCR).GST-π and Ki-67 were determined in vivo by immunohistochemical staining.Apoptosis was evaluated by TUNEL assay.Cell viability and apoptosis were determined by MTT assay and flow cytometry,respectively.Apoptosis-related proteins in SMMC-7721 and HepG2 cells were detected by Western blotting.RESULTS:Immunohistochemical staining and RT-PCR showed that 12-LOX was over-expressed in rat HCC and two HCC cell lines,while the expression was inhibited by baicalein,a specific inhibitor of 12-LOX.Baicalein inhibited cell proliferation and induced apoptosis in rat HCC and both cell lines in a dose-and time-dependent manner.Our in vivo study demonstrated that baicalein also reduced neoplastic nodules.Mechanistically,baicalein reduced Bcl-2 protein expression coupled with a slight increase of the expression of Bax and activation of caspase-3.Furthermore,baicalein inhibited the activation of ERK-1/2(phosphorylated).Interestingly,the effects of baicalein were reversed by 12(S)-HETE,a metabolite of 12-LOX.CONCLUSIONS:Inhibition of 12-LOX leads to reduced numbers of HCC cells,partially caused by increased apoptosis.12-LOX may be a potential molecular target for HCC prevention and treatment. | Xi-Ming Xu,Guang-Jin Yuan,Jun-Jian Deng,Hong-Ting Guo,Miao Xiang,Fang Yang,Wei Ge and Shi-You Chen Cancer Center, Renmin Hospital of Wuhan University, Wuhan 430060, China Cancer Center, the 82nd Hospital of the Chinese PLA, Huai’an 223001, China Department of Physiology, Medical College of Wuhan University, Wuhan 430071, China Department of Physiology & Pharmacology, University of Georgia, Athens, GA 30602, USA | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，2： | 20 |
| 7 | 吸烟是卒中的危险因素显示文摘大量流行病学研定证实吸烟与卒中尤其是与缺血性卒中和蛛网膜下腔出血密切相关,但吸烟是不是原发性脑出血的危险因素尚不能肯定,吸烟与各类卒中的关系尚需积累更多的资料。 | GA Donnan 陈兴洲 | 1995 | 国外医学(脑血管疾病分册)1995，3，3： | 18 |
| 8 | 颈椎前路减压术合并椎动脉损伤显示文摘目的 探讨颈椎前路减压术中椎动脉损伤的危险因素及其处理方法。方法 1980年 1月~ 1998年 12月,对 720例患者行颈椎前路减压术,减压范围包括 1~ 3个椎间隙并行椎体次全切除。术中采用高速磨钻切除骨及椎间盘组织。 630例患者同时行颈椎前路 Caspar钢板内固定术。 3例行椎间减压时向侧方切除过多,导致椎动脉损伤,采用明胶海绵加游离肌片局部填塞止血。结果 720例中椎动脉损伤发生率为 0.4%, 3例均压迫止血成功,无一例出现脑缺血等神经系统症状。结论 颈椎前路减压时不应跨越钩椎关节,局部明胶海绵加游离肌片填塞是有效的椎动脉止血方法。 | 任先军 Caspar W Fuchs GA | 2000 | 中华骨科杂志2000，20，8： | 16 |
| 9 | Change in subfoveal choroidal thickness after argon laser panretinal photocoagulation显示文摘AIM:To evaluate changes in subfoveal choroidal thickness(SFCT) and macular thickness as measured by enhanced depth imaging spectral-domain optical coherence tomography(EDI-OCT) after argon laser panretinal photocoagulation(PRP) in patients with severe diabetic retinopathy.·METHODS:This prospective,comparative case series included 21 patients(28 eyes) with severe diabetic retinopathy.All patients underwent three sessions of PRP.The SFCT and macular thickness were measured using EDI-OCT at baseline and one week after completion of 3 sessions of PRP.·RESULTS:SFCT before PRP was(318.1±96.5)μm and increased to(349.9 ±108.3)μm(P =0.001) after PRP.Macular thickness significantly increased at one week after PRP(from 273.1 ±23.9μm at baseline vs 295.8 ±25.3μm at one week;P <0.001).No significant relationship between the changes in macular thickness and SFCT was observed(r =-0.13,P =0.52).·CONCLUSION:PRP induced increases in both SFCT and macular thickness.Changes in SFCT did not correlate with changes in macular thickness. | Ga Eun Cho Hee Yun Cho Yun Taek Kim | 2013 | International Journal of Ophthalmology(English edition)2013，6，4： | 14 |
| 10 | WONCA研究论文摘要汇编——阿奇霉素和左氧氟沙星增加心律失常及死亡风险显示文摘目的:使用阿奇霉素增加高危患者的死亡风险,但对青年人和中年人的影响不大。美国食品和药品管理局对阿奇霉素的使用发出警告,其风险与左氧氟沙星类似。本研究针对美国退伍军人进行了回顾性的群组研究,提出了与阿莫西林相比,阿奇霉素和左氧氟沙星增加了心血管病的死亡和心律失常风险的假设。 | Rao GA Mann JR Shoaibi A 周淑新 | 2014 | 中国全科医学2014，17，20： | 13 |
| 11 | Potential mechanisms of hepatitis B virus induced liver injury显示文摘Chronic active hepatitis(CAH) is acknowledged as an imperative risk factor for the development of liver injury and hepatocellular carcinoma.The histological end points of CAH are chronic inflammation,fibrosis and cirrhosis which are coupled with increased DNA synthesis in cirrhotic vs healthy normal livers.The potential mechanism involved in CAH includes a combination of processes leading to liver cell necrosis,inflammation and cytokine production and liver scaring(fibrosis).The severity of liver damage is regulated by Hepatitis B virus genotypes and viral components.The viral and cellular factors that contribute to liver injury are discussed in this article.Liver injury caused by the viral infection affects many cellular processes such as cell signaling,apoptosis,transcription,DNA repair which in turn induce radical effects on cell survival,growth,transformation and maintenance.The consequence of such perturbations is resulted in the alteration of bile secretion,gluconeogenesis,glycolysis,detoxification and metabolism of carbohydrates,proteins,fat and balance of nutrients.The identification and elucidation of the molecular pathways perturbed by the viral proteins are important in order to design effective strategy to minimize and/or restore the hepatocytes injury. | Mohd Suhail Hany Abdel-Hafiz Ashraf Ali Kaneez Fatima Ghazi A Damanhouri Esam Azhar Adeel GA Chaudhary Ishtiaq Qadri | 2014 | World Journal of Gastroenterology2014，20，35： | 12 |
| 12 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 13 | Interferon-c and interleukin-4 detected in serum and saliva from patients with oral lichen planus显示文摘Our previous salivary study had demonstrated an apparent T helper 2(Th2)-predominance in saliva of oral lichen planus(OLP) patients and suggested a potential of salivary interleukin-4(IL-4) as a biomarker for monitoring disease severity. To further determine the consistency of Th1/Th2 bias of OLP, this study investigated the expression profile of interferon-c(IFN-c) and IL-4 in serum and the relationship of the serum levels of these cytokines with their saliva partners. Sixty ethnic Chinese patients with OLP(40 of the erythematous/ulcerative form and 20 of the reticular form) were recruited for this study, with 40 age–sex-matched healthy volunteers as control group. IFN-c and IL-4 levels in serum and paired saliva samples were screened by enzyme-linked immunosorbent assay. OLP patient showed a low-level IFN-c but high-level IL-4 expression profile in both serum and saliva, with a lower IFN-c/IL-4 ratio. Serum IL-4 level in the erythematous/ulcerative group was significantly higher than that in the reticular group. Serum levels of IFN-c and IL-4 were significantly and positively correlated with their saliva partners. These results provided more evidence for Th2 cytokinepredominant immune imbalance in OLP, as well as the potential of IL-4 as the biomarker for monitoring severity of OLP. | Wen-Zhao Liu Ming-Jing He Long Long Dong-Liang Mu Ming-Shu Xu Xue Xing Xin Zeng Ga Liao Hong-Xia Dan Qian-Ming Chen | 2014 | International Journal of Oral Science2014，6，1： | 10 |
| 14 | Magnetic nanoparticles based cancer therapy: current status and applications显示文摘Nanotechnology holds a promising potential for developing biomedical nanoplatforms in cancer therapy. The magnetic nanoparticles, which integrate uniquely appealing features of magnetic manipulation, nanoscale heat generator, localized magnetic field and enzyme-mimics, prompt the development and application of magnetic nanoparticles-based cancer medicine. Considerable success has been achieved in improving the magnetic resonance imaging(MRI) sensitivity, and the therapeutic function of the magnetic nanoparticles should be given adequate attention. This work reviews the current status and applications of magnetic nanoparticles based cancer therapy. The advantages of magnetic nanoparticles that may contribute to improved therapeutics efficacy of clinic cancer treatment are highlighted here. | Huan Zhang Xiao Li Liu Yi Fan Zhang Fei Gao Ga Long Li Yuan He Ming Li Peng Hai Ming Fan | 2018 | Science China(Life Sciences)2018，61，4： | 8 |
| 15 | In-plane bistatic backward scattering from seabottom with randomly inhomogeneous sediment and rough interface显示文摘The in-plane bistatic backward scattering caused by seabottom with random inhomogeneities and rough interface is studied. This work combines the ray tube integral method of Ivakin et al. and the complex-ray/steepest descent method of Hines. For a given incident grazing angle, the theoretical expression can easily be used to calculate scattering strength for different backward scattering angles. (This is essential for modeling shallow water reverberation by the normal mode approach.) The model is tested against published scattering measurements. The frequency/angle dependence of backward scattering and effects of volume inhomogeneity parameters on backward scattering are also discussed. | PENG Zhaohui1,,ZHOU Jixun1,& ZHANG Renhe1 2 2 1.Institute of Acoustics,Chinese Academy of Sciences,Beijing 100080,China 2.School of Mechanical Engineering,Georgia Institute of Technology,Atlanta,GA 30332,USA | 2004 | Science China(Physics,Mechanics & Astronomy)2004，47，6： | 8 |
| 16 | Honokiol:a promising small molecular weight natural agent for the growth inhibition of oral squamous cell carcinoma cells显示文摘Honokiol (HNK) is a small organic molecule purified from magnolia species and has demonstrated anticancer activities in a variety of cancer cell lines; however, its effect on oral squamous cell carcinoma (OSCC) cells is unknown. We investigated the antitumor activities of HNK on OSCC cells in vitro for the first time. The inhibitory effects of HNK on the growth and proliferation of OSCC cells were demonstrated via in vitro 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and propidium iodide (PI) assays, and the apoptotic cells were investigated by the observation of morphological changes and detection of DNA fragmentation via PI, TdT-mediated dUTP-biotin nick end labeling (TUNEL), and DNA ladder assays, as well as flow cytometry assay. The results showed that HNK inhibited the growth and proliferation of OSCC cells in vitro in a time and dose-dependent manner. The inhibitory effect was associated with the cell apoptosis induced by HNK, evidenced by the morphological features of apoptotic cells, TUNEL-positive cells and a degradation of chromosomal DNA into small internucleosomal fragments. The study also demonstrated here that the inhibition or apoptosis mediated by 15 μg·mL-1 or 20 μg·mL-1 of HNK were more stronger compared with those of 20 μg·mL-1 5-fluorouracil (5-Fu, the control) applied to OSCC cells, when the ratio of OSCC cell numbers were measured between the treatment of different concentrations of HNK to the 5-Fu treatment for 48 h. HNK is a promising compound that can be potentially used as a novel treatment agent for human OSCC. | Xi-rui Chen Rui Lu Hong-xia Dan Ga Liao Min Zhou Xiao-yu Li Ning Ji | 2011 | International Journal of Oral Science2011，3，1： | 8 |
| 17 | The Oral Microbiome Bank of China显示文摘The human microbiome project(HMP) promoted further understanding of human oral microbes. However, research on the human oral microbiota has not made as much progress as research on the gut microbiota. Currently, the causal relationship between the oral microbiota and oral diseases remains unclear, and little is known about the link between the oral microbiota and human systemic diseases. To further understand the contribution of the oral microbiota in oral diseases and systemic diseases, a Human Oral Microbiome Database(HOMD) was established in the US. The HOMD includes 619 taxa in 13 phyla, and most of the microorganisms are from American populations. Due to individual differences in the microbiome, the HOMD does not reflect the Chinese oral microbial status. Herein, we established a new oral microbiome database—the Oral Microbiome Bank of China(OMBC,http://gffzz1f92d53390b34408hwcpo0699cpn66b0x.ffgz.tsg.suse.edu.cn/ombc). Currently, the OMBC includes information on 289 bacterial strains and 720 clinical samples from the Chinese population, along with lab and clinical information. The OMBC is the first curated description of a Chinese-associated microbiome; it provides tools for use in investigating the role of the oral microbiome in health and diseases, and will give the community abundant data and strain information for future oral microbial studies. | Xian Peng Xuedong Zhou Xin Xu Yuqing Li Yan Li Jiyao Li Xiaoquan Su Shi Huang Jian Xu Ga Liao | 2018 | International Journal of Oral Science2018，10，2： | 8 |
| 18 | Analysis of combustion instability via constant volume combustion in a LOX/RP-1 bipropellant liquid rocket engine显示文摘Turbulent two-phase reacting flow in the chamber of LOX/RP-1 bipropellant liquid rocket engine is numerically investigated in this paper. The predicted pressure and mean axial velocity are qualitatively consistent with the experimental measurements. The self-excited pressure oscillations are obtained without any disturbance introduced through the initial and boundary conditions. It is found that amount of abrupt pressure peaks appear frequently and stochastically in the head regions of the chamber, which are the important sources to drive and strengthen combustion instability. Such abrupt pressures are induced by local constant volume combustion, because local combustible gas mixtures with high temperature are formed and burnt out suddenly due to some fuel droplets reaching their critical state in a rich oxygen surrounding. A third Damkhler number is defined as the ratio of the characteristic time of a chemical reaction to the characteristic time of a pressure wave expansion to measure the relative intensity of acoustic propagation and combustion process in thrusters. The analysis of the third Damkhler number distributions in the whole thrust chamber shows that local constant volume combustion happens in the head regions, while constant pressure combustion presents in the downstream regions. It is found that the combustion instability occurs in the head regions within about 30 mm from the thruster head. | ZHANG HuiQiang GA YongJing WANG Bing WANG XiLin | 2012 | Science China(Technological Sciences)2012，55，4： | 8 |
| 19 | 再发性低血糖致幼鼠脑损伤的实验研究显示文摘目的探讨再发性低血糖幼鼠脑Caspase-3表达及神经元变性的动态变化。方法将48只15日龄C57BL/6野生型小鼠,分为正常对照组(n=8)及低血糖组(n=40),再分为低血糖后12h,24h,48h,72h组,每组10只)。低血糖组给予短效胰岛素腹腔注射3次,每次剂量为5U/kg。采用免疫组化方法观察小鼠脑内caspase-3表达的动态变化;FJB染色观察小鼠脑内神经元变性的时程及分布情况。结果再发性低血糖后12h幼鼠脑内caspase-3表达即增多,24h达高峰,至72h仍高于正常对照组;开始阳性染色主要位于细胞质,以后逐渐向细胞核转移,caspase-3表达最强的部位是海马齿状回,皮质次之,海马CA1区仅见少量caspase-3阳性细胞。再发性低血糖后12h,脑内即可见FJB阳性细胞,24h及48hFJB阳性细胞逐渐增多,至72h阳性细胞最多,染色最强;从分布上看,纹状体内FJB阳性细胞数最多(尤以枕部皮质与纹状体交界处为著),皮质次之,海马回仅见少量FJB阳性细胞。结论再发性低血糖可致幼鼠脑损伤,神经元凋亡与坏死并存,易损部位为海马齿状回、枕部皮质与纹状体交界处,以选择性神经元死亡为主。 | 辛颖 WERTHER GA RUSSO VC | 2006 | 中国现代医学杂志2006，16，5： | 6 |
| 20 | Effects of salinity on methane gas hydrate system显示文摘Using an approximately analytical formation, we extend the steady state model of the pure methane hydrate system to include the salinity based on the dynamic model of the methane hydrate system. The top and bottom boundaries of the methane hydrate stability zone (MHSZ) and the actual methane hy-drate zone (MHZ), and the top of free gas occurrence are determined by using numerical methods and the new steady state model developed in this paper. Numerical results show that the MHZ thickness becomes thinner with increasing the salinity, and the stability is lowered and the base of the MHSZ is shifted toward the seafloor in the presence of salts. As a result, the thickness of actual hydrate occur-rence becomes thinner compared with that of the pure water case. On the other hand, since lower solubility reduces the amount of gas needed to form methane hydrate, the existence of salts in sea-water can actually promote methane gas hydrate formation in the hydrate stability zone. Numerical modeling also demonstrates that for the salt-water case the presence of methane within the field of methane hydrate stability is not sufficient to ensure the occurrence of gas hydrate, which can only form when the methane concentration dissolved in solution with salts exceeds the local methane solubility in salt water and if the methane flux exceeds a critical value corresponding to the rate of diffusive methane transport. In order to maintain gas hydrate or to form methane gas hydrate in marine sedi-ments, a persistent supplied methane probably from biogenic or thermogenic processes, is required to overcome losses due to diffusion and advection. | YANG DingHui1 & XU WenYue2 1 Department of Mathematical Sciences, Tsinghua University, Beijing 100084, China 2 School of Earth & Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA | 2007 | Science China Earth Sciences2007，50，11： | 5 |
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