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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Common variation in the LMNA gene (encoding lamin A/C) and type 2 diabetes - Association analyses in 9,518 subjects显示文摘 | Owen, KR Groves, CJ Hanson, RL Knowler, WC Shuldiner, AR Elbein, SC Mitchell, BD Froguel,P Ng, MCY Chan, JC Jia, WP Deloukas, P Hitman, GA Walker, M Frayling, TM Hattersley, AT Zeggini, E McCarthy, MI | 2007 | 中国生物学文摘2007，21，11： | 2 |
| 3 | Meta-analysis of the studies assessing temporal changes in coronary plaque volume using intravascular ultrasound显示文摘 | Agostoni P Garcia-Garcia HM | 2007 | Am J Cardiol2007，99，： | 1 |
| 4 | Ventricular late potentials: a critical overview and current applications 显示文摘 | Santangeli P Infusino F Sgueglia GA | 2008 | Journal of Electrocardiology2008，41，： | 1 |
| 5 | Carcinoma of the vagi- na-experience at the princess margaret hospital显示文摘 | Kirkbride P Fyles A Rawlings GA | 1995 | Gynecol On- col1995，56，： | 1 |
| 6 | Glucose induce beta-cell apoptosis via upregulation of the Fas receptor in human islets显示文摘 | Maedler K Spinas GA Lehmann R Sergeev P Weber M Fontana A | 2001 | Diabetes2001，50，8： | 1 |
| 7 | Detection of extended-spectrum beta-lactamases in clinical isolates of Klebsiella pneumoniae and Escherichia coli显示文摘 | Jacoby GA Han P | 1996 | J Clin Microbiol1996，34，： | 1 |
| 8 | Human brain activity related to speed discrimination tasks显示文摘 | Orban GA Dupont P De Bruyn B | 1998 | Exp Brain Res1998，122，1： | 1 |
| 9 | Mortality effect of coronary calcification and phosphate binder choice in incident hemodialysis patients显示文摘 | Block GA Raggi P Bellasi A | 2007 | Kidney Int2007，71，5： | 1 |
| 10 | Serum cystatin C is sen- sitive to small changes in thyroid function 显示文摘 | Wiesli P Schwegler B Spinas GA | 2003 | Clin Chin Acta2003，338，12： | 1 |
| 11 | Minimally elevated cardiac troponin T and elevated N terminal B-type natriuretic peptide predict mortality in older adults:results from the Rancho Study显示文摘 | Daniels LB Lauphlin GA Clopton P | | 0，，06： | 1 |
| 12 | Comparative analysis of flow eytometry and polymerase chain reaction for the detection of minimal residual disease in childhood acute lymphoblastic leukemia显示文摘 | Neale GA Coustan-Smith E Stow P Pan Q Chen X Pui CH Campana D | 2004 | Leukemia2004，18，5： | 1 |
| 13 | Relaxin increases ubiquitin-dependent degradation of fibronectin in vitro and ameliorates renal fibrosis in vivo 显示文摘 | Mcdonald GA Sarkar P Rennke H | 2003 | Am J Physiol Renal Physiol2003，285，1： | 1 |
| 14 | Non-epileptic attack disorder (NEAD):a comprehensive review显示文摘 | Francis P Bader GA | 1999 | Seizure1999，8，： | 1 |
| 15 | Involvement of DNA methylation in memory processing in the honey bee 显示文摘 | Lockett GA Helliwell P Maleszka R | 2010 | Neuroreport2010，21，12： | 1 |
| 16 | Serum cystatin C is sensitive to small changes in throid function显示文摘 | Wiesli P Schwegler B Spinas GA | 2003 | Clin Chim Acta2003，338，12： | 1 |
| 17 | Coronary arteryremodelling is related to plaque composition显示文摘 | GA Rodriguez-Granillo P W Serruys H M Garcia- Garcia | 2006 | Heart2006，92，1： | 1 |
| 18 | The pathophysiology of the aqueduct stroke volume in normal pressure hydrocephalus: can co- morbidity with other forms of dementia be excluded显示文摘 | Bateman GA Levi CR Schofield P | 2005 | Neuroradiol- ogy2005，47，： | 1 |
| 19 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 20 | Testing intravitreal toxicity of bevacizumab (Avastin)显示文摘 | Manzano RP Peyman GA Khan P Kivilcim M | 2006 | Retina2006，26，3： | 1 |
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