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| 1 | 利拉鲁肽与格列美脲在单药治疗2型糖尿病中的比较(LEAD-3 Mono):一项随机、双盲、平行分组、52周的Ⅲ期临床试验显示文摘背景 2型糖尿病新的治疗策略,需要针对胰岛素-葡萄糖的相互作用,且同时要降低体重增加和发生低血糖的风险。本文作者旨在调查利拉鲁肽单药治疗2型糖尿病的安全性与有效性。
方法 采用双盲、双模拟、治疗一对照、平行分组的研究,746例早期2型糖尿病患者被随机分配到1次/d利拉鲁肽组[1.2mg(n=251)或1.8mg(n=247)]或格列美脲8mg组(n=248),分别治疗52周。主要结局指标为糖化血红蛋白(HbA1c)的改变程度。采用意向性治疗进行分析。该试验在ClinicalTrials.gov网站的注册编码为NTC00294723.
结果52周时,格列美脲组HbA,。下降了0.51%(s=1.20),而利拉鲁肽1.2mg组下降了0.84%(s=1.23)(差值为-0.33.95%CI-0.53~-0.13;P=0.0014),利拉鲁肽1.8mg组下降了1.14%(S=1.24)(差值为-062,95%CI-0.83—-0.42;P〈0.0001)。利拉鲁肽1.2mg组和1.8mg组各有5例和1例患者因呕吐停止治疗,而格列美脲组未出现这种情况。
结论 利拉鲁肽作为2型糖尿病的初始治疗药物安全有效,与格列美脲相比更能降低HbA1c以及体重、血压和低血糖的发生率。 | Alan Garber Robert Henry Robert Rather Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvero-Alvarez Paula M Hale, Milan Zdravkovic Bruce Bode 邓斌(译) | 2009 | 世界临床医学2009，，6： | 5 |
| 2 | Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial显示文摘 | Alan Garber Robert Henry Robert Ratner Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvera-Alvarez Paula M Hale Milan Zdravkovic Bruce Bode | 2009 | The Lancet2009，，9662： | 2 |
| 3 | Stomach contents of juvenile Cobia, Rachycentron canadum, from the northern Gulf of Mexico 显示文摘 | Franks J S Garber N M Warren J R | 1996 | Fishery Bulletin1996，94，2： | 1 |
| 4 | American Associa- tion of Clinical Endocrinologists' comprehensive diabetes manage- ment algorithm 2013 consensus statement-executive summary显示文摘 | Garber A J Abrahamson M J Barzilay J I | 2013 | Endocr Praet2013，19，3： | 1 |
| 5 | Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters 显示文摘 | Cliffe A R Garber D A Knipe D M | 2009 | J Virol2009，83，16： | 1 |
| 6 | Itraconazole(IT)compared with amphotericin B (AMB)as empirical therapy for persistent fever of unknown origin(FUO)in neutropenic patients(PTS)显示文摘 | Boogaerts M Garber G Winston D | 1999 | Bone Marrow Transplant1999，23，1： | 1 |
| 7 | The guanylyl cyclase-deficient mouse defines differential pathways of natriuretic peptide signaling显示文摘 | LOPEZ M J GARBERS D L KUHN M | 1997 | J Biol Chem1997，272，37： | 1 |
| 8 | Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: Guidance for prescribing exercise显示文摘 | Garber C E Blissmer B Deschenes M R | 2011 | Medicine & Science in Sports & Exercise2011，43，7： | 1 |
| 9 | Ab initio reconstruction of cell type-specific transcriptomes in mouse reveals the conserved muhi-exonie structure of lincRNAs显示文摘 | Guttman M Garber M Levin JZ | 2010 | Nat Biotechnol2010，28，5： | 1 |
| 10 | AmericanAs- sociation of Clinical Endocrinologists comprehensive dia- betesmanagement algorithm 2013 consensus statementexecu- tivesummaryl显示文摘 | Garber A J Abrahamson M J Barzilayj I | 2013 | Endocr Pract2013，47，19： | 1 |
| 11 | Oral poly(ADP-ribose) polymer- ase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial 显示文摘 | Tutt A Robson M Garber JE | 2010 | Lancet2010，376，9737： | 1 |
| 12 | Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome显示文摘 | Frebourg T Barbier N Yan Y X Garber J E Dreyfus M Fraumeni J | 1995 | Am J Human Genet1995，56，： | 1 |
| 13 | Two-stage versus one-stage-is there really a controversy 显示文摘 | GARBER D A SALAMA H S ALAMA M A | 2001 | J Periodentol2001，72，3： | 1 |
| 14 | Length-based conjugacy search in the braid group 显示文摘 | GARBER D KAPLAN S TEICHER M | 2006 | Contemp Math2006，418，： | 1 |
| 15 | Feasibility of immunodiagnostic devices for the detection of ricin, amanitin, and T-2 toxin in food显示文摘 | GARBER E A EPPLEY R M STACK M E | 2005 | Journal of Food Protection2005，68，： | 1 |
| 16 | Theoretical analysis of the stability of slopes显示文摘 | Baker R Garber M | 1978 | Geotechnique1978，28，4： | 1 |
| 17 | Bearing capacity by variational method显示文摘 | Garber M Baker R | 1977 | Journal of Geotechnical Engineering Division ASCE1977，103，11： | 1 |
| 18 | AACE Comprehen- sive Diabetes Management Algorithm 2013显示文摘 | Garber A J Abrahamson M J Barzilay JI | 2013 | Endocr Pract2013，19，2： | 1 |
| 19 | Oral poly(ADP-ribose) poly- merase inhibitor olaparib in patients with BRCA1 or BRCA2 muta- tions and advanced breast cancer: a proof-of-concept trial 显示文摘 | Tutt A Robson M Garber JE | 2010 | Lan- cet2010，376，9737： | 1 |
| 20 | Preoperative cere- bral oxygen saturation and clinical outcomes in cardiac surgery 显示文摘 | Heringlake M Garbers C Kabler JH | 2011 | Anesthesiology2011，114，1： | 1 |
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