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| 1 | Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1显示文摘17β-estradiol (E2) treatment of cells results in an upregulation of SIRT1 and a down-regulation of PPARγ. The decrease in PPARγ expression is mediated by increased degradation of PPARγ. Here we report that PPARγ is ubiquitinated by HECT E3 ubiquitin ligase NEDD4-1 and degraded, along with PPARγ, in response to E2 stimulation. The PPARγ interacts with ubiquitin ligase NEDD4-1 through a conserved PPXY-WW binding motif. The WW3 domain in NEDD4-1 is critical for binding to PPARΓ. NEDD4-1 overexpression leads to PPARγ ubiquitination and reduced expression of PPARγ. Conversely, knockdown of NEDD4-1 by specific siRNAs abolishes PPARΓ ubiquitination. These data indicate that NEDD4-1 is the E3 ubiquitin ligase responsible for PPARγ ubiquitination. Here, we show that NEDD4-1 delays cellular senescence by degrading PPARΓ expression. Taken together, our data show that E2 could upregulate SIRT1 expression via promoting the PPARΓ ubiquitination-proteasome degradation pathway to delay the process of cell senescence. | Limin Han Pan Wang Ganye Zhao Hui Wang Meng Wang Jun Chen Tanjun Tong | 2013 | Protein & Cell2013，4，4： | 3 |
| 2 | Distiguishing neurogenic from non-neurogenic destrusor of lower uninary tract symptoms in patients with and without parkinsons disease显示文摘 | Gina A Ganye D | 2003 | Urology2003，62，4： | 1 |
| 3 | Cytotoxicity of Novel Sulfanilamides Towards Sensitive and Multidrugresistant Leukemia Cells显示文摘 | T. AlSalim M.E.M. Saeed J.S. Hadi M. Zeino R. Gany O. Kadioglu S.J.J. Titinchi H.S. Abbo T. Efferth | 2014 | Current Medicinal Chemistry2014，，23： | 1 |
| 4 | Two-Phase marine ramjet propulsion research显示文摘 | Gany A | | 0，，02： | 1 |
| 5 | High speed bubbly nozzle flow with heat,mass,and momentum interactions显示文摘 | Albagli D Gany A | | 0，，11： | 1 |
| 6 | The twofactor structure of future-oriented coping and its mediating role in student engagement显示文摘 | GanY YangM ZhouY ZhangY | 2007 | Personality and Individual Difference2007，43，4： | 1 |
| 7 | Chlamydia, Mycoplasma and Ureaplasma infections in infertile couples and effects of these infections on fertility显示文摘 | Ganyeli Abike F Dander I | 2011 | Arch Gynecol Obstet2011，283，2： | 1 |
| 8 | Investigation of a solid fuel scramjet combustor显示文摘 | Ben Y A Natan B Gany A | | 0，，04： | 1 |
| 9 | Combustion of activated aluminum显示文摘 | Hahma A Gany A | | 0，，： | 1 |
| 10 | Analysis and testing of similarity and scale effects in hybrid rocket motors显示文摘 | Rajeshwar Dayal Swami Alon Gany | 2002 | Acta Astronautica2002，，8： | 1 |
| 11 | Geometric effects on the combustion in solid fuel ramjet显示文摘 | Zvuloni R Gany A Levy Y | | 0，，01： | 1 |
| 12 | Burning and flameholding characteristics of a miniature solid fuel ramjet combustor显示文摘 | Gany A Netzer A | | 0，，05： | 1 |
| 13 | Theoretical study of a solid fuel scramjet combustor显示文摘 | Rachel Ben-Arosh Benveniste Natan Elyeser Spiegler Alon Gany | 1999 | Acta Astronautica1999，，3： | 1 |
| 14 | Arab American immigrants in New York:Health care and cancer knowledge,attitudes,and beliefs显示文摘 | Shah S.M Ayash C Pharaon N.A Gany F.M | | 0，，： | 1 |
| 15 | Burning and Flame-holding Characteristics of a Miniature Solid Fuel Ramjet Combustor显示文摘 | Amnon Netzer Aoln Gany | | 0，，3： | 1 |
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