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| 1 | Cancer stem cell impact on clinical oncology显示文摘Cancer is a widespread worldwide chronic disease. In most cases, the high mortality rate from cancer correlates with a lack of clear symptoms, which results in late diagnosis for patients, and consequently, advanced tumor disease with poor probabilities for cure, since many patients will show chemo-and radio-resistance. Several mechanisms have been studied to explain chemo-and radio-resistance to anti-tumor therapies, including cell signaling pathways, anti-apoptotic mechanisms, stemness, metabolism, and cellular phenotypes. Interestingly, the presence of cancer stem cells(CSCs), which are a subset of cells within the tumors, has been related to therapy resistance. In this review, we focus on evaluating the presence of CSCs in different tumors such as breast cancer, gastric cancer, lung cancer, and hematological neoplasias, highlighting studies where CSCs were identified in patient samples. It is evident that there has been a great drive to identify the cell surface phenotypes of CSCs so that they can be used as a tool for anti-tumor therapy treatment design. We also review the potential effect of nanoparticles, drugs, natural compounds, aldehyde dehydrogenase inhibitors, cell signaling inhibitors, and antibodies to treat CSCs from specific tumors. Taken together, we present an overview of the role of CSCs in tumorigenesis and how research is advancing to target these highly tumorigenic cells to improve oncology patient outcomes. | Mariel E Toledo-Guzmán Gabriele D Bigoni-Ordonez Miguel Ibanez Hernandez Elizabeth Ortiz-Sánchez | 2018 | World Journal of Stem Cells2018，10，12： | 4 |
| 2 | Dexamethasone mediates protection against acute pancreatitis via upregulation of pancreatitis-associated proteins显示文摘AIM: To examine the influence of dexamethasone on pancreatitis-associated protein (PAP) gene expression using both in vitro and in vivo models of acute pancreati- tis and to study how PAP gene expression correlates with severity of pancreatitis. METHODS: In vitro, IL-6 stimulated pancreas acinar AR42J cells were cultured with increasing concentrations of dexamethasone and assayed for PAP expression (RT-PCR). In vivo , pancreatitis was induced in rats by retrograde injection of 40 g/L taurocholate into the pancreatic duct. Animals were pretreated with dexamethasone (2 mg/kg) daily or saline for 4 d. Pancreata and serum were harvested after 24 h and gene expression levels of PAPⅠ, Ⅱ and Ⅲ were measured by RT-PCR. Severity of pancreatitis was based on serum amylase, pancreatic wet weight, and histopathological score. RESULTS: In vitro, dexamethasone and IL-6 induced a marked transcription of PAPⅠ, Ⅱ and Ⅲ genes in AR42J cells at 24 h (P < 0.05 for all comparisons). In vivo, pancreas mRNA levels of PAPⅠ, Ⅱ or Ⅲ increased by 2.6-fold, 1.9-fold, and 1.3-fold respectively after dexa- methasone treatment, compared with saline treated ani- mals. Serum amylase levels and edema were significantly lower in the dexamethasone group compared with the saline group. Histopathologic evaluation revealed less inflammation and necrosis in pancreata obtained from dexamethasone treated animals (P < 0.05). CONCLUSION: Dexamethasone significantly decreases the severity of pancreatitis. The protective mechanism ofdexamethasone may be via upregulating PAP gene ex- pression during injury. | Emad Kandil Yin-Yao Lin Martin H Bluth Hong Zhang Gabriel Levi Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，42： | 3 |
| 3 | Obesity and cardiometabolic disease risk factors among US adolescents with disabilities显示文摘AIM: To generate prevalence estimates of weight status and cardiometabolic disease risk factors among adolescents with and without disabilities.METHODS: Analysis of the 1999-2010 National Health and Nutrition Examination Survey data was conducted among 12-18 years old with(n = 256) and without disabilities(n = 5020). Mean values of waist circumference, fasting glucose, high-density-lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure and metabolic syndrome(Met S, ≥ 3 risk factors present) were examined by the following standardized body mass index(BMI) categories for those with and without disabilities; overweight(BMI ≥ 85th- < 95 th percentile for age and sex), obesity(BMI ≥ 95 th percentile) and severe obesity(BMI ≥35 kg/m2). Linear regression models were fit with each cardiometabolic disease risk factor independently as continuous outcomes to show relationships with disability status. RESULTS: Adolescents with disabilities were significantlymore likely to be overweight(49.3%), obese(27.6%) and severely obese(12%) vs their peers without disabilities(33.1%, 17.5% and 3.6%, respectively, P ≤ 0.01 for all). A higher proportion of overweight, obese and severely obese children with disabilities had abnormal SBP, fasting lipids and glucose as well as Met S(18.9% of overweight, 32.3% of obese, 55% of severely obese) vs their peers without disabilities(9.7%, 16.8%, 36.3%, respectively). US adolescents with disabilities are over three times as likely to have Met S(OR = 3.45, 95%CI: 1.08-10.99, P = 0.03) vs their peers with no disabilities.CONCLUSION: Results show that adolescents with disabilities are disproportionately affected by obesity and poor cardiometabolic health vs their peers with no disabilities. Health care professionals should monitor the cardiometabolic health of adolescents with disabilities. | Sarah E Messiah Denise C Vidot Gabriel Somarriba Kanathy Haney Semra Aytur Ruby A Natale Jeffrey P Brosco Kristopher L Arheart | 2015 | World Journal of Diabetes2015，6，1： | 2 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | Evaluation of a low-rate DoS attack against iterafive servers, computer networks显示文摘 | GABRIEL MACLA-FERNANDEZ JESUS E DIAZ-VERDEJO | 2007 | The International Journal of Computer and Networking2007，51，4： | 1 |
| 6 | Prevalence of scoliosis in neurofibromatosis显示文摘 | Akbarnia BA Gabriel KR Beckman E | 1992 | Spine1992，17，8： | 1 |
| 7 | The dielectrie properties of biological tissues:I Literature survey显示文摘 | GABRIEL C GABRIEL S CORTHOUT E | 1996 | Physics in Medicine and Biology1996，41，11： | 1 |
| 8 | Establishing a standard Sonoran reference plant and its application in monitoring industrial and urban pollution throughout the Sonoran desert 显示文摘 | Patten D T | 1995 | Environ Monitor Assess1995，36，： | 1 |
| 9 | Distribution of in situ forces in the anterior cruciate ligament in response to rotatory loads 显示文摘 | Gabriel M T Wong E K Woo S L Y | 2004 | Journal of Orthopaedics Research2004，22，1： | 1 |
| 10 | Development and evaluation of a CERES-type model for winter oilseed rape显示文摘 | Gabrielle B Denoroy P Gosse G Justes E Andersen M N | 1998 | Field Crops Research1998，57，： | 1 |
| 11 | In situ modification of micro- porous membranes 显示文摘 | GABRIEL E GILLBERG G | 1993 | J Appl Polym Sci1993，48，12： | 1 |
| 12 | Synthesis and light gas separations in cross-linked Gemini room tempertature ionic liquid polymer membranes 显示文摘 | Bara J E Hatakeyama E S Gabriel C J | 2008 | J Membrane Science2008，316，12： | 1 |
| 13 | A low voltage, low quiescent current, low dropout regulator 显示文摘 | GABRIEL A R PHILLIP E A | 1998 | IEEE Journal of Solid-State Circuits1998，33，1： | 1 |
| 14 | A functional cloning strategy, based on a binary PVX-expression vector, to isolate HR-inducing cDNAs of plant pathogens 显示文摘 | Takken F L W Luderer R Gabriels S H E J | 2000 | The Plant Journal2000，24，2： | 1 |
| 15 | Aneurysmal and clinical characteris- tics as risk factors for intracerebral haematoma from aneurysmal rupture显示文摘 | Liu XM Gabriel J Rinkel E | 2011 | Neurol2011，258，5： | 1 |
| 16 | Development of reduced kidney function in rheumatoid arthritis显示文摘 | Hickson L J Crowson C S Gabriel S E | 2014 | Am J Kidney Dis2014，63，2： | 1 |
| 17 | Diagnostic potential of breath analysis-focus on volatile organic compounds显示文摘 | MIEKISCH W SCHUBERT J K GABRIELE F E | 2004 | Clinica Chimica Acta2004，，347： | 1 |
| 18 | Approximation in nonhierarchical system optimization 显示文摘 | RENAUD J E GABRIELE G A | 1994 | AIAA J1994，32，1： | 1 |
| 19 | Weak expression of focal adhesion kinase (pp125FAK) in patients with cervical cancer is associated with poor disease outcome 显示文摘 | Gabriel B zur Hausen A Stickeler E | 2006 | Clln Cancer Res2006，12，8： | 1 |
| 20 | Dielectric parameters relevant to microwave dielectric heating显示文摘 | GABRIEL C GABRIEL S BRANT E H | 1998 | Chemical Society Review1998，27，： | 1 |
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