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| 1 | Circulating microRNAs in patients with non-alcoholic fatty liver disease显示文摘AIM: To identify novel non-invasive biomarkers for non-alcoholic fatty liver disease(NAFLD). METHODS: Twenty patients with histologically proven NAFLD and 20 controls were included. All NAFLD cases were scored using the NAFLD activity score. The rela-tive expressions of miR-197, miR-146 b, miR-10 b, miR-181d, miR-34 a, miR-122, miR-99 a and miR-29 a were analyzed using real-time polymerase chain reaction. RESULTS: Serum levels of miR-181 d, miR-99 a, miR-197 and miR-146 b were significantly lower in biopsy-proven NAFLD patients than in the healthy controls. Serum lev-els of miR-197 and miR-10 b were inversely correlated with degree of inflammation and miR-181 d and miR-99 a were inversely correlated with serum gamma glu-tamyl transferase levels in non-alcoholic steatohepatitis patients. CONCLUSION: NAFLD is associated with altered se-rum miRNA expression pattern. This study provides clues for defining the non-invasive diagnosis of NAFLD. | Serkan Dogan Gokmen Zararsiz Sebnem Gursoy Kadri Guven Omer Ozbakir Munis Dundar Mehmet Yucesoy | 2014 | World Journal of Hepatology2014，6，8： | 13 |
| 2 | Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma显示文摘AIM: To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma(HCC).METHODS: Sixty-eight patients with HCC(mean age of 69.1 ± 10.1), 31 cirrhosis patients(mean age of59.3 ± 6.3) and 33 healthy volunteers(mean age of51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein(AFP) values with HCC clinicopathological features, such as tumor size,number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion(diameters; ≤ 3 cm, 3-5 cmand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer(BCLC)criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at-80 ℃ until use.Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay.RESULTS: In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number,presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls(P <0.001). Prolidase levels were significantly associated with tumor size and number(P < 0.001, P = 0.002,respectively). Prolidase levels also differed in patients in terms of BCLC staging classification(P < 0.001).Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis(P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately(P = 0.032,P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation(r = 0.616; P< 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification,whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels.CONCLUSION: Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. | Sevil Uygun Ilikhan Muammer Bilici Hatice Sahin Ayse Semra Demir Akca Murat Can Ibrahim Ilker Oz Berrak Guven M Cagatay Buyukuysal Yucel Ustundag | 2015 | World Journal of Gastroenterology2015，21，22： | 8 |
| 3 | Heavy metals partitioning in the sediments of Izmir Inner Bay显示文摘伊兹密尔海湾被知道被重金属和有机污染物的高集中弄脏。在伊兹密尔内部海湾从 7 个不同车站拿的沉积样品为他们的全部的有机物内容被分析并且, Cu, Cr, Pb 和 Zn。另外,金属的化学分发借助于 BCR (参考的社区局) 被决定抽取过程(为标准由欧洲佣金发展了,测量并且严峻) 它允许象四部分固定的金属的决心;可交换、酸可溶,可约(到铁锰氧化物的界限) ,可氧化(到 organics 的界限) 并且剩余。结果证明那个伊兹密尔内部海湾与高金属集中包含沉积。根据金属的化学分发, Cr 和 Cu 趋于主要在沉积的器官的部分上积累。Pb 主要在 Zn 在沉积是活动的可约的部分被发现,并且它在每部分上均匀地是分布式的。 | GUVEN Duyusen E AKINCI Gorkem | 2008 | Journal of Environmental Sciences2008，20，4： | 7 |
| 4 | Risk factors and clinical responses of pneumonia patients with colistin-resistant Acinetobacter baumannii-calcoaceticus显示文摘BACKGROUND Nosocomial infections with carbapenem-resistant Acinetobacter baumanniicalcoaceticus complex(ABC)strains are great problem for intensive care units.ABC strains can develop resistance to all the antibiotics available.Carbapenem resistance is common and colistin resistance is rare in our country.Knowing the risk factors for colistin resistance is important since colistin seems to be the only remaining therapeutic option for the patients with pneumonia due to extensively drug resistant ABC for our country.AIM To investigate the comparison of clinical responses and outcomes between pneumonia patients with colistin-susceptible and-resistant Acinetobacter sp.Strains.METHODS During the study period,108 patients with pneumonia due to colistin-susceptible strains and 16 patients with colistin-resistant strains were included retrospectively.Continuous variables were compared with the Mann-Whitney U test,and categorical variables were compared using Pearson’s chi-square test or Fisher’s Exact chi-square test for two groups.A binary logistic regression model was developed to identify the potential independent factors associated with colistin resistance in patients with colistin-resistant strains.RESULTS High Acute Physiology and Chronic Health Evaluation II scores(OR=1.9,95%CI:1.4-2.7;P<0.001)and prior receipt of teicoplanin(OR=8.1,95%CI:1.0-63.3;P=0.045)were found to be independent risk factors for infection with colistin-resistant Acinetobacter sp.Different combinations of antibiotics including colistin,meropenem,ampicillin/sulbactam,amikacin and trimethoprim/sulfamethoxazole were used for the treatment of patients with colistin-resistant strains.Although the median duration of microbiological cure(P<0.001)was longer in the colistin-resistant group,clinical(P=0.703),laboratory(P=0.277),radiological(P=0.551),microbiological response(P=1.000)and infection related mortality rates(P=0.603)did not differ between the two groups.Among the patients with infections due to colistin-resistant strains,seven were treated with antibiotic combinations that included sulbactam.Clinical(6/7)and microbiological(5/7)response rates were quite high in these patients.CONCLUSION The optimal therapy regimen is unclear for colistin-resistant Acinetobacter sp.infections.Although combinations with sulbactam seems to be more effective in our study patients,data supporting the usefulness of combinations with sulbactam is very limited. | Hande Aydemir Hande Idil Tuz Nihal Piskin Guven Celebi Canan Kulah Furuzan Kokturk | 2019 | World Journal of Clinical Cases2019，7，10： | 7 |
| 5 | Noninvasive assessment of liver damage in chronic hepatitis B显示文摘AIM:To evaluate the efficacy of the aspartate aminotransferase/platelet ratio index(APRI)and neutrophillymphocyte(N/L)ratio to predict liver damage in chronic hepatitis B(CHB).METHODS:We analyzed 89 patients diagnosed with CHB by percutaneous liver biopsy and 43 healthy subjects.Liver biopsy materials were stained with hematoxylin-eosin and Masson’s trichrome.Patients’fibrosis scores and histological activity index(HAI)were calculated according to the Ishak scoring system.Fibrosis score was recognized as follows:F0-1 No/early-stage fibrosis,F2-6 significant fibrosis,F0-4 non-cirrhotic and F5-6 cirrhotic.Significant liver fibrosis was defined as an Ishak score of≥2.APRI and N/L ratio calculation was made by blood test results.RESULTS:The hepatitis B and control group showed no difference in N/L ratios while there was a significant difference in terms of APRI scores(P<0.001).Multiple logistic regression analysis revealed that the only independent predictive factor for liver fibrosis in CHB was platelet count.APRI score was significantly higher in cirrhotic patients than in non-cirrhotic patients.However,this significance was not confirmed by multiple logistic regression analysis.The optimum APRI score cut-off point to identify patients with cirrhosis was 1.01with sensitivity,specificity,positive predictive value and negative predictive value of 62%(36%-86%),74%(62%-83%),29%(13%-49%)and 92%(82%-97%),respectively.In addition,correlation analyses revealed that N/L ratio has a negative and significant relationship with HAI(r=-0.218,P=0.041).CONCLUSION:N/L ratio was negatively correlated with HAI.APRI score may be useful to exclude cirrhosis in CHB patients. | Mehmet Celikbilek Serkan Dogan Sebnem Gursoy Gokmen Zararsιz Alper Yurci Omer Ozbakιr Kadri Guven Mehmet Yucesoy | 2013 | World Journal of Hepatology2013，5，8： | 5 |
| 6 | Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats显示文摘Daidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery occlusion were intraperitoneally administered daidzein. Biochemical and immunohistochemical tests showed that superoxide dismutase and nuclear respiratory factor 1 expression levels in the brain tissue decreased after ischemia and they increased obviously after daidzein administration; malondialdehyde level and apoptosis-related cysteine peptidase caspase-3 and caspase-9 immunoreactivity in the brain tissue increased after ischemia and they decreased obviously after daidzein administration. Hematoxylin-eosin staining and luxol fast blue staining results showed that intraperitoneal administration of daidzein markedly alleviated neuronal damage in the ischemic brain tissue. These findings suggest that daidzein exhibits neuroprotective effects on ischemic brain tissue by decreasing oxygen free radical production, which validates the aforementioned hypothesis. | Adem Bozkurt Aras Mustafa Guven Tar?k Akman Adile Ozkan Halil Murat Sen Ugur Duz Y?ld?ray Kalkan Coskun Silan Murat Cosar | 2015 | Neural Regeneration Research2015，10，1： | 4 |
| 7 | Epinephrine plus argon plasma or heater probe coagulation in ulcer bleeding显示文摘AIM:To compare the effectiveness of argon plasma coagulation (APC) and heater probe coagulation (HPC) in non-variceal upper gastrointestinal bleeding.METHODS:Eighty-five (18 female,67 male) patients admitted for acute gastrointestinal bleeding due to gastric or duodenal ulcer were included in the study.Upper endoscopy was performed and HPC or APC were chosen randomly to stop the bleeding.Initial hemostasis and rebleeding rates were primary and secondary end-points of the study.RESULTS:Initial hemostasis was achieved in 97.7% (42/43) and 81% (36/42) of the APC and HPC groups,respectively (P < 0.05).Rebleeding rates were 2.4% (1/42) and 8.3% (3/36) in the APC and HPC groups,respectively,at 4 wk (P > 0.05).CONCLUSION:APC is an effective hemostatic method in bleeding peptic ulcers.Larger multicenter trials are necessary to confirm these results. | Ahmet Karaman Mevlut Baskol Sebnem Gursoy Edip Torun Alper Yurci Banu Demet Ozel Kadri Guven Omer Ozbakir Mehmet Yucesoy | 2011 | World Journal of Gastroenterology2011，17，36： | 4 |
| 8 | Ultrasound biomicroscopic evaluation of anterior segment cysts as a risk factor for ocular hypertension and closure angle glaucoma显示文摘AIM:To investigate the relationship between the ultrasound biomicroscopic(UBM) features of anterior-segment cysts(ASCs) and increased intraocular pressure(IOP) as a risk factor for closed-angle glaucoma(CAG).·METHODS:Totally 24 eyes with recently diagnosed ASCs were divided into two groups.First group with ASC and ocular normotension(n =13),second group with ASC and ocular hypertension(n =11).An ophthalmologic examination,including tonometry,slit-lamp biomicro-scopy(SLBM),gonioscopy,fundoscopy,pentacam,and UBM,was performed.The features of the ASCs were compared with the IOP.·RESULTS:ASCs were accurately diagnosed and delineated in 24 eyes using UBM.IOP was elevated in those ASCs with a secondary aetiology(P =0.027),iridociliary location(P =0.006),deformed shape(P =0.013),increased size(P =0.001) and elongated pupillary aperture(P =0.009).However,the count(P =0.343) of ASCs,anterior chamber depth(ACD;P =0.22) and axial lenght(AL;P =0.31) were not associated with ocular hypertension.Correlations were found between the IOP and ASC size(r =-0.712;P =0.003),anterior chamber angle(ACA;r =-0.985;P <0.001),angle opening area(AOA;r =0.885;P<0.001),angulation of iris(r =-0.776,P <0.001),and affected iris quadrant(r =-0.655,P =0.002).·CONCLUSION:Ocular hypertension in some eyes with ASC might be associated with various mechanisms,including secondary aetiology,iridociliary location,deformed shape,increased size and elongated pupill,which can be determined by UBM. | Abdurrahim Dusak Mehmet Baykara Guven Ozkaya Cuneyt Erdogan Hikmet Ozcetin Ercan Tuncel | 2013 | International Journal of Ophthalmology(English edition)2013，6，4： | 3 |
| 9 | Comparison of retrograde intrarenal surgery, shockwave lithotripsy, and percutaneous nephrolithotomy for treatment of medium-sized radiolucent renal stones显示文摘 | Berkan Resorlu Ali Unsal Tevfik Ziypak Akif Diri Gokhan Atis Selcuk Guven Ahmet Ali Sancaktutar Abdulkadir Tepeler Omer Faruk Bozkurt Derya Oztuna | 2013 | World Journal of Urology2013，，6： | 2 |
| 10 | Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties显示文摘There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondiadehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and-9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These findings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis. | Aras Adem Bozkurt Guven Mustafa Akman Tar?k Ozkan Adile Sen Halil Murat K?l?coglu Mesut Kalkan Y?ld?ray Silan Coskun Cosar Murat | 2014 | Neural Regeneration Research2014，9，21： | 2 |
| 11 | Hemodynamic alterations in diabetic retinopathy显示文摘 | Guven Ozdemir H Hasanreisoglu B | 1996 | Ophthalmology1996，8，： | 2 |
| 12 | The effect of α-blocker therapy on erectile functions in patients with lower urinary tract symptoms due to benign prostate hyperplasia显示文摘 | Omer Demir Ismail Ozdemir Ozan Bozkurt Guven Asian Ahmet Adil Esen | 2009 | Asian Journal of Andrology2009，11，6： | 2 |
| 13 | Liver enzyme alterations after laparoscopic cholecystectomy显示文摘 | Guven H E Oral S | 2007 | J Gastrointestin Liver Dis2007，16，4： | 1 |
| 14 | Prevention of superficial wound disruption in Pfannenstiel incisions by using a subcutaneous drain显示文摘 | Guvenal T Duran B Demirkoprulu N | 2002 | Int J Gynaecol Obstet2002，772，： | 1 |
| 15 | Thyroid function tests in non-alcoholic cirrhotic patients with hepatic encephalopathy 显示文摘 | Guven K Keletimur F Yucesoy M | 1993 | Eur J Med1993，2，： | 1 |
| 16 | Comparison of the effect of single-dose and multiple-dose methotrexate therapy on tubal patency显示文摘 | Guven ES Dilbaz S Dilbaz B | 2007 | Fertil Steril2007，88，5： | 1 |
| 17 | The effects of fresh frozen plasma on cholinesterase levels and outcomes in patients with organophosphate poisoning显示文摘 | Guven M Sungur M Eser B | 2004 | J Toxicol Clin Toxicol2004，42，5： | 1 |
| 18 | Proanthocyanidin protects intes-tine and remote organs against mesenteric ischemia/reperfusion in-jury显示文摘 | Sizlan A Guven A Uysal B | 2009 | World J Surg2009，33，7： | 1 |
| 19 | Effect of nasal continuous positive airway pressure in uncontrolled nocturnal asthmatic patients with obstructive sleep apnea syndrome显示文摘 | Ciftci TU Ciftci B Guven SF | | 0，，05： | 1 |
| 20 | New algebraic formulations of evap- otranspiration extracted from gene-expression programming in the tropical seasonally dry regions of West Africa 显示文摘 | Traore Seydou Guven Aytac | 2013 | Irrigation Sci- ence2013，31，1： | 1 |
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