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| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | Synthesis of novel 3,7-substituted-2-(3'4'-dihydroxyphenyl)flavones with improved antioxidant activity显示文摘 | FREDERIQE A A V A JOS A H GUIDO R M M H | 2000 | Journal of Medicinal Chemistry2000，43，20： | 1 |
| 3 | Health effects of quer- cetin: from antioxidant to nutraceutical 显示文摘 | AGNES W B GUIDO R H ALAT B | 2008 | European Jour- nal of Pharmacology2008，585，23： | 1 |
| 4 | The 10 × ' 20 Initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020显示文摘 | Gilbert D N Guidos R J Boucher H W | 2010 | Clin Infect Dis2010，50，8： | 1 |
| 5 | The extraordinary antioxidant activity of Vitamin E phosphate显示文摘 | Bashir M R Guido R M M H Wim J F var der Vijgh | 2004 | Biochimica et Biophysica Acta2004，1683，： | 1 |
| 6 | Health Effects of Quercetin: From Antioxidant to Nutraceutieal显示文摘 | Boots AW Guido R M M Bast H A B | 2008 | European Journal of Pharmacology2008，585，23： | 1 |
| 7 | Advanced drug delivery devices via self-assembly of amphiphilic block copolymers显示文摘 | Guido W M Klok H A | 2001 | Adv Drug Deliv Rev2001，53，： | 1 |
| 8 | Synthesis of novel 3,7-substituted-2-( 3', 4'-dihydroxyphenyl ) flavones with improved antioxidant activity显示文摘 | Frederique A A A Jos A H Guido R M M H | 2000 | J Med Chem2000，43，： | 1 |
| 9 | Health effects of quercetin:from antioxidant to nutraceutical显示文摘 | AGNES W B GUIDO R M M H AALT B | | 0，，2： | 1 |
| 10 | Health effects of quercetin: From antioxidant to nutraceutical显示文摘 | Agnes W B Guido R H Aalt B | 2008 | European Journal of Pharmacology2008，，585： | 1 |
| 11 | Health effects of quercetin:From antioxidant to nutraceutical显示文摘 | Agnes W B Guido R M M H Aalt B | | 0，，2： | 1 |
| 12 | Polybrominated Diphenyl Ethers Induce Developmental Neurotoxicity in a Human in Vitro Model: Evidence for Endocrine Disruption显示文摘 | Schreiber Timm Gassmann Kathrin G?tz Christine Hübenthal Ulrike Moors Michaela Krause Guido Merk Hans F Nguyen Ngoc-Ha Scanlan Thomas S Abel Josef Rose Christine R Fritsche Ellen | 2010 | Environmental Health Perspectives2010，，4： | 1 |
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