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| 1 | Improved Brassica rapa reference genome by single-molecule sequencing and chromosome conformation capture technologies显示文摘Brassica rapa comprises several important cultivated vegetables and oil crops.Current reference genome assemblies of Brassica rapa are quite fragmented and not highly contiguous,thereby limiting extensive genetic and genomic analyses.Here,we report an improved assembly of the B.rapa genome(v3.0)using single-molecule sequencing,optical mapping,and chromosome conformation capture technologies(Hi-C).Relative to the previous reference genomes,our assembly features a contig N50 size of 1.45 Mb,representing a~30-fold improvement.We also identified a new event that occurred in the B.rapa genome~1.2 million years ago,when a long terminal repeat retrotransposon(LTR-RT)expanded.Further analysis refined the relationship of genome blocks and accurately located the centromeres in the B.rapa genome.The B.rapa genome v3.0 will serve as an important community resource for future genetic and genomic studies in B.rapa.This resource will facilitate breeding efforts in B.rapa,as well as comparative genomic analysis with other Brassica species. | Lei Zhang Xu Cai Jian Wu Min Liu Stefan Grob Feng Cheng Jianli Liang Chengcheng Cai Zhiyuan Liu Bo Liu Fan Wang Song Li Fuyan Liu Xuming Li Lin Cheng Wencai Yang Mai-he Li Ueli Grossniklaus Hongkun Zheng Xiaowu Wang | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | 慢性荨麻疹、银屑病和异位性皮炎对生活质量影响的比较研究 | Grob J.J. Revuz J. Ortonne J.P. 罗素菊 冯义国 | 2005 | 世界核心医学期刊文摘(皮肤病学分册)2005，0，7： | 2 |
| 3 | Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model显示文摘AIM: To investigate the effects of catalytically superior gene-directed enzyme prodrug therapy systems on a rat hepatoma model.METHODS: To increase hepatoma cell chemosensitivity for the prodrug 5-fluorocytosine (5-FC), we generated a chimeric bifunctional SuperCD suicide gene, a fusion of the yeast cytosine deaminase (YCD) and the yeast uracil phosphoribosyltransferase (YUPRT) gene.RESULTS: In vitro stably transduced Morris rat hepatoma cells (MH) expressing the bifunctional SuperCD suicide gene (MH SuperCD) showed a clearly marked enhancement in cell killing when incubated with 5-FC as compared with MH ceils stably expressing YCD solely (MH YCD) or the cytosine deaminase gene of bacterial origin(MH BCD), respectively. In vivo, MH SuperCD tumors implanted both subcutaneously as well as orthotopically into the livers of syngeneic ACI rats demonstrated significant tumor regressions (P<0.01) under both high dose as well as low dose systemic 5-FC application,whereas MH tumors without transgene expression (MH naive) showed rapid progression. For the first time, an order of in vivo suicide gene effectiveness (SuperCD>>YCD > > BCD > > > negative control) was defi ned as a result of a directin vivo comparison of all three suicide genes.CONCLUSION: Bifunctional SuperCD suicide gene expression is highly effective in a rat hepatoma model,thereby significantly improving both the therapeutic index and the efficacy of hepatocellular carcinoma killing by fluorocytosine. | Florian Graepler Marie-Luise Lemken Wolfgang A Wybranietz Ulrike Schmidt Irina Smirnow Christine D GroB Martin Spiegel Andrea Schenk Schenk Hansj(o|¨)rg Graf Ulrike A Lauer Reinhard Vonthein Michael Gregor Sorin Armeanu Michael Bitzer Ulrich M.Lauer | 2005 | World Journal of Gastroenterology2005，11，44： | 2 |
| 4 | Author Correction:Improved Brassica rapa reference genome by single-molecule sequencing and chromosome conformation capture technologies显示文摘Since the publication of this article,the authors have noticed that the total gene models(45,985),tandem arrays(2077),tandem genes(4963),redundancy removed(43,099),syntenic genes(39,858),nonsyntenic genes(3241),genes on chromosomes(45,411),genes on scaffolds(574)of B.rapa reference genome v3.0 were mistaken in the article. | Lei Zhang Xu Cai Jian Wu Min Liu Stefan Grob Feng Cheng Jianli Liang Chengcheng Cai Zhiyuan Liu Bo Liu Fan Wang Song Li Fuyan Liu Xuming Li Lin Cheng Wencai Yang Mai-he Li Ueli Grossniklaus Hongkun Zheng Xiaowu Wang | 2019 | Horticulture Research2019，6，1： | 2 |
| 5 | CDMA/HDR: A bandwidth-efficient high-speed wireless data service for nomadic users 显示文摘 | P Bender P Black M Grob R Padovani N Sindhushayana A Viterbi | 2000 | IEEE Communication Magazine (S0733-8716)2000，38，7： | 1 |
| 6 | Invariance properties of a triple matrix product involving generalized inverses显示文摘 | Tian Y | 2006 | Linear Algebra and Applications2006，417，： | 1 |
| 7 | CDMA/HDR: A bandwidth-efficient high-speed wireless data service for nomadic users显示文摘 | BENDER P BLACK P GROB M | 2000 | IEEE Communications Magazine2000，38，7： | 1 |
| 8 | Urticaria and quality of life 显示文摘 | Grob JJ Gaudy MC | 2006 | Clin Rev Al- lergy Immuno12006，30，： | 1 |
| 9 | Contamination of vegetable oils marketed in Italy by phthalic acid esters 显示文摘 | NANNI N FISELIER K GROB K | 2011 | Food Control2011，22，： | 1 |
| 10 | Lunrbar facet joint effusion in MRI: a sign of instability in degenerative spondylolisthesis? 显示文摘 | Latting F Fekete TF Grob D | 2012 | Eur Spine J2012，21，2： | 1 |
| 11 | A Structural Model of Environmental Attitudes and Bc- haviour显示文摘 | Grob A | 1995 | Journal Of Environmental Psychology1995，，3： | 1 |
| 12 | Translaminar screw fixation of the lumbar spine : long - term outcome 显示文摘 | Aepli M Mannion AF Grob D | 2009 | Spine ( Phila Pa 1976)2009，34，14： | 1 |
| 13 | Clinical experience with the Dynesys semirigid fixation system for the lumbar spine:surgical and patient-oriented outcome in 50 cases after an average of 2 years显示文摘 | Benini A Junge A | 2005 | J Spine2005，30，3： | 1 |
| 14 | IRAP and REMAP: two new retrotransposon based DNA fingerprinting techniques显示文摘 | Kalendar R Grob T Regina M T | 1999 | Theoretical and Applied Genetics1999，98，： | 1 |
| 15 | The benefits of wearing a compression sleeve after ACL reconstruction 显示文摘 | KUSTER M S GROB K KUSTER M | 1999 | Med Sci Sports Exe1999，31，3： | 1 |
| 16 | Titanium mesh cages (TMC) in spine surgery显示文摘 | Dieter Grob Sylvia Daehn Anne F. Mannion | 2005 | European Spine Journal2005，，3： | 1 |
| 17 | Comprehensive analysis of migrates from food-packaging materials: a challenge显示文摘 | K. Grob | 2002 | Food Additives & Contaminants: Part A2002，，： | 1 |
| 18 | Radical transurethral resection in the man-agement of muscle invasive bladder canoer显示文摘 | Grob BM Macchia RJ | 2001 | J Endourol2001，15，4： | 1 |
| 19 | Randomized phase Ⅲ study of temozolomide versus dacarbazine in the treatment of patients with advanced metastatic malignant melanoma显示文摘 | Middleton MR Grob J J Aaronson N | 2000 | J Clin Oncol2000，18，： | 1 |
| 20 | A deletion in the bovine myostatin gene cause the double-muscled phenotype in cattle 显示文摘 | Grob I Martin L J Poncelet D | 1997 | Nat Genet1997，17，1： | 1 |
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