8篇
您的检索式：作者名="GRAVES Stephen"
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| 1 | Protein array of Coxiella burnetii probed with Q fever sera显示文摘Coxiella burnetii is the etiological agent of Q fever.To identify its major seroreactive proteins,a subgenomic protein array was developed.A total of 101 assumed virulence-associated recombinant proteins of C.burnetii were probed with sera from mice experimentally infected with C.burnetii and sera from Q fever patients.Sixteen proteins were recognized as major seroreactive antigens by the mouse sera.Seven of these 16 proteins reacted positively with at least 45% of Q fever patient sera.Notably,HspB had the highest fluorescence intensity value and positive frequency of all the proteins on the array when probed with both Q fever patient sera and mouse sera.These results suggest that these seven major seroreactive proteins,particularly HspB,are potential serodiagnostic and subunit vaccine antigens of Q fever. | WANG XiLe XIONG XiaoLu GRAVES Stephen STENOS John WEN BoHai | 2013 | Science China(Life Sciences)2013，56，5： | 2 |
| 2 | A Review of Production Scheduling 显示文摘 | Stephen C Graves | 1981 | Operations Research (S0030-364X)1981，29，： | 1 |
| 3 | A multi-echelon inventory model for a repairable item with one for one replenishment显示文摘 | Graves Stephen C | 1985 | Management Science1985，31，10： | 1 |
| 4 | A multi-echelon inventory model for a repairable item with one-for-one replenishment显示文摘 | Stephen C Graves | 1985 | Management Science1985，31，： | 1 |
| 5 | Knee replacement显示文摘 | Andrew J Carr Otto Robertsson Stephen Graves Andrew J Price Nigel K Arden Andrew Judge David J Beard | 2012 | The Lancet2012，，9823： | 1 |
| 6 | A Single-Item Inventory Model for a Nonstationary Demand Process显示文摘 | Stephen C. Graves | 1999 | Manufacturing & Service Operations Management1999，，1： | 1 |
| 7 | Knee replacement 显示文摘 | Andrew J Carr Otto Robertsson Stephen Graves | 2012 | Lancet2012，379，9823： | 1 |
| 8 | Diversity of reptile sex chromosome evolution revealed by cytogenetic and linked-read sequencing显示文摘Reptile sex determination is attracting much attention because the great diversity of sex-determination and dosage compensation mechanisms permits us to approach fundamental questions about mechanisms of sex chromosome turnover. Recent studies have made significant progress in better understanding diversity and conservation of reptile sex chromosomes, with however no reptile master sex determination genes identified. Here we describe an integrated genomics and cytogenetics pipeline,combining probes generated from the microdissected sex chromosomes with transcriptome and genome sequencing to explore the sex chromosome diversity in non-model Australian reptiles. We tested our pipeline on a turtle, two species of geckos, and a monitor lizard. Genes identified on sex chromosomes were compared to the chicken genome to identify homologous regions among the four species. We identified candidate sex determining genes within these regions, including conserved vertebrate sex-determining genes pdgfa,pdgfra amh and wt1, and demonstrated their testis or ovary-specific expression. All four species showed gene-by-gene rather than chromosome-wide dosage compensation. Our results imply that reptile sex chromosomes originated by independent acquisition of sex-determining genes on different autosomes,as well as translocations between different ancestral macro-and microchromosomes.We discuss the evolutionary drivers of the slow differentiation and turnover of reptile sex chromosomes. | Ze-Xian Zhu Kazumi Matsubara Foyez Shams Jason Dobry Erik Wapstra Tony Gamble Stephen DSarre Arthur Georges Jennifer AMarshall Graves Qi Zhou Tariq Ezaz | 2022 | Zoological Research2022，43，5： | 0 |
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