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您的检索式：作者名="STENOS John"
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| 1 | Protein array of Coxiella burnetii probed with Q fever sera显示文摘Coxiella burnetii is the etiological agent of Q fever.To identify its major seroreactive proteins,a subgenomic protein array was developed.A total of 101 assumed virulence-associated recombinant proteins of C.burnetii were probed with sera from mice experimentally infected with C.burnetii and sera from Q fever patients.Sixteen proteins were recognized as major seroreactive antigens by the mouse sera.Seven of these 16 proteins reacted positively with at least 45% of Q fever patient sera.Notably,HspB had the highest fluorescence intensity value and positive frequency of all the proteins on the array when probed with both Q fever patient sera and mouse sera.These results suggest that these seven major seroreactive proteins,particularly HspB,are potential serodiagnostic and subunit vaccine antigens of Q fever. | WANG XiLe XIONG XiaoLu GRAVES Stephen STENOS John WEN BoHai | 2013 | Science China(Life Sciences)2013，56，5： | 2 |
| 2 | Q热血清分析贝氏柯克斯体亚基因组蛋白质芯片和鉴定主要血清反应蛋白显示文摘贝氏柯克斯体是Q热的病原菌.为了鉴定贝氏柯克斯体的免疫反应蛋白,本实验室研发了该病原体的亚基因组蛋白芯片.该芯片由101个贝氏柯克斯体的毒力相关重组蛋白构成,用于贝氏柯克斯体感染小鼠血清及Q热患者血清对这些蛋白质做血清学分析.小鼠血清鉴定出16个血清反应阳性蛋白,其中有7个蛋白能够与至少45%的Q热患者发生血清反应.值得注意的是,热休克蛋白B(HspB)与Q热患者和小鼠血清的反应最强,阳性率最高.本研究鉴定出7个主要Q热血清反应蛋白,这些蛋白,特别是HspB是Q热诊断试剂和亚单位疫苗研制的候选靶标. | 王锡乐 熊小路 Stephen Greaves John Stenos 温博海 | 2013 | 中国科学:生命科学2013，43，5： | 0 |
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