|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nano-Graphene Oxide for Cellular Imaging and Drug Delivery显示文摘Two-dimensional graphene offers interesting electronic,thermal,and mechanical properties that are currently being explored for advanced electronics,membranes,and composites.Here we synthesize and explore the biological applications of nano-graphene oxide(NGO),i.e.,single-layer graphene oxide sheets down to a few nanometers in lateral width.We develop functionalization chemistry in order to impart solubility and compatibility of NGO in biological environments.We obtain size separated pegylated NGO sheets that are soluble in buffers and serum without agglomeration.The NGO sheets are found to be photoluminescent in the visible and infrared regions.The intrinsic photoluminescence(PL)of NGO is used for live cell imaging in the near-infrared(NIR)with little background.We found that simple physisorption viaπ-stacking can be used for loading doxorubicin,a widely used cancer drug onto NGO functionalized with antibody for selective killing of cancer cells in vitro.Owing to its small size,intrinsic optical properties,large specifi c surface area,low cost,and useful non-covalent interactions with aromatic drug molecules,NGO is a promising new material for biological and medical applications. | Xiaoming Sun Zhuang Liu Kevin Welsher Joshua Tucker Robinson Andrew Goodwin Sasa Zaric Hongjie Dai | 2008 | Nano Research2008，1，3： | 118 |
| 2 | 地下水位较高条件下不同根区湿润方式对梨树根与茎液流及其水分平衡的影响显示文摘为了探讨地下水位较高条件下根区湿润方式对梨树根和茎液流及水分平衡的影响 ,开展了较系统的试验研究。试验共设三种处理 ,即传统畦灌 (CFI) ,部分根干燥灌溉 (PRD)和分根区交替灌溉 (ARDI) ,分别使用土壤水分监测系统 (Enviro SCAN)和热脉冲探针监测土壤水分动态和梨树根和茎液流。结果表明在 PRD和 ARDI情况下湿润根区的根液流不仅大于干燥根区 ,而且也大于 CFI情况下的相同区域。复水后 ,ARDI干燥区的根液流比 PRD的恢复和提高快得多 ,并且比 CFI的大 ;ARDI的茎液流比 CFI的小 ,但比 PRD保持一侧根干燥时的大。在只有一侧根区灌溉时 ,ARDI和 PRD的日耗水量比 CFI的小。 ARDI和 PRD中湿润侧的根系具有水分吸收补偿效应 ,当干燥根区复水后能够提高水分的吸收能力 ,其程度与根区持续干燥的时间长短有关。逐日根液流与参考作物蒸发蒸腾量关系密切 ,但随着表面灌溉方式和湿润根区的不同这些关系明显的不一样。逐日茎液流与参考作物蒸发蒸腾量有关 ,而且在不同的表面灌溉方式下 ,土壤含水率相同时茎液流和参考作物蒸发蒸腾量的比率不同。与 CFI相比 ,ARDI和 PRD大约少用 5 0 %的灌溉水量 ,但是梨树的水分消耗量和茎液流并没减少相同的比例。表面湿润方式对水量平衡和液流的作用明显受到地下水位的影响。 | 康绍忠 胡笑涛 Ian Goodwin Peter Jerie | 2001 | 农业工程学报2001，17，3： | 10 |
| 3 | Identification and characterization of a new member of the TNF family that induces apoptosis显示文摘 | Steven R. Wiley Ken Schooley Pamela J. Smolak Wenie S. Din Chang-Pin Huang Jillian K. Nicholl Grant R. Sutherland Terri Davis Smith Charles Rauch Craig A. Smith Raymond G. Goodwin | 1995 | Immunity1995，，6： | 6 |
| 4 | Classical epithelial-mesenchymal transition(EMT)and alternative cell death process-driven blebbishield metastaticwitch(BMW)pathways to cancer metastasis显示文摘Metastasis is a pivotal event that accelerates the prognosis of cancer patients towards mortality.Therapies that aim to induce cell death in metastatic cells require a more detailed understanding of the metastasis for better mitigation.Towards this goal,we discuss the details of two distinct but overlapping pathways of metastasis:a classical reversible epithelial-to-mesenchymal transition(hybrid-EMT)-driven transport pathway and an alternative cell death process-driven blebbishield metastatic-witch(BMW)transport pathway involving reversible cell death process.The knowledge about the EMT and BMW pathways is important for the therapy of metastatic cancers as these pathways confer drug resistance coupled to immune evasion/suppression.We initiallydiscuss the EMT pathway and compare it with the BMW pathway in the contexts of coordinated oncogenic,metabolic,immunologic,and cell biological events that drive metastasis.In particular,we discuss how the cell death environment involving apoptosis,ferroptosis,necroptosis,and NETosis in BMW or EMT pathways recruits immune cells,fuses with it,migrates,permeabilizes vasculature,and settles at distant sites to establish metastasis.Finally,we discuss the therapeutic targets that are common to both EMT and BMW pathways. | Goodwin G.Jinesh Andrew S.Broh | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 4 |
| 5 | Persistence and adherence to nucleos(t)ide analogue treatment for chronic hepatitis B显示文摘 | Watcharasak Chotiyaputta Carolyn Peterson Fausta A. Ditah Diane Goodwin Anna S.F. Lok | 2010 | Journal of Hepatology2010，，： | 3 |
| 6 | Multiple sclerosis:integration of modeling with biology,clinical and imaging measures to provide better monitoring of disease progression and prediction of outcome显示文摘Multiple Sclerosis(MS) is a major cause of neurological disability in adults and has an annual cost of approximately $28 billion in the United States. MS is a very complex disorder as demyelination can happen in a variety of locations throughout the brain; therefore, this disease is never the same in two patients making it very hard to predict disease progression. A modeling approach which combines clinical, biological and imaging measures to help treat and fight this disorder is needed. In this paper, I will outline MS as a very heterogeneous disorder, review some potential solutions from the literature, demonstrate the need for a biomarker and will discuss how computational modeling combined with biological, clinical and imaging data can help link disparate observations and decipher complex mechanisms whose solutions are not amenable to simple reductionism. | Shikha Jain Goodwin | 2016 | Neural Regeneration Research2016，11，12： | 2 |
| 7 | Design issues in adaptive control显示文摘 | Middleton R H Goodwin G C Hilland D J | 1988 | IEEE transactions on automatic control1988，40，1： | 2 |
| 8 | Application of hysteresis switching in parameter adaptive control显示文摘 | Morse A S Mayse D Q Goodwin G C | 1992 | IEEE transactions on automatic control1992，40，9： | 2 |
| 9 | Rayleigh-Taylor instability experiments examining feed through growth in an incompressible convergent geometry显示文摘 | Weir S T Chandler E A Goodwin B T | 1998 | Phys Rev Lett1998，80，17： | 2 |
| 10 | Effect of Steatohepatitis Associated with Irinotecan or Oxaliplatin Pretreatment on Resectability of Hepatic Colorectal Metastases显示文摘 | Felix G. Fernandez John Ritter J. Wendell Goodwin David C. Linehan William G. Hawkins Steven M. Strasberg | 2005 | Journal of the American College of Surgeons2005，，6： | 2 |
| 11 | Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies显示文摘 | P. : Richardson W. Rapporteur: McKenna M. Committee: Bristow B. Maisch B. Mautner J. O'Connell E. Olsen G. Thiene J. Consultant: Goodwin I. WHO Staff: Gyarfas I. Martin P. Nordet | 1996 | Circulation1996，，5： | 2 |
| 12 | Keeping nephrotic syndrome on the emergency department edema differential: A case report显示文摘Dear editor,Nephrotic syndrome is defined by the presence of peripheral edema,heavy proteinuria(greater than 3.5 g/24h),and hypoalbuminemia(less than 3 g/dL).^[1]Nephrotic syndrome is relatively rare,with an incidence of 3 new patients per 100,000 per year in adults.^[1]Despite being a known cause for new onset edema in patients at any age,nephrotic syndrome is often neglected in considering differential diagnoses for this presentation in primary care settings,and initial workups often focus on ruling out cardiac and hepatic causes of edema.^[1-3]In this case report,we describe a 25-year-old male patient who presented to the emergency department(ED)complaining of a 10-day history of anasarca.He was later diagnosed with nephrotic syndrome secondary to minimal change disease.This case served as a reminder to include the differential diagnosis of nephrotic syndrome early in the workup of an adult with peripheral edema presenting to the ED. | Joshua Goodwin Bijon Das | 2019 | World Journal of Emergency Medicine2019，10，2： | 2 |
| 13 | Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of Cardiomyopathies显示文摘 | P. : Richardson W. Rapporteur: McKenna M. Committee: Bristow B. Maisch B. Mautner J. O’Connell E. Olsen G. Thiene J. Consultant: Goodwin I. WHO Staff: Gyarfas I. Martin P. Nordet | 1996 | Circulation1996，，5： | 2 |
| 14 | Bacterial pathogens in Hawaiian coastal streams—Associations with fecal indicators, land cover, and water quality显示文摘 | Emily J. Viau Kelly D. Goodwin Kevan M. Yamahara Blythe A. Layton Lauren M. Sassoubre Siobhán L. Burns Hsin-I Tong Simon H.C. Wong Yuanan Lu Alexandria B. Boehm | 2011 | Water Research2011，，11： | 2 |
| 15 | BRCA mutated pancreatic cancer:A change is coming显示文摘Pancreatic cancer remains a leading cause of cancer-related death with few available therapies for advanced disease.Recently,patients with germline BRCA mutations have received increased attention due to advances in the management of BRCA mutated ovarian and breast tumors.Germline BRCA mutations significantly increase risk of developing pancreatic cancer and can be found in up to 8%of patients with sporadic pancreatic cancer.In patients with germline BRCA mutations,platinum-based chemotherapies and poly(ADP-ribose)polymerase inhibitors are effective treatment options which may offer survival benefits.This review will focus on the molecular biology,epidemiology,and management of BRCA-mutated pancreatic cancer.Further-more,we will discuss future directions for this area of research and promising active areas of research. | Michael N Rosen Rachel A Goodwin Michael M Vickers | 2021 | World Journal of Gastroenterology2021，27，17： | 2 |
| 16 | Local economic impacts of dragon tourism in Indonesia显示文摘 | Matthew J. Walpole Harold J. Goodwin | 2000 | Annals of Tourism Research2000，，3： | 2 |
| 17 | Regulation of multidrug resistance-associated protein 2(ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor显示文摘 | Kast HR Goodwin B Tart FF | 2002 | J Biol Chem2002，277，4： | 1 |
| 18 | Isolation and characterization oftwo calf --thymus chromatin nonhistone proteinswithhigh contents ofacidic andbasie amino acids显示文摘 | Goodwin G H Johns E W | 1973 | Eur J Bioehem1973，40，1： | 1 |
| 19 | A Security-ConstrainedBid-ClearingSystem for the New Zealand Wholesale Elecrieity Market显示文摘 | Goodwin D Ma X | 1998 | IEEE Transactions on Power Systems1998，13，3： | 1 |
| 20 | The CYP3A4*1B polymorphism has no functional significance and is not associated with risk of breast or ovarian cancer显示文摘 | Goodwin B Hodgson E | 2002 | Pharmaco Genetics2002，12，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员