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| 1 | Intra-cardiac distribution of late gadolinium enhancement in cardiac sarcoidosis and dilated cardiomyopathy显示文摘Cardiac involvement of sarcoid lesions is diagnosed by myocardial biopsy which is frequently false-negative,and patients with cardiac sarcoidosis(CS) who have impaired left ventricular(LV) systolic function are sometimes diagnosed with dilated cardiomyopathy(DCM).Late gadolinium enhancement(LE) in magnetic resonance imaging is now a critical finding in diagnosing CS,and the novel Japanese guideline considers myocardial LE to be a major criterion of CS.This article describes the value of LE in patients with CS who have impaired LV systolic function,particularly the diagnostic and clinical significance of LE distribution in comparison with DCM.LE existed at all LV segments and myocardial layers in patients with CS,whereas it was localized predominantly in the midwall of basal to mid septum in those with DCM.Transmural(nodular),circumferential,and subepicardial and subendocardial LE distribution were highly specific in patients with CS,whereas the prevalence of striated midwall LE were high both in patients with CS and with DCM.Since sarcoidosis patients with LE have higher incidences of heart failure symptoms,ventricular tachyarrhythmia and sudden cardiac death,the analyses of extent and distribution of LE are crucial in early diagnosis and therapeutic approach for patients with CS. | Makoto Sano Hiroshi Satoh Kenichiro Suwa Masao Saotome Tsuyoshi Urushida Hideki Katoh Hideharu Hayashi Takeji Saitoh | 2016 | World Journal of Cardiology2016，8，9： | 2 |
| 2 | 扩张型心肌病患者外周血单个核细胞miR-155表达及意义显示文摘目的探讨微小RNA-155(miR-155)在扩张型心肌病(DCM)患者外周血单个核细胞(PBMC)中的表达变化及其与心功能的关系。方法选择DCM患者(观察组)及同期健康志愿者(对照组)各30例,观察组NYHA心功能Ⅱ级10例、Ⅲ级11例、Ⅳ级9例。采用Ficoll-Hypaque密度梯度离心法分离两组空腹静脉血中的PBMC,实时荧光定量PCR法检测PBMC中miR-155的相对表达量。比较观察组不同NYHA心功能分级者PBMC中miR-155的相对表达量,并分析其相关性。观察组同时行彩色多普勒检查,记录其左心室射血分数(LVEF)、左心室舒张末期内径(LVEDd),分析两者与miR-155表达的相关性。结果观察组miR-155相对表达量为0.50±0.24,对照组为1.00±0.23;两组比较,P<0.01。观察组NYHA心功能Ⅱ、Ⅲ、Ⅳ级者miR-155相对表达量分别为0.77±0.10、0.47±0.10、0.23±0.08,多组间及组内两两比较,P均<0.01。观察组LVEF为28%±10%,LVEDd为(70±7)mm。观察组miR-155相对表达量与NYHA心功能分级、LVEF、LVEDd均呈负相关(r分别为-0.94、-0.67、-0.53,P<0.05或<0.01)。结论 DCM患者PBMC中miR-155表达降低,与患者心功能受损的严重程度有关。 | 颜小飞 黄粮 严莲花 胡芬 王亚 马闻晗 卢帅 汪朝晖 | 2015 | 山东医药2015，55，32： | 0 |
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