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| 1 | Matrix metalloproteinase gene expressions might be oxidative stress targets in gastric cancer cell lines显示文摘Objective: Oxidative stress is linked to increased risk of gastric cancer and matrix metalloproteinases (MMPs) are important in the invasion and metastasis of gastric cancer. We aimed to analyze the effect of the accumulation of oxidative stress in the gastric cancer MKN-45 and 23132/87 cells following hydrogen peroxide (H 2 O 2 ) exposure on the expression patterns of MMP-1, MMP-3, MMP-7, MMP-9, MMP-10, MMP- 11, MMP-12, MMP-14, MMP-15, MMP-17, MMP-23, MMP-28, and β-catenin genes. Methods: The mRNA transcripts in the cells were determined by RT-PCR. Following H 2 O 2 exposure, oxidative stress in the viable cells was analyzed by 2',7'-dichlorofluorescein diacetate (DCFH-DA). Caffeic acid phenethyl ester (CAPE) was used to eliminate oxidative stress and the consequence of H 2 O 2 exposure and its removal on the expressions of the genes were evaluated by quantitative real-time PCR. Results: The expressions of MMP-1, MMP-7, MMP-14, MMP-15, MMP-17 and β-catenin in MKN-45 cells and only the expression of MMP-15 in 23132/87 cells were increased. Removal of the oxidative stress resulted in decrease in the expressions of MMP genes of which the expressions were increased after H 2 O 2 exposure. β-catenin, a transcription factor for many genes including MMPs, also displayed decreased levels of expression in both of the cell lines following CAPE treatment. Conclusions: Our data suggest that there is a remarkable link between the accumulation of oxidative stress and the increased expressions of MMP genes in the gastric cancer cells and MMPs should be considered as potential targets of therapy in gastric cancers due to its continuous exposure to oxidative stress. | Salih Gencer Anil Cebeci Meliha Burcu Irmak-Yazicioglu | 2013 | Chinese Journal of Cancer Research2013，25，3： | 13 |
| 2 | Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis显示文摘 | Sahar A. Saddoughi Salih Gencer Yuri K. Peterson Katherine E. Ward Archana Mukhopadhyay Joshua Oaks Jacek Bielawski Zdzislaw M. Szulc Raquela J. Thomas Shanmugam P. Selvam Can E. Senkal Elizabeth Garrett‐Mayer Ryan M. De Palma Dzmitry Fedarovich Angen Liu | 2012 | EMBO Mol Med2012，，1： | 2 |
| 3 | Comparison of trifocal toric and bifocal toric intraocular lens implantation in patients with cataract and high corneal astigmatism显示文摘AIM:To investigate and compare the quality of life,satisfaction,contrast sensitivity,glare,depth perception,and intraocular lens(IOL)rotation in patients who underwent trifocal toric and bifocal toric IOLs.METHODS:A total of 80 eyes of 40 patients were included in this prospective study.Twenty patients in each group were implanted with trifocal toric and bifocal toric IOL,respectively.Preoperative and postoperative 6-month measurements were recorded for both patient groups.Comprehensive anterior and posterior segment examinations,distance-intermediate-near visual acuity values and the visual function scale questionnaire results were evaluated at these examinations.Patient satisfaction,contrast sensitivity,glare,intermediate-near and distance stereopsis and IOL rotation were also evaluated.RESULTS:No significant difference was found between the groups in terms of distance and near visual acuities(P=0.269,P=0.451).Intermediate visual acuity was significantly increased in the trifocal toric group(P<0.001).The visual function scale results were increased after surgery in both groups(P=0.001 and P<0.001),with no difference determined between them(P=0.158 and P=0.691).The number of patients wearing glasses was low in both groups and there was no significant difference between the groups(P>0.05).The overall satisfaction in the trifocal toric group was significantly higher than in the bifocal toric group(P=0.03).The highest sensitivity was observed at 6 cpd spatial frequency in all patients under photopic conditions(1.80±0.24 logU,1.74±0.20 logU).Distance-intermediate-near binocular depth perception results in both groups were higher in the trifocal toric group(P=0.02,0.048,0.003,respectively).Although there was no significant difference for 3 meters stereopsis,the trifocal toric group had higher depth perception(P=0.577).Mean rotation was 5.76°±3.93°in the trifocal toric group and 12°±7.1°in the bifocal toric group.CONCLUSION:Better results in the middle distance are obtained in the trifocal toric group and less IOL rotation due to digital system-coordinated surgery.Moreover,the overall satisfaction in the trifocal toric group is significantly higher than in the bifocal toric group. | Merve Bozkurt Gencer Hikmet Basmak Erdogan Yasar Ozkan Onal | 2021 | International Journal of Ophthalmology(English edition)2021，14，12： | 2 |
| 4 | Plasma electrolytic surface carburizing and hardening of pure iron显示文摘 | Tarkci M Korkmaz K Gencer Y | | 0，，2： | 1 |
| 5 | Clinical utility of F-wave parameters in unilateral S1 radiculopathy 显示文摘 | Gencer M Uluc K Cetinkaya Y | 2011 | Neuroscienees (Riyadh)2011，16，3： | 1 |
| 6 | DSP based fuzzy-neural speed tracking control of brushless DC motor 显示文摘 | GENCER C SAYGIN A COSKUN I | 2006 | Lecture Notes in Computer Science2006，39，49： | 1 |
| 7 | Silencing of the MMP-3 gene by siRNA transfection in gastric cancer AGS cells 显示文摘 | Gencer S Cebeci A Rada JA | 2011 | J Gastrointestin Liver Dis2011，，1： | 1 |
| 8 | PON1 55/192 polymorphism, oxidative stress, type, prognosis and severity of stroke 显示文摘 | Aydin M Gencer M Cetinkaya Y | 2006 | IUBMB Life2006，58，3： | 1 |
| 9 | Studies on the magnetic properties of martensitic phase in an Fe-Cr-C alloy显示文摘 | S. AKTURK A. GENCER T. N. DURLU | 1997 | Journal of Materials Science Letters1997，，5： | 1 |
| 10 | Plasma electro- lytic surface earburizing and hardening of pure iron显示文摘 | TARAKCI M KORKMAZ K GENCER Y | 2005 | Surface and Coatings Technology2005，199，2： | 1 |
| 11 | Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts显示文摘 | Gencer B Collet TH Virgini V | 2012 | Circulation2012，126，9： | 1 |
| 12 | A shortest route formulation of simpleU-type assembly line balancing problem显示文摘 | Gokcen H Agpak K Gencer C | 2005 | AppliedMathenaticalMode-lling2005，29，4： | 1 |
| 13 | Electrical conductivity imaging via contactless measurement:An experiment study显示文摘 | Karbey B U Gencer N G | 2003 | IEEE Trans Med Imag2003，4，： | 1 |
| 14 | Expected impact of applying new 2013 AHA/ACC cholesterol guidelines criteria on the recommended lipid target achievement after acute coronary syndromes显示文摘 | Gencer B Auer 1L Nanchen D | 2014 | Atheroselerosis2014，239，1： | 1 |
| 15 | Heli- cobacter pylori seroprevalence in patients with chro- nic obstructive pulmonary disease and its relation to pulmonary function tests显示文摘 | Gencer M Ceylan E Yildiz Zeyrek F | 2007 | Respiration2007，74，2： | 1 |
| 16 | Serum uric acid levels correlate with benign paroxysmal positional vertigo 显示文摘 | Celikbilek A Gencer ZK Saydam L | 2014 | Eur J Neuro12014，21，1： | 1 |
| 17 | Subclinical thyroid dysfunction and the risk of heart failure events:an individual participant data analysis from 6 prospective cohorts显示文摘 | Gencer B Collet TH Virgini V | 2012 | Circulation2012，126，9： | 1 |
| 18 | Analytic network process in supplier selection:a case study in an electronic firm显示文摘 | Gencer C Gürpinar D | 2007 | Applied Mathematical Modeling2007，31，11： | 1 |
| 19 | Electrical Impedance Tomography Using Induced Currents显示文摘 | N G Gencer M Kuzuoglu Y Z Ider | 1994 | IEEE Transactions on Medical Imaging1994，13，2： | 1 |
| 20 | Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPKl- dependent necroptosis显示文摘 | Saddoughi SA Gencer S Peterson YK | 2013 | EMBO Mol Med2013，5，1： | 1 |
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