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| 1 | Parkin deficiency accentuates chronic alcohol intake-induced tissue injury and autophagy defects in brain,liver and skeletal muscle显示文摘Alcoholism leads to organ injury including mitochondrial defect and apoptosis with evidence favoring a role for autophagy dysregulation in alcoholic damage.Parkin represents an autosomal recessive in herited gene for Parkins on's disease and an important member of selective autophagy for mitoch on dria.The associati on between Parkins on's disease and alcoholic injury remains elusive.This study aimed to examine the effect of parki n deficiency on chr onic alcohol in takeinduced organ injury in brain,liver and skeletal muscle(rectus femoris muscle).Adult parkinknockout(PRK-/-)and wild-type mice were placed on Liber-De Carli alcohol liquid diet(4%)for 12 weeks prior to assessment of liver enzymes,intraperitoneal glucose toleranee,protein carbonyl content apoptosis,hematoxylin and eosin morphological staining,and mitochondrial respiration(cytochrome c oxidase,NADH:cytochrome c reductase and succinate:cytochrome c reductase).Autophagy protein markers were monitored by western blot analysis.Our data revealed that chronic alcohol intake imposed liver injury as evidenced by elevated aspartate aminotransferase and alanine transaminase,glucose intoleranee,elevated protein carbonyl formation,apoptosis,focal inflammation,necrosis,microvesiculation,autophagy/mitophagy failure and dampened mitochondrial respiration(complexⅣ,complexesⅠandⅢ,and complexesⅡandⅢ)in the brain,liver and rectus femoris skeletal muscle.Although parkin ablation itself did not generate any notable effects on liver enzymes,insulin sensitivity,tissue carbonyl damage,apoptosis,tissue morphology,autophagy or mitochondrial respiration,it accentuated alcohol intake-induced tissue damage,apoptosis,morphological change,autophagy/mitophagy failure and mitochondrial injury without affecting insulin sensitivity.These data suggest that parkin plays an integral role in the preservation against alcohol-induced organ injury,apoptosis and mitochondrial damage. | Hu Peng Xing Qin Sainan Chen Asli E Ceylan Maolong Dong Zhaofen Lin Jun Ren | 2020 | Acta Biochimica et Biophysica Sinica2020，52，6： | 3 |
| 2 | The con- stituents of essential oil and in vitro antimicrobial activity of Micromeria cilicica from Turkey 显示文摘 | DURU M E OZTURK MU A CEYLAN O | 2004 | J Ethnopharmacol2004，94，1： | 1 |
| 3 | Changes in some Macro Minerals and Biochemical Parameters in Female Healthy Siirt Hair Goat Before and after Parturation 显示文摘 | Tanritanir P Dede S Ceylan E | 2009 | J Anita Vet Advances2009，8，3： | 1 |
| 4 | Antimicrobial activity of spices显示文摘 | Ceylan E Fung D Y C | 2004 | Journal of Rapid Methods and Automation in Microbiology2004，12，： | 1 |
| 5 | Improved nitrogen nutrition enhances root uptake, root-to-shoot translocation and remobilization of zinc (65Zn) in wheat 显示文摘 | Erenoglu E B Kutman U B Ceylan Y | 2011 | New Phytologist2011，189，： | 1 |
| 6 | Sexual life following total abdominal hysterectomy显示文摘 | Kuscu NK Orue S Ceylan E | 2005 | Arch Gynecol Obstet2005，271，31： | 1 |
| 7 | Long-time solutions to heat conduction transients with time-dependent inputs 显示文摘 | Ceylan H T G E Myers | 1980 | ASME Journal of Heat Transfer1980，102，1： | 1 |
| 8 | Soft tissue uptake observed on ^99mTc-MDP bone scans显示文摘 | Ergun EL Ceylan E | 2001 | Clin Nucl Med2001，26，： | 1 |
| 9 | Pretreatment of afyon alcaloide factory's wastewater by wet air oxidation (WAO) 显示文摘 | Kacar Y Alpay E Ceylan V K | 2003 | Water Research2003，37，： | 1 |
| 10 | Antimicrobial activity of spices显示文摘 | CeyLan E Fung D Y C | 2004 | Journal of Rapid Methods and Automation in Microbiology2004，12，： | 1 |
| 11 | OVULATION INDUCTION WITH GONADOTROPINS CAUSES INCREASED SISTER CHROMATID EXCHANGES显示文摘 | Tongu? E Ceylaner G Var T Zülfikaroglu E Ceylaner S | 2011 | Genetic Counseling2011，，2： | 1 |
| 12 | Adiponeetin as a biomarker of systemic inflammatory response in smoker patients with stable and exacerbation phases of chronic obstructive pulmonary disease 显示文摘 | Krdar S Serter M Ceylan E | 2009 | Scand J Clin Lab Invest2009，69，2： | 1 |
| 13 | Adiponectin as a biomarker of systemic inflammatory response in smoker patients with stable and exacerbation phases of chronic ob- structive pulmonary disease 显示文摘 | Kirdar S Serter M Ceylan E | 2009 | Scand J Clin Lab Invest2009，69，2： | 1 |
| 14 | The evaluation of myocardial function of patients in the early stage of acute ischemic stroke by two-dimensional speckle tracking echocardiography显示文摘 | Ermis E Demirelli S Ceylan M | 2016 | J Clin Ultrasound2016，44，5： | 1 |
| 15 | Adiponectin as a bio- marker of systemic inflammatory response in smoker patients withstable and exacerbation phases of chronic obstructive pulmonary disease显示文摘 | Kirdar S Serter M Ceylan E | 2009 | Scand J Clin Lab Invest2009，69，2： | 1 |
| 16 | Pretreatment of afyon alcaloide factory's wastewater by wet air oxidation(WAO) 显示文摘 | Kacar Y Alpay E Ceylan V K | 2003 | War Res2003，37，1： | 1 |
| 17 | Heli- cobacter pylori seroprevalence in patients with chro- nic obstructive pulmonary disease and its relation to pulmonary function tests显示文摘 | Gencer M Ceylan E Yildiz Zeyrek F | 2007 | Respiration2007，74，2： | 1 |
| 18 | Soft tissue uptake observed on 99Tcm-MDP bone scans显示文摘 | Ergtn EL Ceylan E | 2001 | Clin Nucl Med2001，26，： | 1 |
| 19 | Pretreatment of afyon alcaloide factory's wastewater by wet air oxidation (WAO) 显示文摘 | Kacar Y Alpay E Ceylan V K | 2003 | Water Research2003，37，： | 1 |
| 20 | Extracion of pins from the aiway with flexible bronchoscopy显示文摘 | Gencer M Ceylan E Koksal N | | 0，，06： | 1 |
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