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| 1 | Detection of composition of functional component theabrownins in Pu-erh tea by degradation method显示文摘Habitual tea consumption can reduce the risk of ASCVD morbidity and mortality and all-cause mortality in China,and long-term adherence to this habit can provide greater protection.Pu-erh tea is one of the representatives of post-fermented teas,and the polymers in Pu-erh tea have anti-cancer and anti-hyperlipidemic activities,but their chemical composition is still unknown.In this study,the chemical composition of Pu-erh tea was investigated in detail and eight(1–8)known compounds were isolated.The polymers in Pu-erh tea were also degraded by thiol degradation,and the fragments of quercetin and(–)-epicatechin-3-O-gallate were found in the thiol degradation products of Pu-erh tea polymers by UPLC observation and separation and purification.This is the first time that this fragment was obtained in Pu-erh tea polymer. | Simin Hu Xiaolei Li Chuangchuang Gao Xianyu Meng Mingchao Li Yuqian Li Tianrui Xu Qian Hao | 2022 | Food Science and Human Wellness2022，11，3： | 3 |
| 2 | Layered double hydroxide monolayers for controlled loading and targeted delivery of anticancer drugs显示文摘二维(2D ) 因为他们的高特定的表面区域和迷人的物理化学的性质, nanomaterials 在 biomedicine 的地里获得了巨大的注意。此处, 2D monolayered 两倍氢氧化物( MLDH ) nanosheets 被采用本地化 doxorubicin (纪录影片), anticancer 药,与一个装载能力象 3.6 mg 一样高??釯??鶋???????鐿骢鯡????鮪???銬????雞??????飝鱎?鶬微隬悑傘?辬?銬???颬疞???徬?????鶝?铍?鳓钫?鵀?亘??鎪蒠?????????斪?鎬頿??悑?讬鶝???墑???鎛??亘??宫?? | Xuan Mei Simin Xu Tongyang Hu Liuqi Peng Rui Gao Ruizheng Liang Min Wei David G. Evans Xue Duan | 2018 | Nano Research2018，11，1： | 2 |
| 3 | n-Channel Organic Transistors Processed from Halogen-Free Solvents: Solvent Effect on Thin-Film Morphology and Charge Transport显示文摘非使氯化的溶剂为由于他们的环境地友好的特征的器官的电子处理高度更好。四不同没有卤素的溶剂, tetrafuran,甲苯,元二甲苯和 1,2,4-trimethylbenzene,被选择制作 n 隧道基于 3-hexylundecyl,代替的萘 diimides 熔化了与的器官的薄电影晶体管(OTFT )(1,3-dithiol-2-ylidene ) malononitrile 组(NDI3HU-DTYM2 ) 。OTFT 在周围的状况下面基于 NDI3HU-DTYM2 显示出多达 1.37 厘米 2·V−1·s−1 的电子活动性。这在为从没有卤素的溶剂处理的 n 隧道 OTFT 的最高的设备表演之中。不同薄电影的形态学,从无特色的低水晶的形态学到排列得好的 nanofibres,在设备表演上有大效果。这些结果可能为器官的电子设备阐明溶剂选择和产生解决方案进程。 | Simin Gao Yonghui Hu Zhiming Duan Xike Gao | 2016 | Chinese Journal of Chemistry2016，34，7： | 1 |
| 4 | Surface-enhanced Raman scattering of uracil and uracil dimer on silver by density functional method显示文摘 | Simin Gao Hongyan Wang Baomei Zhang Yuexia Lin | 2013 | Journal of Molecular Structure2013，，： | 1 |
| 5 | Tectonic features,genetic mechanisms and basin evolution of the eastern Doseo Basin,Chad显示文摘The features of the unconformity,fault and tectonic inversion in the eastern Doseo Basin,Chad,were analyzed,and the genetic mechanisms and basin evolution were discussed using seismic and drilling data.The following results are obtained.First,four stratigraphic unconformities,i.e.basement(Tg),Mangara Group(T10),lower Upper Cretaceous(T5)and Cretaceous(T4),four faulting stages,i.e.Barremian extensional faults,Aptian–Coniacian strike-slip faults,Campanian strike-slip faults,and Eocene strike-slip faults,and two tectonic inversions,i.e.Santonian and end of Cretaceous,were developed in the Doseo Basin.Second,the Doseo Basin was an early failed intracontinental passive rift basin transformed by the strike-slip movement and tectonic inversion.The initial rifting between the African and South American plates induced the nearly N-S stretching of the Doseo Basin,giving rise to the formation of the embryonic Doseo rift basin.The nearly E-W strike-slip movement of Borogop(F1)in the western section of the Central African Shear Zone resulted in the gradual cease of the near north-south rifting and long-term strike-slip transformation,forming a dextral transtension fault system with inherited activity but gradually weakened in intensity(interrupted by two tectonic inversions).This fault system was composed of the main shear(F1),R-type shear(F2-F3)and P-type shear(F4-F5)faults,with the strike-slip associated faults as branches.The strike-slip movements of F1 in Cretaceous and Eocene were controlled by the dextral shear opening of the equatorial south Atlantic and rapid expanding of the Indian Ocean,respectively.The combined function of the strike-slip movement of F1 and the convergence between Africa and Eurasia made the Doseo Basin underwent the Santonian dextral transpressional inversion characterized by intensive folding deformation leading to the echelon NE-SW and NNE-SSW nose-shaped uplifts and unconformity(T5)on high parts of the uplifts.The convergence between Africa and Eurasia caused the intensive tectonic inversion of Doseo Basin at the end of Cretaceous manifesting as intensive uplift,denudation and folding deformation,forming the regional unconformity(T4)and superposing a nearly E-W structural configuration on the Santonian structures.Third,the Doseo Basin experienced four evolutional stages with the features of short rifting and long depression,i.e.Barremian rifting,Aptian rifting–depression transition,Albian–Late Cretaceous depression,and Cenozoic extinction,under the control of the tectonic movements between Africa and its peripheral plates. | GAO Huahua DU Yebo WANG Lin GAO Simin HU Jie BAI Jianfeng MA Hong WANG Yuhua ZHANG Xinshun LIU Hao | 2023 | Petroleum Exploration and Development2023，50，5： | 0 |
| 6 | Detection and classification of breast lesions using multiple information on contrast-enhanced mammography by a multiprocess deep-learning system: A multicenter study显示文摘Objective: Accurate detection and classification of breast lesions in early stage is crucial to timely formulate effective treatments for patients. We aim to develop a fully automatic system to detect and classify breast lesions using multiple contrast-enhanced mammography(CEM) images.Methods: In this study, a total of 1,903 females who underwent CEM examination from three hospitals were enrolled as the training set, internal testing set, pooled external testing set and prospective testing set. Here we developed a CEM-based multiprocess detection and classification system(MDCS) to perform the task of detection and classification of breast lesions. In this system, we introduced an innovative auxiliary feature fusion(AFF)algorithm that could intelligently incorporates multiple types of information from CEM images. The average freeresponse receiver operating characteristic score(AFROC-Score) was presented to validate system’s detection performance, and the performance of classification was evaluated by area under the receiver operating characteristic curve(AUC). Furthermore, we assessed the diagnostic value of MDCS through visual analysis of disputed cases,comparing its performance and efficiency with that of radiologists and exploring whether it could augment radiologists’ performance.Results: On the pooled external and prospective testing sets, MDCS always maintained a high standalone performance, with AFROC-Scores of 0.953 and 0.963 for detection task, and AUCs for classification were 0.909[95% confidence interval(95% CI): 0.822-0.996] and 0.912(95% CI: 0.840-0.985), respectively. It also achieved higher sensitivity than all senior radiologists and higher specificity than all junior radiologists on pooled external and prospective testing sets. Moreover, MDCS performed superior diagnostic efficiency with an average reading time of 5 seconds, compared to the radiologists’ average reading time of 3.2 min. The average performance of all radiologists was also improved to varying degrees with MDCS assistance.Conclusions: MDCS demonstrated excellent performance in the detection and classification of breast lesions,and greatly enhanced the overall performance of radiologists. | Yuqian Chen Zhen Hua Fan Lin Tiantian Zheng Heng Zhou Shijie Zhang Jing Gao Zhongyi Wang Huafei Shao Wenjuan Li Fengjie Liu Simin Wang Yan Zhang Feng Zhao Hao Liu Haizhu Xie Heng Ma Haicheng Zhang Ning Mao | 2023 | Chinese Journal of Cancer Research2023，35，4： | 0 |
| 7 | The linear and nonlinear optical effects of white light显示文摘An overview of our research group’s experimental and theoretical developments is provided on the linear and nonlinear optical effects of white light since 2003. Their work includes the experimental researches on the white light one-dimensional photovoltaic dark spatial solitons and the waveguides and directional couplers induced by them, the circular and elliptic white-light dark spatial solitons and the white-light photorefractive phase masks, two-dimensional white-light photonic lattices and the applications of the white-light dark spatial solitons in the digital image transmission field, the interaction between the two-dimensional white-light dark spatial solitons to enhance or to improve the correlated degree of the white light through the interaction between the white-light beam and coherent dark spatial solitons, the interaction between the one- or two-dimensional white-light dark spatial solitons and the two-dimensional white-light photonic lattices, respectively. We also numerically simulate the interaction between two or more partially incoherent bright spatial solitons and the white bright spatial soliton pairs in the saturated logarithmic nonlinear medium. We have observed experimentally for the first time, the modulation instability of the coherent light and white light, respectively, in self-defocusing medium and so on. | QI XinYuan LIU SiMin GUO Ru LU Yi GAO YuanMei LIU ZhaoHong HUANG ChunFu ZHANG XiaoHua ZHU Nan XU JingJun | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，5： | 0 |
| 8 | Three-dimensional porous In_(2)O_(3) arrays for self-powered transparent solar-blind photodetectors with high responsivity and excellent spectral selectivity显示文摘Transparent solar-blind ultraviolet photodetectors(SBUV PDs)have extensive applications in versatile scenarios,such as optical communication.However,it is still challenging to simultaneously achieve high responsivity,high transparency,and satisfying self-powered capability.Here,we demonstrated high-performance,transparent,and self-powered photoelectrochemical-type(PEC)SBUV PDs based on vertically grown ultrathin In_(2)O_(3) nanosheet arrays(NAs)with a three-dimensional(3D)porous structure.The 3D porous structure simultaneously improves the transmittance in the visible light region,accelerates interfacial reaction kinetics,and promotes photogenerated carrier transport.The performance of In_(2)O_(3) NAs photoanodes exceeds most reported self-powered PEC SBUV PDs,exhibiting a high transmittance of approximately 80%in the visible light region,a high responsivity of 86.15 mA/W for 254 nm light irradiation,a fast response speed of 15/18 ms,and good multicycle stability.The In_(2)O_(3) NAs also show excellent spectral selectivity with an ultrahigh solar-blind rejection ratio of 1319.30,attributed to the quantum confinement effect induced by the ultrathin feature(2-3 nm).Furthermore,In_(2)O_(3) NAs photoanodes show good capability in underwater optical communication.Our work demonstrated that a 3D porous structure is a powerful strategy to synchronously achieve high responsivity and transparency and provides a new perspective for designing high-performance,transparent,and self-powered PEC SBUV PDs. | Nana Zhang Xinyu Gao Haoran Guan Simin Sun Jiaming Liu Zhitao Shao Qiyue Gao Yuan Zhang Ruyu Sun Guang Yang Feng Gao Wei Feng | 2024 | Nano Research2024，17，5： | 0 |
| 9 | Improving current and mitigating energy loss in ternary organic photovoltaics enabled by two well-compatible small molecule acceptors显示文摘Ternary organic photovoltaic(OPV)strategy is an effective but facile approach to enhance the photovoltaic performance for single-junction devices.Herein,a series of ternary OPVs were fabricated by employing a wide bandgap donor(PBDB-TF)and two acceptor-donor-acceptor(A-D-A)-type nonfullerene small molecule acceptors(NF-SMAs,called F-2 Cl and 3 TT-OCIC).As the third component,the near-infrared SMA,3 TT-OCIC,has complementary absorption spectrum,narrow bandgap and wellcompatible crystallization property to the host acceptor(F-2 Cl)for efficient ternary OPVs.With these,the optimal ternary devices yield significantly enhanced power conversion efficiency of 15.23%,one of the very few examples with PCE higher than15%other than Y6 systems.This is mainly attributed to the increased short-circuit current density of 24.92 m A cm^(-2) and dramatically decreased energy loss of 0.53 e V.This work presents a successful example for simultaneously improving current,minimizing energy loss and together with modifying the morphology of active layers in OPVs,which will contribute to the further construction of high performance ternary OPVs. | Yanna Sun Huan-Huan Gao Simin Wu Lingxian Meng Xiangjian Wan Mengyang Li Zaifei Ma Ziqi Guo Shitong Li Hongtao Zhang Chenxi Li Yongsheng Chen | 2021 | Science China Chemistry2021，64，4： | 0 |
| 10 | Deubiquitinase ubiquitin-specific protease 3 (USP3) inhibits HIV-1 replication via promoting APOBEC3G (A3G) expression in both enzyme activity-dependent and -independent manners显示文摘Background: Ubiquitination plays an essential role in many biological processes, including viral infection, and can be reversed by deubiquitinating enzymes (DUBs). Although some studies discovered that DUBs inhibit or enhance viral infection by various mechanisms, there is lack of information on the role of DUBs in virus regulation, which needs to be further investigated.Methods: Immunoblotting, real-time polymerase chain reaction,in vivo/in vitro deubiquitination, protein immunoprecipitation, immunofluorescence, and co-localization biological techniques were employed to examine the effect of ubiquitin-specific protease 3 (USP3) on APOBEC3G (A3G) stability and human immunodeficiency virus (HIV) replication. To analyse the relationship between USP3 and HIV disease progression, we recruited 20 HIV-infected patients to detect the levels of USP3 and A3G in peripheral blood and analysed their correlation with CD4^(+) T-cell counts. Correlation was estimated by Pearson correlation coefficients (for parametric data).Results: The results demonstrated that USP3 specifically inhibits HIV-1 replication in an A3G-dependent manner. Further investigation found that USP3 stabilized 90% to 95% of A3G expression by deubiquitinating Vif-mediated polyubiquitination and blocking its degradation in an enzyme-dependent manner. It also enhances the A3G messenger RNA (mRNA) level by binding to A3G mRNA and stabilizing it in an enzyme-independent manner. Moreover, USP3 expression was positively correlated with A3G expression (r= 0.5110) and CD4^(+) T-cell counts (r= 0.5083) in HIV-1-infected patients.Conclusions: USP3 restricts HIV-1 viral infections by increasing the expression of the antiviral factor A3G. Therefore, USP3 may be an important target for drug development and serve as a novel therapeutic strategy against viral infections. | Simin Zhao Baisong Zheng Liuli Wang Wenzhe Cui Chunlai Jiang Zhuo Li Wenying Gao Wenyan Zhang | 2022 | Chinese Medical Journal2022，135，22： | 0 |
| 11 | AlphaMat: a material informatics hub connecting data, features, models and applications显示文摘The development of modern civil industry,energy and information technology is inseparable from the rapid explorations of new materials.However,only a small fraction of materials being experimentally/computationally studied in a vast chemical space.Artificial intelligence(AI)is promising to address this gap,but faces many challenges,such as data scarcity and inaccurate material descriptors.Here,we develop an AI platform,AlphaMat,that can complete data preprocessing and downstream AI models.With high efficiency and accuracy,AlphaMat exhibits strong powers to model typical 12 material attributes(formation energy,band gap,ionic conductivity,magnetism,bulk modulus,etc.).AlphaMat’s capabilities are further demonstrated to discover thousands of new materials for use in specific domains.AlphaMat does not require users to have strong programming experience,and its effective use will facilitate the development of materials informatics,which is of great significance for the implementation of AI for Science(AI4S). | Zhilong Wang An Chen Kehao Tao Junfei Cai Yanqiang Han Jing Gao Simin Ye Shiwei Wang Imran Ali Jinjin Li | 2023 | npj Computational Materials2023，，1： | 0 |
| 12 | Copper-catalyzed C(sp)-H aryl amination enables modular synthesis of quinolines and 2-quinolinones显示文摘Herein,we disclose a novel copper-catalyzed C(sp)-H aryl amination of terminal alkynes with anthranils,enabling the rapid generation of highly reactive secondary N-aryl ynamines for the modular synthesis of structurally diverse C2-substituted quinolines and 2-quinolinones.The in-situ formed carbonyl-ynamines are prone to tautomerize to carbonyl-ketenimines,which can efficiently react with a series of nucleophiles,including amines,alcohols,phenols,thiols,thiophenols,active-methylene compounds,and even water to produce various quinoline derivatives with the generation of H_(2)O as a sole and green byproduct.This method also unlocks a practical route to create various quinoline-fused heterocycles and can be successfully applied to the late-stage modification of complex molecules and the concise synthesis of bioactive targets.Mechanistic studies reveal a coppercatalyzed inner-sphere nitrene transfer process by using anthranils as novel aryl nitrene precursors. | Yang Gao Haixia Li Simin Yang Yanping Huo Qian Chen Xianwei Li Zhe Wang Xiao-Qiang Hu | 2024 | Science China Chemistry2024，67，2： | 0 |
| 13 | 3D Joint inversion of gravity and gravity tensor data显示文摘The processing and interpretation of gravity and gradient data plays an important role in geophysics.The cross gradient joint inversion is usually used for achieving structure coupling of multiple geophysical models. In order to realize the coupling of gravity and gravity tensor data,the authors analyzed each component.The results show that different types of data contain different direction information,and derived the joint inversion based on cross gradient function and applied it to model data. The theoretical model results show that the cross gradient method can reduce the multi solution and significantly improve the resolution of the inversion.The method was also applied to inverse the gravity tensor data in Vinton salt dome,showing that this method can get higher resolution results than the separate linear inversion,and be closer to the real density from drilling data. | ZHAO Simin GAO Xiuhe QIAO Zhongkun JIANG Dandan ZHOU Fei LIN Song | 2018 | Global Geology2018，21，1： | 0 |
| 14 | Biological Tissue-Inspired Ultrasoft,Ultrathin,and Mechanically Enhanced Microfiber Composite Hydrogel for Flexible Bioelectronics显示文摘Hydrogels offer tissue-like softness,stretchability,fracture toughness,ionic conductivity,and compatibility with biological tissues,which make them promising candidates for fabricating flexible bioelectronics.A soft hydrogel film offers an ideal interface to directly bridge thin-film electronics with the soft tissues.However,it remains difficult to fabricate a soft hydrogel film with an ultrathin configuration and excellent mechanical strength.Here we report a biological tissue-inspired ultrasoft microfiber composite ultrathin(<5μm)hydrogel film,which is currently the thinnest hydrogel film as far as we know.The embedded microfibers endow the composite hydrogel with prominent mechanical strength(tensile stress~6 MPa)and anti-tearing property.Moreover,our microfiber composite hydrogel offers the capability of tunable mechanical properties in a broad range,allowing for matching the modulus of most biological tissues and organs.The incorporation of glycerol and salt ions imparts the microfiber composite hydrogel with high ionic conductivity and prominent anti-dehydration behavior.Such microfiber composite hydrogels are promising for constructing attaching-type flexible bioelectronics to monitor biosignals. | Qiang Gao Fuqin Sun Yue Li Lianhui Li Mengyuan Liu Shuqi Wang Yongfeng Wang Tie Li Lin Liu Simin Feng Xiaowei Wang Seema Agarwal Ting Zhang | 2023 | Nano-Micro Letters2023，15，9： | 0 |
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