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| 1 | Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2显示文摘肝炎 B 病毒 X 蛋白质(HBx ) 在 hepatocellular 癌的发展起一个关键作用。这里,我们寻求了识别 HBx 由调停的机制肝房间增长。我们发现那 HBx upregulated cyclooxygenase-2 (COX-2 ) 的层次, 5-lipoxygenase (5 哈鱼) 和 phosphorylated 在肝房间的细胞外的调整信号的蛋白质 kinases 1/2 (p-ERK1/2 ) 。导致 HBx 的 p-ERK1/2 被 Gi/o 蛋白质,艇长或哈鱼的抑制废除。另外, HBx 增加了前列腺素 E2 (PGE2 ) 的数量,免除房间线的 leukotriene B4 (LTB4 ) 源于 hepatocytes。而且,这些释放 arachidonic 酸代谢物能激活 ERK1/2。有趣地,激活 ERK1/2 能 upregulate 以一种积极反馈方式的 COX-2 和 5 哈鱼的表示。在结论, HBx 经由包含 COX-2, 5 哈鱼,释放 arachidonic 酸代谢物, Gi/o 蛋白质和 p-ERK1/2 的一个积极反馈环提高并且维持肝房间增长。 | Changliang Shan Fuqing Xu Shuai Zhang Jiacong YOU Xiaona You Liyan Qiu Jie Zheng Lihong Ye Xiaodong Zhang | 2010 | Cell Research2010，20，5： | 15 |
| 2 | Geochemical character and material source of sediments in the eastern Philippine Sea显示文摘Based upon analyses of grain-size, rare earth element (REE) compositions, elemental occurrence phases of REE, and U-series isotopic dating, the sediment characteristics and material sources of the study area were examined for the recently formed deep-sea clays in the eastern Philippine Sea. The analytical results are summarized as follows. (1) Low accumulation rate, poor sorting and roundness, and high contents of grains coarser than fine silt indicate relatively low sediment input, with localized material source without long distance transport. (2) The REE Contents are relatively high. Shale-normalized patterns of REE indicate weak enrichment in heavy REE (HREE), Ce-passive anomaly, and Eu-positive anomaly. (3) Elemental occurrence phases of REE between the sediments with and without crust are similar. REE mainly concentrate in residual phase and then in ferromanganese oxide phase. The light REE (LREE) enrichment, Ce-positive anomaly, and Eu-positive anomaly occur in re- sidual phase. Ferromanganese oxide phase shows the characteristics of relatively high HREE content and Ce-passive anomaly. (4) There are differences in each above mentioned aspect between the sedi- ments with and without ferromanganese crust. (5) Synthesizing the above characteristics and source discriminant analysis, the study sediments are deduced to mainly result from the alteration of local and nearby volcanic materials. Continental materials transported by wind and/or river (ocean) flows also have minor contributions. | XU ZhaoKai LI AnChun JlANG FuQing XU FangJian | 2008 | Chinese Science Bulletin2008，53，6： | 14 |
| 3 | A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice显示文摘The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI).However,the calcium channels responsible for this process have remained unknown.Here,we show that rice CDSI(CELL DEATH and SUSCEPTIBLE to BLAST 1)encoding OsCNGC9;a cyclic nucleotide-gated channel protein,positively regulates the resistance to rice blast disease.We show that OsCNGC9 mediates PAMP-induced Ca2+influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression.We further show that a PTI related receptor-lih cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity.Our results suggest a signaling cascade linking pattern recognition to calcium channel activation,which is required for initiation of PTI and disease resistance in rice. | Jiachang Wang Xi Liu An Zhang Yulong Ren Fuqing Wu Gang Wang Yang Xu Cailin Lei Shanshan Zhu Tian Pan Yongfei Wang Huan Zhang Fan Wang Yan-Qiu Tan Yupeng Wang Xin Jin Sheng Luo Chunlei Zhou Xiao Zhang Jinling Liu Shuai Wang Lingzhi Meng Yihua Wang Xi Chen Qibing Lin Xin Zhang Xiuping Guo Zhijun Cheng Jiulin Wang Yunlu Tian Shijia Liu Ling Jiang Chuanyin Wu Ertao Wang Jian-Min Zhou Yong-Fei Wang Haiyang Wang Jianmin Wan | 2019 | Cell Research2019，29，10： | 13 |
| 4 | Geochemistry of rare earth elements in the mid-late Quaternary sediments of the western Philippine Sea and their paleoenvironmental significance显示文摘Based on a δ18O chronology,rare earth elements(REE) and other typical elements in sediments from core MD06-3047 in the western Philippine Sea were analyzed to constrain the provenances of the sediments and investigate quantitative changes in the Asian eolian input to the study area over the last 700 ka.Among the competing processes that might affect REE compositions,sediment provenance is the most important one.Provenance analysis suggests that the study sediments have two provenance end-members;local volcanic sources are dominant,and eolian dust from the Asian continent has a smaller contribution.During glacial periods,eolian input to the western Philippine Sea was enhanced.In contrast,material supply from local volcanics increased during interglacial periods.Changes in eolian input to the study area were probably related to the strength of the East Asian winter monsoon(EAWM) as well as aridity in the Asian continent on an orbital time scale,and were partly influenced by local control factors on shorter time scales.Therefore,we propose that the present study expands the application of the REE-based method for quantitatively estimating the eolian component from the mid-latitude northern Pacific to the low-latitude western Pacific.Additionally,the study preliminarily confirms the influence of EAWM-transported eolian material on sedimentation in the western Philippine Sea since 700 ka. | XU ZhaoKai LI TieGang WAN ShiMing YIN XueBo JIANG FuQing SUN HanJie JinYong CHOI DhongIl LIM | 2014 | Science China Earth Sciences2014，57，4： | 10 |
| 5 | Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice显示文摘Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely elusive.Here we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold tolerance.Mechanistically,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+influx.Moreover,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,OsDREB1A.Taken together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation. | Jiachang Wang Yulong Ren Xi Liu Sheng Luo Xiao Zhang Xin Liu Qibing Lin Shanshan Zhu Hua Wan Yang Yang Yu Zhang Bin Lei Chunlei Zhou Tian Pan Yongfei Wang Mingming Wu Ruonan jing Yang Xu Meng Han Fuqing Wu Cailin Lei Xiuping Guo Zhijun Cheng Xiaoming Zheng Yihua Wang Zhigang Zhao Ling Jiang Xin Zhang Yong-Fei Wang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 10 |
| 6 | Construction of a sustainable 3-hydroxybutyrate-producing probiotic Escherichia coli for treatment of colitis显示文摘Colitis is a common disease of the colon that is very difficult to treat.Probiotic bacteria could be an effective treatment.The probiotic Escherichia coli Nissle 1917(EcN)was engineered to synthesize the ketone body(R)-3-hydroxybutyrate(3HB)for sustainable production in the gut lumen of mice suffering from colitis.Components of heterologous 3HB synthesis routes were constructed,expressed,optimized,and inserted into the EcN genome,combined with deletions in competitive branch pathways.The genome-engineered EcN produced the highest 3HB level of 0.6 g/L under microaerobic conditions.The live therapeutic was found to colonize the mouse gastrointestinal tract over 14 days,elevating gut 3HB and short-chain-length fatty acid(SCFA)levels 8.7-and 3.1-fold compared to those of wild-type EcN,respectively.The sustainable presence of 3HB in mouse guts promoted the growth of probiotic bacteria,especially Akkermansia spp.,to over 31%from the initial 2%of all the microbiome.As a result,the engineered EcN termed EcNL4 ameliorated colitis induced via dextran sulfate sodium(DSS)in mice.Compared to wild-type EcN or oral administration of 3HB,oral EcNL4 uptake demonstrated better effects on mouse weights,colon lengths,occult blood levels,gut tissue myeloperoxidase activity and proinflammatory cytokine concentrations.Thus,a promising live bacterium was developed to improve colonic microenvironments and further treat colitis.This proof-of-concept design can be employed to treat other diseases of the colon. | Xu Yan Xin-Yi Liu Dian Zhang Yu-Dian Zhang Zi-Hua Li Xu Liu Fuqing Wu Guo-Qiang Chen | 2021 | Cellular & Molecular Immunology2021，18，10： | 8 |
| 7 | Paleoenvironment evolution of the East Philippine Sea recorded in the new-type ferromanganese crust since the terminal Late Miocene显示文摘From systemic research of microstructure, geochemistry, uranium-series and 10Be isotope dating on a new-type deepwater ferromanganese crust from the East Philippine Sea, the paleoenvironment evolu-tion of the target area since the terminal Late Miocene was recovered. The vertical section changes of microstructure and chemical composition are consistent in the studied crust, which indicate three major accretion periods and corresponding paleoenvironment evolution of the crust. The bottom crust zone was formed in the terminal Late Miocene (5.6 Ma) with loose microstructure, high detritus content and high growth rate. Reductions of mineral element content, accretion rate and positive Ce-anomaly degree at 4.6 Ma indicate temporal warming, which went against the crust accretion and finally formed an accretion gap in the terminal Middle Pliocene (2.8―2.7 Ma). The more active Antarctic bottom sea-waters in the Late Pliocene (2.7 Ma) facilitated the fast transfer to the top pure crust zone. Hereafter, with the further apart of volcanic source and the keeping increase of eolian material (1.0 Ma), although surrounding conditions were still favorable, mineral element content still shows an obvious reducing trend. It thereby offers new carrier and data for the unclear paleoceanographic research of the target area since the terminal Late Miocene. | XU ZhaoKai LI AnChun JIANG FuQing LI TieGang MENG QingYong JIN Ning | 2007 | Science China Earth Sciences2007，50，8： | 4 |
| 8 | Inhibitive effects of three compositae plants on Microcystis aeruginosa显示文摘Based on common phenomena of biochemical interaction between plants and microorganisms,the inhibitive effects of three common terrestrial compositae plants,namely Artemisia lavandulaefolia DC.,Conyza canadensis(L.)Cronq.,and Kalimeris indica(L.)Sch.-Bip.on the blue algae Microcystis aeruginosa was studied.Live compositae plants are co-cultivated with algae in two different inoculation doses for 10 days in 5-pools incubators,in order to exclude the influence of bacteria and nutrients.The results show that Artemisia lavandulaefolia DC has the most inhibitive potential among the three plants as evidenced by the most drastic decrease in optical density(OD680)of the algae.The inhibition rate is 93.3%(with initial inoculation dose of 2.0×10^(6) Cells/mL)and 89.3%(with initial inoculation dose of 4.0×10^(6) Cells/mL)respectively on the 10th day of cultivation.The average inhibition rate during the later half of the experiment is 0.76(with initial inoculation dose of 2.0×10^(6) Cells/mL)and 0.71(with initial inoculation dose of 4.0×10^(6) Cells/mL),respectively.Logistic model analysis shows that compositae plants such as A.lavandulaefolia DC.causes the reduction of the habitat’s carrying capacity of algae.ANOVA analysis is used to determine the similarity and differences between every experimental group and an average inhibitive rate model is used to evaluate the inhibition effects.The results show that A.lavandulaefolia DC.,which grow well in the aquatic environment,may have a great potential in controlling algae bloom in eutrophic water. | Weihao ZHANG Fuqing XU Wei HE Xing ZHENG Chen YANG | 2009 | Frontiers of Environmental Science & Engineering2009，3，1： | 3 |
| 9 | Preservation Effect of Prochloraz-manganese Chloride Complex on Postharvest ‘Shatangju'( Citrus reticulata)Fruits显示文摘[Objective]The paper was to solve the weakness of heavy postharvest diseases and non-endurable storage of‘Shatangju',to improve the preservation effect of‘Shatangju'. [Method] Fruits were dipped in different concentrations of prochloraz-manganese chloride complex solutions. The postharvest weight loss rate,soluble solids content and decay rate of fruits were determined,and the safety of chemical agents was observed and evaluated. [Result]Prochloraz-manganese chloride complex had significant preservation effect on postharvest‘Shatangju'fruits,and the appropriate concentration was 0. 15%-0. 20%( effective content);the decay rates of fruits stored at room temperature for 15,30,45,60 and 90 d were 0,5%,< 10%,< 10% and < 30%; there was no specific changes in smell and flavor of non-decayed fruits. [Conclusion] Prochloraz-manganese chloride complex solution had significant preservation effect on ‘Shatangju'by inhibiting and reducing the growth and development of pathogenic bacteria,and the effect was much better under refrigeration condition. | Xu Chengxiang Zheng Fuqing Ma Yanping Zhang Xujia | 2016 | Plant Diseases and Pests2016，7，5： | 2 |
| 10 | Effects of total ammonia nitrogen concentration on solid-state anaerobic digestion of corn stover 显示文摘 | Wang Zhongjiang Xu Fuqing Li Yebo | 2013 | Bioresource Technology2013，144，： | 1 |
| 11 | Effects of total ammonia nitrogen concentration on solid-state anaerobic digestion of corn stover 显示文摘 | Wang Zhongjiang Xu Fuqing Li Yebo | 2013 | Bioresource Technology2013，144，： | 1 |
| 12 | Pretreatment of lignocellulosic biomass for enhanced biogas production显示文摘 | Zheng Yi Zhao Jia Xu Fuqing | 2014 | Progress in Energy and Combustion Science2014，42，： | 1 |
| 13 | IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells显示文摘 | Shuguang Zuo Chang Liu Jianguo Wang Fuqing Wang Wanling Xu Shao Cui Lei Yuan Xudong Chen Wenjuan Fan Mingchen Cui Guohua Song | 2012 | Journal of Cancer Research and Clinical Oncology2012，，6： | 1 |
| 14 | Pretreatment of lignocellulosic biomass for enhanced biogas production 显示文摘 | Zheng Yi Zhao ]ia Xu Fuqing | 2014 | Prog Energ Combust2014，42，4： | 1 |
| 15 | Expression and significance of Oct4 in bladder cancer显示文摘 | Kai Xu Zhaohui Zhu Fuqing Zeng Jihua Dong | 2008 | Journal of Huazhong University of Science and Technology2008，，6： | 1 |
| 16 | Pretreat ment of lignocellulosie biomass for enhanced biogas production显示文摘 | ZHENG Yi ZHAO Jia XU Fuqing | 2014 | Progress in Energy and Combustion Science2014，42，： | 1 |
| 17 | Pretreatment of lignocellulosic biomass for enhanced biogas production 显示文摘 | Yi Zheng Jia Zhao Fuqing Xu | 2014 | Progress in Energy and Combustion Science2014，42，6： | 1 |
| 18 | Solid-state anaerobic co-digestion of hay and soybean processing waste for biogas production显示文摘 | Jiying Zhu Yi Zheng Fuqing Xu Yebo Li | 2013 | Bioresource Technology2013，154，： | 1 |
| 19 | CHHE-MRT Method for Three-Body Problem显示文摘Continuum hyperspherical harmonics expansion momentum representation transformation(CHHE-MRT)method for three-body problem is briefly introduced,including two-body T matrix and hyperradial function of three-body in bound state or in scattering state.As a check of this method,the binding energies and hyperradial functions in bound states of 3N(^(3)H)and 3α(12C)systems are calculated by using Gauss,exponential and Yukawa potentials,respectively. | LI Shiqing XU Dingan JIAO Shuqing LIU Fuqing | 1992 | Chinese Physics Letters1992，9，6： | 0 |
| 20 | Study on sterols from brown algae (Sargassum muticum)显示文摘Various △5-3β-sterenols, whose carbon numbers range from C19―C23 to C26―C30 and some compounds have many stereomers maximal up to six, have been detected out from the extract of brown algae (Sargassum muticum), which means that steranes with lower carbon numbers are likely dif- ferent in the origin, and some corresponding sterol stereoisomers may have already existed in their precursor organisms. This provides some experi- mental evidence for supplementing and amending the traditional interpretation of the sterol stereoisomer transformation during the deposition and diagenesis of organic matter. | WANG Peirong XU Guanjun BIAN Lizeng ZHANG Shuichang SONG Fuqing | 2006 | Chinese Science Bulletin2006，51，20： | 0 |
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