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| 1 | Peginterferon and ribavirin treatment for hepatitis C virus infection显示文摘Pegylated interferon α (IFNα) in combination with ribavirin is currently recommended as a standard-of-care treatment for chronic hepatitis C virus (HCV) infection. This combination therapy has drastically improved the rate of sustained virological response, specifically in difficult-to-treat patients. Recently, individualized treatment, such as response-guided therapy, is being developed based on host-, HCV- and treatment-related factors. Furthermore, modified regimens with currently available medications, novel modified IFNα and ribavirin or combinations with specifically targeted antiviral therapy for HCV agents, are currently being investigated. The purpose of this review is to address some issues and epoch-making topics in the treatment of chronic HCV infection, and to discuss more optimal and highly individualized therapeutic strategies for HCV-infected patients. | Akihito Tsubota Kiyotaka Fujise Yoshihisa Namiki Norio Tada | 2011 | World Journal of Gastroenterology2011，17，4： | 16 |
| 2 | 一个新型的毫米波无线信号光纤传输系统及本振信号远程传送结构(英文)显示文摘提出一个新型的毫米波光纤传输系统及本振信号远程传送的结构.此技术能为将来使用皮蜂窝网络提供宽带无线接入服务给出一个简单的基站接入点解决方案.计算和仿真结果表明,在激光器输出功率为-6.5 dBm,光放大增益为6 dB,激光线宽为1 MHz,75 MHz或150 MHz,误码率不超过10-9的情形下,622 Mbit/s的下行相移键控信号能够在传统单模光纤上传输超过30 km的距离.在具有相对大的激光器线宽150 MHz和光纤距离为30 km时,由激光器相位噪音和光纤色散所引起的(通过远程传送的)毫米波本振信号的额外相位误差的方差仅为1.74°. | 周明拓 Sharma A B 张建国 Fujise M | 2006 | 光子学报2006，35，11： | 7 |
| 3 | Risk factors for complications of endoscopic submucosal dissection in gastric tumors: analysis of 478 lesions显示文摘 | Kotaro Mannen Seiji Tsunada Megumi Hara Kanako Yamaguchi Yasuhisa Sakata Takehiro Fujise Takahiro Noda Ryo Shimoda Hiroyuki Sakata Shinichi Ogata Ryuichi Iwakiri Kazuma Fujimoto | 2010 | Journal of Gastroenterology2010，，1： | 3 |
| 4 | A mutation of the start codon in the X region of hepatitis B virus DNA in a patient with non-B,non-C chronic hepatitis显示文摘There are cases of hepatitis involving occult hepatitis B virus(HBV)infection in which,even though the HB surface antigen(HBsAg)is negative,HBV-DNA is detected by a polymerase chain reaction(PCR).We con-ducted a sequence analysis of the entire HBV region in a case of non-B non-C chronic hepatitis in a 46-yearold female.A diagnosis of non-B non-C chronic hepatitis was made.Although HBV markers,such as HBs antibody(anti-HBs),anti-HBc,HBeAg and anti-HBe,were negative,HBV-DNA was positive.Nested PCR was performed to amplify the precore region of HBV-DNA and all remaining regions by long nested PCR.Sequence analysis of the two obtained bands was conducted by direct sequencing.Compared with the control strains,the ATG(Methionine)start codon in the X region had mut ated to GTG(Valine).It is assumed that a mutation at the start codon in the X region may be the reason why HBV markers are negative in some cases of hepatitis that involve occult HBV infection. | Kiyotaka Fujise Keiko Tatsuzawa Midori Kono Sadayori Hoshina Akihito Tsubota Minoru Niiya Yoshihisa Namiki Norio Tada Hisao Tajiri | 2011 | World Journal of Hepatology2011，3，2： | 3 |
| 5 | New combination test for hepatitis C virus genotype and viral load determination using Amplicor GT HCV MONITOR test v2.0显示文摘AIM: To develop a new sensitive and inexpensive hepatitis C virus (HCV) combination test (HCV Guideline test) that enables the determination of HCV genotypes 1, 2 and 3,and simultaneous determination of HCV viral load using commercial Amplicor GT HCV MONITOR test v2.0 (microwell version).METHODS: The HCV Guideline test used the PCR product generated in commercial Amplicor GT HCV Monitor test v2.0 for viral load measurement using microwell plate version of Amplicor HCV Monitor and also captured on separate plates containing capture probes and competitive oligonucleotide probes specific for HCV genotypes 1, 2 and 3, The HCV genotype was subsequently determined using the biotin-labeled PCR product and five biotin-labeled HCV-specific probes.RESULTS: The sensitivity of the HCV Guideline test was 0.5 KIU/mL. Specificity of the HCV Guideline test was confirmed by direct sequencing of HCV core region and molecular evolutionary analyses based on a panel of 31 samples. The comparison of the HCV Guideline test and an in-house HCV core genotyping assay using 252 samples from chronic hepatitis C patients indicated concordant results for 97.2% of samples (59.5% genotype 1, 33.7% genotype 2, 6.0% genotype 3, and 0.8% mixed genotypes).Similarly, the HCV Guideline test showed concordance with a serological test, and the serological test failed to assign any serotype in 12.7% of the samples, indicating a better sensitivity of the HCV Guideline test.CONCLUSION: Clinically, both viral load and genotypes (1, 2 and 3) have been found to be major predictors of antiviral therapy outcome regarding chronic hepatitis C based on guidelines and they are, in normal circumstances,performed as separate stand-alone assays. The HCV Guideline test is a useful method for screening large cohorts in a routine clinical setting for determining the treatment regimen and for predicting the outcome of antiviral therapy of chronic hepatitis C. | Motokazu Mukaide Yasuhito Tanaka Hirokazu Kakuda Kei Fujiwara Fuat Kurbanov Eturo Orito Kentaro Yoshioka Kiyotaka Fujise Shoji Harada Takazumi Kozaki Kazuo Takemura Kazumasa Hikiji Masashi Mizokami | 2005 | World Journal of Gastroenterology2005，11，4： | 3 |
| 6 | Early apoptosis and cell death induced by ATX-S10Na(Ⅱ)-mediated photodynamic therapy are Bax- and p53-dependent in human colon cancer cells显示文摘AIM: To investigate the roles of Bax and p53 proteins in photosensitivity of human colon cancer cells by using lysosome-localizing photosensitizer, ATX-S10Na (Ⅱ).METHODS: HCT116 human colon cancer cells and Bax-null or p53-null isogenic derivatives were irradiated with a diode laser. Early apoptosis and cell death in response to photodynamic therapy were determined by MTT assays, annexin V assays, transmission electron microscopy assays, caspase assays and western blotting.RESULTS: Induction of early apoptosis and cell death was Bax- and p53-dependent. Bax and p53 were required for caspase-dependent apoptosis. The levels of anti-apoptotic Bcl-2 family proteins, Bcl-2 and Bcl-xL, were decreased in Bax- and p53-independent manner.CONCLUSION: Our results indicate that early apoptosis and cell death of human colon cancer cells induced by photodynamic therapy with lysosome-localizing photosensitizer ATX-S10Na (Ⅱ) are mediated by p53-Bax network and low levels of Bcl-2 and Bcl-xL proteins. Our results might help in formulating new therapeutic approaches in photodynamic therapy. | Makoto Mitsunaga Akihito Tsubota Kohichi Nariai Yoshihisa Namiki Makoto Sumi Tetsuya Yoshikawa Kiyotaka Fujise | 2007 | World Journal of Gastroenterology2007，13，5： | 3 |
| 7 | Risk factors for complications of endoscopic submucosal dissection in gastric tumors: analysis of 478 lesions显示文摘 | Kotaro Mannen Seiji Tsunada Megumi Hara Kanako Yamaguchi Yasuhisa Sakata Takehiro Fujise Takahiro Noda Ryo Shimoda Hiroyuki Sakata Shinichi Ogata Ryuichi Iwakiri Kazuma Fujimoto | 2010 | Journal of Gastroenterology2010，，1： | 3 |
| 8 | Four-week pegylated interferon a-2a monotherapy for chronic hepatitis C with genotype 2 and low viral load:A pilot,randomized study显示文摘AIM:To assess the efficacy and advantages of 4-wk pegylated interferon a-2a(peg-IFN-a2a) monotherapy for chronic hepatitis C patients with strong predictors of sustained virologic response(SVR).METHODS:Patients(n = 33) with genotype 2 and low viral load(< 100 KIU/mL),who became HCV RNA negative after 1 wk of IFN treatment,were randomly allocated to receive a 4-or 12-wk treatment course at a ratio of 2:1,respectively,with a subsequent 24-wk follow-up period.Peg-IFN-a2a was administered subcutaneously at a dose of 180 μg or 90 μg once weekly.SVR was defined as absence of serum HCV RNA at the end of the follow-up period.RESULTS:All patients completed the treatment schedule,and more than half were symptom-free during the treatment.In the 4-wk treatment group,20 of 22(91%) patients achieved SVR.Two patients relapsed,but achieved SVR following re-treatment with peg-IFN-a2a alone.In the 12-wk treatment group,11 of 11(100%) patients attained SVR.CONCLUSION:Our results show that a 4-wk course of peg-IFN-a2a monotherapy can achieve a high SVR rate in 'IFN-sensitive' patients,without negatively affecting outcome. | Akihito Tsubota Ken-ichi Satoh Mashu Aizawa Seishi Takamatsu Yoshihisa Namiki Toshifumi Ohkusa Kiyotaka Fujise Hisao Tajiri | 2008 | World Journal of Gastroenterology2008，14，47： | 3 |
| 9 | Involvement of Porphyromonas gingivdis fimA genotype in treatment outcome following non-surgical periodontal therapy显示文摘 | Fujise O Miura M Hamachi T | 2005 | J Periodontol2005，76，10： | 1 |
| 10 | Studies on the dry matterproduction of sweet potato显示文摘 | Yukind Tsuno Kazuma Fujise | 1963 | The Crop Science Society ofJapan1963，32，4： | 1 |
| 11 | The effects of the lateral position on cardiopulmonafy function during laparoscopic urological surgery 显示文摘 | Fujise K Shingu K Matsumoto S | 1998 | Anesth Analg1998，87，4： | 1 |
| 12 | Intracoronary adenosine administered during rotational atherectomy of compjlex lesions in native coronaryu arteries reduces the incidence of no-reflow phenomenon显示文摘 | Yhiop P Fujise K | 1999 | Interv1999，48，： | 1 |
| 13 | Breeding distribution and maternal genetic lineages in Lulu,a dwarf cattle population in Nepal显示文摘 | Fujise H Murakami M Devkota B | 2003 | Animal Science Journal2003，74，： | 1 |
| 14 | Characterization of fortilin, a novel antiapoptotic protein显示文摘 | Li F Zhang D Fujise K | 2001 | J Biol Chem2001，276，47： | 1 |
| 15 | Morphological characteristics of human fat-storing cells fractionated and cultured by newly techniques显示文摘 | Matsuura T Nagamori S Fujise K | 1989 | Hum Cell1989，2，2： | 1 |
| 16 | Involvement of Porphyromonas gingivalis fim A genotype in treatment outcome following non-surgical periodontal therapy显示文摘 | Fujise O Miura M Hamachi T | | 0，，10： | 1 |
| 17 | Preventive effects of the deleted form of hepatocyte growth factor against various liver injuries显示文摘 | Masunaga H Fujise N Shiota A | 1998 | Eur J Pharmacol1998，342，23： | 1 |
| 18 | Highly active antiret-roviral therapy improved persistent lamivudine-resistant vire-mia in acute hepatitis B virus genotype Ae infection with coin-fection of human immunodeficiency virus显示文摘 | Aizawa M Tsubota A Fujise Kf | 2010 | Hepatol Rse2010，40，2： | 1 |
| 19 | Several factors including ITPA polymorphism influence ribavirin-induced anemia in chronic hepatitis C显示文摘AIM:To construct formulae for predicting the likelihood of ribavirin-induced anemia in pegylated interferon plus ribavirin for chronic hepatitis C.METHODS:Five hundred and sixty-one Japanese patients with hepatitis C virus genotype 1b who had received combination treatment were enrolled and assigned randomly to the derivation and confirmatory groups.Single nucleotide polymorphisms at or nearby ITPA were genotyped by real-time detection polymerase chain reaction.Factors influencing significant anemia(hemoglobin concentration < 10.0 g/dL at week 4 of treatment) and significant hemoglobin decline(declining concentrations > 3.0 g/dL at week 4) were analyzed using multiple regression analyses.Prediction formulae were constructed by significantly independent factors.RESULTS:Multivariate analysis for the derivation group identified four independent factors associated with significant hemoglobin decline:hemoglobin decline at week 2 [P = 3.29 × 10-17,odds ratio(OR) = 7.54(g/dL)],estimated glomerular filtration rate [P = 2.16 × 10-4,OR = 0.962(mL/min/1.73 m 2)],rs1127354(P = 5.75 × 10-4,OR = 10.94) and baseline hemoglobin [P = 7.86 × 10-4,OR = 1.50(g/dL)].Using the model constructed by these factors,positive and negative predictive values and predictive accuracy were 79.8%,88.8% and 86.2%,respectively.For the confirmatory group,they were 83.3%,91.0% and 88.3%.These factors were closely correlated with significant anemia.However,the model could not be constructed,because no patients with rs1127354 minor genotype CA/AA had significant anemia.CONCLUSION:Reliable formulae for predicting the likelihood of ribavirin-induced anemia were constructed.Such modeling may be useful in developing individual tailoring and optimization of ribavirin dosage. | Akihito Tsubota Noritomo Shimada Hiroshi Abe Kai Yoshizawa Rie Agata Yoko Yumoto Makiko Ika Yoshihisa Namiki Keisuke Nagatsuma Hiroshi Matsudaira Kiyotaka Fujise Norio Tada Yoshio Aizawa | 2012 | World Journal of Gastroenterology2012，18，41： | 1 |
| 20 | Venous congestion induces mucosal apoptosis via tumor necrosis factor-α-mediated cell death in the rat small intestine显示文摘 | Bin Wu Takehiro Fujise Ryuichi Iwakiri Akifumi Ootani Sadahiro Amemori Seiji Tsunada Shuji Toda Kazuma Fujimoto | 2004 | Journal of Gastroenterology2004，，11： | 1 |
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