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| 1 | CYP1A1 , GSTM1 , GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men显示文摘AIM: To investigate the role of functional genetic poly-morphisms of metabolic enzymes of tobacco carcinogens in the development of colorectal adenomas. METHODS: The study subjects were 455 patients with colorectal adenomas and 1052 controls with no polyps who underwent total colonoscopy in a preretirement health examination at two Self Defense Forces hospitals. The genetic polymorphisms studied wereCYP1A1*2A (rs 4646903), CYP1A1*2C (rs 1048943), GSTM1 (null or non-null genotype), GSTT1 (null or non-null genotype) and NQO1 C609T (rs 1800566). Genotypes were determined by the polymerase chain reaction (PCR)-restriction fragment length polymorphism or PCR method using genomic DNA extracted from the buffy coat. Cigarette smoking and other life-style factors were ascertained by a self-administered questionnaire. The associations of the polymorphisms with colorectal adenomas were examined by means of OR and 95%CI, which were derived from logistic regression analysis. Statistical adjustment was made for smoking, alcohol use, body mass index and other factors. The gene-gene interaction and effect modification of smoking were evaluated by the likelihood ratio test. RESULTS: None of the five polymorphisms showed a significant association with colorectal adenomas, nor was the combination of GSTM1 and GSTT1 . A borderline significant interaction was observed for the combination of CYP1A1*2C and NQO1 (P = 0.051). The OR associated with CYP1A1*2C was significantly lower than unity among individuals with the NQO1 609CC genotype. The adjusted OR for the combination of the CYP1A1*2C allele and NQO1 609CC genotype was 0.61 (95%CI: 0.42-0.91). Although the interaction was not statistically significant (P = 0.24), the OR for individuals carrying the CYP1A1*2C allele and GSTT1 null genotype decreased significantly compared with those who had neither CYP1A1*2C allele nor GSTT1 null genotype (adjusted OR: 0.69, 95%CI: 0.49-0.97). Smoking did not modify the associations of the individual polymorphisms with colorectal adenomas. There was no measurable effect modification of smoking even regarding the combination of the genetic polymorphisms of the phaseⅠ and phase Ⅱ enzymes. CONCLUSION: Combination of the CYP1A1*2C and NQO1 609CC genotypes was associated with a decreased risk of colorectal adenomas regardless of smoking status. | Tadamichi Hamachi Osamu Tajima Kousaku Uezono Shinji Tabata Hiroshi Abe Keizo Ohnaka Suminori Kono | 2013 | World Journal of Gastroenterology2013，19，25： | 3 |
| 2 | Involvement of Porphyromonas gingivdis fimA genotype in treatment outcome following non-surgical periodontal therapy显示文摘 | Fujise O Miura M Hamachi T | 2005 | J Periodontol2005，76，10： | 1 |
| 3 | Involvement of Porphyromonas gingivalis fim A genotype in treatment outcome following non-surgical periodontal therapy显示文摘 | Fujise O Miura M Hamachi T | | 0，，10： | 1 |
| 4 | The role of maerophages in the periodontal regeneration using Emdogaingel显示文摘 | Fujishiro N Anan H Hamachi T | 2008 | J Periodontal Res2008，43，2： | 1 |
| 5 | Dynamic modelling of crossflow microfiltration of bentonite suspension using recurrent neural networks显示文摘 | HAMACHI M CABASSUD M DAVIN A | 1999 | Chem Eng Process1999，38，3： | 1 |
| 6 | Detection of interleukin-1β mRNA in rat periapical lesions显示文摘 | Hamachi T Anan H Akamine A | 1995 | J Endodo1995，21，3： | 1 |
| 7 | Time required to achieve a stable cuff pressure by repeated aspiration of the cuff during anaesthesia with nitrous oxide显示文摘 | Karasawa F Hamachi T Takamatsu I | 2003 | Eur J Anaesthesiol2003，20，6： | 1 |
| 8 | Synthesis of side-chain derivatives of 2,-2 bipyridine显示文摘 | Ciana LD Hamachi I Meyer TJ | 1989 | J Org Chem1989，54，7： | 1 |
| 9 | Experimental investigations of cake characteristics in crossflow microfiltration显示文摘 | Hamachi M Mietton- Peuchot M | 1999 | Chem Eng Sci1999，54，： | 1 |
| 10 | Expression lev- els of adiponectin receptors and periodontitis 显示文摘 | Yamaguchi N Hamachi T Kamio N | 2010 | J Perio- dontal Res2010，45，2： | 1 |
| 11 | Single wall biolayer liposome functionalized with the artificial flavolipid(Ⅱ):Its efficient electron flux coversion from NADH model of an appropriate structure in the transmembrane electron transfer显示文摘 | I Tabushi I Hamachi | 1987 | Tetrahedron Lett1987，28，29： | 1 |
| 12 | Waist circumference and insulin resistance :a cross-sectional study of Japanese men 显示文摘 | TABATA S YOSHIMITSU S HAMACHI T | 2009 | BMC Endocr Disord2009，9，： | 1 |
| 13 | Experimental investigation of cake characteristics in crossflow microfiltration显示文摘 | Hamachi M Mietton- Peuchot M | 1999 | Chem Eng Sci1999，54，： | 1 |
| 14 | Risk of Porphyromonas gingivalis recolonization during the early period of periodontal maintenance in initially severe periodontitis sites 显示文摘 | Fujise O Miura M Hamachi T | 2006 | J Periodontol2006，77，8： | 1 |
| 15 | Cake thickness measurement with an optical laser sensor 显示文摘 | Hamachi M Mietton - Peuchot M | 2001 | Chem Eng Res Des2001，79，2： | 1 |
| 16 | Ultrafiltration: A means for decolorization of cane sugar solution 显示文摘 | Gupta B B Aim R Ben | 2003 | Separation and Purification Technology2003，30，3： | 1 |
| 17 | Detection of IL-1β mRNA in rat periapical lesions显示文摘 | Hamachi T Ahatr H Kamine AA | 1995 | J Endodontics1995，21，3： | 1 |
| 18 | The role of macrophages in the periodontal regeneration using Emdogain gel显示文摘 | Fujishiro N Arian H Hamachi T | 2008 | J Periodontal Res2008，43，2： | 1 |
| 19 | Time required to achieve stable cuff pressure by repeated aspiration of the cuff during the anesthesia with nitrous oxside显示文摘 | Karaswa F Hamachi T Tacmatsu I | 2003 | Eur J anaesthsiol2003，20，6： | 1 |
| 20 | Cake thickness measurement with an optical laser sensor显示文摘 | Hamachi M Mietton-Peuchot M | 2001 | Chem Eng Res Des2001，79，2： | 1 |
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