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	题名	作者	年代	出处	被引量
1	Effects of icariin on cGMP-specific PDE5 and cAMP-specific PDE4 activities显示文摘Aim:To clarify the mechanism of the therapeutic action of icariin on erectlile dysfunction(ED).Methods:PDE5 was isolated from the human platelet and PDE4 form the rat liver tissue using the FPLC system (Pharmacia,Milton Keynes,UK)and the Mono Q column.The inhibitory effects of icariin on PDE5 and PDE4 activities were investigated by the two-step radioisotope procedure with [^3H]-c GMP/[^3H]-cAMP.Papaverine served as the control drug.Results:Icariin and papaverine showed dose-dependent inhibitory effects on PDE5 and PDE4 activities.The IC50 of Icariin and papaverine on PDE5 were 0.432μ mol/L and 0.680μmol/L,respectively and those on PDE4,73.50μmol/L and 3.07μmol/L,respectively.The potencies of selectivity of icariin and papaverine on PDE5(PDE4/PDE5 of IC50)were 167.67 times and 4.54 times,respectively.Conclusion:Icariin is a cGMP-specific PDE5 inhibitor that may be developed into an oral effective agent for the treatment of ED.	ZC Xin EK Kim CS Lin WJ Liu L Tian YM Yuan J Fu	2003	Asian Journal of Andrology2003，5，1：	38
2	Effect of manganese chloride exposure on liver and brain mitochondria function in rats 显示文摘	Zhang SR Zhou ZC Fu JL	2003	Environmental Research2003，93，2：	1
3	The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroLdo- genic acute regulatory (STAR) protein expression 显示文摘	Chang J Fu JL Zhou ZC	2003	Toxicology2003，187，：	1
4	In vitro effect of manganese chloride exposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain 显示文摘	Zhang SR Fu JL Zhou ZC	2004	Toxicology in Vitro2004，18，1：	1
5	Changes in the brain mitochondrial proteome of male Sprague-Dawley rats treated with manganese chloride 显示文摘	Zhang SR Fu JL Zhou ZC	2005	Toxicology and Applied Pharmacology2005，202，1：	1
6	The mechanism of manganese- induced inhibition of steroidogenesis in rat primary Leydig cells 显示文摘	Cheng J Fu JL Zhou ZC	2005	Toxicology2005，211，12：	1
7	The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression 显示文摘	Cheng J Fu JL Zhou ZC	2003	Toxicology2003，187，23：	1
8	IMRT combined with ADT for intermediate and advanced prostate cancer:long-term outcome of Chinese patients显示文摘	Luo HC Cheng HH Fu ZC	2012	APJCP2012，14，8：	1
9	Long-term QOL outcomes in patients with locally advanced prostate cancer after IMRT combined with ADT显示文摘	Luo HC Cheng LP Fu ZC	2014	Med Oncol2014，31，6：	1
10	Flexible ureteroscopy and laser lithotripsy for bilateral multiple intrarenal stones: is this a valuable choice?显示文摘	HUANG ZC FU FJ ZHONG ZH	2012	Urology2012，80，4：	1
11	Liquid chromatography-tandem mass spectrometry analysis of protocatechuic aldehyde and its phase I and II metabolites in rat显示文摘	Xu M Zhang ZC Fu G	2007	J Chromatogr B2007，856，12：	1
12	The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression显示文摘	Cheng J Fu JL Zhou ZC	2003	Toxicology2003，187，23：	1
13	The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (stAR) protein expression 显示文摘	Cheng J Fu JL Zhou ZC	2003	Toxicology2003，187，23：	1
14	In vitro effect of manganese chloride xposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain 显示文摘	Zhang SR Fu JL Zhou ZC	2004	Toxicol In Vitro2004，18，1：	1
15	The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory(stAR) protein expression 显示文摘	Cheng J Fu JL Zhou ZC	2003	Toxicology2003，187，：	1
16	Effect of manganese chloride exposure on liver and brain mitochondria function in rats 显示文摘	Zhang SR Zhou ZC Fu JL	2003	EnviroRes2003，93，2：	1
17	In vitro effect of manganese chloride exposure on reactive oxygen species generation and respiratory chain complexes activities of mitochondria isolated from rat brain 显示文摘	Zhang SR Fu JL Zhou ZC	2004	Toxicol in Vitro2004，18，1：	1
18	Changes in the brain mitochondrial proteome of male Sprague-Dawley rats treated with manganese chloride 显示文摘	Zhang SR Fu JL Zhou ZC	2005	Toxicol Appl Pharmacol2005，202，1：	1
19	Emergence of dengue virus 4 genotype II in Guangzhou, China, 2010: survey and molecular epidemiology of one community outbreak 显示文摘	Jing QL Yang ZC Luo L Xiao XC Di B He P Fu CX Wang M Lu JH	2012	BMC Infect Dis2012，12，：	1
20	The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory(STAR) protein expression显示文摘	Cheng J Fu JL Zhou ZC	2003	Toxicology2003，187，23：	1

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