|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lactate metabolism in human health and disease显示文摘The current understanding of lactate extends from its origins as a byproduct of glycolysis to its role in tumor metabolism,as identified by studies on the Warburg effect.The lactate shuttle hypothesis suggests that lactate plays an important role as a bridging signaling molecule that coordinates signaling among different cells,organs and tissues.Lactylation is a posttranslational modification initially reported by Professor Yingming Zhao’s research group in 2019.Subsequent studies confirmed that lactylation is a vital component of lactate function and is involved in tumor proliferation,neural excitation,inflammation and other biological processes.An indispensable substance for various physiological cellular functions,lactate plays a regulatory role in different aspects of energy metabolism and signal transduction.Therefore,a comprehensive review and summary of lactate is presented to clarify the role of lactate in disease and to provide a reference and direction for future research.This review offers a systematic overview of lactate homeostasis and its roles in physiological and pathological processes,as well as a comprehensive overview of the effects of lactylation in various diseases,particularly inflammation and cancer. | Xiaolu Li Yanyan Yang Bei Zhang Xiaotong Lin Xiuxiu Fu Yi An Yulin Zou Jian-Xun Wang Zhibin Wang Tao Yu | 2022 | Signal Transduction and Targeted Therapy2022，7，10： | 9 |
| 2 | Changes in T lymphocyte subsets after severe traumatic brain injury显示文摘BACKGROUND: Besides local changes of cranial parenchymal cells, hemorrhage, etc., severe traumatic brain injuries also cause the changes of total body fluid and various functions, and the changes of lymphocytes and T lymphocyte subsets should be paid more attention to. OBJECTIVE: To reveal the changing laws of T lymphocyte subsets after severe traumatic brain injury, and compare with mild to moderate brain injury. DESIGN: A comparative observation. SETTINGS: Department of Neurosurgery, Longgang District Buji People's Hospital of Shenzhen City; Central Laboratory of Shenzhen Hospital of Prevention and Cure for Chronic Disease. PARTICIPANTS: All the subjects were selected from the Department of Neurosurgery, Longgang District Buji People's Hospital of Shenzhen City from August 2002 to August 2005. Thirty patients with severe brain injury, whose Glasgow coma score (GCS) was ≤ 8 points, were taken as the experimental group, including 21 males and 9 females, aging 16–62 years. Meanwhile, 30 patients with mild traumatic brain injury were taken as the control group (GCS ranged 14–15 points), including 18 males and 12 females, aging 15–58 years. All the subjects were in admission at 6 hours after injury, without disease of major organs before injury. Informed consents were obtained from all the patients or their relatives. METHODS: ① The T lymphocytes and the subsets in peripheral blood were detected with immunofluorescent tricolor flow cytometry at 1, 3, 7 and 14 days after injury in both groups. ② The conditions of pulmonary infections were observed at 4 days after injury. The differences of measurement data were compared with the t test. MAIN OUTCOME MEASURES: Changes of T lymphocytes subsets at 1–14 days after severe and mild or moderate traumatic injury. RESULTS: Finally, 28 and 25 patients with mild to moderate traumatic brain injury, whereas 25 and 21 patients with severe traumatic brain injury were analyzed at 7 and 14 days respectively, and the missed ones died due to the development of disease. ① Changes of T lymphocyte subsets: At 1 and 3 days after injury, CD3, CD4, CD8, CD4/CD8 began to decrease, whereas CD8 increased in the experimental group, which were very significantly different from those in the control group (t =2.77–3.26, P < 0.01), and began to recover at 7 days, which were significantly different from those in the control group (t = 2.06–2.24, P < 0.05), and generally recovered to the normal levels at 14 days (P > 0.05). ② Conditions of pulmonary infections: At 4 days after injury, the rate of pulmonary infection was significantly different between the experimental group and control group [73% (22/30), 0, χ2=37.29, P < 0.01]. CONCLUSION: Patients with severe traumatic brain injury suffer from damages of cellular immune function at early period (within 7 days), and they are easily to be accompanied by pulmonary infections. | Yulu Miao Mingxia Zhang Yulin Nie Wan Zhao Bin Huang Zhengming Jiang Shaoxiong Yu Zhibin Huang Hongjin Fu | 2007 | Neural Regeneration Research2007，2，2： | 7 |
| 3 | Effects of urban street trees on human thermal comfort and physiological indices: a case study in Changchun city, China显示文摘Planting trees along urban streets is one of the most important strategies to improve the urban thermal environment.However,the net impacts of urban street trees on human thermal comfort and physiological parameters are still less clear.On three similar east-west orientated streets with different degrees of tree cover-low(13%),medium(35%),and high(75%),urban microclimatic parameters and human physiological indices for six male students were simultaneously measured on three cloudless days in summer 2018.The results show that the differences in tree cover were predominant in influencing urban thermal environment and comfort.The street with the highest tree cover had significantly lower physiological equivalent temperature(PET) and more comfortable than the other two streets.The frequency of strong heat stress(PET> 35℃) was 64%,11 %,and 0%,respectively,for streets with low,medium,and high tree cover.For the six male university students,human physiological indices varied greatly across the three streets with different tree cover.Systolic blood pressure,diastolic blood pressure,and pulse rate increased with decreasing tree cover.The results also suggest that urban thermal environment and comfort had considerable impact on human physiological parameters.Our study provides reasons for urban planners to plant trees along streets to improve the thermal environment and promote urban sustainability. | Zhibin Ren Hongbo Zhao Yao Fu Lu Xiao Yulin Dong | 2022 | Journal of Forestry Research2022，33，3： | 4 |
| 4 | Patterns of gas hydrate accumulation in mass transport deposits related to canyon activity: Example from Shenhu drilling area in the South China Sea显示文摘Since 2017, a plenty of gas hydrates have been drilled in a new area of Shenhu, and good heterogeneity has been found throughout the spatial distribution of the reservoir. After distinguishing different sedimentary sequence types and matching their formation with slope deposition settings, this study proposes three mass transport deposit(MTD) patterns related to canyon activity that occurred contemporaneously or epigenetically with it: well preserved MTDs, MTDs eroded by canyon migration, and MTDs dislocated by contemporaneous faults. Based on seismic reflection characteristics, this study proposed methods of quantitatively analyzing sedimentary factors,such as measuring the turbidities flow rate in the canyon, and results are interpreted with respect to canyon activity. Combining the above parameters and their relationship with gas hydrate accumulation, fine-grained seals overlapping coarse MTDs reservoirs are found to be indispensable to gas hydrate accumulation, as they prevent the release of free gas. Based on grain size data of hydrate samples from drilling wells, multi-layered gas hydrate reservoirs capped by fine-grained sediments and overlapping mud show favorable hydrate-bearing prospects. The release of gas hydrates, however, is mostly caused by the lack of mud sealing in relation to canyon activity, such as turbidities flow erosion and contemporaneous fault breaking. Canyon migration with respect to MTDs may be the actual cause of erosion of overlapping syn-sedimentary layers, and high bottom flows may contribute to an increase in the release of free gas. It is believed that contemporaneous faults caused by unstable canyon walls may break the muddy over layers and decrease the accumulation pressure of gas hydrate bearing.Thus, according to the sedimentary characteristics of MTDs and the hydrate accumulation process, three responding accumulation or releasing patterns are proposed, which respond to the different types of MTDs distinguished above: a well-preserved MTD accumulation pattern; a canyon migration eroded MTD release pattern; and a micro-contemporaneous fault dislocated MTD release pattern. | Chao Fu Shengli Li Xinghe Yu Jinqiang Liang Zenggui Kuang Yulin He Lina Jin | 2019 | Acta Oceanologica Sinica2019，38，5： | 3 |
| 5 | Modes of genetic adaptations underlying functional innovations in the rumen显示文摘The rumen is the hallmark organ of ruminants and hosts a diverse ecosystem of microorganisms that facilitates efficient digestion of plant fibers.We analyzed 897 transcriptomes from three Cetartiodactyla lineages:ruminants,camels and cetaceans,as well as data from ruminant comparative genomics and functional assays to explore the genetic basis of rumen functional innovations.We identified genes with relatively high expression in the rumen,of which many appeared to be recruited from other tissues.These genes show functional enrichment in ketone body metabolism,regulation of microbial community,and epithelium absorption,which are the most prominent biological processes involved in rumen innovations.Several modes of genetic change underlying rumen functional innovations were uncovered,including coding mutations,genes newly evolved,and changes of regulatory elements.We validated that the key ketogenesis rate-limiting gene(HMGCS2)with five ruminant-specific mutations was under positive selection and exhibits higher synthesis activity than those of other mammals.Two newly evolved genes(LYZ1 and DEFB1)are resistant to Gram-positive bacteria and thereby may regulate microbial community equilibrium.Furthermore,we confirmed that the changes of regulatory elements accounted for the majority of rumen gene recruitment.These results greatly improve our understanding of rumen evolution and organ evo-devo in general. | Xiangyu Pan Yudong Cai Zongjun Li Xianqing Chen Rasmus Heller Nini Wang Yu Wang Chen Zhao Yong Wang Han Xu Songhai Li Ming Li Cunyuan Li Shengwei Hu Hui Li Kun Wang Lei Chen Bin Wei Zhuqing Zheng Weiwei Fu Yue Yang Tingting Zhang Zhuoting Hou Yueyang Yan Xiaoyang Lv Wei Sun Xinyu Li Shisheng Huang Lixiang Liu Shengyong Mao Wenqing Liu Jinlian Hua Zhipeng Li Guojie Zhang Yulin Chen Xihong Wang Qiang Qiu Brian PDalrymple Wen Wang Yu Jiang | 2021 | Science China(Life Sciences)2021，64，1： | 3 |
| 6 | High performance liquid chromatographic separation of eight drugs collected in Chinese Pharmacopoeia 2010 on amylose ramification chiral stationary phase显示文摘The enantiomers separation of ei ght pharmaceutical racemates collected in Chinese Pharmacopoeia 2010(Ch.P2010),including nitrendipine,felodipine,omeprazole,praziquantel,sulpiride,clenbuterol hydrochloride,verapamil hydrochloride and chlorphenamine maleate,was performed on chiral stationary phase of amylose ramification by high performance liquid chromatography(HPLC)on Chiralpak AD-H column and Chiralpak AS-H column with the mobile phase consisted of isopropanol and n-hexane.The detection wavelength and the flow rate were set at 254 nm and 0.7 mL/min,respectively.The effects of proportion of organic additives,alcohol displacer and temperature on the separation were investigated.The results indicated that eight chiral drugs were separated on chiral stationary phase of amylase ramification in normal phase chroma tographic system.The chromatographic retention and resolution of enantiomers were adjusted by factors,including the changes of the concentration of alcohol displacer in mobile phase,organic alkaline modifier and column temperature.It was shown that the resolution was improved with reducing concentration of alcohol displacer.When the concentration of organic alkaline modifier was 0.2%,the resolution and the peak shape were fairly good.Most racemates mentioned above had the best resolution at column temperature of 25℃.The best temperature should be kept unchanged in the process of separation so as to obtain stable separation results. | Yan Wang Ying Zhou Chao Ma Beibei Yang Ru Feng Yiying Zhang Jie Fu Wenjing Chen Yupeng Sun Jingyi Ma Qiming Zhang Yulin Deng Yukui Zhang Wenyi He | 2012 | Acta Pharmaceutica Sinica B2012，2，5： | 3 |
| 7 | An atlas of CNV maps in cattle, goat and sheep显示文摘Copy number variation(CNV)is the most prevalent type of genetic structural variation that has been recognized as an important source of phenotypic variation in humans,animals and plants.However,the mechanisms underlying the evolution of CNVs and their function in natural or artificial selection remain unknown.Here,we generated CNV region(CNVR)datasets which were diverged or shared among cattle,goat,and sheep,including 886 individuals from 171 diverse populations.Using 9 environmental factors for genome-wide association study(GWAS),we identified a series of candidate CNVRs,including genes relating to immunity,tick resistance,multi-drug resistance,and muscle development.The number of CNVRs shared between species is significantly higher than expected(P<0.00001),and these CNVRs may be more persist than the single nucleotide polymorphisms(SNPs)shared between species.We also identified genomic regions under long-term balancing selection and uncovered the potential diversity of the selected CNVRs close to the important functional genes.This study provides the evidence that balancing selection might be more common in mammals than previously considered,and might play an important role in the daily activities of these ruminant species. | Yongzhen Huang Yunjia Li Xihong Wang Jiantao Yu Yudong Cai Zhuqing Zheng Ran Li Shunjin Zhang Ningbo Chen Hojjat Asadollahpour Nanaei Quratulain Hanif Qiuming Chen Weiwei Fu Chao Li Xiukai Cao Guangxian Zhou Shudong Liu Sangang He Wenrong Li Yulin Chen Hong Chen Chuzhao Lei Mingjun Liu Yu Jiang | 2021 | Science China(Life Sciences)2021，64，10： | 2 |
| 8 | Nonlinear hyperbolic systems of higher order of generalized Sine-Gordon type 显示文摘 | Zhou Yulin Fu Hongyuan | 1983 | Aeta Mathematiea Siniea1983，，26： | 1 |
| 9 | Effect of matrix toughness on the brittle-ductile transition of HDPE / CaCO3 blends 显示文摘 | Fu Qiang Zhang Yulin Wang Guiheng | 1994 | Chinese Journal of Polymer Science ( English Edition )1994，12，4： | 1 |
| 10 | Screen of Bacillus thuringiensis toxins for transgenic rice to control Sesamia inferens and Chilo suppressalis显示文摘 | Yulin Gao Yang Hu Qiang Fu Jie Zhang Brenda Oppert Fengxiang Lai Yufa Peng Zhitao Zhang | 2010 | Journal of Invertebrate Pathology2010，，1： | 1 |
| 11 | Rapid determination of ethanol in fermentation liquor by full evaporation headspace gas chromatography显示文摘 | Li Hailong Chai Xin-Sheng Deng Yulin Zhan Huaiyu Fu Shiyu | 2008 | Journal of Chromatography A2008，，： | 1 |
| 12 | Research of the Assembly Model Based on Petri Net显示文摘Assembly model plans an important role in assembly sequence planning.Flexible assembly system (FAS) is a dis- crete event system (DES),so Petri net,as an important analytical tool for the DES,is used for modeling of an FAS.All of the feasible assembly sequences can be obtained by firing the Petri net model.In order to enhancing the efficiency of the assembly sequence planning,knowledge-based Petri net,combining an usual Petri net with expert’s knowledge and experiences,is proposed to con- struct the assembly model.So the feasible assembly sequences can be reduced greatly,and the optimum assembly sequence could be generated without the combinatorial explosion of solutions. | LI Rong FU Yili MA Yulin FENG Haibo (Advanced Manu.Tech.Cent.,Harbin Inst.Of Tech.,Harbin 15000,China | 2006 | 武汉理工大学学报2006，28，S2： | 1 |
| 13 | Quantity-effect relationship of elcctroaeupuncture for urge incontinence: A multieenter randomized controlled trial显示文摘 | Feng Qifan Fu Yulin Chen Chao | 2012 | J Acupunct Tuina Sci2012，10，1： | 1 |
| 14 | Different initial density turbidite sediments with coarse grain injection and their corresponding flow pattern: Additional insights from numerical simulation in a study case of South China Sea显示文摘The work presents the sedimentology and depositional results of the turbidity flow from Miocene to Pliocene along the North Slope of South China Sea(SCS).The integration of the core-log-seismic data has enabled us to clarify turbidity flow with different density and characterize their corresponding seismic geomorphic sedimentation.Based on the differences between the initial density and the later,we classified the turbidity flow into two types,namely:low-and high-density flow with coarse grain injection.According to the hydrodynamic numerical simulation results,we constructed different subcritical turbidity flow models with various density and rebuilt the depositional pattern along the slope.As to the numerical simulation model,we introduced the erosion rate into the classical full Reynolds-averaged N-S(RANS)equation,which is suitable to the deep-sea slope area.Through comparison of the above simulation models,the results show that the high-density turbidites with coarse-grained injection are mostly developed with lower vertical erosion rates and higher lateral abrasion rates.They are characterized with multi-branched and lobe-shaped sedimentary volumes,while low-density turbidites with coarse-grained injection are characterized with higher vertical erosion rates and lower lateral abrasion rates.And this kind of turbidites can generate single-branched and banding deposits.In addition,the fluctuating sea levels and the varying topographies are important to influence the subcritical turbidity flow models in the deep-water slope. | Chao Fu Xinghe Yu Yulin He Jianqiang Liang Zenggui Kuang | 2019 | Petroleum Research2019，4，1： | 1 |
| 15 | Derivation of totipotent-like stem cells with blastocyst-like structure forming potential显示文摘It is challenging to derive totipotent stem cells in vitro that functionally and molecularly resemble cells from totipotent embryos.Here,we report that a chemical cocktail enables the derivation of totipotent-like stem cells,designated as totipotent potential stem(TPS)cells,from 2-cell mouse embryos and extended pluripotent stem cells,and that these TPS cells can be stably maintained long term in vitro.TPS cells shared features with 2-cell mouse embryos in terms of totipotency markers,transcriptome,chromatin accessibility and DNA methylation patterns.In vivo chimera formation assays show that these cells have embryonic and extraembryonic developmental potentials at the single-cell level.Moreover,TPS cells can be induced into blastocyst-like structures resembling preimplantation mouse blastocysts.Mechanistically,inhibition of HDAC1/2 and DOT1L activity and activation of RARγsignaling are important for inducing and maintaining totipotent features of TPS cells.Our study opens up a new path toward fully capturing totipotent stem cells in vitro. | Yaxing Xu Jingru Zhao Yixuan Ren Xuyang Wang Yulin Lyu Bingqing Xie Yiming Sun Xiandun Yuan Haiyin Liu Weifeng Yang Yenan Fu Yu Yu Yinan Liu Rong Mu Cheng Li Jun Xu Hongkui Deng | 2022 | Cell Research2022，32，6： | 1 |
| 16 | Investigation into the epidemiology,genetic characteristics,and clinical manifestations of the first monkeypox outbreak in Shenzhen,China显示文摘This paper comprehensively analyses the first-ever monkeypox outbreak in Shenzhen,China,encompassing clinical symptomatology,therapeutic approaches,epidemiological research,and comprehensive laboratory tests,aiming to establish a robust reference for future monkeypox mitigation and management strategies.The investigation involved a thorough investigation of all identified positive cases,including extensive molecular analysis by nucleic acid detection and whole-genome sequencing of the monkeypox virus.Contact tracing and containment of the infected individuals were also undertaken.Three distinct monkeypox cases were identified in this unique outbreak,exhibiting mild and atypical clinical manifestations,primarily fever and rash.All cases were associated with a single transmission chain,primarily facilitated through close contact and homosexual behavior,indicative of a high-risk factor for monkeypox transmission. | Jia Wan Xiaomin Zhang Jing Qu Bo Peng Dongfeng Kong Jianhua Lu Qinghua Hu Zhifeng Zhou Haiduan Lin Xiangjie Yao Yulin Fu Qing Xu Ying Lin Yan Yang Jinzhen Tang Lin Lin Huimin Li Ziquan Lv Zhen Zhang Xuan Zou Xiaolu Shi | 2023 | Biosafety and Health2023，5，5： | 0 |
| 17 | Study on the Manufacturability Evaluation Based on Double-layer Model of Manufacturing Resources显示文摘Virtual organization is a new production patter and a principal part in advanced manufacturing systems such as agile manufacturing. Manufacturability evaluation is the necessary condition to form the virtual organization. A new manufacturability evaluation approach is described in this paper, which is carried out based on every process feature under the double-layer model of manufacturing resources proposed by authors. The manufacturing resources that build up the virtual organization are selected according to the results of manufacturability evaluation. | 石旭东 FU Yili Dai Yong Ma Yulin | 2001 | High Technology Letters2001，7，2： | 0 |
| 18 | An Important Insect of the Genus Pseudips: Pseudips mexicanus Hopkins显示文摘At present, there are three species of Pseudips known in the world, and P. mexicanus is an important one. The paper mainly introduced the taxonomic status, morphological characteristics and biological characteristics of P. mexicanus, and provided a key to P. mexicanus and its allied species. There is no distribution of P. mexicanus in China, and the results can provide the reference for further study of the insect. | Jie PAN Yang LI Peize SHAO Yunqing CHEN Maoqiang FU Hongbin ZHU Yulin AN | 2022 | Plant Diseases and Pests2022，13，5： | 0 |
| 19 | Comprehensive Commissioning Test of Cold Neutron Source with Deuterium with Reactor Power Operation in CARR显示文摘The single-phase liquid deuterium was adopted and used as the moderator of cold neutron in China Advanced Research Reactor(CARR).Liquid deuterium moderator go through in-pile device where heat exchanger and thermosiphon loop located and was cooled by the closed naturally cycling and helium interlining | LI Jianlong LANG Yuqing FU Ziliang YANG Yuchen Victor Mitiukhliae ZHEN Jianxiao ZHU Jiyin WANG Yulin | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 20 | Sedimentary characteristics comparison and genesis analysis of the deepwater channel in the hydrate enrichment zones on the north slope of the South China Sea显示文摘Natural gas hydrate(NGH) is one of the important clean energy at present and even in the future. The study of its sedimentary environment and minerogenetic condition has long been a hot issue that has received much concern from geologists all over the world. China has successfully obtained the samples of NGH in Shenhu and Dongsha sea areas in 2007, 2013 and 2015, respectively. From this, the continental slope north of the South China Sea becomes an important test site for the study of NGH sedimentary genesis and minerogenetic condition. NGH has been found in Shenhu, Dongsha and Qiongdongnan areas within the continental slope north of South China Sea,at different depths of water, with different sedimentary characteristics, gas genesis, and minerogenetic conditions.Using a seismic sedimentology theory, combining seismic facies results of each facies, sedimentary facies and evolution of each area are documented in turn establishing a sedimentary model by considering palaeogeomorphology, sea level change and tectonic movement. The channel system and MTD(Mass Transport Deposition) system among these three areas were compared focusing on the developing position, appearance and controlling factors. Relative location among three areas is firstly defined that Dongsha area in a nearprovenance steep upper slope, Shenhu area in a normal gentle slope and Qiongdongnan area in an awayprovenance flat plain. Besides, their channel systems are classified into erosional, erosional-aggradational and aggradational channel, and MTD systems into headwall domain, translational domain and toe domain. | Chao Fu Xinghe Yu Yiis Dong Yulin He Jinqiang Liang Zenggui Kuang | 2019 | Acta Oceanologica Sinica2019，38，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员