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| 1 | Advances in the treatment of traumatic scars with laser,intense pulsed light,radiofrequency,and ultrasound显示文摘Traumatic scarring is one of the most common complications after soft tissue injury caused by burns and trauma,which affects tens of millions of people worldwide every year.Traumatic scars diminish the quality of life due to disfigurement,symptoms of pain and itch,and restricted motion.The pathogenesis and pathophysiology of traumatic scar remain elusive.The management for traumatic scars is comprised of surgical and non-surgical interventions such as pressure therapy,silicone,corticosteroid,and radiotherapy,which are chosen by clinicians based on the physical examinations of scars.Recently,great progress in treating traumatic scars has been achieved by the development of novel technologies including laser,intense pulsed light(IPL),radiofrequency,and ultrasound.The aim of this review article was to summarize the advances of these technologies for traumatic scars intervention. | Xiujun Fu Jiying Dong Shen Wang Min Yan Min Yao | 2019 | Burns & Trauma2019，7，1： | 12 |
| 2 | HSP70 alleviates sepsis-induced cardiomyopathy by attenuating mitochondrial dysfunction-initiated NLRP3 inflammasome-mediated pyroptosis in cardiomyocytes显示文摘Background:Sepsis-induced cardiomyopathy(SIC)is an identified serious complication of sepsis that is associated with adverse outcomes and high mortality.Heat shock proteins(HSPs)have been implicated in suppressing septic inflammation.The aim of this study was to investigate whether HSP70 can attenuate cellular mitochondrial dysfunction,exuberated inflammation and inflammasome-mediated pyroptosis for SIC intervention.Methods:Mice with cecal ligation plus perforation(CLP)and lipopolysaccharide(LPS)-treated H9C2 cardiomyocytes were used as models of SIC.The mouse survival rate,gross profile,cardiac function,pathological changes and mitochondrial function were observed by photography,echocardiography,hematoxylin-eosin staining and transmission electron microscopy.In addition,cell proliferation and the levels of cardiac troponin I(cTnI),interleukin-1β(IL-1β)and tumor necrosis factor-α(TNF-α)were determined by Cell Counting Kit-8,crystal violet staining and enzyme-linked immunosorbent assay.Moreover,mitochondrial membrane potential was assessed by immunofluorescence staining,and dynamin-related protein 1 and pyroptosis-related molecules[nucleotide-binding domain,leucine-rich-repeat containing family pyrin domain-containing 3(NLRP3),caspase-1,gasdermin-D(GSDMD),gasdermin-D N-terminal(GSDMD-N)]were measured by western blotting,immunoprecipitation and immunoblotting.Finally,hsp70.1 knockout mice with CLP were used to verify the effects of HSP70 on SIC and the underlying mechanism.Results:Models of SIC were successfully established,as reduced consciousness and activity with liparotrichia in CLP mice were observed,and the survival rate and cardiac ejection fraction(EF)were decreased;conversely,the levels of cTnI,TNF-αand IL-1βand myocardial tissue damage were increased in CLP mice.In addition,LPS stimulation resulted in a reduction in cell viability,mitochondrial destabilization and activation of NLRP3-mediated pyroptosis molecules in vitro.HSP70 treatment improved myocardial tissue damage,survival rate and cardiac dysfunction caused by CLP.Additionally,HSP70 intervention reversed LPS-induced mitochondrial destabiliza-tion,inhibited activation of the NLRP3 inflammasome,caspase-1,GSDMD and GSDMD-N,and decreased pyroptosis.Finally,knockout of hsp70.1 mice with CLP aggravated cardiac dysfunction and upregulated NLRP3 inflammasome activity,and exogenous HSP70 significantly rescued these changes.It was further confirmed that HSP70 plays a protective role in SIC by attenuating mitochondrial dysfunction and inactivating pyroptotic molecules.Conclusions:Our study demonstrated that mitochondrial destabilization and NLRP3 inflammasome activation-mediated pyroptosis are attributed to SIC.Interestingly,HSP70 ameliorates sepsis-induced myocardial dysfunction by improving mitochondrial dysfunction and inhibiting the acti-vation of NLRP3 inflammasome-mediated pyroptosis,and such a result may provide approaches for novel therapies for SIC. | Chenlu Song Yiqiu Zhang Qing Pei Li Zheng Meiyu Wang Youzhen Shi Shan Wu Wei Ni Xiujun Fu Yinbo Peng Wen Zhang Min Yao | 2022 | Burns & Trauma2022，10，1： | 2 |
| 3 | Printability during projection-based 3D bioprinting显示文摘Since projection-based 3D bioprinting(PBP)could provide high resolution,it is well suited for printing delicate structures for tissue regeneration.However,the low crosslinking density and low photo-crosslinking rate of photocurable bioink make it difficult to print fine structures.Currently,an in-depth understanding of the is lacking.Here,a research framework is established for the analysis of printability during PBP.The gelatin methacryloyl(GelMA)-based bioink is used as an example,and the printability is systematically investigated.We analyze the photo-crosslinking reactions during the PBP process and summarize the specific requirements of bioinks for PBP.Two standard quantized models are established to evaluate 2D and 3D printing errors.Finally,the better strategies for bioprinting five typical structures,including solid organs,vascular structures,nerve conduits,thin-wall scaffolds,and micro needles,are presented. | Kang Yu Xinjie Zhang Yuan Sun Qing Gao Jianzhong Fu Xiujun Cai Yong He | 2022 | Bioactive Materials2022，7，5： | 2 |
| 4 | Singularity of the bloch theorem in the fluid,/solid phononic crystal 显示文摘 | HOU Zhilin FU Xiujun LIU Youyan | 2005 | Physical Review B2005，71，02： | 1 |
| 5 | Singularity of the Bloch theorem in the fluid/solid phononic crystal显示文摘 | Hou Zhilin Fu Xiujun Liu Youyan | | 0，，02： | 1 |
| 6 | Singularity of the bloch theorem in the fluid/solid phononic crystal 显示文摘 | HOU Zhilin FU Xiujun LIU ouyan | 2005 | Physical Review B2005，71，02： | 1 |
| 7 | Singularity of the Bloch theorem in the fluid/solid phononic crystal显示文摘 | Hou Zhilin Fu Xiujun Liu Youyan | | 0，，： | 1 |
| 8 | Singularity of the Bloch theorem in the fluid/solid phononic crystal显示文摘 | HOU Zhilin FU Xiujun LIU Youyan | 2005 | Physical Review B2005，71，02： | 1 |
| 9 | Singularity of the Bloeh theorem in the fluid/solid phononic crystal显示文摘 | Hou Zhilin Fu Xiujun Liu Youyan | 2005 | Physical Review B2005，71，02： | 1 |
| 10 | Singularity of the Bloch theorem in the fluid/solid phononic crystal显示文摘 | HOU Zhilin FU Xiujun LIU Youyan | | 0，，2： | 1 |
| 11 | Singularity of the Bloch theorem in the fluid/solid phononic crystal显示文摘 | Hou Zhilin Fu Xiujun Liu Youyan | 2005 | Physical Review B2005，71，02： | 1 |
| 12 | Singularity of the Bloch theorem in the fluid/solid phononic crystal显示文摘 | HOU Zhilin FU Xiujun LIU Youyan | 2005 | Physical Review B2005，71，02： | 1 |
| 13 | Damage spreading on the two-dimensional trivalent structures with Glauber dynamics:Hierarchical and Random lattices显示文摘 | Guo Z Z Szeto K Y Fu Xiujun | 2004 | Phys Rev E2004，70，01： | 1 |
| 14 | Universal Topological Properties of Two-Dimensional Trivalent Cellular Patterns显示文摘 | Szeto K Y Fu Xiujun Tam W Y | 2002 | Phys Rev Lett2002，88，13： | 1 |
| 15 | Singularity of the Bloch theorem in the fluid/solid phononic crystal显示文摘 | Hou Zhilin Fu Xiujun Liu Youyan | 2005 | Physical Review B2005，71，02： | 1 |
| 16 | Singularity of the Bloch theorem in the fluid/solid phononie crystal显示文摘 | Hou Zhilin Fu Xiujun Liu Youyan | 2005 | Physical Review B2005，71，02： | 1 |
| 17 | Singularity of the Bloch theorem in the fluid/solid phononic crystal显示文摘 | Hou Zhilin Fu Xiujun Lin Youyan | 2005 | Physical Review B2005，71，02： | 1 |
| 18 | Calculational method to study the transmission properities of phononic crystals 显示文摘 | Hou Zhilin Fu Xiujun Liuyouyan | 2004 | Phys Rev B2004，70，14： | 1 |
| 19 | Damage spreading on the two-dimensional trivalent structures with Glauber dynamics:Hierarchical and Random lattices显示文摘 | Guo Zizheng Szeto K Y Fu Xiujun | 2004 | Phys Rev E2004，70，01： | 1 |
| 20 | Universal topological properties of two-dimensional trivalent cellular patterns 显示文摘 | Szeto K Y Fu Xiujun Tam W Y | 2002 | Phys Rev Lett2002，88，13： | 1 |
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