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| 1 | The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy显示文摘蜕膜的生来的杀手(dNK ) 房间活跃地对感染作为本地保护者参予母亲胎儿的有免疫力的忍耐和行为的建立和维护。然而, dNK 房间怎么在怀孕期间维持在忍耐和反感染免疫者回答之间的有免疫力的平衡,仍然保持未知。这里,我们证明禁止的分子 T 房间免疫球蛋白领域和粘蛋白包含域的 molecule-3 (Tim-3 ) 在超过 60 % 上被表示;dNK 房间。Tim-3 + dNK 房间显示更高的 interleukin (IL )-4 和更低的肿瘤坏死因素(TNF )-α并且 perforin 生产。人的 trophoblast 房间能经由 galectin-9 (Gal-9 ) 和在 Gal-9 和 Tim-3 之间的相互作用的分泌物导致外部 NK 房间的转变进象 dNK 一样显型。另外, trophoblasts 禁止导致的 lipopolysaccharide (LPS ) 由 dNK 房间的支持 inflammatory cytokine 和 perforin 生产,它能被抵销抗体的 Tim-3 稀释。有趣地, Tim-3-expressing dNK 房间的一个减少的百分比在人的流产和鼠科的流产容易的模型被观察。而且, T 助手(Th )2 类型 cytokines 被减少, Th1 类型 cytokines 从人和老鼠流产在 Tim-3 + 然而并非 Tim-3 − dNK 房间被增加。因此,我们的结果建议 Gal-9/Tim-3 信号为 dNK 房间功能的规定是重要的,它为正常怀孕的维护是有益的。 | Yan-Hong Li Wen-Hui Zhou Yu Tao Song-Cun Wang Yun-Lan Jiang Di Zhang Hai-Lan Piao Qiang Fu Da-Jin Li Mei-Rong Du | 2016 | Cellular & Molecular Immunology2016，13，1： | 40 |
| 2 | Landscape Ecology:Coupling of Pattern,Process,and Scale显示文摘Landscape ecology provides new theoretical frameworks and methodologies for understanding complex ecological phenomena at multiple scales.Studies of landscape ecology focus on understanding the dynamics of eco-logical patterns and processes,and highlight the integration of multiple disciplines.In this paper,we discussed the problems and challenges that landscape ecology is currently facing,emphasizing the limitations of current methods used to describe dynamic landscape patterns and processes.We suggested that the focus should be on the integration of ground-based observation,mobile monitoring,transect survey,and remote-sensing monitoring,as well as improved coupling of experimental and model simulations.In addition,we outlined the research frontiers in landscape ecology,including scaling,integrated pattern and process modeling,and regional synthesis.Lastly,a brief review of pat-tern-process-scale coupling studies in China was provided.We concluded by pointing out that pattern-process-scale interactions,correlations between natural,economic,and social processes,and the coupling of human and natural systems will be major research areas in landscape ecology in the future. | FU Bojie LIANG Di LU Nan | 2011 | Chinese Geographical Science2011，21，4： | 24 |
| 3 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 4 | Molecular epidemic survey on co-prevalence of scrub typhus and marine typhus in Yuxi city,Yunnan province of China显示文摘背景人的 rickettsioses 是世界范围的动物病,因为他们的不正常的表明,把他们区分开来与另外的传染疾病不是容易的。在最近的年里有从 Hongta 区域 CDC 的未知原因的发烧的病人的数字,云南省的 Yuxi 城市在夏天显著地一直在增加。诊断擦洗斑诊伤寒被本地临床医生做。以便查明疾病,我们从 8 月 18 日为如此的病人带了实验室调查去 26, 2005 .Methods 活跃监视从 2002 ~ 2004 由云南省的 Hongta 区域 CDC Yuxi 城市被进行,基本数据从根据临床的定义证实的盒子被获得。平均发生和镇级的发生在学习时期期间被计算。血样品被 PCR 和血清学的测试分析。把一个配对的将军基于 groEL 基因序列指向斑诊伤寒的外部教材( Gro-1 和 Gro-2 ),看到的发烧象一样擦洗斑诊伤寒和二份配对的内部教材( SF1 , SR2 和 TF1 , TR2 )为和看到的发烧的斑诊伤寒并且分别地,擦洗斑诊伤寒被设计执行复合巢的 PCR 。血清学的试金被间接 immunofluorescence 试金与 7 不同立克次氏体属微生的抗原执行,即, R。mossori, R。sibirica, R。conorii, O。tsutsugamushi, B。quintana, B。henselae 和 Coxilella burnetii 阶段 Ag.Results 流行病学的监视从 2002 ~ 2004 显示出那, scrub 斑诊伤寒的平均发生或与鼠科的斑诊伤寒擦洗斑诊伤寒分别地是 222.1/105, 204.3/105 和 109.6/105。在病的尖锐舞台期间拿的 13 件血样品, 6 显示出放大产品为擦洗斑诊伤寒和百分之百显示出的定序的产品, 99% , 99% , 99% , 99% , 99% 类似到 O。tsutsugamushi Karp 而是他们分享了一样的推出的氨基酸序列,它与 O 的热吃惊蛋白质显示了 100% 身份。tsutsugamushi Karp 紧张。百分之百,为鼠科的斑诊伤寒和他们的相应核苷酸序列的五个产出的 PCR 产品展出了 100%99% , 99% 和 99% 类似到 R。mossori Wilmington 和预言的氨基酸序列的分析显示了 100% , 100%,98% ,有 R 的热吃惊蛋白质的 98% 和 98% 身份。mossoriWilmington 紧张。8 个 PCR 积极病人, 3 显示出合作感染与鼠科的斑诊伤寒擦洗斑诊伤寒。从热性的病人的所有 13 件浆液样品对 O 是积极的。tsutsugamushi 并且他们中的 8 个对 R 是积极的。mossori。所有对 O 8 个配对的标本有抗体的四折的举起。为斑诊伤寒的 tsutsugamushi,和 seroconversion 在 3 件配对的浆液样品被表明。另一在学习发现是 Q 发烧的高 seropositive 流行(76.9%) 是它证实了的 detected.Conclusion 那合作流行与鼠科的斑诊伤寒擦洗斑诊伤寒正在发生在云南省的 Yuxi 城市里,中国。另外的立克次氏体属微生的疾病也需要在这些区域被调查。 | ZHANG Li-juan LI Xue-mei ZHANG De-rong ZHANG Jing-shan DI Ying LUAN Ming-chun FU Xiu-ping | 2007 | Chinese Medical Journal2007，，15： | 18 |
| 5 | Serum osteocalcin levels are inversely associated with plasma glucose and body mass index in healthy Chinese women显示文摘目的: Osteocalcin,骨头形成的一个生物化学的标记,被建议了涉及精力的规定新陈代谢。这研究的目的是在健康中国女人的一件大样品调查在浆液 osteocalcin 和葡萄糖和类脂化合物新陈代谢的标记之间的可能的协会。 | Wei-wei HU Yao-hua KE Jin-wei HE Wen-zhen FU Yu-juan LIU Di CHEN Zhen-lin ZHANG | 2014 | Acta Pharmacologica Sinica2014，35，12： | 16 |
| 6 | CD56^brightCD25^+ NK cells are preferentially recruited to the maternal/fetal interface in early human pregnancy显示文摘蜕膜的生来的杀手(dNK ) 房间被相信批评因为维持母亲 / 胎儿的忍耐并且调整胎盘的脉管的改变在早怀孕期间在他们的丰富和唯一的显型之上基于。然而, dNK 房间怎么在成功的怀孕起如此的重要作用的机制仍然保持未定义。这里,我们识别了作为有 CD3 − CD56 明亮的 CD25 + 显型。我们发现那 CD56 明亮的 CD25 + NK 房间优先地在早人的怀孕期间本地化到母亲 / 胎儿的接口。CD25 + dNK 房间说明约 75 %表示 CD25 蜕膜的有免疫力的房间(DIC ) 。然而,不到 5 %CD25 积极的外部血 mononuclear 中,房间是 CD25 + NK 房间。而且, CD25 + 和 CD25 − dNK 房间展出不同显型:CD25 + dNK 房间显示更多的激活的显型和更大的秘密 cytokine 能力。有趣地,有主要 trophoblasts upregulates 的外部 NK (pNK ) 房间的 coculture 表示 CD25 pNK 房间的百分比,由 pNK 房间导致激活标记和 cytokine 生产的增加的表示。另外,我们证明 CXCL12/CXCR4 轴为 CD25 + dNK 房间的招募是关键的并且贡献 CD3 − CD56 明亮的 在母亲 / 胎儿的接口的 CD25 + dNK 房间。因此,我们的数据表明在 trophoblasts 之间的串音和 pNK 房间导致 CD3 − CD56 明亮的 CD25 + dNK 房间,它在母亲 / 胎儿的接口施加调整效果。 | Yu Tao Yan-Hong Li Hai-Lan Piao Wen-Jie Zhou Di Zhang Qiang Fu Song-Cun Wang Da-Jin Li Mei-Rong Du | 2015 | Cellular & Molecular Immunology2015，12，1： | 14 |
| 7 | Apolipoprotein A-I inhibits LPS-induced atherosclerosis in ApoE-/- mice possibly via activated STAT3-mediated upregulation of tristetraprolin显示文摘 | Kai YIN Shi-lin TANG Xiao-hua YU Guang-hui TU Rong-fang HE Jin-feng LI Di XIE Qing-jun GUI Yu-chang FU Zhi-sheng JIANG Jian TU Chao-ke TANG | 2013 | Acta Pharmacologica Sinica2013，34，6： | 11 |
| 8 | Hot workability characteristics of Rene88DT superalloy with directionally solidified microstructure显示文摘The hot deformation characteristics of Rene88 DT superalloy with directionally solidified microstructure produced by electroslag remelting continuous directionally solidification(ESR-CDSò) were studied in the temperature range of 1,040–1,140 °C and strain rate range of 0.001–1.000 s-1by hot compression tests. Flow curves for Rene88 DT alloy with initial directionally solidified(DS)microstructure exhibit pronounced peak stresses at the early stage of deformation followed by the occurrence of dynamic softening phenomenon. Rene88 DT alloy with DS microstructure shows higher flow peak stresses compared with HIPed P/M superalloy FGH4096, but the disparities in peak stresses between ESR-CDSed Rene88 DT and HIPed P/M superalloy FGH4096 reduce as temperature increases. The improvement of hot workability of DS alloy with columnar grains avoiding the maximum shear stress comes true. A hot deformation constitutive equation as a function of strain that describes the dependence of flow stress on strain rate and temperature is established. Hot deformation apparent activation energy(Q) varies not only with the strain rate and temperature but also with strain. The strain rate sensitivity exponent(m) map is established at the strain of 0.8, which reveals that global dynamic recrystallization(DRX) shows a relatively high m value in a large strain compression.Optimum parameters are predicted in two regions:T = 1,100–1,130 °C,_e = 0.100–1.000 s-1and T = 1,080–1,100 °C,_e = 0.010–0.100 s-1, which is based on processing maps and deformation microstructure observations. | Fu-Lin Li Rui Fu Di Feng Zhi-Ling Tian | 2015 | Rare Metals2015，34，1： | 9 |
| 9 | Improving Damping Properties and Thermal Stability of Epoxy/Polyurethane Grafted Copolymer by Adding Glycidyl POSS显示文摘Modified castor oil-based epoxy resin (EP)/polyurethane (PU) grafted copolymer by glycidyl polyhedral oligomeric silsesquioxane (glycidyl POSS) was synthesized. The damping properties, thermal stability, mechanical properties and morphology of the grafted copolymer modified by glycidyl POSS were studied systematically. The results revealed that the incorporation of glycidyl POSS improved the damping performance evidently and broadened damping temperature range, especially when the glycidyl POSS content was0.2%–1%. At the same time, there was a slight increase in thermal stability with the increase of POSS content. The tensile properties changed with the change of the copolymer's Tg, decreased at low POSS contents and increased at high POSS contents. This modified copolymer has the potential to be used as film damping material or constrained damping layer. | Ge-Liang Zhu Di Han Ye Yuan Feng Chen Qiang Fu | 2018 | Chinese Journal of Polymer Science2018，36，11： | 8 |
| 10 | Expression of long non-coding RNAs in complete transection spinal cord injury: a transcriptomic analysis显示文摘Long non-coding RNAs(lncRNAs)are abundantly expressed in the central nervous system and exert a critical role in gene regulation via multiple biological processes.To uncover the functional significance and molecular mechanisms of lncRNAs in spinal cord injury(SCI),the expression signatures of lncRNAs were profiled using RNA sequencing(RNA-seq)technology in a Sprague-Dawley rat model of the 10th thoracic vertebra complete transection SCI.Results showed that 116 of 14,802 detected lncRNAs were differentially expressed,among which 16—including eight up-regulated(H19,Vof16,Hmox2-ps1,LOC100910973,Ybx1-ps3,Nnat,Gcgr,LOC680254)and eight down-regulated(Rmrp,Terc,Ngrn,Ppp2r2b,Cox6a2,Rpl37a-ps1,LOC360231,Rpph1)—demonstrated fold changes>2 in response to transection SCI.A subset of these RNA-seq results was validated by quantitative real-time PCR.The levels of 821 mRNAs were also significantly altered post-SCI;592 mRNAs were up-regulated and 229 mRNAs were down-regulated by more than 2-fold.Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analyses showed that differentially expressed mRNAs were related to GO biological processes and molecular functions such as injury and inflammation response,wound repair,and apoptosis,and were significantly enriched in 15 KEGG pathways,including cell phagocytosis,tumor necrosis factor alpha pathway,and leukocyte migration.Our results reveal the expression profiles of lncRNAs and mRNAs in the rat spinal cord of a complete transection model,and these differentially expressed lncRNAs and mRNAs represent potential novel targets for SCI treatment.We suggest that lncRNAs may play an important role in the early immuno-inflammatory response after spinal cord injury.This study was approved by the Administration Committee of Experimental Animals,Guangdong Province,China. | Lu Ding Wen-Jin Fu Hong-Yan Di Xiao-Min Zhang Yu-Tian Lei Kang-Zhen Chen Tao Wang Hong-Fu Wu | 2020 | Neural Regeneration Research2020，15，8： | 8 |
| 11 | Crystalline Silica Promotes Rat Fibrocyte Differentiation in Vitro,and Fibrocytes Participate in Silicosis in Vivo显示文摘Objective The aim of this study was to investigate the effects of Si O2 on fibrocytes and whether fibrocytes participate in silicosis in vivo. Methods A macrophagocyte(AM)/fibrocyte coculture system was established, and AMs were treated with 100 μg/mL SiO 2. Flow cytometry was used to detect the number of fibrocytes. Real‐time PCR was performed to measure the expression of collagen I, collagen III, and α‐SMA mR NA. The levels of collagen I, collagen III, and TGF‐β1 protein were determined by ELISA. Immunohistochemical staining was performed to measure α‐SMA protein expression. A rat silicosis model was induced by intratracheal instillation of SiO 2. Lung histopathological evaluation was conducted using HE and Masson's trichrome staining after 1 and 9 weeks. The number of fibrocytes in peripheral blood or lung tissue of rat was detected by flow cytometry. Double‐color immunofluorescence was applied to identify fibrocytes in the lung tissue. Results Peripheral blood monocytes were found to differentiate into fibrocytes in vitro in a time‐dependent manner, and exposure to crystalline silica might potentiate fibrocyte differentiation. In addition, fibrocytes were able to migrate from peripheral blood to the lung tissue, and the number of fibrocytes was increased after SiO 2 exposure. Conclusion Silica exposure potentiates fibrocyte differentiation, and fibrocytes may participate in silicosis in vivo. | LI Juan YAO Wu HOU Jian Yong Zhang Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao HAO Chang Fu | 2017 | Biomedical and Environmental Sciences2017，30，9： | 7 |
| 12 | 激光选区熔化设备及生物医学金属材料的研究与应用进展(英文)显示文摘本文主要介绍了华南理工大学(SCUT)在激光选区熔化(SLM)成型设备以及医用金属材料SLM成型的基础研究与应用的最新成果。首先,采用DiMetal-100设备研究316L不锈钢、CoCrMo与Ti6Al4V三种医用金属粉末SLM成型的工艺参数、微观组织和力学性能。其次,详细介绍了SLM成型316L不锈钢在个性化舌侧正畸托槽和手术导板的应用,SLM成型CoCrMo在膝关节假体和牙冠牙桥的应用,以及SLM成型Ti6Al4V在骨盆骨折接骨板和个性化颅骨修复体方面的研究成果。最后,介绍了SCUT在SLM技术方面的发展方向和研究计划,具体包括实现新型多孔结构的SLM直接成型、实现多种材料SLM一次成型、实现SLM与减材复合成型、增加SLM设备的负反馈系统以及开发陶瓷和新型金属的SLM成型工艺。总结:SCUT对SLM设备及其医学应用进行了长期深入的研究,研究了医用金属材料316L不锈钢、CoCrMo合金以及Ti6Al4V合金的SLM成型工艺和微观组织,获得了性能优异的零件。SCUT成功将SLM成型的316L不锈钢应用于舌侧正畸托槽和手术导板,将SLM成型的CoCrMo合金应用于膝关节假体和牙冠牙桥,以及将SLM成型的Ti6Al4V合金应用于个性化接骨板和颅骨多孔修复体。其中,舌侧正畸托槽和牙冠固定桥已经进入商业应用。目前,SCUT正在进一步开展面向植入体内部结构的设计和制造技术研究,同时开始对SLM多材料成型、SLM与切削复合成型进行研究,并逐步开展SLM设备负反馈系统的开发及陶瓷、锌合金、镍钛合金等SLM成型工艺的研究等。 | Yu-chao BAI Fan FU Ze-feng XIAO Ming-kang ZHANG Di WANG Yong-qiang YANG Chang-hui SONG | 2018 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2018，19，2： | 7 |
| 13 | Is routine drainage necessary after pancreaticoduodenectomy?显示文摘With the development of imaging technology and surgical techniques, pancreatic resections to treat pancreatic tumors, ampulla tumors, and other pancreatic diseases have increased. Pancreaticoduodenectomy, one type of pancreatic resection, is a complex surgery with the loss of pancreatic integrity and various anastomoses. Complications after pancreaticoduodenectomy such as pancreatic fistulas and anastomosis leakage are common and significantly associated with patient outcomes. Pancreatic fistula is one of the most important postoperative complications; this condition can cause intraperitoneal hemorrhage, septic shock, or even death. An effective way has not yet been found to avoid the occurrence of pancreatic fistula. In most medical centers, the frequency of pancreatic fistula has remained between 9% and 13%. The early detection and routine drainage of anastomotic fistulas, pancreatic fistulas, bleeding, or other intra-abdominal fluid collections after pancreatic resections are considered as important and effective ways to reduce postoperative complications and the mortality rate. However, many recent studies have argued that routine drainage after abdominal operations, including pancreaticoduodenectomies, does not affect the incidence of postoperative complications. Although inserting drains after pancreatic resectionscontinues to be a routine procedure, its necessity remains controversial. This article reviews studies of the advantages and disadvantages of routine drainage after pancreaticoduodenectomy and discusses the necessity of this procedure. | Qiang Wang Yong-Jian Jiang Ji Li Feng Yang Yang Di Lie Yao Chen Jin De-Liang Fu | 2014 | World Journal of Gastroenterology2014，20，25： | 7 |
| 14 | Accuracy of routine multidetector computed tomography to identify arterial variants in patients scheduled for pancreaticoduodenectomy显示文摘AIM:To assess the efficacy of cross-sectional multidetector computed tomography(MDCT) imaging without arterialreconstruction to identify aberrant right hepatic artery(RHA) and celiac artery stenosis(CAS) in patients scheduled for pancreaticoduodenectomy.METHODS:Patients with peri-ampullary and pancreatic head tumors who underwent routine preoperative MDCT and subsequent computed tomography(CT) angiography(CTA),conventional angiography or pancreaticoduodenectomy between September 2007 and August 2013 were identified.Retrospective analysis of imaging data was undertaken using CTA,conventional angiographic and surgical findings as the reference standards.The accuracy,sensitivity,specificity,positive predictive value(PPV) and negative predictive value(NPV) of MDCT in evaluation of aberrant RHA and CAS were calculated.RESULTS:A group of 458 patients met the inclusion criteria of this study to detect aberrant RHA,and 181 cases were included to identify CAS.Fifty-four(11.8%) patients were confirmed to have aberrant RHA,while 12(6.6%) patients with CAS were demonstrated.MDCT yielded an accuracy of 98.5%,sensitivity of 96.3% and specificity of 98.8% in the detection of aberrant RHA.The sensitivity,specificity,PPV and NPV of MDCT for detecting CAS were 58.3%,98.2%,70% and 97.1%,respectively.CONCLUSION:Routine MDCT is recommended such that surgeons and radiologists be alerted to the importance of arterial variants on preoperative CT scans in patients scheduled for pancreaticoduodenectomy. | Feng Yang Yang Di Ji Li Xiao-Yi Wang Lie Yao Si-Jie Hao Yong-Jian Jiang Chen Jin De-Liang Fu | 2015 | World Journal of Gastroenterology2015，21，3： | 6 |
| 15 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 16 | Immobilization of laccase by Cu^(2+) chelate affinity interaction on surface modified magnetic silica particles and its use for the removal of pentachlorophenol显示文摘把 polyacrylamide 用作金属螯的 ligand 的磁性的螯 Cu2+ 的硅石粒子被开发并且由协作为 laccase 的固定使用了。为五氯苯酚(PCP ) 的使不能调动的 laccase 和它的催化能力的酶的性质上的 pH 和温度的效果降级全身地被评估。与免费 laccase 相比,使不能调动的 laccase 显示出改进的酸适应性和热稳定性。在这个工作准备的使不能调动的 laccase 从水的答案为 PCP 移动展出了一个好催化能力。 | Ying Wang Di Zhang Fu Rong He Xiao Chun Chen | 2012 | Chinese Chemical Letters2012，23，2： | 5 |
| 17 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 18 | Preparation of large-size Al_(2)O_(3)/GdAlO_(3)/ZrO_(2)ternary eutectic ceramic rod by laser directed energy deposition and its microstructure homogenization mechanism显示文摘Laser 3D printing based on melt growth has great potential in rapid preparation of Al_(2)O_(3)-based eutectic ce ramics.In this work,la rge-scale Al_(2)O_(3)/GdAlO_(3)/ZrO_(2)ternary eutectic ceramic rod with diameter of 4-5 mm and height higher than 250 mm was additively manufactured by laser directed energy deposition.Especially,heat treatment was applied to eliminate the microstructure heterogeneity in the as-deposited eutectic ceramic,and the microstructure homogenization mechanism was studied in depth.The results indicate that colonies and banded structures completely disappear after the heat treatment,producing a homogeneous network eutectic structure.The microstructure homogenization is revealed to experience three stages of discontinuous coarsening,continuous coarsening and microstructure coalescence.Additionally,it is found that the eutectic spacing linearly increases with the heat treatment time,meaning that the coarsening behavior of the laser 3D-printed Al_(2)O_(3)/GdAlO_(3)/ZrO_(2)eutectic ceramic satisfies well with the Graham-Kraft model. | Haifang Liu Haijun Su Zhonglin Shen Di Zhao Yuan Liu Yinuo Guo Min Guo Jun Zhang Lin Liu Hengzhi Fu | 2021 | Journal of Materials Science & Technology2021，，26： | 5 |
| 19 | Risk factors for ventilator-associated pneumonia among patients undergoing major oncological surgery for head and neck cancer显示文摘为头和颈癌症(SHNC ) 经历主要 oncological 外科的病人有医院的感染的特别地高的风险。我们试图在经历 SHNC 的病人为联系通风机的肺病(VAP ) 识别风险因素。学习包括了经历了在 2011 年 6 月和 2014 年 6 月之间的 SHNC 的 465 个病人。VAP,为 VAP 的风险因素,和 VAP 的生物方面的率回顾地被评估。VAP 的发生是 19.6%(n=95 ) 在要求了机械通风的超过 48 h 的病人。葡萄球菌(37.7%) , Enterobacteriaceae (32.1%) , Pseudomonas (20.8%) ,和 Haemophilus (16.9%) 是引起了 VAP 的主要细菌的种类。为 VAP 的独立风险因素被预付年龄,当前的吸烟地位,长期的妨碍的肺的疾病,和一个更高简化的尖锐生理学分数在承认之上的系统 II。Tracheostomy 是为 VAP 的一个独立保护的因素。在为确实开发了 VAP 的病人的 ICU 的停留的中部的长度是 8.0 和 6.5 天,分别地(P=0.006 ) 。在确实开发了 VAP 的病人之中的死亡是 16.8% 和 8.4% ,分别地(P < 0.001 ) 。因为通风的显著地扩大的持续时间, VAP 的潜在的经济影响高。一个预兆的回归模型与 95.3% 的敏感和 69.4% 的特性被开发。VAP 在并且谁正在经历 SHNC 的病人是普通的要求机械通风的超过 48 h。因此,创新预防措施应该在这张高风险的人口被开发并且适用。 | Yutao Liu Yaxia Di Shuai Fu | 2017 | Frontiers of Medicine2017，11，2： | 5 |
| 20 | The relationship between SPARC expression in primary tumor and metastatic lymph node of resected pancreatic cancer patients and patients' survival显示文摘BACKGROUND: Previous researches in pancreatic cancer demonstrated a negative correlation between secreted protein acidic and rich in cysteine(SPARC) expression in primary tumor and survival, but not for SPARC expression in lymph node. In the present study, we aimed to evaluate the SPARC expression in various types of tissues and its impact on patients' prognosis.METHODS: The expression of SPARC was examined by immunohistochemistry in resected pancreatic cancer specimens. Kaplan-Meier analyses and Cox proportional hazards regression were applied to assess the mortality risk.RESULTS: A total of 222 tissue samples from 73 patients were collected to evaluate the SPARC expression, which included 73 paired primary tumor and adjacent normal tissues, 38 paired metastatic and normal lymph nodes. The proportion of positive SPARC expression in metastatic lymph node was high(32/38), whereas in normal lymph node it was negative(0/38). Positive SPARC expression in primary tumor cells was associated with a significantly decreased overall survival(P=0.007) and disease-free survival(P=0.003), whereas in other types of tissues it did not show a predictive role for prognosis. Univariate and multivariate analyses both confirmed this significance.CONCLUSION: SPARC can serve a dual function role as both predictor for prognosis and potentially biomarker for lymph node metastasis in resected pancreatic cancer patients. | Xin-Zhe Yu Zhong-Yi Guo Yang Di Feng Yang Qi Ouyang De-Liang Fu Chen Jin | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，1： | 5 |
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