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| 1 | Community responses to extreme climatic conditions显示文摘 | Frederic JIGUET Lluis BROTONS Vincent DEVICTOR | 2011 | Current Zoology2011，57，3： | 2 |
| 2 | Study of intracellular anabolism of 5-fluorouracil and incorporation in nucleic acids based on an LC-HRMS method显示文摘5-Fluorouracil(5-FU)is an anticancer drug extensively used for different cancers.Intracellular metabolic activation leads to several nucleoside and nucleotide metabolites essential to exert its cytotoxic activity on multiple cellular targets such as enzymes,DNA and RNA.In this paper,we describe the development of a method based on liquid chromatography coupled with high resolution mass spectrometry suitable for the simultaneous determination of the ten anabolic metabolites(nucleoside,nucleotide and sugar nucleotide)of 5-FU.The chromatographic separationwas optimized on a porous graphitic carbon column allowing the analysis of the metabolites of 5-FU as well as endogenous nucleotides.The detection was performed on an Orbitrap■tandem mass spectrometer.Linearity of the method was verified in intracellular content and in RNA extracts.The limit of detection was equal to 12 pg injected on column for nucleoside metabolites of 5-FU and 150 pg injected on column for mono-and tri-phosphate nucleotide metabolites.Matrix effect was evaluated in cellular contents,DNA and RNA extracts for nucleoside and nucleotides metabolites.The method was successfully applied to i)measure the proportion of each anabolic metabolite of 5-FU in cellular contents,ii)follow the consequence of inhibition of enzymes on the endogenous nucleotide pools,iii)study the incorporation of metabolites of 5-FU into RNA and DNA,and iv)to determine the incorporation rate of 5-FUrd into 18 S and 28 S sub-units of rRNA. | Christelle Machon Frederic Catez Nicole Dalla Venezia Floriane Vanhalle Laetitia Guyot Anne Vincent Maxime Garcia Beatrice Roy Jean-Jacques Diaz Jerome Guitton | 2021 | Journal of Pharmaceutical Analysis2021，11，1： | 1 |
| 3 | Reli-ability Study of Complex Physical Systems Using SysML显示文摘 | PIERRE David VINCENT Idasiak FREDERIC Kratz | 2010 | Reliability Engineering and System Safety2010，95，： | 1 |
| 4 | Arbitrary dispersion control of ultrashort optical pulses with acoustic waves显示文摘 | Frederic V Vincent L Huignard J P | 2000 | J Opt Soc Am B2000，17，： | 1 |
| 5 | Amplitude and phase control of ultrashort pulses by use of an acousto-optic programmable dispersive filter: pulse compression and shaping显示文摘 | Frederic V Vincent L Cheng Z | 2000 | Opt Lett2000，25，8： | 1 |
| 6 | HACD1,a regulator of membrane composition and fluidity,promotes myoblast fusion and skeletal muscle growth显示文摘The reduced diameter of skeletal myofibres is a hallmark of several congenital myopathies,yet the underlying cellular and molecular mechanisms remain elusive.In this study,we investigate the role of HACD1/PTPLA,which is involved in the elongation of the very long chain fatty acids,in muscle fibre formation.In humans and dogs,HACD1 deficiency leads to a congenital myopathy with fibre size disproportion associated with a generalized muscleweakness.Throughanalysis of HACD1-deficient Labradors,Hacd1-knockout mice,and Hacd1-deficient myoblasts,we provide evidence that HACD1 promotes myoblast fusion during muscle development and regeneration.We further demonstrate that in normal differentiating myoblasts,expression of the catalytically active HACD1 isoform,which is encoded by a muscle-enriched splice variant,yields decreased lysophosphatidylcholine content,a potent inhibitor of myoblast fusion,and increased concentrations of≥C18 and monounsaturated fatty acids of phospholipids.These lipid modifications correlate with a reduction in plasma membrane rigidity.In conclusion,we propose that fusion impairment constitutes a novel,non-exclusive pathological mechanism operating in congenital myopathies and reveal that HACD1 is a key regulator of a lipid-dependent muscle fibre growth mechanism. | Jordan Blondelle Yusuke Ohno Vincent Gache Stephane Guyot Sebastien Storck Nicolas Blanchard-Gutton Ines Barthelemy Gemma Walmsley Anaelle Rahier Stephanie Gadin Marie Maurer Laurent Guillaud Alexandre Prola Arnaud Ferry Genevieve Aubin-Houzelstein Jean Demarquoy Frederic Relaix Richard JPiercy Stephane Blot Akio Kihara Laurent Tiret Fanny Pilot-Storck | 2015 | Journal of Molecular Cell Biology2015，7，5： | 1 |
| 7 | Induced structural modifications in ZnS nanowires via physical state of catalyst:Highlights of 15R crystal phase显示文摘Peculiar and unique growth mechanisms involved in semiconductor nanowires(NWs)pave the way to the achievement of new crystallographic phases and remarkable material properties,and hence,studying polytypism in semiconductor NWs arouses a strong interest for the next generation of electronic and photonic applications.In this context,the growth of ZnS nanowires has been investigated,as bulk ZnS compound exhibits numerous unstable polytypes at high temperatures,but their stable occurrence is highly anticipated in a nanowire due to its special quasi-dimensional shape and growth modes.In this work,the idea is to provide a change in the growth mechanism via the physical state of catalyst droplet(liquid or solid)and hence,study the induced structural modifications in ZnS nanowires.The HRTEM images of VLS(via liquid alloyed catalyst)grown ZnS NWs show periodic stacking faults,which is precisely identified as a stacking sequence of cubic or hexagonal individual planes leading to an astonishing 15R crystal polymorph.This crystallographic phase is observed for the first time in nanowires.Contrastingly,NWs grown with VSS(via solid catalyst)show crystal polytypes of zinc blende and wurtzite.We calculate and discuss the role of cohesive energies in the formation of such ZnS polytypes.Further,we present the selection rules for the crystallization of such 15R structure in NWs and discuss the involved VLS and VSS growth mechanisms leading to the formation of different crystal phases. | Sumit Kumar Frederic Fossard Gaelle Amiri Jean-Michel Chauveau Vincent Sallet | 2022 | Nano Research2022，15，1： | 1 |
| 8 | Concept of smart integrated life consumption monitoring system for electronics 显示文摘 | Vincent Rouet Frederic Minauh Gnillaume Dianeourt Bruno Foueher | 2007 | Microelectronics Reliability 2007 (47)2007，，： | 1 |
| 9 | Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis显示文摘 | Vlad Ratziu Luminita Bonyhay Vincent Di Martino Frederic Charlotte Lucas Cavallaro Marie-Hélène Sayegh-Tainturier Philippe Giral André Grimaldi Pierre Opolon Thierry Poynard | 2002 | Hepatology2002，，6： | 1 |
| 10 | Characteristics of Recurrent Ventricular Fibrillation Associated With Inferolateral Early Repolarization显示文摘 | Michel Ha?ssaguerre Frederic Sacher Akihiko Nogami Nohiriro Komiya Anne Bernard Vincent Probst Sinikka Yli-Mayry Pascal Defaye Yoshifusa Aizawa Robert Frank Roberto Mantovan Riccardo Cappato Christian Wolpert Antoine Leenhardt Luc de Roy Hein Heidbuchel I | 2009 | Journal of the American College of Cardiology2009，，7： | 1 |
| 11 | SCN5A Mutations and the Role of Genetic Background in the Pathophysiology of Brugada Syndrome显示文摘 | Vincent Probst Arthur A.M. Wilde Julien Barc Frederic Sacher Dominique Babuty Philippe Mabo Jacques Mansourati Solena Le Scouarnec Florence Kyndt Cedric Le Caignec Pascale Guicheney Laetitia Gouas Juliette Albuisson Paola G. Meregalli Hervé Le Marec Hanno | 2009 | Circulation: Cardiovascular Genetics2009，，6： | 1 |
| 12 | Liver fibrosis in overweight patients显示文摘 | Vlad Ratziu Philippe Giral Frederic Charlotte Eric Bruckert Vincent Thibault Ioannis Theodorou Lina Khalil Gérard Turpin Pierre Opolon Thierry Poynard | 2000 | Gastroenterology2000，，6： | 1 |
| 13 | Territorial Accessibility and Decision-Making Structure Related to Debris Flow Impacts on Roads in the French Alps显示文摘The Alps are highly impacted by debris flows that cause major problems for companies and transport networks located in the valley bottoms. One such event occurred in the Rif Blanc catchment and affected the road network in the French Alps, as well as adjacent areas across the Italian border, for several days in June 2012. This article presents two independent approaches to vulnerability assessment. Based on investigations conducted during a survey of local authorities following the event, we compared theoretical risk management and real crisis management in terms of decision making and modes of intervention. Functional vulnerability and territorial consequences were analyzed using a best travel time model of accessibility. We show that a bottom-up approach is practiced in case of actual management planning with a central coordination of general council. Conversely theoretical crisis management shows prefect as the key actor supported by several other state institutions. Our analysis also revealed that a debris flow event with a local impact on the road network has territorial consequences at a regional scale. This study contributes to the discussion about how to minimize the vulnerability of alpine transport networks prone to debris flows. Our results could serve as a decision support tool for public authorities. | Marina Utasse Vincent Jomelli Delphine Grancher Frederic Leone Daniel Brunstein Clement Virmoux | 2016 | International Journal of Disaster Risk Science2016，7，2： | 1 |
| 14 | Accretion in strong field gravity with eXTP显示文摘In this paper we describe the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTP has the unique capability of using advanced 'spectral-timing-polarimetry' techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process. | Alessandra De Rosa Phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo Piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen Paolo Pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue YuPeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio Pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini Paul T.O'Brien Julian P.Osborne Pierre Olivier Petrucci Andrea Possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 1 |
| 15 | Accuracy of interpolationtechniques for the derivation of digital elevation models inrelation to landform types and data density 显示文摘 | Vincent C Frederic D Hocine B | 2006 | Geomor-phology2006，77，12： | 1 |
| 16 | XML Repository and Active Views Demonstration 显示文摘 | Serge 'Abiteboul Vincent Aguilera Sebastien Ailleret Bernd Amann Sophie Chet Brendan Hills Frederic Hubert Jean - Claude Mamou Amelie Marian Laurent Mignet Tova Milo Cassio Souza dos Santos xruno Tessier Anne- Marie Vercoustre | 1999 | VLDB1999，，： | 1 |
| 17 | Multicenter,randomized comparative trial of fludarabine and the combination of cyclophosphamide-doxorubicin-prednisone in 92patients with Waldenstrom macroglobulinemia in first relapse or with primary refractory disease显示文摘 | VERONIQUE L VINCENT L FREDERIC M | 2001 | Blood2001，98，5： | 1 |
| 18 | 假如爆发核事故……确定人人都能听到警报吗?显示文摘在法国,如果反应堆发生严重事故,核电站的警报将会拉响。附近居民都能识别这三声时长1分41秒、间隔5秒的长鸣。但不一定所有人都会听到信号!因为现代住宅的隔音效果相当好…… | Vincent Nouyrigat Frederic Pajak 周佩琼 | 2014 | 新发现2014，0，12： | 0 |
| 19 | Livestock induces strong spatial heterogeneity of soil CO2, N2O and CH4 emissions within a semi-arid sylvo-pastoral landscape in West Africa显示文摘Greenhouse gas(GHG) emissions from the surface soils and surface water receiving animal excreta may be important components of the GHG balance of terrestrial ecosystems, but the associated processes are poorly documented in tropical environments, especially in tropical arid and semi-arid areas. A typical sylvo-pastoral landscape in the semi-arid zone of Senegal, West Africa, was investigated in this study. The study area(706 km2 of managed pastoral land) was a circular zone with a radius of 15 km centered on a borehole used to water livestock. The landscape supports a stocking rate ranging from 0.11 to 0.39 tropical livestock units per hectare depending on the seasonal movements of the livestock. Six landscape units were investigated(land in the vicinity of the borehole, natural ponds, natural rangelands, forest plantations, settlements, and enclosed plots). Carbon dioxide(CO_2), nitrous oxide(N_2O) and methane(CH_4) fluxes were measured with static chambers set up at 13 sites covering the six landscape units, and the 13 sites are assumed to be representative of the spatial heterogeneity of the emissions. A total of 216 fluxes were measured during the one-year study period(May 2014 to April 2015). At the landscape level, soils and surface water emitted an average 19.8 t C-CO_2 eq/(hm2·a)(CO_2: 82%, N_2O: 15%, and CH_4: 3%), but detailed results revealed notable spatial heterogeneity of GHG emissions. CO_2 fluxes ranged from 1148.2(±91.6) mg/(m2·d) in rangelands to 97,980.2(±14,861.7) mg/(m2·d) in surface water in the vicinity of the borehole. N_2O fluxes ranged from 0.6(±0.1) mg/(m2·d) in forest plantations to 22.6(±10.8) mg/(m2·d) in the vicinity of the borehole. CH_4 fluxes ranged from –3.2(±0.3) mg/(m2·d) in forest plantations to 8788.5(±2295.9) mg/(m2·d) from surface water in the vicinity of the borehole. This study identified GHG emission 'hot spots' in the landscape. Emissions from the surface soils were significantly higher in the landscape units most frequently used by the animals, i.e., in the vicinity of the borehole and settlements; and emissions measured from surface water in the vicinity of the borehole and from natural ponds were on average about 10 times higher than soil emissions. | Mohamed H ASSOUMA Dominique SERCA Frederic GUERIN Vincent BLANFORT Philippe LECOMTE Ibra TOURE Alexandre ICKOWICZ Raphael J MANLAY Martial BERNOU Jonathan VAYSSIERES | 2017 | Journal of Arid Land2017，9，2： | 0 |
| 20 | Exploring the effects of dietary inulin in rainbow trout fed a high‑starch,100%plant‑based diet显示文摘Background High dietary carbohydrates can spare protein in rainbow trout(Oncorhynchus mykiss)but may affect growth and health.Inulin,a prebiotic,could have nutritional and metabolic effects,along with anti-inflammatory properties in teleosts,improving growth and welfare.We tested this hypothesis in rainbow trout by feeding them a 100%plant-based diet,which is a viable alternative to fishmeal and fish oil in aquaculture feeds.In a two-factor design,we examined the impact of inulin(2%)as well as the variation in the carbohydrates(CHO)/plant protein ratio on rainbow trout.We assessed the influence of these factors on zootechnical parameters,plasma metabolites,gut microbiota,production of short-chain fatty acids and lactic acid,as well as the expression of free-fatty acid receptor genes in the mid-intestine,intermediary liver metabolism,and immune markers in a 12-week feeding trial.Results The use of 2%inulin did not significantly change the fish intestinal microbiota,but interestingly,the high CHO/protein ratio group showed a change in intestinal microbiota and in particular the beta diversity,with 21 bacterial genera affected,including Ralstonia,Bacillus,and 11 lactic-acid producing bacteria.There were higher levels of butyric,and valeric acid in groups fed with high CHO/protein diet but not with inulin.The high CHO/protein group showed a decrease in the expression of pro-inflammatory cytokines(il1b,il8,and tnfa)in liver and a lower expression of the genes coding for tight-junction proteins in mid-intestine(tjp1a and tjp3).However,the 2%inulin did not modify the expression of plasma immune markers.Finally,inulin induced a negative effect on rainbow trout growth performance irrespective of the dietary carbohydrates.Conclusions With a 100%plant-based diet,inclusion of high levels of carbohydrates could be a promising way for fish nutrition in aquaculture through a protein sparing effect whereas the supplementation of 2%inulin does not appear to improve the use of CHO when combined with a 100%plant-based diet. | Raphaël Defaix Jep Lokesh Laura Frohn Mickael Le Bechec Thierry Pigot Vincent Veron Anne Surget Sandra Biasutti Frederic Terrier Sandrine Skiba-Cassy Jerome Roy Stephane Panserat Karine Ricaud | 2024 | Journal of Animal Science and Biotechnology2024，15，2： | 0 |
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