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| 1 | Role of Helicobacter pylori infection on nutrition and metabolism显示文摘Helicobacter pylori(H. pylori) is a gram-negative pathogen that is widespread all over the world, infecting more than 50% of the world's population. It is etiologically associated with non-atrophic and atrophic gastritis, peptic ulcer and shows a deep association with primary gastric B-cell lymphoma and gastric adenocarcinoma. Recently, the medical research focused on the modification of the gastric environment induced by H. pylori infection, possibly affecting the absorption of nutrients and drugs as well as the production of hormones strongly implicated in the regulation of appetite and growth. Interestingly, the absorption of iron and vitamin B12 is impaired by H. pylori infection, while infected subjects have lower basal and fasting serum levels of ghrelin and higher concentration of leptin compared to controls. Since leptin is an anorexigenic hormone, and ghrelin stimulates powerfully the release of growth hormone in humans, H. pylori infection may finally induce growth retardation if acquired very early in the childhood and in malnourished children. This review is focused on the nutritional effects of H. pylori infection, such as the reduced bioavailability or the malabsorbption of essential nutrients, and of gastrointestinal hormones, as well as on the relationship between H. pylori and the metabolic syndrome. | Francesco Franceschi Tortora Annalisa Di Rienzo Teresa D'Angelo Giovanna Gianluca Ianiro Scaldaferri Franco Gerardi Viviana Tesori Valentina Lopetuso Loris Riccardo Gasbarrini Antonio | 2014 | World Journal of Gastroenterology2014，20，36： | 11 |
| 2 | Comparison of four proton pump inhibitors for the short-term treatment of esophagitis in elderly patients显示文摘AIM: To compare efficacy and tolerability of four proton pump inhibitors (PPIs) commonly used in the short-term therapy of esophagitis in elderly patients.METHODS: A total of 320 patients over 65 years with endoscopically diagnosed esophagitis were randomly assigned to one of the following treatments for 8 wk: (1) omeprazole 20 mg/d; (2) lansoprazole 30 mg/d; (3) pantoprazole 40 mg/d, or (4) rabeprazole 20 mg/d. Major symptoms, compliance, and adverse events were recorded. After 8 wk, endoscopy and clinical evaluation were repeated.RESULTS: Per protocol and intention to treat healing rates of esophagitis were: omeprazole = 81.0% and 75.0%, lansoprazole = 90.7% (P = 0.143 vs omeprazole) and 85.0%, pantoprazole = 93.5% (P = 0.04 vs omeprazole) and 90.0% (P = 0.02 vs omeprazole), rabeprazole = 94.6% (P = 0.02 vs omeprazole) and 88.8% (P = 0.04 vs omeprazole). Dividing patients according to the grades of esophagitis, omeprazole was significantly less effective than the three other PPIs in healing grade 1 esophagitis (healing rates: 81.8% vs 100%, 100% and 100%, respectively, P = 0.012). Pantoprazole and rabeprazole (100%) were more effective vs omeprazole (89.6%, P = 0.0001)and lansoprazole (82.4%, P = 0.0001) in decreasing heartburn. Pantoprazole and rabeprazole (92.2% and 90.1%, respectively) were also more effective vs lansoprazole (75.0%, P < 0.05) in decreasing acid regurgitation. Finally, pantoprazole and rabeprazole (95.2% and 100%) were also more effective vs lansoprazole (82.6%, P < 0.05) in decreasing epigastric pain.CONCLUSION: In elderly patients, pantoprazole and rabeprazole were significantly more effective than omeprazole in healing esophagitis and than omeprazole or lansoprazole in improving symptoms. H pylori infection did not influence the healing rates of esophagitis after a short-term treatment with PPI. | Alberto Pilotto Marilisa Franceschi Gioacchino Leandro Carlo Scarcelli Luigi Piero D'Ambrosio Francesco Paris Vito Annese Davide Seripa Angelo Andriulli Francesco Di Mario | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 3 | Antibodies Anti‐Caga Cross‐React with Trophoblast Cells: A Risk Factor for Pre‐Eclampsia?显示文摘 | Francesco Franceschi Nicoletta Di Simone Silvia D’Ippolito Roberta Castellani Fiorella Di Nicuolo Giovanni Gasbarrini Yoshio Yamaoka Tullia Todros Giovanni Scambia Antonio Gasbarrini | 2012 | Helicobacter2012，，6： | 2 |
| 4 | The unusual varianit显示文摘 | Lieberman MD Franceschi D Marsan B Esophageal carcinoma | 1994 | J Thoarac Cardiovasc Surg1994，108，： | 1 |
| 5 | Acute oxcarbazepine, benazepril,and hydrochlorothiazide overdose with alcohol 显示文摘 | Furlaunt M Franceschi L Poz D | 2006 | The Drug Monit2006，28，2： | 1 |
| 6 | The Cytoskeleton Maintains Organelle Partitioning Required for Singlecell C4 Photosynthesis in Chenopodiaceae Species 显示文摘 | CHUONG S D FRANCESCHI V R VINCENT R I | 2006 | The Plant Cell2006，18，9： | 1 |
| 7 | Extent of resection in the management of duodenal adenocarcinoma显示文摘 | Kaklamanos IG Bathe OF Franceschi D | 2000 | Am J Surg2000，179，1： | 1 |
| 8 | Heterogeneity of brain glucose metabolism in mild cognitive impair ment and clinical progression to Alzheimer disease显示文摘 | ANCHISI D BORRONI B FRANCESCHI M | 2005 | Arch Neurol2005，62，11： | 1 |
| 9 | Outcomes for soft tissue sarcoma in 8249 cases from a large state cancer registry显示文摘 | Gutierrez J C Perez E A Franceschi D | 2007 | J Surg Res2007，141，1： | 1 |
| 10 | 1990, Photosynthetic characteristics of cassava(Manihot esculenta), a C3 species with ehlorenchymatous bundle sheath cell 显示文摘 | Edwards G E Sheta E Moore B D Dai Z Franceschi V R Cheng S H Lin C H Ku M S B | 1990 | Plant and Cell Physiology1990，31，8： | 1 |
| 11 | Apoptosis, DNA damage and ubiquitin expression in normal and mdx muscle fibers after exercise显示文摘 | Sandri M Carraro U Podhorska-Okolov M Rizzi C Arslan P Monti D Franceschi C | 1995 | FEBS Lett1995，373，3： | 1 |
| 12 | Improved survival in the treatment of squamous eareinoma of the oral tongue显示文摘 | Franceschi D Gupta R Spiro RH | 1993 | Am-J-Surg1993，166，： | 1 |
| 13 | Gene therapy for bone formati oin: in vitro and in vitro osteogenic activity of an adenovirus expression BMP7 显示文摘 | Wang D Krbsbach PH | 2000 | J Cell Biochem2000，78，3： | 1 |
| 14 | Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity 显示文摘 | De Martinis M Franceschi C Monti D | 2005 | FEBS Lett2005，579，10： | 1 |
| 15 | Improved survival in the treatment of squamous carcinoma of the oral tongue显示文摘 | Franceschi D Gupta R Spiro RH | 1993 | Am J Surg1993，166，6： | 1 |
| 16 | A systematic review of the prevalence of mucosal and cutaneous human papillomavirus types 显示文摘 | Bzhalava D Guan P Franceschi S | 2013 | Virology2013，445，12： | 1 |
| 17 | Extent of resection in the management of duodenal adenocarcino-ma显示文摘 | Kaklamanos IG Bathe OF Franceschi D | 2000 | Am JSurg2000，179，1： | 1 |
| 18 | Extent of resection in the management of duodenal adenocarcinoma显示文摘 | Kaklamanos IG Bathe OF Franceschi D | 2000 | Am J Surg2000，179，： | 1 |
| 19 | Extent of resection in the management of duodenal adenocarcinoma显示文摘 | Kaklamanos IG Bathe OF Franceschi D | 2000 | Am J Surg2000，179，： | 1 |
| 20 | Pinhole SPECT: An approach to in vivo high resolution SPECT imaging in small laboratory animals 显示文摘 | WEBER D A IVANOVIC M FRANCESCHI D | 1994 | Journal of Nuclear Medicine1994，35，： | 1 |
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