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| 1 | Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies显示文摘Background:Because of the increasing life expectancy in our society,aging-related neurodegenerative disorders are one of the main issues in global health.Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline.Among these diseases,Alzheimer’s disease(AD)and dementia with Lewy bodies(DLB)are the most common types of degenerative dementia.Although both show specific features,an important neuropathological and clinical overlap between them hampers their correct diagnosis.In this work,we identified molecular biomarkers aiming to improve the misdiagnosis between both diseases.Methods:Plasma extracellular vesicles(EVs)-from DLB,AD and healthy controls-were isolated using size-exclusion chromatography(SEC)and characterized by flow cytometry,Nanoparticle Tracking Analysis(NTA)and cryo-electron microscopy.Next Generation Sequencing(NGS)and related bibliographic search was performed and a selected group of EV-associated microRNAs(miRNAs)was analysed by qPCR.Results:Results uncovered two miRNAs(hsa-miR-451a and hsa-miR-21-5p)significantly down-regulated in AD samples respect to DLB patients,and a set of four miRNAs(hsa-miR-23a-3p,hsa-miR-126-3p,hsa-let-7i-5p,and hsamiR-151a-3p)significantly decreased in AD respect to controls.The two miRNAs showing decreased expression in AD in comparison to DLB provided area under the curve(AUC)values of 0.9 in ROC curve analysis,thus suggesting their possible use as biomarkers to discriminate between both diseases.Target gene analysis of these miRNAs using prediction online tools showed accumulation of phosphorylation enzymes,presence of proteasome-related proteins and genes involved in cell death among others.Conclusion:Our data suggest that plasma-EV associated miRNAs may reflect a differential profile for a given dementia-related disorder which,once validated in larger cohorts of patients,could help to improve the differential diagnosis of DLB versus AD. | Ana Gámez-Valero Jaume Campdelacreu Dolores Vilas Lourdes Ispierto Ramón Reñé RamiroÁlvarez MPilar Armengol Francesc E.Borràs Katrin Beyer | 2019 | Translational Neurodegeneration2019，8，1： | 4 |
| 2 | Laparoscopy-assisted versus open colectomy for treatment of colon cancer in the elderly: morbidity and mortality outcomes in 545 patients显示文摘 | Francesc Vallribera Valls Filippo Landi Eloy Espín Basany José Luis Sánchez García Luis Miguel Jiménez Gómez Marc Martí Gallostra Luis Salgado Cruz Manuel Armengol Carrasco | 2014 | Surgical Endoscopy2014，，12： | 2 |
| 3 | Technical efficiency and costanalysis in wastewater treatment processes : a DEA approach 显示文摘 | FRANCESC H S RAMON S G | 2009 | Desalination2009，249，1： | 1 |
| 4 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro- exction and gas chromatography-mass detection 显示文摘 | Alfredo D Francesc V M Teresa G | 2005 | Journal of Chromatography A2005，1064，： | 1 |
| 5 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro-extraction and gas chromatography-mass detection 显示文摘 | ALFREDO D FRANCESC V M TERESA G | 2005 | Journal of Chromatography A2005，，97： | 1 |
| 6 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro-extraction and gas chromatography-mass detection 显示文摘 | Alfredo D Francesc V M Teresa G | 2005 | Journal of Chromatography A2005，1064，： | 1 |
| 7 | Induction of gynogenesis in the turbot (Scophthalmus maximus) : Effects of UV irradiation on sperm motility, the Hertwig effect and viability during the flint 6 months of age 显示文摘 | Francesc P Rosa M C Castora G | 2004 | Aquaculture2004，238，： | 1 |
| 8 | Induction of gynogenesis in the turbot (Scophthalmus maximus):Effects of UV irradiation on sperm motility,the Hertwig effect and viability during the first 6 months of age显示文摘 | FRANCESC P ROSA M C CASTORA G | 2004 | Aquaculture2004，238，： | 1 |
| 9 | Economic feasibility study for wastewater treatment:A cost-benefit analysis显示文摘 | María M S Francesc H S Ramón S G | 2010 | Science of the Total Environment2010，408，20： | 1 |
| 10 | Determination of aflatoxins B1, G1, B2 and G2 in medicinal herbs by liquid chromatography- tandem mass spectrometry显示文摘 | MERITXELL V ANTONIO G IANAYA J FRANCESC B MONTSERRAT A LLU C | 2004 | J Chromatogr: A2004，1048，1： | 1 |
| 11 | Determination of odorous mixed chloro-bromoanisoles in water by solid-phase micro2extraction and gas chromatography-mass detection 显示文摘 | Alfredo D Francesc V M Teresa G | 2005 | Journal of Chromatography A2005，1064，： | 1 |
| 12 | Anti-Huassociated paraneoplastic encephalomyelitis:analysis of 200 patients显示文摘 | Francesc G Florence KG Ramon R | 2001 | Brain2001，124，6： | 1 |
| 13 | Comparative mapping and marker-assisted selection in Rosaceae fruit crops显示文摘 | ELISABETH D ENRIQUE G TAREK J FRANCESC G C PATRICK C WERNER H PERE A | 2004 | PNAS2004，101，26： | 1 |
| 14 | Induction of gynogenesis in the turbot ( Scophthalmus maximus ): Effects of UV irradiation on sperm motility, the Hertwig effect and viability during the first 6 months of age 显示文摘 | Francesc P Rosa M C Castora G | 2004 | Aquaculture2004，238，： | 1 |
| 15 | Monoidal t-morm based logic:towards a logic for left-continuoust-norms显示文摘 | Francesc E Lluis G | 2001 | Fuzzy sets and systems2001，，124： | 1 |
| 16 | Local oxidation of silicon surfaces by dynamic force microscopy: Nanofabri- cation and water bridge formation 显示文摘 | Ricardo G Montserrat C Francesc P | 1998 | Applied Physics Let- ters1998，72，18： | 1 |
| 17 | Induction of gynogenesis in the turbot (Scophthalmus maximus): Efects of UV irradiation on sperm motility, the Hertwig efect and viability during the flint 6 months of age 显示文摘 | Francesc P Rosa M C Castora G | 2004 | Aquaculture2004，238，： | 1 |
| 18 | Sustainability in the construction industry : A review of recent developments based on LCA显示文摘 | Ortiz O Francesc C Sonnemann G | 2009 | Construction and Building Materials2009，23，1： | 1 |
| 19 | GOECP/SEOR radiotherapy guidelines for small-cell lung cancer显示文摘Small cell lung cancer(SCLC)accounts for approximately 20%of all lung cancers.The main treatment is chemotherapy(Ch).However,the addition of radiotherapy significantly improves overall survival(OS)in patients with non-metastatic SCLC and in those with metastatic SCLC who respond to Ch.Prophylactic cranial irradiation reduces the risk of brain metastases and improves OS in both metastatic and non-metastatic patients.The 5-year OS rate in patients with limited-stage disease(non-metastatic)is slightly higher than 30%,but less than 5%in patients with extensive-stage disease(metastatic).The present clinical guidelines were developed by Spanish radiation oncologists on behalf of the Oncologic Group for the Study of Lung Cancer/Spanish Society of Radiation Oncology to provide a current review of the diagnosis,planning,and treatment of SCLC.These guidelines emphasise treatment fields,radiation techniques,fractionation,concomitant treatment,and the optimal timing of Ch and radiotherapy.Finally,we discuss the main indications for reirradiation in local recurrence. | Felipe Couñago Carolina de la Pinta Susana Gonzalo Castalia Fernández Piedad Almendros Patricia Calvo Begoña Taboada Antonio Gómez-Caamaño JoséLuis López Guerra Marisa Chust JoséAntonio GonzálezFerreira AnaÁlvarez González Francesc Casas | 2021 | World Journal of Clinical Oncology2021，12，3： | 1 |
| 20 | Determination of lipid and protein hydroperoxides u- sing the fluorescent probe diphenyl-l-pyrenylphos-phine显示文摘 | RICHARD B BINGCAN C FRANCESC G | 2010 | Food Chem2010，123，： | 1 |
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