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| 1 | Comparative transcriptomics of Central Asian Vitis vinifera accessions reveals distinct defense strategies against powdery mildew显示文摘Grape powdery mildew(PM),caused by the biotrophic ascomycete Erysiphe necator,is a devastating fungal disease that affects most Vitis vinifera cultivars.We have previously identified a panel of V.vinifera accessions from Central Asia with partial resistance to PM that possess a Ren1-like local haplotype.In this study,we show that in addition to the typical Ren1-associated late post-penetration resistance,these accessions display a range of different levels of disease development suggesting that alternative alleles or additional genes contribute to determining the outcome of the interaction with the pathogen.To identify potential Ren1-dependent transcriptional responses and functions associated with the different levels of resistance,we sequenced and analyzed the transcriptomes of these Central Asian accessions at two time points of PM infection.Transcriptomes were compared to identify constitutive differences and PM-inducible responses that may underlie their disease resistant phenotype.Responses to E.necator in all resistant accessions were characterized by an early up-regulation of 13 genes,most encoding putative defense functions,and a late down-regulation of 32 genes,enriched in transcriptional regulators and protein kinases.Potential Ren1-dependent responses included a hotspot of co-regulated genes on chromosome 18.We also identified 81 genes whose expression levels and dynamics correlated with the phenotypic differences between the most resistant accessions‘Karadzhandahal’,DVIT3351.27,and O34-16 and the other genotypes.This study provides a first exploration of the functions associated with varying levels of partial resistance to PM in V.vinifera accessions that can be exploited as sources of genetic resistance in grape breeding programs. | Katherine C H Amrine Barbara Blanco-Ulate Summaira Riaz Dániel Pap Laura Jones Rosa Figueroa-Balderas M Andrew Walker Dario Cantu | 2015 | Horticulture Research2015，2，1： | 3 |
| 2 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 3 | Historical CO2 emission and concentrations due to land use change of croplands and pastures by country显示文摘 | Campos C P D Muylaert M S Rosa L P | 2005 | Science of the Total Environment2005，346，： | 1 |
| 4 | Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant tochemotherapy显示文摘 | Rosas C Sinning M Ferreira A | 2014 | Biol Res2014，47，1： | 1 |
| 5 | 查看详情显示文摘 | Skrobot F C Rosa L V M arques P A | | 0，，： | 1 |
| 6 | Chemical stabilization of air pollution control residues from municipal solid waste incineration 显示文摘 | Margarida J Quina Joao C M Bordadob Rosa M Quinta-Ferreira | 2010 | Journal of Hazardous Materials2010，179，123： | 1 |
| 7 | Optimization of BFO microwave hydrothermal synthesis:influence of process parameter显示文摘 | C Ponzoni R Rosa M Cannio | 2013 | J Alloys Compd2013，558，： | 1 |
| 8 | Efficient constitutive expression of Bacillus subtilis xylanase A in Eseherichia coil DH5alpha under the control of the Bacillus BsXA promoter显示文摘 | Kuller K Rosa J C Faca V M | 2006 | Biotechnol Appl Biochem2006，43，1： | 1 |
| 9 | Is the application of carbendazimharmful to healthy plants?Evidence of weak phytotoxicity in tobacco显示文摘 | Pablo C G Juan M R Rosa M R | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 10 | Corrosion of low carbon steel by microorganisms from the ' pigging' operation debris in water injection pipelines 显示文摘 | COTE C ROSAS O SZTYLER M | 2014 | Bioelectrochemistry2014，97，： | 1 |
| 11 | IgG fe receptors provide an alternative infection route for murine gamma-herpesvirus-68显示文摘 | Rosa G T Gillet L Smith C M de Lima B D Stevenson P G | 2007 | PLoS ONE2007，2，： | 1 |
| 12 | Mycobiota And Mycotoxins In Malted Barley And Brewer's Spent Grain From Argentinean Breweries 显示文摘 | Gonzalez Pereyra M L Rosa C A Dalcero A M | 2011 | Letters In Applied Microbiology2011，55，6： | 1 |
| 13 | Effects of low UV-B doses on the accumulation of UV-B absorbing compounds and total phenolics and carbohydrate metabolism in the peel of harvest lemons显示文摘 | Interdonato R Rosa M Nieva C B | 2011 | Environmental and Experimental Botany2011，，70： | 1 |
| 14 | A validated solid - liquid extraction method for the HPLC determination of polyphenols in apple tissues Comparison with pressurised liquid extraction显示文摘 | ROSA M ALEJANDRO B EDURNE C LUIS A BLANCA G FRANCISCA V | 2005 | Talanta2005，，65： | 1 |
| 15 | Femtosecond laser versus mechanical microkera- tomes for flap creation in laser in situ keratomileusis and effect of postoperative measurement interval on estimated femtosec- ond flap thickness 显示文摘 | Rosa AM Neto-Murta J Quadrado M J Tavares C Lobo C Van Velze R | 2009 | J Cataract Refract Surg2009，35，5： | 1 |
| 16 | Perceived value of the purchase of a tourism product显示文摘 | Javier S Luis C Rosa M | | 0，，： | 1 |
| 17 | Amino acid mobilization and growth of juvenile Octopus maya(Mollusca:Cephalopoda)under inanition and re-feeding显示文摘 | George-Zamora A Viana M T Rodriguez S Espinoza G Rosas C | | 0，，： | 1 |
| 18 | P450cl7 deficiency : clinical andmolecular characterization of six patients 显示文摘 | Rosa S Duff C Meyer M | 2006 | J Clin Endocrinol Metab2006，92，： | 1 |
| 19 | Gliotoxin naturalincidence and toxigenicity of Aspergillus fumigatus isolatedfrom corn silage and ready dairy cattle feed显示文摘 | Pereyra C M Alonso V A Rosa C A | 2008 | World Myco-toxin Journal2008，1，4： | 1 |
| 20 | Superficial ovarian cortex vascularization is inversely related to the follicle reserve in normal cycling ovaries and is increased in polycystic ovary syndrome 显示文摘 | Delgado - Rosas F Gayta' n M Morales C | 2009 | Hum Reprod2009，24，5： | 1 |
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