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| 1 | Superior growth performance in broiler chicks fed chelated compared to inorganic zinc in presence of elevated dietary copper显示文摘Background: The goal of this study was to compare the antagonism of elevated dietary Cu(250 mg/kg) from Cu SO4 on three different Zn sources(Zn SO4· H2O; [Zn bis(-2-hydroxy-4-(methylthio)butanoic acid)], Zn(HMTBa)2,a chelated Zn methionine hydroxy analogue; and Zn-Methionine), as measured using multiple indices of animal performance in ROSS 308 broilers.Methods: Three experiments were conducted in broiler chicks fed a semi-purified diet. Al birds were fed a Zn-deficient diet(8.5 mg/kg diet) for 1 wk, and then provided with the experimental diets for 2 wks.Results: Experiment 1 was a 2 × 2 factorial design with two levels of Cu(8 vs. 250 mg/kg diet from Cu SO4) and two Zn sources at 30 mg/kg [Zn SO4· H2 O vs. Zn(HMTBa)2]. Elevated Cu impaired growth performance only in birds fed Zn SO4.Compared to Zn SO4· H2 O, Zn(HMTBa)2improved feed intake(12 %; P < 0.001) and weight gain(12 %, P < 0.001) and the benefits were more pronounced in the presence of 250 mg/kg diet Cu. Experiment 2 was a dose titration of Zn SO4· H2 O and Zn(HMTBa)2at 30, 45, 60, and 75 mg/kg diet in the presence of 250 mg/kg Cu SO4. Feed:gain was decreased and tibia Zn was increased with increasing Zn levels from 30 to 75 mg/kg. Birds fed Zn(HMTBa)2consumed more food and gained more weight compared to birds fed Zn SO4, especially at lower supplementation levels(30 and45 mg/kg; interaction P < 0,05). Experiment 3 compared two organic Zn sources(Zn(HMTBa)2vs. Zn-Methionine)at 30 mg/kg with or without 250 mg/kg Cu SO4. No interactions were observed between Zn sources and Cu levels on performance or tissue mineral concentrations. High dietary Cu decreased weight gain(P < 0.01). Tibia Cu and liver Cu were significantly increased with 250 mg/kg dietary Cu supplementation(P < 0.01). No difference was observed between the two Zn sources.Conclusions: Dietary 250 mg/kg Cu significantly impaired feed intake and weight gain in birds fed Zn SO4· H2 O,but had less impact in birds fed Zn(HMTBa)2. No difference was observed between the two organic zinc sources.These results are consistent with the hypothesis that chelated organic Zn is better utilized than inorganic zinc in the presence of elevated Cu. | Junmei Zhao Robert B. Shirley Julia J. Dibner Karen J. Wedekind Frances Yan Paula Fisher Thomas R. Hampton Joseph L. Evans Mercedes Vazquez-Anon | 2016 | Journal of Animal Science and Biotechnology2016，7，4： | 6 |
| 2 | Public impact, prevention, and treatment of cataracts显示文摘The human lens is composed anteriorly of a single layer of epithelial cells,which undergo mitosis and migrate to the lens equator where they differentiate into lens fiber cells[1].The elongated lens fiber cells express high levels of soluble crystallin proteins that do not undergo turnover and | WU Frances WANG Sha ZHU Jie RUTGARD Jeff YAN Yong-Bin ZHANG Kang ZHAO Ling | 2015 | Science China(Life Sciences)2015，58，11： | 2 |
| 3 | 羽毛粉的营养价值显示文摘虽然由于羽毛粉所含的氨基酸不平衡,使它从来没被认为是家禽饲料的主要蛋白质来源,但是它能够提供家禽所需的一些必需氨基酸。 | 刘建霞 Park W.Waldroup Frances Yan | 2009 | 国外畜牧学(猪与禽)2009，，6： | 2 |
| 4 | Randomized Trial of Endoscopic Sphincterotomy With Balloon Dilation Versus Endoscopic Sphincterotomy Alone for Removal of Bile Duct Stones显示文摘 | Anthony Yuen Bun Teoh Frances Ka Yin Cheung Bing Hu Ya Min Pan Larry Hin Lai Philip Wai Yan Chiu Simon Kin Hung Wong Francis Ka Leung Chan James Yun Wong Lau | 2013 | Gastroenterology2013，，： | 2 |
| 5 | Randomized Trial of Endoscopic Sphincterotomy With Balloon Dilation Versus Endoscopic Sphincterotomy Alone for Removal of Bile Duct Stones显示文摘 | Anthony Yuen Bun Teoh Frances Ka Yin Cheung Bing Hu Ya Min Pan Larry Hin Lai Philip Wai Yan Chiu Simon Kin Hung Wong Francis Ka Leung Chan James Yun Wong Lau | 2013 | Gastroenterology2013，，： | 1 |
| 6 | Effect on blood pressure of a continued nursing intervention using chronotherapeutics for adult Chinese hypertensive patients显示文摘 | Xiao‐YingZang Jin‐FengLiu Yan‐FenChai Frances Kam YuetWong YueZhao | 2010 | Journal of Clinical Nursing . 2010 (7‐8)2010，，7： | 1 |
| 7 | Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells显示文摘 | Oekyung Kim Yan Sun Frances W. Lai Cheng Song Dongwan Yoo | 2010 | Virology2010，，2： | 1 |
| 8 | Health Problems Encountered by Dying Patients Receiving Palliative Home Care Until Death显示文摘 | Frances KYW Chun Fong Liu Yan Szeto | 2004 | Cancer Nursing2004，27，3： | 1 |
| 9 | TECTONIC DEVELOPMENT OF THE METAMORPHIC CORE COMPLEX OF THE WUGONGSHAN IN THE NORTHERN JIANGXI PROVINCE显示文摘 | Sun Yan 1) Shu Liangshu 1) M.Faure 2) J.Charvet 2) ( 1)Department of Eatrh Sciences Nanjing University 210093 Nanjing PRC 2)Department of Earth Science Orleans University 45067 Orleans. Cedex 2 France) Keywords me | 1997 | 南京大学学报(自然科学版)1997，，03： | 1 |
| 10 | Developing Curricula to Encourage Students to Write Reflective Journals显示文摘 | David Kember Alice Jones Alice Loke Jan McKay Kit Sinclair Harrison Tse Celia Webb Frances Wong Marian Wong Po Wa Yan Ella Yeung | 1996 | Educational Action Research1996，，3： | 1 |
| 11 | Absorption of methionine sources in animals-is there more to know?—— Clarification显示文摘Our publication on absorption of methionine sources(Becquet et al.,2023a)is a thorough analysis of 129 references dealing with absorption of sources of methionine,with the objective to critically evaluate the methodologies used and their impact on the conclusions of the studies.As the focus of our publicationwas on the evaluation of absorption,efficacy studies and reports not having information on absorption were not considered(Elwert et al.,2008;Rychen et al.,2008). | Philippe Becquet Mercedes Vazquez-Anon Yves Mercier Dolores I.Batonon-Alavo Frances Yan Karen Wedekind Tahir Mahmood | 2023 | Animal Nutrition2023，，3： | 0 |
| 12 | Absorption of methionine sources in animals-is there more to know?显示文摘This literature review evaluates the absorption of methionine (Met) sources such as 2-hydroxy-4-methylthiobutyric acid (HMTBa), its calcium salts (HMTBa-Ca), and DL-methionine (DL-Met) by focusing on the state of knowledge regarding the absorption mechanism, experimental methodology, and factors affecting their absorption. The 2 Met sources differ in mechanism and site of absorption due to differences in their chemical characteristics and enzymatic conversion. This review addresses diffusion- and transport-mediated absorption systems for amino acids and carboxylic compounds, best elucidated by in vitro, ex vivo, and in vivo experimental models. Opportunities and limitations in the use of radioisotopes to depict absorption sites as well as host and microbial metabolism are described. Physiological and environmental conditions that lead to changes in gut absorptive capacity and the impact of Met source absorption are also evaluated. This review concludes that any comparison between HMTBa and DL-Met should consider their different behaviors during the absorption phase. Hence, the chemical characteristics of these 2 molecules entail different absorption sites and mechanisms, from passive absorption in the case of HMTBa and HMTBa-Ca to active transporters for DL-Met, HMTBa, and HMTBa-Ca. In addition, the different conversion modes of these 2 molecules further differentiate their absorption modes. Considering these important differences, it is easier to understand the apparent divergence between the conclusions of existing publications. When comparing these 2 molecules, it is recommended to properly adapt to the conditions under which the absorption of Met sources is evaluated. | Philippe Becquet Mercedes Vazquez-Anon Yves Mercier Dolores I.Batonon-Alavo Frances Yan Karen Wedekind Tahir Mahmood | 2023 | Animal Nutrition2023，，1： | 0 |
| 13 | A systematic review of metabolism of methionine sources in animals:One parameter does not convey a comprehensive story显示文摘The goal of this review article,based on a systematic literature search,is to critically assess the state of knowledge and experimental methodologies used to delineate the conversion and metabolism of the 2 methionine(Met)sources DL-methionine(DL-Met)and DL-2-hydroxy-4-(methylthio)butanoic acid(HMTBa).The difference in the chemical structures of HMTBa and DL-Met indicates that these molecules are absorbed and metabolized differently in animals.This review explores the methodologies used to describe the 2-step enzymatic conversion of the 3 enantiomers(D-HMTBa,L-HMTBa and D-Met)to L-Met,as well as the site of conversion at the organ and tissue levels.Extensive work was published documenting the conversion of HMTBa and D-Met into L-Met and,consequently,the incorporation into protein using a variety of in vitro techniques,such as tissue homogenates,cell lines,primary cell lines,and everted gut sacs of individual tissues.These studies illustrated the role of the liver,kidney,and intestine in the con-version of Met precursors into L-Met.A combination of in vivo studies using stable isotopes and infusions provided evidence of the wide conversion of HMTBa to L-Met by all tissues and how some tissues are net users of HMTBa,whereas others are net secreters of L-Met derived from HMTBa.Conversion of D-Met to L-Met in organs other than the liver and kidney is poorly documented.The methodology cited in the literature to determine conversion efficiency ranged from measurements of urinary,fecal,and respiratory excretion to plasma concentration and tissue incorporation of isotopes after intraperitoneal and oral in-fusions.Differences observed between these methodologies reflect differences in the metabolism of Met sources rather than differences in conversion efficiency.The factors affecting conversion efficiency are explored in this paper and are mostly associated with extreme dietary conditions,such as noncommercial crystalline diets that are very deficient in total sulfur amino acids with respect to requirements.Impli-cations in the diversion of the 2 Met sources toward transsulfuration over transmethylation pathways are discussed.The strengths and weaknesses of some methodologies used are discussed in this review.From this review,it can be concluded that due to the inherent differences in conversion and metabolism of the 2 Met sources,the experimental methodologies(e.g.,selecting different organs at different time points or using diets severely deficient in Met and cysteine)can impact the conclusions of the study and may explain the apparent divergences of conclusion found in the literature.It is recommended when con-ducting studies or reviewing the literature to properly select the experimental models that allow for differences in how the 2 Met precursors are converted to L-Met and metabolized by the animal to enable a proper comparison of their bioefficacy. | Philippe Becquet Mercedes Vazquez-Anon Yves Mercier Karen Wedekind Tahir Mahmood Dolores I.Batonon-Alavo Frances Yan | 2023 | Animal Nutrition2023，，2： | 0 |
| 14 | A GENERALIZED MODELING FOR CEMENT-BASED MATERIALS UNDER LARGE RANGE OF COMPRESSION STATE显示文摘The aim of this study is to describe the main behavior of cement-based materials under large compression state based on the recent experimental research. In this paper, the strainstress relations are firstly analyzed and confining pressure state is regarded as low/medium/high state. A generalized cup modeling is introduced by a coupled deviatoric shearing, pore collapse and damage mechanism within thermodynamic framework. A series of numerical simulations are performed for the considered cement paste and concrete. Comparisons between numerical predictions and experimental results show that the proposed model is able to describe the main features of mechanical behavior under large range of compression state. | Yan Zhang 1 ,2 Jianfu Shao 2 Shouyi Xie 2 ( 1 College of Mechanics and Materials, Hohai University, Nanjing 210098, China) ( 2 Laboratory of Mechanics of Lille, UMR 8107 CNRS, Polytech’Lille, Villeneuve d’Ascq 59655, France) | 2011 | Acta Mechanica Solida Sinica2011，24，S1： | 0 |
| 15 | 吉非替尼与多西紫杉醇在化疗后非小细胞肺癌患者中的疗效对比(INTEREST):一项随机Ⅲ期临床试验显示文摘背景两项在既往接受过治疗的晚期非小细胞肺癌患者中进行的Ⅱ期临床试验结果表明,吉非替尼的疗效优于化疗,且毒副作用更小:局部晚期或转移性非小细胞肺癌患者在接受以铂类药物为基础的化疗后,继续使用吉非替尼和多西紫杉醇进行治疗,观察并比较两类药物的疗效:方法2004年3月1日至2006年2月17日,采用开放标记的Ⅲ期临床研究的方法,在全球24个国家的149家中心招募受试者。1466例晚期非小细胞肺癌患者在接受铂类药物化疗后(铂类药物化疗至少1个疗程),经随机分组,分别接受吉非替尼(250mg口服,每日1次;n=733)或多西紫杉醇(75mg/m^2静脉注射,1h注射完毕,每3周1次;n=733)治疗,并保持两组间样本数量的动态平衡。本研究的主要目的是采用协同主要分析法,比较两组间的存活情况,以此评估吉非替尼在总体符合方案人群中的非劣效性,在意向治疗人群高表皮生长因子受体(EGFR)基因拷贝数患者中的优效性。本临床研究在ClinicalTrials.gov上注册,编号为NCT00076388。结果本研究分析了两种治疗方案下的共计1433例患者(吉非替尼组723例,多西紫杉醇组710例)。总体存活情况确认了吉非替尼相对于多西紫杉醇的非劣效性(事件593例Fs576例,HR1.020,96%C10.905~1.150,达到预定非劣效性标准;中位存活时间7.6月 vs8.0月):具有高EGFR基因拷贝数的患者(85例 vs 89例)未显示出吉非替尼治疗的优效性证据(事件72例vs 71例,HR1.09,95%C10.78-1.51,P=0.62;中位存活时间8.4个月Fs7.5个月)?在吉非替尼治疗组中,最常见的不良事件包括皮疹或痤疮[360例(49%)vs 73例(10%)]以及腹泻[255例(35%)vs 177例(25%)];然而,在多西紫杉醇治疗组中,中性粒细胞减少症[35例(5%)vs 514例(74%)]、乏力不适[182例(25%)vs 334例(47%)]以及脱发[23例(3%)vs 254例(36%)1是最常见的不良事件。结论INTEREST研究确立了吉非替尼与多西紫杉醇相比在存活率方面的非劣效性,提示吉非替尼对于既往接受过治疗的晚期非小细胞肺癌患者是一项有效的治疗措施。 | Edward SKim Vera Hirsh Tony Mok Mark A Socinski Radj Gervais Yi-Long Wu Long-Yun Li Claire L Watkins Mark V Sellers Elizabeth S Lowe Yan Sun Mei-Lin Liao Kell Osterlind Martin Reck Alison A Armour Frances A Shepherd Scott M Lippman lean-Yves Douillard | 2009 | 世界临床医学2009，，7： | 0 |
| 16 | Cross-section Measurement for 238U(9Be, 5n)242Cm Reaction显示文摘 | Hua Wei Zhang Yuhu Guo Yingxiang Zhou Xiaohong Lei Xiangguo Ma Fei Guo Song Qiang Yuhua Liu Mingliang Wang Haixia Li Guangshun Zhou Houbing Ding Bin Zhang Ningtao Li Shicheng Yan Xinliang G. Georgiev G. de France D. L. Balabanski | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 0 |
| 17 | An alternative evolution scenario for OAO 1657-415 and IGR J18483-0311显示文摘The relation between the spin period and the orbital period in high-mass X-ray binaries is investigated.Be/X-ray binaries and SG/X-ray binaries occupy different areas in Corbet's diagram.The two SG/X-ray binaries,IGR J18483-0311 and OAO 1657-415,however,appear to occupy a transition region between Be/X-ray binaries and wind-fed SG/X-ray binaries.This can be understood by noting that the neutron stars in the two SG/X-ray binaries have not reached their equilibrium spin periods when the donors evolved off the main sequence.Here,we provide an alternative scenario to explain their location in Corbet's diagram:the SG/X-ray binaries are the descendants of Be/X-ray binaries,i.e.the supergiants in these systems were formed from O-type emission line stars instead of normal main-sequence stars.Furthermore,we suggest that there are two types of SG/X-ray binaries:one is directly evolved from a normal OB-type main sequence and neutron star system without an X-ray history,and the other evolved from a Be/X-ray binary with an X-ray history. | LIU QingZhong1,2,LI Hui1,3 & YAN JingZhi1,2 1 Purple Mountain Observatory,Chinese Academy of Sciences,Nanjing 210008,China 2 Service d’Astrophysique,CEA Saclay and University Paris Diderot,91191 Gif-sur-Yvette,France 3 Graduate University of Chinese Academy of Sciences,Beijing 100049,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，S1： | 0 |
| 18 | Optical results of the black hole microquasar SS 433显示文摘We present optical spectroscopic observations of SS 433 during different precessional and orbital phases.Our 2004,2007 and 2008 data provide us a good chance to study the variability of the Hα line at different orbital phases for nearly the same disk inclination.The data show that the Hα of SS 433 usually had a symmetric profile between orbital phases 0.25-0.75,while an asymmetric structure with a strong red peak was observed for other orbital phases.We suggest that the orbital variability of Hα emission is connected with accretion flow from the donor star to the accretion disk.In addition,we attribute the dramatic increase of Hα emission during our 2007 observational run,which had a time scale of one day,to the emergence of strong jets. | LI Hui1,2 & YAN JingZhi1,3 1 Purple Mountain Observatory,Chinese Academy of Sciences,Nanjing 210008,China 2 Graduate University of Chinese Academy of Sciences,Beijing 100049,China 3 Service d’Astrophysique,CEA Saclay and University Paris Diderot,91191 Gif-sur-Yvette,France | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，S1： | 0 |
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