6篇
您的检索式：作者名="Fran oise Smets"
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| 1 | Stem cells for liver tissue repair:Current knowledge and perspectives显示文摘Stem cells from extra-or intrahepatic sources have been recently characterized and their usefulness for the generation of hepatocyte-like lineages has been demonstrated. Therefore, they are being increasingly considered for future applications in liver cell therapy. In that field, liver cell transplantation is currently regarded as a possible alternative to whole organ transplantation, while stem cells possess theoretical advantages on hepatocytes as they display higher in vitro culture performances and could be used in autologous transplant procedures. However, the current research on the hepatic fate of stem cells is still facing difficulties to demonstrate the acquisition of a full mature hepatocyte phenotype, both in vitro and in vivo. Furthermore, the lack of obvious demonstration of in vivo hepatocyte-like cell functionality remains associated to low repopulation rates obtained after current transplantation procedures. The present review focuses on the current knowledge of the stem cell potential for liver therapy. We discuss the characteristics of the principal cell candidates and the methods to demonstrate their hepatic potential in vitro and in vivo. We finally address the question of the future clinical applications of stem cells for liver tissue repair and the technical aspects that remain to be investigated. | Philippe A Lysy David Campard Fran oise Smets Mustapha Najimi Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，6： | 22 |
| 2 | Liver cell transplantation for Crigler-Najjar syndrome type Ⅰ: Update and perspectives显示文摘Liver cell transplantation is an attractive technique to treat liver-based inborn errors of metabolism. The feasibility and efficacy of the procedure has been demonstrated, leading to medium term partial metabolic control of various diseases. Crigler-Najjar is the paradigm of such diseases in that the host liver is lacking one function with an otherwise normal parenchyma. The patient is at permanent risk for irreversible brain damage. The goal of liver cell transplantation is to reduce serum bilirubin levels within safe limits and to alleviate phototherapy requirements to improve quality of life. Preliminary data on Gunn rats, the rodent model of the disease, were encouraging and have led to successful clinical trials. Herein we report on two additional patients and describe the current limits of the technique in terms of durability of the response as compared to alternative therapeutic procedures. We discuss the future developments of the technique and new emerging perspectives. | Philippe A Lysy Mustapha Najimi Xavier Stéphenne Annick Bourgois Franoise Smets Etienne M Sokal | 2008 | World Journal of Gastroenterology2008，14，22： | 9 |
| 3 | Postendoscopic duodenal hematoma in children: Ultrasound diagnosis and follow‐up显示文摘 | Dana Dumitriu Renaud Menten Fran?oise Smets Philippe Clapuyt | 2014 | J. Clin. Ultrasound2014，，： | 1 |
| 4 | Sustained Engraftment and Tissue Enzyme Activity After Liver Cell Transplantation for Argininosuccinate Lyase Deficiency显示文摘 | Xavier Stéphenne Mustapha Najimi Catherine Sibille Marie–Cécile Nassogne Fran?oise Smets Etienne M. Sokal | 2006 | Gastroenterology2006，，4： | 1 |
| 5 | Hepatocyte transplantation in a 4-year-old girl with peroxisomal biogenesis disease: technique, safety, and metabolic follow-up1显示文摘 | Etienne M. Sokal Fran?oise Smets Annick Bourgois Lionel Van Maldergem Jean-Paul Buts Raymond Reding Jean Bernard Otte Veerle Evrard Dominique Latinne Marie Fran?oise Vincent Anne Moser Humberto E. Soriano | 2003 | Transplantation2003，，4： | 1 |
| 6 | INDICATIONS AND RESULTS OF CHEMOTHERAPY IN CHILDREN WITH POSTTRANSPLANT LYMPHOPROLIFERATIVE DISEASE AFTER LIVER TRANSPLANTATION1显示文摘 | Fran?oise Smets Pietro Vajro Guy Cornu Raymond Reding Jean Bernard Otte Em Sokal | 2000 | Transplantation2000，，5： | 1 |
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