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| 1 | Hepatitis B virus mutations potentially conferring adefovir/ tenofovir resistance in treatment-naive patients显示文摘Anti-hepatitis B virus(HBV)therapy leads to the emer- gence of mutant viral strains during the treatment of chronic hepatitis B with nucleos(t)ides analogues. The existence of HBV variants with primary antiviral resistance may be important for treatment choice. We studied two patients with chronic HBV infection by sequencing the HBV polymerase gene.They had adefovir-and tenofovir-related mutations in the viral polymerase,although they had never been treated. These mutations were rtV214A/rtN238T in one patient and rtA194T in the other.Thus,mutations in untreated patients deserve cautious surveillance.These data indicate that mutations that can theoretically confer adefovir or tenofovir resistance may emerge in treatmentnaive patients. | Rebecca Pastor Franois Habersetzer Samira Fafi-Kremer Michel Doffoёl Thomas F Baumert Jean-Pierre Gut Franoise Stoll-Keller Evelyne Schvoerer | 2009 | World Journal of Gastroenterology2009，15，6： | 6 |
| 2 | Neutralizing antibodies in hepatitis C virus infection显示文摘Hepatitis C virus (HCV) is a major cause of hepatitis world-wide. The majority of infected individuals develop chronic hepatitis which can then progress to liver cirrhosis and hepatocellular carcinoma. Spontaneous viral clearance occurs in about 20%-30% of acutely infected individuals and results in resolution of infection without sequaelae. Both viral and host factors appear to play an important role for resolution of acute infection. A large body of evidence suggests that a strong, multispecific and long-lasting cellular immune response appears to be important for control of viral infection in acute hepatitis C. Due too the lack of convenient neutralization assays, the impact of neutralizing responses for control of viral infection had been less defined. In recent years, the development of robust tissue culture model systems for HCV entry and infection has finally allowed study of antibody-mediated neutralization and to gain further insights into viral targets of host neutralizing responses. In addition, detailed analysis of antibody-mediated neutralization in individual patients as well as cohorts with well defined viral isolates has enabled the study of neutralizing responses in the course of HCV infection and characterization of the impact of neutralizing antibodiesfor control of viral infection. This review will summarize recent progress in the understanding of the molecular mechanisms of antibody-mediated neutralization and its impact for HCV pathogenesis. | Mirjam B Zeisel Samira Fafi-Kremer Isabel Fofana Heidi Barth Franoise Stoll-Keller Michel Doffo■l Thomas F Baumert | 2007 | World Journal of Gastroenterology2007，13，36： | 3 |
| 3 | Low doses of intravenous epinephrine for refractory sustained monomorphic ventricular tachycardia显示文摘We report three cases of sustained monomorphic ventricular tachycardia(VT) in the setting of coronary artery disease,resistant to beta-blockers in two patients and to amiodarone in all,successfully terminated by low doses of intravenous(IV) epinephrine.VT was the first manifestation of coronary artery disease in one patient,whereas the other two patients had a previous history of myocardial infarction and were recipients of an implantable cardioverter-defibrillator(ICD).One of these two patients experienced an arrhythmic storm.All had hemodynamic instability at the time of epinephrine administration.A single slow administration of IV epinephrine(0.5 to 1 mg administered over 30 to 60 s) restored sinus rhythm after 30-90 s with only minor side effects.In the ICD patient with recurrent VT and several cardioversions due to transformation of VT to ventricular fibrillation,epinephrine injection led to the avoidance of further shocks.Although potentially harmful,low doses of IV epinephrine used alone or in combination with beta-blocker treatment and electrical cardioversion may be an alternative effective therapy for sustained monomorphic VT refractory to amiodarone.The role of epinephrine in the termination of VT should be studied further,especially in patients pre-treated with amiodarone in combination with beta-blockers. | Aimé Bonny Antonio De Sisti Manlio F Márquez Richard Megbemado Franoise Hidden-Lucet Guy Fontaine | 2012 | World Journal of Cardiology2012，4，10： | 3 |
| 4 | Splenic and portal venous obstruction in chronic pancreatitis显示文摘 | Pr. Pierre Bernades André Baetz Philippe Lévy Jacques Belghiti Yves Menu Fran?ois Fékété | 1992 | Digestive Diseases and Sciences1992，，3： | 2 |
| 5 | Biocontrol of sheath blight by Trichoderma asperellum in tropical lowland rice 显示文摘 | de Fran~a S K S Cardoso A F Lustosa D C | 2015 | Agronomy for Sustainable Development2015，35，1： | 1 |
| 6 | Immunoglobulin coating of faecal bacteria in inflammatory bowel disease显示文摘 | Laurens A van der Waaij Frans GM Kroese Annie Visser Gerardus F Nelis Bram D Westerveld Peter LM Jansen John O Hunter | 2004 | European Journal of Gastroenterology & Hepatology2004，，7： | 1 |
| 7 | Accuracy accessment of sattelite derived land-cover data:a review显示文摘 | LUCAS I F FRANS J M WEI V D | 1994 | Potogramatic Engineering & Remote Sensing1994，60，4： | 1 |
| 8 | Stochastic security for operations planning with significant wind power generation显示文摘 | Fran(c)ois Bouffard Galiana F D | 2008 | IEEE Trans on Power Systems2008，23，2： | 1 |
| 9 | Accuracy assessment of satellite derived land-cover data:a review显示文摘 | LUCAS I F FRANS J M WEL V D | 1994 | Photogrammetric Engineering & Remote Sensing1994，60，4： | 1 |
| 10 | A switching controller for uncertain nonlinear systems显示文摘 | Fran H F Peter K S | 2002 | IEEE Control system Magazine2002，22，1： | 1 |
| 11 | A 2.5 kb NcoI fragment of Ogura radish mitochondrial DNA is correlated with cytoplasmic male-sterility in Brassica cybrids显示文摘 | Sandrine Bonhomme Fran?oise Budar Madina Férault Georges Pelletier | 1991 | Current Genetics1991，，2： | 1 |
| 12 | Changes in metabolism of cerebral glucose after stereotactic leucotomy for refractory obsessive-compulsive disorder:a case report显示文摘 | Biver F Goldman S Franois S | 1995 | Neurol Neurosurg Psychiatry1995，59，4： | 1 |
| 13 | Ilmenite mineral's recovery from beach sand tailings显示文摘 | Mulaba-Bafubiandi F Antoine Mukendi-Ngalula David Waanders B Frans | | 0，，： | 1 |
| 14 | Ni-exchanged AlMCM-41:An efficient bifunctional catalyst for ethylene oligomerization显示文摘 | Fran(c)ois F | 2004 | Journal of Catalysis2004，225，： | 1 |
| 15 | Accuracy assessment of satellite derived land-cover data: review 显示文摘 | Lucas I F J Frans J M Wel V D | 1994 | Photogram-metric Engineering & Remote Sensing1994，60，4： | 1 |
| 16 | Biofilm formation on brass coupons exposed to a cooling system of an oil refinery显示文摘 | M A N Almeida F P de Fran?a | 1998 | Journal of Industrial Microbiology & Biotechnology1998，，1： | 1 |
| 17 | Accuracy assessment of satellite derived land-cover data= a review显示文摘 | LUCASI F J FRANS J M WEL V D | 1994 | Photogram- metric Engineering & Remote Sensing1994，60，4： | 1 |
| 18 | Pereutaneous angioplasty and stenting of left subclavian artery lesions for the treatment of patients with concomitant vertebral and coronary subclaviansteal syndrome显示文摘 | Filippo F Francesco M Fran ceseo P | 2006 | Cardiovasc Intervent Radiol2006，29，3： | 1 |
| 19 | Concrete-filled steel tubes subjected to axial compression and lateral cyclic loads显示文摘 | Amir F Fran K S Q Sami R | 2004 | Journal of Structural Engineering2004，130，4： | 1 |
| 20 | Effects of medication review on drug--related problems in patients using automated drugdispensing systems: A pragmatic randomized controlled study显示文摘 | Frans KH Adrianne F Jacobijn G | 2011 | Drugs and Aging2011，4，28： | 1 |
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