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| 1 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 2 | Size-dependent structural and magnetic properties of chemically synthesized Co-Ni-Ga nanoparticles显示文摘形状记忆材料的阶段转变和磁性能被调节成分材料的尺寸定制,例如 nanoparticles。由于为控制尺寸的 Heusler nanoparticles 的合适的合成方法的缺乏,然而,他们的性质和功能的尺寸依赖上没有报告。在这贡献,我们在场选择尺寸的 Co-Ni-Ga Heusler nanoparticles 的第一化学合成。我们也在 30-84 nm 的范围与尺寸报导 biphasic Co-Ni-Ga nanoparticles 的结构和磁性,由一条 SBA-15 nanoporous silicatemplated 途径准备了。粒子尺寸能被控制装载和先锋的集中乐意地调节。部分和 Co-Ni-Ga nanoparticles 的每个阶段的雏晶尺寸是仔细与他们的粒子尺寸有关。提高的磁化和减少的 coercivity 与增加粒子尺寸被观察。居里温度(T Co-Ni-Ga nanoparticles 的 c ) 也取决于他们的尺寸。84 个缩放 nm 的粒子展出最高的 T 在所有已知的 Heusler 之中的 c (1,174 K ) 加重。Co-Ni-Ga nanoparticles 的高级居里温度显示他们在高温度的形状记忆为申请答应候选人基于合金的设备。 | Changhai Wang Aleksandr A. Levin Julie Karel Simone Fabbrici Jinfeng Qian Carlos E. ViolBarbosa Siham Ouardi Franca Albertini Walter Schnelle Jan Rohlicek Gerhard H. Fecher Claudia Felser | 2017 | Nano Research2017，10，10： | 2 |
| 3 | Assessment of oocyte quality following repeated gonadotropin stimulation in the mouse 显示文摘 | Combelles C M Albertini D F | 2003 | Biology of Reproduction2003，68，3： | 1 |
| 4 | Somatic cell gene mutations in humans : biomarkers for genotoxicity 显示文摘 | ALBERTINI R J NICKLAS J A O'NEILL J P | 1993 | Environ Health Perspect1993，101，： | 1 |
| 5 | Inter- pretation of lipoprotein-associated phospholipase A2 levels is influenced by cardiac disease, comorbidities, ex- tension of atherosclerosis and treatments显示文摘 | Charniot JC Khani-Bittar R Albertini JP | 2013 | Int J Car diol2013，168，1： | 1 |
| 6 | Demecolcine induced o ocyte enucleation for somatic cell cloning: coordination between cell cycle egress, kinetics of cortical cytoskeletal interrections, and second polar body extrution显示文摘 | Ibanez E Albertini D F Overstrom E W | 2003 | Biology of Reproduction2003，68，： | 1 |
| 7 | HPRT mutations in humans:biomarkers for mechanistic studies显示文摘 | Albertini RJ | 2001 | Mutat Res2001，489，1： | 1 |
| 8 | Testing individual risk of acute mountain sickness at greater altitudes 显示文摘 | TANNHEIMER M ALBERTINI N ULMER H V | 2009 | Mil Med2009，174，4： | 1 |
| 9 | Computational comparison of the bending behavior of aortic stent-grafts显示文摘 | Nicolas Demanget Stéphane Avril Pierre Badel Laurent Orgéas Christian Geindreau Jean-No?l Albertini Jean-Pierre Favre | 2011 | Journal of the Mechanical Behavior of Biomedical Materials2011，，1： | 1 |
| 10 | Performance characteristics of the hemoflow F60 in high-flux hemodiafiltration 显示文摘 | VON ALBERTINI B MILLER J H GARDNER P W | 1985 | Contrib Nephrol1985，46，1： | 1 |
| 11 | Induced enucleation of mouse and goat oocytes: Kinetic and phenotypic characterizations显示文摘 | Ibanez E Sanfins A Albertini D F | 2002 | Theriogenology2002，57，： | 1 |
| 12 | Assessment of oocyte quality following repeated gonadotropin stimulation in the mouse显示文摘 | COMBELLES C M ALBERTINI D F | 2003 | Biol Reprod2003，68，3： | 1 |
| 13 | Pulsed laser deposited hard TiC, ZrC, HfC and TaC films on titanium: Hardness and an energy -dispersive X -ray diffraction study 显示文摘 | Ferro D Rau J V Rossi Albertini | 2008 | Surface and Coatings Technology2008，202，8： | 1 |
| 14 | Cellular and Molecular Consequences of Peroxisome Proliferator-Activated Receptor-gamma Activation in Ovarian Cancer Cells显示文摘 | Vignati S Albertini V rinaldi A | 2006 | Neoplasia2006，8，10： | 1 |
| 15 | B-type natriuretic peptide, a marker of aympttomatic left ventficular dysfunction in type 2 diabetic patients 显示文摘 | Albertini JP Cohen R Valensi P | 2008 | Diabetes Metab2008，34，： | 1 |
| 16 | Strain-rate effect on the tensile behavior of concrete at different relative humidity levels显示文摘 | Cadoni E Labibes K Albertini C | 2001 | Materials and Structures/ Materiaux et Constructions2001，34，235： | 1 |
| 17 | Anemia of chronic disease and defective erythropoietin production in patients with celiac disease显示文摘 | Bergamaschi G Markopoulos K Albertini M | 2008 | Hematologica2008，93，12： | 1 |
| 18 | Radiation quality affects the efficiency of induction and the molecular spectrum of HPRT mutations in human T cells显示文摘 | Albertini RJ Clark LS Nicklas JA | 1997 | Radiat Res1997，148，5： | 1 |
| 19 | Lymphatic mapping and sentinel node biopsy in the patient with breast cancer 显示文摘 | Albertini J J Lyman GH Cox C | 1996 | JAMA1996，276，22： | 1 |
| 20 | Distinct cerebrospinal fluid amyloid-beta peptide signatures in cognitive decline associated with Alzheimer's disease and schizophrenia显示文摘 | ALBERTINI V BENUSSI L PATERLINI A | 2012 | Electrophoresis2012，33，24： | 1 |
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