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| 1 | Eviendep~ reduces number and size of duodenal polyps in familial adenomatous polyposis patients with ileal pouchanal anastomosis显示文摘AIM:To evaluate if 3 mo oral supplementation with Eviendep was able to reduce the number of duodenal polyps in familial adenomatous polyposis(FAP)patients with ileal pouch-anal anastomosis(IPAA).METHODS:Eleven FAP patients with IPAA and duodenal polyps were enrolled.They underwent upper gastrointestinal(GI)endoscopy at the baseline and after 3 mo of treatment.Each patient received 5 mg Eviendep twice a day,at breakfast and dinner time,for3 mo.Two endoscopists evaluated in a blinded manner the number and size of duodenal polyps.Upper GI endoscopies with biopsies were performed at the baseline(T0)with the assessment of the Spigelman score.Polyps>10 mm were removed during endoscopy and at the end of the procedure a new Spigelman score was determined(T1).The procedure was repeated 3 mo after the baseline(T2).Four photograms were examined for each patient,at T1 and T2.The examined area was divided into 3 segments:duodenal bulb,second and third portion duodenum.Biopsy specimens were taken from all polyps>10 mm and from all suspicious ones,defined by the presence of a central depression,irregular surface,or irregular vascular pattern.Histology was classified according to the updated Vienna criteria.RESULTS:At baseline the mean number of duodenal detected polyps was 27.7 and mean sizes were 15.8mm;the mean Spigelman score was 7.1.After polypectomy the mean number of duodenal detected polyps was 25.7 and mean sizes were 7.6 mm;the mean Spigelman score was 6.4.After 3 mo of Eviendep bid,all patients showed a reduction of number and size of duodenal polyps.The mean number of duodenal polyps was 8(P=0.021)and mean size was 4.4 mm;the mean Spigelman score was 6.6.Interrater agreement was measured.Lesions>1 cm found a very good degree of concordance(kappa 0.851)and a good concordance was as well encountered for smaller lesions(kappa 0.641).CONCLUSION:Our study demonstrated that shortterm(90 d)supplementation with Eviendep in FAP patients with IPAA and with recurrent adenomas in the duodenal mucosa,resulted effective in reducing polyps number of 32%and size of 51%. | Carlo Calabrese Chiara Praticò Andrea Calafiore Maurizio Coscia Lorenzo Gentilini Gilberto Poggioli Paolo Gionchetti Massimo Campieri Fernando Rizzello | 2013 | World Journal of Gastroenterology2013，19，34： | 2 |
| 2 | Multiple gestations in female kidney transplant recipients maintained on calcineurin inhibitors显示文摘 | Coscia LA Cardonick EH Moritz M J | 2003 | Am J Transplant2003，，35： | 1 |
| 3 | Holder continuity of the gradient of p(x) harmonic mappings显示文摘 | Coscia A Mingione G | 1999 | C R Acad Sci Paris Sér I Math1999，328，4： | 1 |
| 4 | Total posterior vertebrectomy of the thoracic or lumbar spine显示文摘 | Magerl F and Coscia M F | 1988 | Clin Orthop Rel Res1988，232，1： | 1 |
| 5 | A classification for community discovery methods in complex networks显示文摘 | Coscia Michele Giannotti Fosca Pedreschi Dino | | 0，，5： | 1 |
| 6 | Structural, optical and electrical characterizations of μc-Si : H films deposited by PECVD 显示文摘 | Ambrosone G Coscia U Mufti R | 2005 | Solar Energy Materials and Solar Cells2005，87，： | 1 |
| 7 | Postnatal weight increase and growth Velocity of very low birthweight infants 显示文摘 | BERTINO E COSCIA A MOMBRO M | 2006 | Arch Dis Child Fetal Neonatal Ed2006，91，5： | 1 |
| 8 | Report from theNational Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation显示文摘 | Coscia LA Constantinescu S Moritz M J | 2010 | Clin Transpl2010，，： | 1 |
| 9 | Pregnancy after solid organ transplantation: a guide for obstetric management显示文摘 | Deshpande NA Coscia LA Gomez Lobo V | 2013 | Rev Obstet Gyneeol2013，6，11： | 1 |
| 10 | Long-term follow- up in the offspring of Sandimmune treated female kidney recipients显示文摘 | Lavelanet AF Coscia LA Moritz M J | 2006 | Am J Transplant2006，62，： | 1 |
| 11 | Acute cauda equina syndrome compression显示文摘 | Coscia M Leipzig T Cooper D | 1994 | Spine1994，19，： | 1 |
| 12 | Effects of early and intensive neuro-rehabilitative treatment on muscle synergics in acute post-stroke patients: a pilot study 显示文摘 | Tropea P Monaco V Coscia M | 2013 | J Neurocng Rehabil2013，28，5： | 1 |
| 13 | Direct anterior fixation of densfractures with a cannulated screw system显示文摘 | Etter C, Coscia M,Jaberg H | 1991 | Spine1991，，： | 1 |
| 14 | Genetic fusions with viral chemokines target delivery of nonimmunogenic antigen to trigger antitumor immunity independent of chemotaxis显示文摘 | Ruffini P A Biragyn A Coscia M | 2004 | J Leukoc Biol2004，76，1： | 1 |
| 15 | Report from the National Transplantation Pregnancy Registry(NTPR):outcomes of pregnancy after transplantation显示文摘 | Coscia L A Constantinescu S Moritz M J | 2009 | Clin Transpl2009，，： | 1 |
| 16 | Chemokine receptor-mediated delivery directs self-tumor antigen efficiently into the class Ⅱ processing pathway in vitro and induces protective immunity in vivo显示文摘 | Biragyn A Ruffini P A Coscia M | 2004 | Blood2004，104，： | 1 |
| 17 | Fractures of the odontoid process: treatment with anterior screw fixation 显示文摘 | Aebi M Etter C Coscia M | 1989 | Spine1989，14，10： | 1 |
| 18 | Augmented corticotomy com- bined with accelerated orthodontic forces in Class III orthognathic patients : morphologic aspects of the mandibular anterior ridge withcone-beam computed tomography 显示文摘 | Coscia G Coscia Peluso V | 2013 | J Oral Maxillofac Surg2013，71，10： | 1 |
| 19 | Multidimen- sional Networks: Foundations of Structural Analysis 显示文摘 | BERLINGERIO M COSCIA M GIANNOTTI F | 2013 | World Wide Web2013，16，56： | 1 |
| 20 | Evidence for kappa- and mu-opioid receptor expression in C6 glioma cells 显示文摘 | Bohn LM Belcheva MM Coscia CJ | 1998 | J Neurochem1998，70，5： | 1 |
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