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| 1 | Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons显示文摘 | Formisano L Noh K M Miyawaki T | 2007 | Proc Natl Acad Sci U S A2007，104，10： | 1 |
| 2 | SNP genotyping in melons: genetic variation, population structure, and linkage disequilibrium显示文摘 | Cristina Esteras Gelsomina Formisano Cristina Roig Aurora Díaz José Blanca Jordi Garcia-Mas María Luisa Gómez-Guillamón Ana Isabel López-Sesé Almudena Lázaro Antonio J. Monforte Belén Picó | 2013 | Theoretical and Applied Genetics2013，，5： | 1 |
| 3 | Micro RNA - 103 - 1 selectively downregulates brain NCX1 and its inhibi- tion by anti - miRNA ameliorates stroke damage and neurological deficits显示文摘 | VINCIGUERRA A FORMISANO L CERULLO P | 2014 | Mol Ther2014，22，10： | 1 |
| 4 | Reticulocyte count and reticulocyte maturation profile in human umbilical cord blood from healthy newborns显示文摘 | Maconi M Formisano D Cavalca L | 2010 | Lab Hematol2010，16，： | 1 |
| 5 | Nanoengineered surfaces for focal adhesion guidance trigger mesenehymal stem cell seff-organization and tenogenesis显示文摘 | IANNONE M VENTRE M FORMISANO L | 2015 | Nano Lett2015，15，3： | 1 |
| 6 | Ischemic insults pro- mote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons显示文摘 | Formisano L Noh KM Miyawaki T | 2007 | Proc Natl Acad Sci U S A2007，104，： | 1 |
| 7 | The Trichoderma-plant interaction is mediated by avirulence proteins produced by this fungus显示文摘The molecular basis of Trichoderma -plant interaction is very complex and still not completely understood. The colonization of the root system by rhizosphere competent strains of Trichoderma results in increased development of root/aerial systems, in improved yields and in plant disease control. Other beneficial effects, such as the induction of plant systemic resistance, have also been described. To understand the mechanisms involved we are using different approaches, including the making of transformants expressing genes that encode for compounds able to affect plant response to pathogens. Trichoderma transformants carrying the avirulence gene Avr4 from Cladosporium fulvum under the control of constitutive and inducible promoters were obtained and tested on tomato plants having the Cf4 resistance gene. Necrosis and suberification zones, similar to the symptoms appearing during Cladosporium-tomato interaction, were found when the roots of the Cf4 plants were treated with Avr4-Trichoderma. This demonstrates that selected Trichoderma strains are able to transfer to the plant molecules that may deeply affect metabolism, disease resistance etc. Therefore, these beneficial fungi can be regarded as biotechnological tools to provide a variety of crops with useful compounds. Moreover, in in vitro competition assays the transformants were found to be more effective as antagonists against Alternaria alternata than the wild type. Trichoderma sends a variety of biochemical signals to the plants including avirulence molecules; therefore the presence of avr-like proteins in the fungus proteome was investigated. Proteome analysis has permitted us to isolate and sequence many proteins potentially having this function. From the extracellular protein extracts, we have purified and sequenced a protein with structural characteristics similar to Avr4 of C. fulvum. The protein, Hytra1, was found to be a hydrophobin with chitin binding activity, the typical 8 cysteine residues, and 4 disulfide bridges. Infiltrations of the extracellular protein fractions containing Hytra1 resulted in a strong HR reaction on tobacco and tomato leaves, and induction of a novel phytoalexin. | Ruocco M Lanzuise S Woo S L Ambrosino P Marra R Turrà D Gigante S Formisano E Scala F Kip N P J G M de Wit Lorito M | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 1 |
| 8 | TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF - kappaB activation显示文摘 | STILO R LEONARDI A FORMISANO L | 2002 | FEBS lett2002，521，： | 1 |
| 9 | Long-term outcomes ol laparoscopic adjustable silicone gastric banding (LAGB) in moder- ately obese patients with and without co-morbidities 显示文摘 | Angrisani L Cutolo PP Formisano G et at | 2013 | Obes Surg2013，23，89： | 1 |
| 10 | Paraneoplastic sensitiveneuropathy associated with anti-hu antibodies in a neuroendocrinetumor of duodenum : a case report 显示文摘 | Nappi L Formisano L Damiano V | 2010 | Int J Immunopathol Phar-macol2010，23，4： | 1 |
| 11 | Mechanical Disturbances in Fourier Spectrometers 显示文摘 | Saggin B Comolli L Vittorio Formisano | 2007 | Applied Optics2007，46，22： | 1 |
| 12 | Factors that contribute to the mycoparasitism stimulus in Trichoderma atroviride. strain P1显示文摘Trichoderma atroviride strain P1 has been used extensively to study the mycoparasitic mechanisms in the interaction between plant pathogenic host and beneficial antagonistic fungi. Mutants of P1 containing the green fluorescent protein (gfp) or glucose oxidase (gox) reporter systems and different inducible promoters (from the exochitinase nag1 gene, or the endochitinase ech42 gene of P1) were used to determine the factors that activate the biocontrol gene expression cascade in the antagonist. The following compounds were tested singly and in various combinations: purified Trichoderma P1 enzymes (endochitinase, exochitinase, chitobiosidase, glucanase); antagonist culture filtrates (T. atroviride P1 wild-type and relative knock-out mutants, T. harzianum, T. reesei); pathogen culture filtrates (Botrytis, Pythium, Rhizoctonia); purified fungal cell walls (CWs) from Trichoderma, Botrytis, Pythium, Rhizoctonia; colloidal crab shell chitin; and plant extracts from cucumber leaves, stems or roots. Strong induction of mycoparasitism was found with the various digestion products produced by treating fungal CWs and colloidal chitin with purified enzymes or fungal culture filtrates. Filtrates from chitinase knock-out mutants, as well as CWs from Oomycetes fungi, were less active in producing the stimulus for mycoparasitism. The host CW digestion products were separated by molecular weight (MW) to determine which compounds were able to activate Trichoderma. Micromolecules of MW less than 3 kDa were found to trigger mycoparasitism gene expression before physical contact with the host pathogen. These compounds stimulated mycelial growth and spore germination of the antagonist. Purification of these host-derived compounds was conducted by HPLC and in vivo assay. The obtained inducers were able to stimulate both the production of endochitinase and exochitinase enzymes, even under repressing conditions in the presence of glucose. Inducers stimulated the biocontrol effect of P1 in the presence of host fungi. The disease symptom development on bean leaves inoculated with Botrytis and Trichoderma spores was clearly reduced by the addition of the inducers, unless these molecules were not specifically inactivated. Finally, purified inducers added to liquid cultures of T. atroviride P1 stimulated the production of low MW antibiotics and metabolites which inhibited Botrytis spore germination. Mass spectrometry analysis (ESI-MS) of the inducers indicated the presence of hexose oligomers, like cellobiose, while MS/MS analysis by selective fragmentation of peaks in the spectrum demonstrated the presence of at least three distinct compounds that were biologically active. | Woo S L Formisano E Fogliano V Cosenza C Mauro A Turrà D Soriente I Ferraioli S Scala F Lorito M | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 0 |
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