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| 1 | Persistent Epstein-Barr viral load in Epstein-Barr viral na?ve pediatric heart transplant recipients:Risk of late-onset post-transplant lymphoproliferative disease显示文摘AIM To examine the risk of late-onset post-transplant lymphoproliferative disorder(PTLD) in the presence of persisting high Epstein-Barr virus(EBV) in EBV na?ve pediatric heart transplant(HT) recipients. METHODS A retrospective review of the medical records of the 145 pediatric HT recipients who had serial EBV viral load monitoring at our center was performed. We defined EBV naive patients whose EBV serology either IgM or IgG in the blood were negative at the time of HT and excluded passive transmission from mother to child in subjects less than 6 mo of age. RESULTS PTLD was diagnosed in 8 out of 145 patients(5.5%); 6/91(6.5%) in those who were EBV seropositive and 2/54(3.7%) in the EBV na?ve group at the time of HT(P = 0.71). We found 32/145(22%) patients with persistently high EBV load during continuing follow-up; 20/91(22%) in EBV seropositive group vs 12/54(22%) in EBV na?ve group(P = 0.97). There was no significant association between pre-HT serostatus and EBV load after transplant(P > 0.05). In the EBV seropositive group, PTLD was diagnosed in 15%(3/20) of patients with high EBV vs 4.2%(3/71) of patients with low or undetectable EBV load(P = 0.14) whereas in EBV na?ve patients 8.3%(1/12) of those withhigh EBV load and 2.3%(1/42) with low or undetectable EBV load(P = 0.41). There was a highly significant association between occurrence of PTLD in those with high EBV load and duration of follow up(4.3 ± 3.9 years) after HT by Cochran-Armitage test for the entire cohort(P = 0.005). At least one episode of acute rejection occurred in 72%(23/32) of patients with high EBV vs 36%(41/113) patients with low or undetectable EBV after HT(P < 0.05). CONCLUSION There is an association between persistently high EBV load during post-HT follow up and the occurrence of late-onset PTLD in pediatric HT recipients irrespective of serostatus at the time of transplant. The occurrence of allograft rejection increased in patients with high EBV load presumably due to reduction in immunosuppression. | Bibhuti Das Robert Morrow Rong Huang David Fixler | 2016 | World Journal of Transplantation2016，6，4： | 4 |
| 2 | An ultra-sensitive dual-mode imaging system using metal-enhanced fluorescence in solid phantoms显示文摘在这研究,我们用在稳固的幽灵结合到各种各样的 fluorophores 的金 nanoparticles (GNP ) 开发了一个高度敏感的双模式的成像系统。系统为表面成像,为深织物的成像(多达 1 厘米) 的散开思考(医生) ,和提高金属的荧光(MEF ) 由荧光一生成像显微镜学(FLIM ) 组成。我们检测了熄灭在荧光灯为金 nanospheres (GNS ) 和到荧光黄的金 nanorods (GNR ) 的变化形式的紧张(FI ) ,它在比 GNP 的两种类型的表面电浆子回声(SPR ) 短的波长有一座刺激山峰。提高的 FI 在变化形式被检测到玫瑰精 B (RhB ) 和 Sulforhodamine B (SRB ) ,与在 GNP 的 SPR 区域的刺激山峰。提高的 FI 被 FLIM 大小在答案并且在稳固的幽灵检测。医生大小由记录在相应于 GNR 的吸收系列的波长散布的光的掉的率在稳固的幽灵以内检测了 GNR 的存在。与 MEF 的包括,这种有希望的双模式的成像技术启用有效、敏感的分子、功能的成像。 | Eran A. Barnoy Dror Fixler Rachela Popovtzer Tsviya Nayhoz Krishanu Ray | 2015 | Nano Research2015，8，12： | 4 |
| 3 | Multimodal bioimaging based on gold nanorod and carbon dot nanohybrids as a novel tool for atherosclerosis detection显示文摘与多样的性质装备的先进 biocompatible 和柔韧的平台高度为动脉粥样硬化患者的早察觉在生物医学的成像应用程序被要求脉管的疾病和癌症。设计 nanohybrids 高贵金属镇静、荧光灯材料是执行多模式的成像克服单个形式的对应物的限制的一个新方法。此处,我们建议一个多模式的对比代理人的新奇设计;也就是,包括金 nanorods (GNR ) 的提高的 nanohybrid 和碳点(CD ) 与硅石(SiO 2) 作为一座桥。nanohybrid (GNR@SiO 2@CD) 建设基于在 SiO 2 和 silane-functionalized CD 之间结合的共有原子价,它与 CD 连接 GNR 形成典型核心壳单位。新奇结构不仅保留并且甚至高度改进 GNR 和 CD 的光性质,而且与赤裸的 GNR 或荧光染料和 CD 相比在散开思考(医生) 和荧光一生成像显微镜学(FLIM ) 大小拥有优异成像性能。GNR@SiO 2@CD nanohybrids 的优异 bioimaging 性质成功地被利用为,铺平向 vitro 医生和在像织物的幽灵以内的巨噬细胞的 FLIM 大小对比的 theranostic 的道路在为动脉粥样硬化和癌症的代理人。 | Xiaojing Liu Luting Liu Xiujie Hu Shuyun Zhou Rinat Ankri Dror Fixler Zheng Xie | 2018 | Nano Research2018，11，3： | 3 |
| 4 | Market structure and product innova- tion显示文摘 | Ben-Zion U Fixler D J | 1981 | Southern Economic Journal1981，，： | 1 |
| 5 | Atom Interferometer Measurement of the Newtonian Constant of Gravity 显示文摘 | Fixler J B | 2007 | Science2007，315，： | 1 |
| 6 | Market structure and product innovation显示文摘 | Ben -Zion U Fixler D J | 1981 | Southern Economic Journal1981，48，2： | 1 |
| 7 | Firm Behavior and the Externalities of Technological Leadership 显示文摘 | Bental B Fixler D | 1988 | European Economic Review1988，32，： | 1 |
| 8 | The opposing effects of endothelin-1 and C-type natriuretic peptide on apoptosis of neonatal rat cardiac myocytes显示文摘 | Han B Fixler R Beeri R | 2003 | Eur J Pharmacol2003，474，1： | 1 |
| 9 | Satellite thermal control using phase-change materials显示文摘 | Fixler S Z | | 0，，09： | 1 |
| 10 | Cardiopulmonary bypass to repair an atrial septal defect does not affect cognitive function in children显示文摘 | Stavinoha PL Fixler DE Mahony L | 2003 | Circulation2003，107，21： | 1 |
| 11 | The opposing effects of endothelin-1 and C-type natriuretic peptide on apoptosis of neonatal rat cardic myocytes显示文摘 | Han B Fixler R Been R | 2003 | Euro Pharmacol2003，471，1： | 1 |
| 12 | Outsourcing and Productivity Growth in Services显示文摘 | Fixler D Donald S | 1999 | Structural Change and Economic Dynamics1999，10，2： | 1 |
| 13 | Experimental Subendocardial Ischemia in Dogs with Normal Coronary Arteries显示文摘 | GERALD D. BUCKBERG DAVID E. FIXLER JOSEPH P. ARCHIE JULIEN I.E. HOFFMAN | 1972 | Circulation Research1972，，1： | 1 |
| 14 | Thermomechanical characterization of a membrane deformable mirror显示文摘 | Kathleen A Morse Stuart L Mchugh Jeff Fixler | 2008 | Applied Optics2008，47，29： | 1 |
| 15 | Sensitive absolute-gravity gradiometry using atom interferometry显示文摘 | McGuirk J M Foster G T Fixler J B | 2002 | Physical Review A2002，65，03： | 1 |
| 16 | Atom intefferometer measurement of the Newtonian constant of gravity 显示文摘 | Fixler J B Foster G T McGuirk J M | 2007 | Science2007，315，5808： | 1 |
| 17 | Japanese Acupuncture, A Review of four Styles 显示文摘 | Fixler M Kivit O | 2000 | European Journal of Oriental Medicine2000，3，3： | 1 |
| 18 | Outsourcing and productivity growth in services显示文摘 | Fixler D J Siegel D | 1999 | Structural Change and Economic Dynamics1999，10，2： | 1 |
| 19 | Atom interferometer measurement of the Newtonian constant of gravity显示文摘 | Fixler J B Foster G T Mcguirk J M | 2007 | Science2007，315，5808： | 1 |
| 20 | Measuring the price of research and development output显示文摘 | COPELAND A FIXLER D | 2012 | Review of Income&Wealth2012，58，1： | 1 |
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