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1某些主要跟语序有关的语法普遍现象显示文摘1.引言首先读者要知道本文所提出的结论是尝试性的,由于没有对全球语言作更全面的抽样调查,还不能充分保证这里所断言的大多数普遍现象没有例外,诚如题目所示,我们关注的主要是语素和词序问题,当然绝非仅限于此。作出这样的选择是因为以往的经验已显示了语法的这个专门方面即语序方面的很多规律。本文提出一系列普遍现象,它们大部分是蕴含性的,即它们采取这样的形式:某语言中有现象x,就必然有现象y,若不作进一步说明,逆命题即有y必有x就不能成立。当这两种现象分别具有“有”“无”两种可能时,四分表上的典型分布是:四组中有一组是零。就科学方法论而言,这结果无可厚非。Joseph H.Greenberg 陆丙甫 陆致极 1984当代语言学1984,,2:110
2北祁连早古生代花岗质岩浆作用及构造演化显示文摘北祁连山中段花岗岩锆石SHRIMP定年结果表明,柯柯里岩体的斜长花岗岩和石英闪长岩的年龄分别为512Ma和501 Ma,野马咀和金佛寺花岗岩的年龄分别为508Ma和424Ma。结合区内其它花岗岩体的定年资料,根据花岗岩的岩石地球化学特征及岩体产出的构造位置、区域地质资料等,我们认为,早古生代北祁连洋板块向南俯冲,至少引发了两期花岗质岩浆作用,第一次岩浆作用形成柯柯里斜长花岗岩(512Ma)、野马咀花岗岩(508Ma)和柯柯里石英闪长岩(501 Ma),第二次花岗质岩浆作用形成牛心山花岗岩(477Ma)。由于往南俯冲的板块受到柴达木板块向北俯冲的影响,俯冲受阻,继而俯冲极性发生变化,转向北俯冲,形成了民乐窑沟(463Ma)等花岗岩侵入体。大约440Ma之后,洋盆闭合,柴达木陆块和阿拉善陆块对接碰撞,形成北祁连造山带。由于造山带根部岩石圈发生折沉作用,造山带上不同的块体伸展、滑塌,形成一系列碰撞后花岗岩如金佛寺花岗岩(424Ma)及牛心山岩体的石英闪长岩(435Ma)等。吴才来 徐学义 高前明 李向民 雷敏 郜源红 Ronald B FROST Joseph L WOODEN 2010岩石学报2010,26,4:132
3柴达木盆地北缘古生代超高压带中花岗质岩浆作用显示文摘祁连南缘古生代超高压变质带 (榴辉岩年龄为 4 6 6~ 4 95 Ma)上一套中高级变质岩系 (达肯大坂片麻岩 )中存在三类花岗岩组合 : 类 :石英二长闪长岩 -花岗闪长岩 -二长花岗岩 , 类 :二长花岗岩 -二云母花岗岩-含白云母花岗岩 -正长花岗岩 , 类 :花岗闪长岩 -二长花岗岩 -黑云母花岗岩。 类岩石组合中的二长花岗岩锆石SHRIMP年龄为 4 73Ma, 类岩石组合中的正长花岗岩锆石 SHRIMP年龄为 4 4 6 Ma, 类岩石组合中的二长花岗岩锆石 SHRIMP年龄为 397Ma。从三类花岗岩组合的组成矿物来看 , 类和 类的矿物组合主要为斜长石、角闪石、石英、碱性长石、黑云母 , 类的矿物组合为钾长石、石英、白云母、黑云母、斜长石 ;从岩石地球化学特征上看 , 类和 类花岗岩为 型花岗岩 ,岩石的 Si O2 =6 1%~ 6 9% ,Na2 O/ K2 O>1,ANK<1,δEu=0 .7~ 1.0 ; 类花岗岩为 S型花岗岩 ,岩石的 Si O2 =70 %~ 76 % ,Na2 O/ K2 O<1,ANK>1,δEu=0 .1~ 0 .3;从构造环境上看 , 类花岗岩形成于岛弧环境或活动大陆边缘 , 类花岗岩形成于同碰撞 , 类花岗岩形成于碰撞后。结合区域地质特征 ,我们认为 ,早奥陶世 ,南祁连洋板块向北俯冲于祁连陆块之下 ,规模不大的南祁连洋很快闭合 ,但俯冲下去的大洋板块仍拖动柴达木陆块继续俯冲 ,俯冲?吴才来 杨经绥 许志琴 Joseph L.WOODEN Trevor IRELAND 李海兵 史仁灯 孟繁聪 陈松永 Harold PERSING Anders MEIBOM 2004地质学报2004,78,5:91
4成人自发性脑出血处理指南——2007年更新版:美国心脏协会/美国卒中协会卒中委员会、高血压研究委员会、医疗质量和转归研究跨学科工作组指南:美国神经病学学会确认本指南作为神经科医生教学工具的价值显示文摘目的:本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法:通过Medline正式检索截止2006年8月的相关文献,并将撰写委员会已知相关问题的其他论文作为补充,用证据表合并资料。采用美国心脏协会卒中委员会的证据水平分级标准对每项推荐意见进行分级。由5位同行评议专家和卒中委员会领导委员会成员对指南草案进行发表前审阅。预期本指南在3年内完全更新。结果:本文陈述了脑出血的诊断、动脉血压和颅内压增高的处理、脑出血内科并发症的治疗以及复发性脑出血的预防等方面的循证指南。对重组Ⅶ因子延缓早期出血的近期试验进行了讨论。对自发性脑出血治疗的各种外科手术方法提出了推荐意见。最后,对脑出血患者的撤销治疗和临终问题进行了分析。Joseph Broderick Sander Connolly Edward Feldmann Daniel Hanley Carlos Kase Derk Krieger Marc Mayberg Lewis Morgenstern Christopher S. Ogilvy Paul Vespa Mario Zuccarello 王玉洁(译) 刘娟(译) 白璇(译) 李新辉 孙虹(译) 姚志成(译) 张慧(译) 牛英翔(译) 2007国际脑血管病杂志2007,15,7:234
5柴达木盆地北缘大柴旦地区古生代花岗岩锆石SHRIMP定年显示文摘大柴旦地区是柴北缘古生代超高压带的重要组成部分,与超高压岩石相伴的花岗岩十分发育。这些花岗岩具有两类不同的岩石地球化学特征,Ⅰ类以 Na_2O/K_2O 比值小于1、明显的负 Eu 异常和低 Sr、高 Y 为特征,具有 S-型花岗岩的属性,Ⅱ类以 Na_2O/K_2O 比值大于1、弱负 Eu 异常到正 Eu 异常和高 Sr、低 Y 为特征,具有Ⅰ-型花岗岩的属性,反映了它们的源岩及成因上的差异。锆石 SHRIMP U—Ph 定年结果表明,大柴旦地区花岗岩的年龄可分为三组,第一组年龄为446.3±3.9Ma,第二组年龄分别为408.6±4.4Ma、403.3±3.8Ma、401.8±3Ma,第三组年龄分别为374.5±1.6Ma、372±2.1Ma。结合区域地质特征,我们认为,第一组年龄可能反映了柴达木陆块与中南祁连板块碰撞的时代,第二组年龄可能反映了深俯冲地下的板块由于拆沉而折返的时代,第三组年龄可能反映了碰撞隆起后造山带上不同块体之间的伸展、滑塌的时代。吴才来 郜源红 吴锁平 陈其龙 Joseph L.WOODEN Frank K.MAZADAB Chris MATTINSON 2007岩石学报2007,23,8:88
6北阿尔金地区米兰红柳沟蛇绿岩的岩石学特征和SHRIMP定年显示文摘米兰红柳沟蛇绿岩是北阿尔金蛇绿岩带中发育和保留最好的蛇绿岩,主要由地幔橄榄岩、镁铁-超镁铁质堆晶杂岩、岩墙群和基性熔岩等组成。它们以规模不等的构造岩块产出,大者长十余km,宽近1km,组成一条近100km长的蛇绿混杂岩带。地幔橄榄岩以方辉橄榄岩为主,有少量纯橄岩,主要由橄榄石(Fo=91.2~92.7),斜方辉石(En=93~98)和少量单斜辉石(En=46)组成;副矿物尖晶石Cr^#为43~69(平均55),Mg^#为43~64(平均58),表现出深海橄榄岩(Abyssal peridotite)和俯冲带环境(SSZ)橄榄岩成分特点。深成堆晶岩主要由异剥橄榄岩-橄榄二辉石岩-(橄榄)辉石岩-辉长岩-斜长岩,该组合的堆晶岩通常被认为是SSZ构造背景的产物。席状岩墙群的岩石成分与熔岩一致,其TiO2(1%~1.5%)和低含量的K2O〈0.3%和P2O5表明具有MORB型的岩石特征,并得到了不相容元素和LREE平坦型和亏损型的球粒陨石标准化模型等证据的支持。该地区另存在一套高Ti的洋岛型拉斑玄武岩。两类熔岩的存在,以及地幔橄榄岩和堆晶岩的不同特征,表明米兰红柳沟蛇绿岩组合可能来自不同构造背景。带中与洋壳俯冲有关的蓝片岩和榴辉岩组成的高压变质带的存在,以及与俯冲碰撞有关的不同类型花岗岩类的产出,表明米兰红柳沟蛇绿混杂岩带代表了一个复杂的板块缝合带。蛇绿岩中辉长岩的锆石SHRIMP年代为479±8Ma,这是获得的第一个北阿尔金蛇绿岩的锆石SHRIMP U—Pb同位素年龄,认为代表蛇绿岩的形成时代。因此。北阿尔金缝合带无论在年龄和特征等方面,均可以与阿尔金断裂带东部的北祁连缝合带对比,证实两个带曾经是一个带,被阿尔金断裂左旋错断了约400km。杨经绥 史仁灯 吴才来 苏德辰 陈松永 王希斌 WOODEN Joseph 2008岩石学报2008,24,7:115
7自发性脑出血治疗指南美国心脏协会/美国卒中协会对医疗卫生专业人员发布的指南显示文摘目的本指南旨在为急性自发性脑出血的诊断和治疗提供最新的综合性推荐意见。方法通过Medline进行规范的文献检索,利用证据表合并资料。撰写委员会成员通过远程电信会议讨论根据资料得出的推荐意见。采用美国心脏协会卒中委员会的证据分级方案对推荐意见进行分级。由6位同行评议专家以及卒中委员会科学声明监督委员会和卒中委员会领导委员会成员对指南的草案进行发表前审阅。预期本指南在3年内完全更新。结果本文为脑出血患者的医疗诊治提供了循证指南。重点包括诊断、止血、血压管理、院内管理和护理、预防内科合并症、外科治疗、转归预测、康复、预防复发以及将来需要考虑的问题。结论脑出血是一种严重的疾病,早期积极救治可影响其转归。本指南为脑出血患者的目标导向治疗提供了一个框架。Lewis B. Morgenstem J. Claude Hemphill Ⅲ Craig Anderson Kyra Becker Joseph P. Broderick E. Sander Connolly Jr Steven M. Greenberg James N. Huang R. Loch Macdonald Steven R. Messe Pamela H. Mitchell Magdy Selim Rafael J. Tamargo 王玉洁(译) 王健(译) 刘相玉(译) 谢丽丽(译) 2010国际脑血管病杂志2010,,8:259
8中国妇女妊娠前后单纯服用叶酸对神经管畸形的预防效果显示文摘目的 评价妇女在妊娠前后服用单纯 40 0 μg叶酸增补剂对胎 /婴儿神经管畸形 (NTDs)的预防效果。方法 1993~ 1995年在中国北方的NTDs高发地区和南方的NTDs低发地区妇女增补叶酸的推广项目中 ,共募集从孕前或孕后任何时间开始服药的妇女 130 142名 ,未服药的妇女 1176 89名 ;设计的服药方法从婚检时开始到孕满 3个月为止 ,每天服用单纯叶酸片 40 0 μg ;最后对妇女的分娩结局进行监测并进行预防效果的对比评价研究。结果 服药组妇女生育的胎婴儿中共发现 10 2例NTDs ,对照组胎婴儿中共发现 173例NTDs。末次月经前募集的未服药妇女在孕 2 0周以后分娩的胎婴中NTDs发生率 ,北方为 4 8‰ (16 / 3 318) ,南方为 1 0‰ (2 8/ 2 82 6 5 ) ,而妊娠前后服药妇女组则分别为1 0‰ (13/ 13 0 12 )和 0 6‰ (34/ 5 86 38)。与末次月经前募集的未服药妇女组相比 ,北方服药妇女NTDs发生率明显降低 ,其中依从性大于 80 %的服药组妇女预防率达 85 % (95 %CI为 6 2 %~ 94% ) ,南方地区服叶酸的预防率为 41% (95 %CI为 3 %~ 6 4% )。结论 妇女在妊娠前后每天服用单纯叶酸 40 0李竹 RobertJ Berry 李松 J David Erickson 王红 Cynthia A Moore 赵平 Joseph Mulinare 洪世欣 Lee-Yang C Wong 呼和牧人 Jacqueline Gindler 郝玲 Adolfo Correa 朱慧萍 Elaine Gunter 2000中华医学杂志2000,80,7:185
9未破裂颅内动脉瘤患者管理指南美国心脏协会/美国卒中协会针对医疗专业人员的指南显示文摘目的这份更新版指南旨在为未破裂颅内动脉瘤患者的管理提供全面的循证建议。方法写作组采用系统文献回顾(1977年1月至2014年6月),参考同期已发表的循证指南、个人文件和专家意见来总结现有的证据,指出现有知识的差距;如果合适,则根据美国心脏协会( American Heart Association, AHA)标准做出推荐。本指南经过了包括卒中委员会领导层以及AHA科学声明监督委员会在内的广泛同行评议,然后由AHA科学咨询和协调委员会审批通过。结果本指南对未破裂颅内动脉瘤患者的医疗诊治提出了循证建议,涉及临床表现、自然史、流行病学、危险因素、筛查、诊断、影像学以及手术和血管内治疗的转归。B. Gregory Thompson Robert D. Brown Sepideh Amin-Hanjani Joseph P. Broderick Kevin M. Cockroft E. Sander Connolly Gary R. Duckwiler Catherine C. Harris Virginia J. Howard S. Claiborne (Clay) Johnston Philip M. Meyers Andrew Molyneux Christopher S. Ogilvy Andrew J. Ringer James Torner 肖国栋 徐加平 石际俊 尤寿江 张霞 刘慧慧 曹勇军 2015国际脑血管病杂志2015,23,8:127
10Current concepts on osteonecrosis of the femoral head显示文摘It is estimated that 20000 to 30000 new patients are diagnosed with osteonecrosis annually accounting for approximately 10% of the 250000 total hip arthroplasties done annually in the United States. Thelack of level 1 evidence in the literature makes it difficult to identify optimal treatment protocols to manage patients with pre-collapse avascular necrosis of the femoral head, and early intervention prior to collapse is critical to successful outcomes in joint preserving procedures. There have been a variety of traumatic and atraumatic factors that have been identified as risk factors for osteonecrosis, but the etiology and pathogenesis still remains unclear. Current osteonecrosis diagnosis is dependent upon plain anteroposterior and frog-leg lateral radiographs of the hip, followed by magnetic resonance imaging(MRI). Generally, the first radiographic changes seen by radiograph will be cystic and sclerotic changes in the femoral head. Although the diagnosis may be made by radiograph, plain radiographs are generally insufficient for early diagnosis, therefore MRI is considered the most accurate benchmark. Treatment options include pharmacologic agents such as bisphosphonates and statins, biophysical treatments, as well as joint-preserving and joint-replacing surgeries. the surgical treatment of osteonecrosis of the femoral head can be divided into two major branches: femoral head sparing procedures(FHSP) and femoral head replacement procedures(FHRP). In general, FHSP are indicated at pre-collapse stages with minimal symptoms whereas FHRP are preferred at post-collapse symptomatic stages. It is difficult to know whether any treatment modality changes the natural history of core decompression since the true natural history of core decompression has not been delineated.Joaquin Moya-Angeler Arianna L Gianakos Jordan C Villa Amelia Ni Joseph M Lane 2015World Journal of Orthopedics2015,6,8:94
11北祁连东部两类Ⅰ型花岗岩定年及其地质意义显示文摘北祁连东部早古生代地层中产出两种特征不同的I型花岗岩类,其一以井子川岩体为代表,暗色矿物以角闪石为主,稀土总量为90×10^(-6)~106×10^(-6),轻重稀土比值小于8,锆石的SHRIMP年龄为464±15Ma,岩体形成的构造环境类似于岛弧;其二是以黄羊河岩体为代表,暗色矿物以黑云母为主,稀土总量为214×10^(-6)~250×10^(-6),轻重稀土比值大于8,锆石的LA-ICP-MS年龄为383±6 Ma,岩体形成于碰撞后环境。吴才来 杨经绥 杨宏仪 Joseph L.W00DEN 史仁灯 陈松永 郑秋光 2004岩石学报2004,20,3:68
12北祁连洋早古生代双向俯冲的花岗岩证据显示文摘笔者主要对北祁连山中段的牛心山岩体、民乐窑沟岩体进行了锆石SHRIMP定年研究。结果表明:牛心山花岗岩的年龄为476 Ma,民乐窑沟花岗闪长岩的年龄为463 Ma。岩石地球化学显示,两岩体均具有大陆活动边缘的岩浆作用特征,结合岩体产出的区域构造位置及区域地质资料,笔者认为早古生代北祁连洋板块分别发生了向南、向北俯冲,其中向南俯冲形成牛心山花岗岩(476 Ma),向北俯冲,形成了民乐窑沟花岗岩侵入体(463 Ma)。吴才来 姚尚志 杨经绥 曾令森 陈松永 李海兵 戚学祥 Joseph L. Wooden Frank K.Mazdab 2006中国地质2006,33,6:80
13Diabetic cardiomyopathy:Pathophysiology,diagnostic evaluation and management显示文摘Diabetes affects every organ in the body and cardiovascular disease accounts for two-thirds of the mortality in the diabetic population.Diabetes-related heart disease occurs in the form of coronary artery disease(CAD),cardiac autonomic neuropathy or diabetic cardiomyopathy(DbCM).The prevalence of cardiac failure is high in the diabetic population and DbCM is a common but underestimated cause of heart failure in diabetes.The pathogenesis of diabetic cardiomyopathy is yet to be clearly defined.Hyperglycemia,dyslipidemia and inflammation are thought to play key roles in the generation of reactive oxygen or nitrogen species which are in turn implicated.The myocardial interstitium undergoes alterations resulting in abnormal contractile function noted in DbCM.In the early stages of the disease diastolic dysfunction is the only abnormality,but systolic dysfunction supervenes in the later stages with impaired left ventricular ejection fraction.Transmitral Doppler echocardiography is usually used to assess diastolic dysfunction,but tissue Doppler Imaging and Cardiac Magnetic Resonance Imaging are being increasingly used recently for early detection of DbCM.The management of DbCM involves improvement in lifestyle,control of glucose and lipid abnormalities,and treatment of hypertension and CAD,if present.The role of vasoactive drugs and antioxidants is being explored.This review discusses the pathophysiology,diagnostic evaluation and management options of DbCM.Joseph M Pappachan George I Varughese Rajagopalan Sriraman Ganesan Arunagirinathan 2013World Journal of Diabetes2013,4,5:57
14Early diabetic neuropathy:Triggers and mechanisms显示文摘Peripheral neuropathy, and specifically distal peripheral neuropathy (DPN), is one of the most frequent and troublesome complications of diabetes mellitus. It is the major reason for morbidity and mortality among diabetic patients. It is also frequently associated with debilitating pain. Unfortunately, our knowledge of the natural history and pathogenesis of this disease remains limited. For a long time hyperglycemia was viewed as a major, if not the sole factor, responsible for all symptomatic presenta- tions of DPN. Multiple clinical observations and animal studies supported this view. The control of blood glu- cose as an obligatory step of therapy to delay or reverse DPN is no longer an arguable issue. However, while supporting evidence for the glycemic hypothesis has ac- cumulated, multiple controversies accumulated as well. It is obvious now that DPN cannot be fully understood without considering factors besides hyperglycemia. Some symptoms of DPN may develop with little, if any, cor- relation with the glycemic status of a patient. It is also clear that identification of these putative non-glycemic mechanisms of DPN is of utmost importance for our un- derstanding of failures with existing treatments and for the development of new approaches for diagnosis and therapy of DPN. In this work we will review the strengths and weaknesses of the glycemic hypothesis, focusing on clinical and animal data and on the pathogenesis of early stages and triggers of DPN other than hyperglycemia.Maxim Dobretsov Dmitry Romanovsky Joseph R Stimers 2007World Journal of Gastroenterology2007,13,2:55
15北阿尔金巴什考供-斯米尔布拉克花岗杂岩特征及锆石SHRIMPU-Pb定年显示文摘北阿尔金巴什考供-斯米尔布拉克杂岩体位于巴什考供盆地北缘,呈东西向展布,宽约2~6km,长约30km,出露面积约140km2.主要由灰黑色石英闪长岩、灰白色花岗岩、粉红色花岗岩和花岗伟晶岩组成.围岩为前寒武系片岩、变质泥岩及变质凝灰岩.岩石地球化学特征表明,石英闪长岩属钙碱性系列,具有Ⅰ型花岗岩的属性;而粉红色和灰白色花岗岩属高钾钙碱性系列,具有S型花岗岩的属性.锆石SHRIMP定年结果表明,石英闪长岩的年龄为(481.6±5.6)Ma,而灰白色花岗岩和粉红色花岗岩的年龄在误差范围内基本一致,分别为(437.0±3.0)~(433.1±3.4)Ma和(443±11)~(434.6±1.6)Ma.结合区域地质特征,认为石英闪长岩可能形成于洋壳俯冲环境,而灰白色和粉红色花岗岩可能形成于碰撞后环境.吴才来 姚尚志 曾令森 杨经绥 Joseph L.Wooden 陈松永 Frank K.Mazadab 2007中国科学(D辑)2007,37,1:57
16南阿尔金茫崖地区花岗岩类锆石SHRIMP U-Pb定年、Lu-Hf同位素特征及岩石成因显示文摘南阿尔金茫崖地区早古生代花岗岩锆石SHRIMP U-Pb定年结果表明,阿克提山花岗岩为264±1Ma,柴水沟花岗岩分别为404±5Ma、406±4Ma,其中的辉绿岩为454±4Ma,常春沟花岗岩分别为411±5Ma、406±3Ma,茫崖镇北石英闪长岩为466±5Ma,阿卡龙山花岗岩为469±6Ma。锆石Lu-Hf同位素分析表明,εHf(t)值大多数为正值,少数继承性锆石为负值,反映了它们的源岩以新生地壳为主,同时,也混有少量的古大陆壳的成分。结合区域地质特征和各岩体的岩石地球化学特征,将南阿尔金茫崖地区早古生代花岗质岩浆活动划分为3期,第一期(465~469Ma)岩石组合为石英闪长岩+花岗闪长岩+花岗岩,具有岛弧火成岩的地球化学属性,其形成可能与洋壳的俯冲作用有关;第二期(404~411Ma)岩石组合为花岗闪长岩+二长花岗岩+正长花岗岩,具有A型花岗岩的地球化学特征,可能与板块碰撞后造山带块体均衡调整有关,第三期(264Ma)岩石组合为石英闪长岩+二长花岗岩+正长花岗岩,也具有I型花岗岩的特征,可能与阿尔金断裂的活动有关。吴才来 郜源红 雷敏 秦海鹏 刘春花 李名则 B Ronald FROST Joseph L WOODEN 2014岩石学报2014,30,8:56
17Anterior muscle sparing approach for total hip arthroplasty显示文摘The purpose of this review is to examine the validity of positive claims regarding the direct anterior approach(DAA) with a fracture table for total hip arthroplasty. Recent literature regarding the DAA was searched and specific claims investigated including improved early outcomes, speed of recovery, component placement, dislocation rates, and complication rates. Recent literature is positive regarding the effects of total hip arthroplasty with the anterior approach. While the data is not definitive at present, patients receiving the anterior approach for total hip arthroplasty tend to recover more quickly and have improved early outcomes. Component placement with the anterior approach is more often in the 'safe zone' than with other approaches. Dislocation rates tend to be less than 1% with the anterior approach. Complication rates vary widely in the published literature. A possible explanation is that the varianceis due to surgeon and institutional experience with the anterior approach procedure. Concerns remain regarding the 'learning curve' for both surgeons and institutions. In conclusion, it is not a matter of should this approach be used, but how should it be implemented.Joseph T Moskal Susan G Capps John A Scanelli 2013World Journal of Orthopedics2013,4,1:47
18The economic burden of influenza-associated outpatient visits and hospitalizations in China: a retrospective survey显示文摘Background:The seasonal influenza vaccine coverage rate in China is only 1.9%.There is no information available on the economic burden of influenza-associated outpatient visits and hospitalizations at the national level,even though this kind of information is important for informing national-level immunization policy decision-making.Methods:A retrospective telephone survey was conducted in 2013/14 to estimate the direct and indirect costs of seasonal influenza-associated outpatient visits and hospitalizations from a societal perspective.Study participants were laboratory-confirmed cases registered in the National Influenza-like Illness Surveillance Network and Severe Acute Respiratory Infections Sentinel Surveillance Network in China in 2013.Patient-reported costs from the survey were validated by a review of hospital accounts for a small sample of the inpatients.Results:The study enrolled 529 outpatients(median age:eight years;interquartile range[IQR]:five to 20 years)and 254 inpatients(median age:four years;IQR:two to seven years).Among the outpatients,22.1%(117/529)had underlying diseases and among the inpatients,52.8%(134/254)had underlying diseases.The average total costs related to influenza-associated outpatient visits and inpatient visits were US$155(standard deviation,SD US$122)and US$1,511(SD US$1,465),respectively.Direct medical costs accounted for 45 and 69%of the total costs related to influenza-associated outpatient and inpatient visits,respectively.For influenza outpatients,the mean cost per episode in children aged below five years(US$196)was higher than that in other age groups(US$129–153).For influenza inpatients,the mean cost per episode in adults aged over 60 years(US$2,735)was much higher than that in those aged below 60 years(US$1,417–1,621).Patients with underlying medical conditions had higher costs per episode than patients without underlying medical conditions(outpatients:US$186 vs.US$146;inpatients:US$1,800 vs.US$1,189).In the baseline analysis,inpatients reported costs were 18%higher than those found in the accounts review(n=38).Conclusion:The economic burden of influenza-associated outpatient and inpatient visits in China is substantial,particularly for young children,the elderly,and patients with underlying medical conditions.More widespread influenza vaccination would likely alleviate the economic burden of patients.The actual impact and cost-effectiveness analysis of the influenza immunization program in China merits further investigation.Juan Yang Mark Jit Kathy S.Leung Ya-ming Zheng Lu-zhao Feng Li-ping Wang Eric H.Y.Lau Joseph T.Wu Hong-jie Yu 2015Infectious Diseases of Poverty2015,4,1:44
19高速列车空气动力学显示文摘着重描述了高速列车与其它交通工具在空气动力学方面的差异,重点在包括磁悬浮列车(Maglev)在内的现代高速列车.这些差异与下述因素紧密相关:高速列车贴近地面或轨道运行、其长径比远大于其它交通工具、两列火车会擦身而过,与道旁建筑物相互干扰、常受到横风的干扰、通过隧道时会产生隧道出入口效应。本文综述了最新的相关信息,涵盖实验技术和实验结果、理论分析和数值方法。Joseph A Schetz 胡宗民 张德良 姜宗林 施红辉 2003力学进展2003,33,3:48
20Gastrointestinal radiation injury:Symptoms,risk factors and mechanisms显示文摘Ionising radiation therapy is a common treatment modality for different types of cancer and its use is expected to increase with advances in screening and early detection of cancer.Radiation injury to the gastrointestinal tract is important factor working against better utility of this important therapeutic modality.Cancer survivors can suffer a wide variety of acute and chronic symptoms following radiotherapy,which significantly reduces their quality of life as well as adding an extra burden to the cost of health care.The accurate diagnosis and treatment of intestinal radiation injury often represents a clinical challenge to practicing physicians in both gastroenterology and oncology.Despite the growing recognition of the problem and some advances in understanding the cellular and molecular mechanisms of radiation injury,relatively little is known about the pathophysiology of gastrointestinal radiation injury or any possible susceptibility factors that could aggravate its severity.The aims of this review are to examine the various clinical manifestations of post-radiation gastrointestinal symptoms,to discuss possible patient and treatment factors implicated in normal gastrointestinal tissue radiosensitivity and to outline different mechanisms of intestinal tissue injury.Abobakr K Shadad Frank J Sullivan Joseph D Martin Laurence J Egan 2013World Journal of Gastroenterology2013,19,2:35
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