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| 1 | Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression显示文摘我们调查了胎儿的间充质的干细胞(fMSCs ) 的能力区分进棕色、白的 adipocytes 并且比较了很多标记基因和关键规章的因素的表示。我们证明关键 adipocyte 管理者和标记的表示在另外的人、鼠科的 adipocyte 模型在区别期间类似于那,包括 PPAR 纬 2 和 FABP4 的正式就职。尤其是,我们发现 preadipocyte 标记, Pref-1,当这个过程继续,显著地在区别然后衰落早被导致,当他们承诺 adipogenic 系,建议 fMSCs 首先获得 preadipocyte 特征,在他们进成熟 adipocytes 的区别以前。在 adipogenic 正式就职以后,某干细胞孤立区分了进类似于棕色的 adipocytes 和其它进白 adipocytes 的房间。一个的详细调查孤立证明新奇棕色的胖决定的因素 PRDM16 在区别前后两个都被表示。重要地,展出的这些房间提高了基础 UCP-1 表示,它依赖于孤儿的活动原子受体犯错伪,加亮一个新奇角色为犯错在人的棕色的脂肪的伪。因此 fMSCs 代表一在 vitro 有用为人的 adipogenesis 当模特儿,并且提供机会在对 adipocyte 系的承诺以前学习阶段。他们也提供无价的卓见进人的棕色的脂肪的特征。 | Daniel L Morganstein Pensee Wu Meritxell R Mane Nick M Fisk Roger White Malcolm G Parker | 2010 | Cell Research2010，20，4： | 5 |
| 2 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 3 | Effects of by- poxia and oxidative stress on expression of nepri- lysin in human neuroblastoma cells and rat cortical neurones and astrocytes显示文摘 | Fisk L Nalivaeva NN Boyle JP | 2007 | Neurochem Res2007，32，1： | 1 |
| 4 | Designing multi-interface service by platform approach显示文摘 | PATRICIO L FISK R P FALCAO E | 2008 | Journal of Service Research2008，10，4： | 1 |
| 5 | Clinical Outcome of congenital talipes equinonarus diagnosed antenatally by ultrasound显示文摘 | Tiller T L Fisk N M Murphy K | 2000 | J Bone Joint Surg2000，82，： | 1 |
| 6 | Effect of hypoxia/ ischemia and hypoxic preconditioning/reperfusion on expression of some arayloid-degrading enzymes显示文摘 | Nalivaevaa NN Fisk L Kochkina EG | 2004 | Ann N Y Acad Sci2004，1035，： | 1 |
| 7 | A continuum of impression formation,from category-based to individuating pro- cesses:Influences of information and motivation on at- tention and interpretation显示文摘 | Fisk S T Neuberg S L | 1990 | Advances in Experimental Social Psychology1990，，23： | 1 |
| 8 | Postharvest qual- ity of hardy kiwifruit (Actinidia arguta 'Ananas- naya' ) associated with packaging and storage condi- tions 显示文摘 | Fisk C L Silver A M Strik B C | 2007 | Postharvest Biology and Technology2007，47，3： | 1 |
| 9 | Postharvest quality of hardy ki- wifruit ( Actinidia arguta ' Ananasnaya' ) associated with packaging and storage conditions 显示文摘 | Fisk C L Silver A M Strik B C | 2008 | Postharvest Biology and Technology2008，47，3： | 1 |
| 10 | Neuropsychological predic- tors of incident dementia in patients with vascular cognitive im- pairment, without dementia显示文摘 | Ingles J L Wentzel C Fisk J D | 2002 | Stroke2002，33，8： | 1 |
| 11 | Glycogen storage disease type I a in canines:A model for human metabolic and genetic liver disease显示文摘 | Specht A Fiske L Erger K | 2011 | J Biomed Biotechno12011，2011，64： | 1 |
| 12 | Coupling between wrist flexion-extension and radial-ulnar deviation显示文摘 | Zm LI Kuxhaus L Fisk JA | 2005 | Clin Biomech2005，20，2： | 1 |
| 13 | Preclinical vascular cognitive impairment and Alzheimer disease:neuropsychological test performance 5 years before diagnosis显示文摘 | INGLES J L BOULTON D C FISK J D | | 0，，04： | 1 |
| 14 | ACCEL: Automated circuit card etching layout 显示文摘 | Fisk C J Caskey D L West L E | 1967 | Proceedings of the IEEE1967，55，11： | 1 |
| 15 | Acceleration of Suprath-ermal Tails in the Solar Wind显示文摘 | FISK L A GLOECKLER G | 2008 | Astrophys J2008，686，2： | 1 |
| 16 | Targeting amyloid-degrading enzymes as therapeutic strategies in neurodegeneration显示文摘 | Turner AJ Fisk L Nalivaeva NN | 2004 | Ann N Y Acad Sci2004，1035，： | 1 |
| 17 | Improving satisfaction with bank service offerings:measuring the contribution of each delivery'channel显示文摘 | Patrlcio L Fisk R P e Cunha J F | 2003 | Managing Service Quality2003，13，6： | 1 |
| 18 | Designing Muhi-inter- face Service Experiences the Service Experience Blueprint显示文摘 | PATRICIO L FISK R P CUNHA J F | 2008 | Journal of Service Research2008，10，4： | 1 |
| 19 | Targeting amyloid degrading enzymes as therapeutic strategies in neurode- generation 显示文摘 | Turner A J Fisk L Nalivaeva NN | 2004 | Ann NY Acad Sci2004，1035，： | 1 |
| 20 | Effect of hypoxia/ischemia and hypoxic preconditioning/reperfusion on expression of some amyloid-degrading enzymes显示文摘 | Nalivaevaa NN Fisk L Kochkina EG | 2004 | Ann N Y Acad Sci2004，1035，： | 1 |
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