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| 1 | Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery显示文摘AIM: To evaluate the surface expression of triggering receptor on myeloid cell 1 (TREM-1), class Ⅱ major histocompatibility complex molecules (HLA-DR), andthe expression of the splicing variant (svTREM-1) ofTREM-1 in septic patients and those subjected to major abdominal surgery.METHODS: Using flow cytometry, we examined the surface expression of TREM-1 and HLA-DR in peripheral blood monocytes from 11 septic patients, 7 elective gastrointestinal surgical patients, and 10 healthy volunteers. svTREM-1 levels were analyzed by RT-PCR. RESULTS: Basal expression of TREM-1 and HLA-DR in healthy volunteers was 35.91±14.75 MFI and75.8±18.3%, respectively. In septic patients, TREM-1 expression was 59.9±23.9 MFI and HLA-DR expression was 44.39±20.25%, with a significant differencebetween healthy and septic groups (P<0.05) for bothmolecules. In the surgical patients, TREM-1 and HLA-DR expressions were 56.8±20.85 MFI and 71±13.8% before surgery and 72.65±29.92 MlFI and 72.82±22.55% after surgery. TREM-1 expression was significantly different(P = 0.0087) between the samples before and aftersurgery and svTREM-1 expression was 0.8590±0.1451 MF1, 0.8820±0.1460 MF1, and 2.210±0.7873MF1 in the healthy, surgical (after surgery) and septic groups, respectively. There was a significant difference (P = 0.048) in svTREM-1 expression between the healthy and surgical groups and the septic group.CONCLUSION: TREM-1 expression is increased during systemic inflammatory conditions such as sepsis and the postoperative phase. Simultaneous low expression of HLA-DR molecules correlates with the severity of illness and increases susceptibility to infection. Additionally, TREM-1 expression is distinctly different in surgical patients at different stages of the inflammatory response before and after surgery. Thus, surface TREM-1 appears to be an endogenous signal during the course of the inflammatory response. svTREM-1 expression is significantly increased during sepsis, appearing to be an indicator of severity of illness. Together, these data indicate that TREM-1 may play an important role in establishing and amplifying the systemic inflammatory response. TREM-1, HLA-DR, and svTREM-1 expression analysis can provide useful diagnostic and prognostic indicators during SIRS, CARS, and sepsis. | Nestor González-Roldán Eduardo Ferat-Osorio Rosalía Aduna-Vicente Isabel Wong-Baeza Noemí Esquivel-Callejas Horacio Astudillo-de la Vega Patricio Sánchez-Fernández Lourdes Arriaga-Pizano Miguel Angel Villasís-Keever Constantino López-Macías Armando Isibasi | 2005 | World Journal of Gastroenterology2005，11，47： | 9 |
| 2 | The role of leptin/adiponectin ratio in metabolic syndrome and diabetes显示文摘 | Patricio López-Jaramillo Diego Gómez-Arbeláez Jose López-López Cristina López-López Javier Martínez-Ortega Andrea Gómez-Rodríguez Stefany Triana-Cubillos | 2014 | Hormone Molecular Biology and Clinical Investigation2014，，1： | 4 |
| 3 | Inflammatory bowel disease: A descriptive study of 716 local Chilean patients显示文摘AIM: To demographically and clinically characterize inflammatory bowel disease(IBD) from the local registry and update data previously published by our group.METHODS: A descriptive study of a cohort based on a registry of patients aged 15 years or older who were diagnosed with IBD and attended the IBD program at Clínica Las Condes in Santiago, Chile. The registry was created in April 2012 and includes patients registered up to October 2015. The information was anonymously downloaded in a monthly report, and the information on patients with more than one visit was updated. The registry includes demographic, clinical and disease characteristics, including the Montreal Classification, medical treatment, surgeries and hospitalizations for crisis. Data regarding infection with Clostridium difficile(C. difficile) were incorporated in the registry in 2014. Data for patients who received consultations as second opinions and continued treatment at this institution were also analyzed. RESULTS: The study included 716 patients with IBD: 508 patients(71%) were diagnosed with ulcerative colitis(UC), 196 patients(27%) were diagnosed with Crohn's disease(CD) and 12 patients(2%) were diagnosed with unclassifiable IBD. The UC/CD ratio was 2.6/1. The median age was 36 years(range 16-88), and 58% of the patients were female, with a median age at diagnosis of 29 years(range 5-76). In the past 15 years, a sustained increase in the number of patients diagnosed with IBD was observed, where 87% of the patients were diagnosed between the years 2001 and 2015. In the cohort examined in the present study, extensive colitis(50%) and colonic involvement(44%) predominated in the patients with UC and CD, respectively. In CD patients, nonstricturing/non-penetrating behavior was more frequent(80%), and perianal disease was observed in 28% of the patients. There were significant differences in treatment between UC and CD, with a higher use of corticosteroids, and immunosuppressive and biological therapies was observed in the patients with CD(P < 0.05 and P < 0.01). Significant surgical differences were also observed: 5% of the UC patients underwent surgery, whereas 38% of the CD patients required at least one surgery(P < 0.01). The patients with CD were hospitalized more often during their disease course than the patients with UC(55% and 35% of the patients, respectively; P < 0.01). C. difficile infection was acquired by 5% of the patients in each group at some point during the disease course. Nearly half of the patients consulted at the institution for a second opinion, and 32% of these individuals continued treatment at the institution. CONCLUSION: IBD has continued to increase in the study cohort, slowly approaching the level reported in developed countries. | Daniela Simian Daniela Fluxá Lilian Flores Jaime Lubascher Patricio Ibánez Carolina Figueroa Udo Kronberg Raúl Acuna Mauricio Moreno Rodrigo Quera | 2016 | World Journal of Gastroenterology2016，22，22： | 2 |
| 4 | Designing multi-interface service by platform approach显示文摘 | PATRICIO L FISK R P FALCAO E | 2008 | Journal of Service Research2008，10，4： | 1 |
| 5 | Free and forced vibrations of a simply supported rectangular plate partially embedded in an elastic foundation 显示文摘 | Daniel A Hilda L Patricio A A L | 1989 | Applied Acoustics1989，28，4： | 1 |
| 6 | Equilibrium of an inverted mathematical double-link pendulum with a follower force显示文摘 | Lobas L G Patricio L D Boruk I G | 2002 | International Applied Mechanics2002，38，3： | 1 |
| 7 | Photopo- lymerizable and injectable polyurethanes for biomedical applications: synthesis and biocompatibility 显示文摘 | Pereira Ildeu H L Ayres E Patricio P S | 2010 | Acta Biomaterialia2010，6，8： | 1 |
| 8 | Appl Catal B显示文摘 | Patricio Peralta-Zamora Claudia Pereira Elaine R L | 2003 | 42:1312003，42，： | 1 |
| 9 | Cryostabilization mechanism of fish muscle protein by maltodextrins显示文摘 | Patricio A C Grant A M Tyre C L | 1999 | Cryobiology1999，38，： | 1 |
| 10 | Spatial patterns in an old-growth Nothofagus obliqua forest in south-central Chile显示文摘 | Christian S Valerie L Patricio N | | 0，，： | 1 |
| 11 | Genetic variation of sweet potatoes (Ipomoea batatas L.) cultivated in Chile determined by RAPDs显示文摘 | Boris Sagredo Patricio Hinrichsen Horacio López Alberto Cubillos Carlos Mu?oz | 1998 | Euphytica1998，，2： | 1 |
| 12 | Designing Muhi-inter- face Service Experiences the Service Experience Blueprint显示文摘 | PATRICIO L FISK R P CUNHA J F | 2008 | Journal of Service Research2008，10，4： | 1 |
| 13 | Decolorization of reactive dyes by immobilized laccase显示文摘 | PATRICIO P Z CLAUDIA M P ELAINE R L | 2003 | Applied Catalysis B:Environmemal2003，42，2： | 1 |
| 14 | Human polyclonal immunoglobulin labeled with technetium-99 via NHS-MAG3: a comparison of radiochernical behavior and biological efficacy with other labeling methods显示文摘 | Gano L Patricio L Marques E | 1998 | Nucl Med Biol1998，25，4： | 1 |
| 15 | Using waist circumference as a screening tool to identify colombian subjects at cardiovascular risk显示文摘 | Maritza Perez Juan P Casas Luz A Cubillos-Garzón Norma C Serrano Federico Silva Carlos A Morillo Patricio López-Jaramillo | 2003 | European Journal of Cardiovascular Prevention & Rehabilitation2003，，5： | 1 |
| 16 | Is the present cut-point to define type 2 diabetes appropriate in Latin-Americans?显示文摘The diagnosis of diabetes mellitus type 2(DM2) is based either on increased plasma glucose or Glycated hemoglobin levels. Since these measures are the only means for diagnosis of DM2, they must be well adapted to each population according to their metabolic characteristics, given that these may vary in each population. The World Health Organization(WHO) determined the cut-points of plasma glucose levels for the diagnosis of DM2 by associating hyperglycemia with the risk of a specific microvascular complication-retinopathy. Cardiovascular diseases are however the principal causes of mortality in patients with DM2 and we reported that in the Colombo-Ecuadorian population impaired fasting glucose and impaired glucose tolerance are both riskmarkers for myocardial infarction. We propose that the current cut-points accepted by the WHO need to be revaluated in populations such as Latin America and that there should be lower cut points for glycaemia in this population, to reduce the prevalence of cardiovascular complications associated with DM2. | Patricio López-Jaramillo Carlos Velandia-Carrillo Diego Gómez-Arbeláez Martin Aldana-Campos | 2014 | World Journal of Diabetes2014，5，6： | 1 |
| 17 | Epidemic of overweight and obesity in Latin America and the Caribbean显示文摘 | Christian F. Rueda-Clausen Federico A. Silva Patricio López-Jaramillo | 2007 | International Journal of Cardiology2007，，1： | 1 |
| 18 | Decoloration of reactive dyes by immobilized laccase 显示文摘 | Patricio P Z Cloudia M P Tiburtius E R L etal | 2003 | Applied Catalysis B: Environmental2003，42，： | 1 |
| 19 | Understanding value co-creation in complex services with many actors显示文摘 | Pinho N Beiro G Patricio L | 2014 | Journal of Service Management2014，25，4： | 1 |
| 20 | Ten Years'Experience of Pregnancy Outcomes in Women with Cardiac Valvulopathies:Are Valve Prostheses Worst显示文摘 | Monteiro A V Rebelo J Patricio L | 2015 | J Heart Valve Dis2015，24，3： | 1 |
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