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| 1 | Preoperative immunonutrition in patients undergoing liver resection:A prospective randomized trial显示文摘BACKGROUND Preoperative supplementation with immunonutrients, including arginine and n-3 fatty acids, has been shown in a number of systematic reviews to reduce infectious complications in patients who have undergone gastrointestinal surgery. Limited information, however, is available on the benefits of nutritional supplementation enriched with arginine and n-3 fatty acids in patients undergoing liver resection.AIM To evaluate the effects of preoperative nutritional supplementation enriched with arginine and n-3 fatty acids on inflammatory and immunologic markers and clinical outcome in patients undergoing liver resection.METHODS Thirty-four patients undergoing liver resection were randomized to either five days of preoperative Impact? [1020 kcal/d, immunonutrition(IMN) group], or standard care [no supplementation, standard care(STD) group]. Nutritional status was measured at study entry by subjective global assessment(SGA).Functional assessments(grip strength, fatigue and performance status) were carried out at study entry, on the day prior to surgery, and on postoperative day(POD) 7 and 30. Inflammatory and immune markers were measured at study entry, on the day prior to surgery, and POD 1, 3, 5, 7, 10 and 30. Postoperative complications were recorded prospectively until POD30.RESULTS A total of 32 patients(17 IMN and 15 STD) were analysed. All except four patients were SGA class A. The plasma ratio of(eicosapentaenoic acid plus docosahexaenoic acid) to arachidonic acid was higher in IMN patients on the day prior to surgery and POD 1, 3, 5 and 7(P < 0.05). Plasma interleukin(IL)-6 concentrations were elevated in the IMN group(P = 0.017 for POD7). No treatment effect was detected for functional measures, immune response(white cell count and total lymphocytes) or markers of inflammation(C-reactive protein,tumour necrosis factor-α, IL-8, IL-10). There were 10 patients with infectious complications in the IMN group and 4 in the STD group(P = 0.087). Median hospital stay was 9(range 4–49) d in the IMN group and 8(3-34) d in the STD group(P = 0.476).CONCLUSION In well-nourished patients undergoing elective liver resection, this study failed to show any benefit of preoperative immunonutrition. | Kylie Russell Han-Guang Zhang Lyn K GillANDers Adam SJR Bartlett Helena L Fisk Philip C Calder Peter J Swan Lindsay D Plank | 2019 | World Journal of Hepatology2019，11，3： | 3 |
| 2 | Postharvest qual- ity of hardy kiwifruit (Actinidia arguta 'Ananas- naya' ) associated with packaging and storage condi- tions 显示文摘 | Fisk C L Silver A M Strik B C | 2007 | Postharvest Biology and Technology2007，47，3： | 1 |
| 3 | Postharvest quality of hardy ki- wifruit ( Actinidia arguta ' Ananasnaya' ) associated with packaging and storage conditions 显示文摘 | Fisk C L Silver A M Strik B C | 2008 | Postharvest Biology and Technology2008，47，3： | 1 |
| 4 | Neuropsychological predic- tors of incident dementia in patients with vascular cognitive im- pairment, without dementia显示文摘 | Ingles J L Wentzel C Fisk J D | 2002 | Stroke2002，33，8： | 1 |
| 5 | Preclinical vascular cognitive impairment and Alzheimer disease:neuropsychological test performance 5 years before diagnosis显示文摘 | INGLES J L BOULTON D C FISK J D | | 0，，04： | 1 |
| 6 | ACCEL: Automated circuit card etching layout 显示文摘 | Fisk C J Caskey D L West L E | 1967 | Proceedings of the IEEE1967，55，11： | 1 |
| 7 | Establishing luminescence methods to detect irradiated foods显示文摘 | Sanderson D C W Carmichael L Fisk S | 1998 | Food Science and Technology Today1998，12，2： | 1 |
| 8 | Postharvest quality of hardy kiwifruit (Actinidia arguta ' Ananasnaya') asso- ciated with packaging and storage conditions显示文摘 | Fisk C L Silver A M Strik B C | 2008 | Posthar- vest Biology and Technology2008，47，： | 1 |
| 9 | Postharvest quality of hardy kiwifruit (Actinidia arguta 'Ananasnaya') associated with packaging and storage conditions显示文摘 | FISK C L SILVER A M STRIK B C | 2008 | Postharvest Biology and Technology2008，47，3： | 1 |
| 10 | Neuropsychologi- cal predictors of incident dementia in patients with vascu- lar cognitive impairment, without dementia 显示文摘 | Ingles J L Wentzel C Fisk J D | 2002 | Stroke2002，33，8： | 1 |
| 11 | Accurate and robust quantiza-tion of circulating fetal and total DNA in maternal plasma from 5 to41 weeks of gestation显示文摘 | Birch L English C A Fisk N M | 2005 | Clin Chem2005，51，2： | 1 |
| 12 | Post- harvest quality of hardy kiwifruit (Actinidia arguta 'Ananas- nayaassociated with packaging and storage conditions显示文摘 | Connie L Fisk Alissa M Sliver Bernadine C Strik | 2008 | Post- harvest Biology and Technology2008，47，3： | 1 |
| 13 | Postharvest quality of hardy kiwifruit (Actinidia arguta 'Ananasnaya') associated with packaging and storage conditions显示文摘 | Fisk C L Silver A M Strik B C | 2008 | Postharvest Biology and Technology2008，47，： | 1 |
| 14 | Postharvest quality of hardy kiwifruit (Actinidia arguta Ananasnaya') associated with packaging and storage conditions显示文摘 | Fisk C L Silver A M Strik B C | 2008 | Postharvest Biology and Technology2008，47，3： | 1 |
| 15 | Postharvest quality of hardy kiwi fruit (Actinidia arguta Ananasnaya) associated with packaging and storage conditions显示文摘 | Fisk C L Silver A M Strik B C | 2008 | Postharvest Biology and Technology2008，47，3： | 1 |
| 16 | Accurate and robust quantification of circulating and total DNA in maternal plasma from 5 to 41 weeks of gestation显示文摘 | Birch L English C A Fisk N M | 2005 | Clin Chem2005，51，2： | 1 |
| 17 | Accurate and robust quantification of circulating fetal and total DNA in maternal plasma from 5 to 41 weeks of gestation显示文摘 | Birch L English C A Fisk N M | 2005 | Clin Chem2005，51，2： | 1 |
| 18 | Neuropsy - chological predic- tors of incident dementia in patients with vascular cognitive impair- ment, without dementia显示文摘 | Ingles J L Wentzel C Fisk J D | 2002 | Stroke2002，33，8： | 1 |
| 19 | Neuropsychological predictors of incident dementia in patients with vascular cognitive impairment without dementia 显示文摘 | Ingles J L Wentzel C Fisk J D | 2002 | Stroke2002，33，8： | 1 |
| 20 | Establishing lumines- cence methods to detect irradiated foods显示文摘 | Sanderson D C W Carmichael L Fisk S | 1998 | Food Science and Tech- nology Today1998，12，2： | 1 |
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