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| 1 | The challenges of a Big Data Earth显示文摘The potential of big data fused with the vision of a digital Earth offers powerful opportunities to deepen understanding of the whole Earth system and the management of a sustainable planet.It is important to stand back from often confusing detail to clarify what those opportunities are and how they might be seized.The essential scientific potential of data,big or small,is to reveal patterns,which have often been the fundamental first step in stimulating inquiry,leading to new questions,new perspectives and potentially to new answers.The digital revolution has created a“digital microscope”that permits us to see patterns that have not been seen before,and when coupled with machine learning technologies to analyse them in creating statistical predictions of the behaviour of both human and non-human systems.These potentials converge with the imperative to represent an Earth system with interacting non-human and human components,as a vital contribution to the understanding and actions required in working towards planetary sustainability.But a digital Earth is also capable of being represented mathematically as a digitally networked phenomenon,analogous to an analogue computer,and should be an important target for a Big Earth Data Journal.We should also return to Al Gore’s vision of an accessible digital Earth with wide usability.Pre-determining the separate functions of parallel digital Earths risks losing one of the great potentials of big data and learning algorithms,the identification and analysis of unanticipated relationships and processes. | Geoffrey Boulton | 2018 | Big Earth Data2018，2，1： | 7 |
| 2 | 糖尿病足病:流行病学、危险因素和防治的标准显示文摘'糖尿病足病坏疽不是上帝带来的,而是由于人类本身.'这是波士顿著名的糖尿病专家Elliott Joslin于70年代前写下的话,今天仍然正确.这不是不能改变的结局,部分糖尿病患者发生足的病变,大部分问题是可以预防的.然而,最近的统计数字让人沮丧,大约25%的患者在生命的某个时期发生足的溃疡.还有,足部疾病的负担在最近的时间内将增长,因为糖尿病的患病人数增加,有10%的2型糖尿病患者在诊断时有足病的危险因素. | Andrew J.M. Boulton | 2005 | 中华医学信息导报2005，20，24： | 3 |
| 3 | 视网膜色素上皮、Bruch膜及脉络膜的老年性黄斑变性改变(英文)显示文摘目的研究并定量分析视网膜色素上皮(retinalpigment epithelium,RPE)、Bruch膜和脉络膜的老年性改变及在老年黄斑变性眼的改变。方法应用改良Masson三色组织染色法及电脑图像分析软件,对36例不同龄正常眼及6例老年黄斑变性(age—related macular degenera—tion,ARMD)眼的RPE数量和形态、Bruch膜的厚度和脉络膜毛细血管的密度及脉络膜厚度进行定量分析研究及讨论。结果RPE老年性形态改变包括数量的减少及细胞高度的增加伴有Bruch膜增厚(老年性黄斑变性);但脉络膜毛细血管密度及脉络膜的厚度与年龄未见明显的关系。ARMD眼主要表现为RPE形态明显改变及基底膜线样沉着物形成,Bruch膜增厚。结论RPE以及Bruch膜的改变可能是早期和基础性的老年性改变,其进一步的变化可能导致脉络膜及视网膜的损害。 | 张勇进 Grenham Ireland Mike Boulton | 2003 | 国际眼科杂志2003，3，3： | 3 |
| 4 | 视网膜色素上皮、Bruch膜及脉络膜老年性改变的定量分析显示文摘目的 研究及定量分析视网膜色素上皮 (retinal pigment epithelium,RPE)、Bruch膜及脉络膜的老年性改变。 方法 应用改良 Masson三色组织染色法及电脑图像分析软件对 36例不同年龄 (3~ 93岁 )正常眼 RPE数量和高度、Bruch膜厚度、脉络膜毛细血管的密度及脉络膜厚度的老年性改变进行定量分析。 结果 与年龄有显著相关性的老年性改变包括 RPE细胞数量的减少 (8个 / mm2 ·年 )、RPE细胞高度的增加 (0 .0 1μm/年 )以及 Bruch膜增厚 (0 .0 2μm/年 ) ;脉络膜毛细血管密度及脉络膜厚度的改变与年龄之间无显著的相关关系。 结论 RPE细胞数量减少、高度增加以及 Bruch膜的增厚可能是黄斑区最早的老年性改变。 | 张勇进 Grenham Ireland Mike Boulton | 2000 | 中华眼底病杂志2000，16，4： | 3 |
| 5 | Staphylococcus aureus resistant to vancomyein-United States, 2002显示文摘 | Sievert DM Boulton ML Stoltman G | 2002 | MMWR2002，51，26： | 1 |
| 6 | The Diabetic Foot: A Global View 显示文摘 | Boulton AJ | 2000 | Dia- betes Metab Rev(S0742- 4221)2000，，： | 1 |
| 7 | Identification of Discrete Domains within Gonococcal Transfenin- Binding Protein A That Are Necessary for Ligand Binding and Iron Uptake Functions 显示文摘 | Comelissen CN Anderson JE Boulton IC | 2000 | Infect Immunity2000，68，12： | 1 |
| 8 | The normalized protein catabolic rate is a flawed marker of nutrition in CAPD patients显示文摘 | Harty J C Boulton H Curwell J | 1994 | Kidney Int1994，45，1： | 1 |
| 9 | Geminiviruses: major threats to world agriculture 显示文摘 | Boulton M I | 2003 | Ann Appl Biol2003，142，： | 1 |
| 10 | Protocol for treament of diabetic foot ulcers显示文摘 | Brem HSP Boulton AJM | 2004 | Am J Surg2004，187，15： | 1 |
| 11 | Clinical practice:Neuropathic diabetic foot ulcers显示文摘 | Boulton AJ Kirsner RS Vilekyte L | | 0，，23： | 1 |
| 12 | BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans显示文摘 | Boulton S J Martin JS Polanowska J | 2004 | Curr Biol2004，14，1： | 1 |
| 13 | Macular pigment and risk for age-related macular degeneration in subjects form a Northern European population 显示文摘 | Beatty S Murray I J Henson DB Carden D Koh H Boulton ME | 2001 | Invest Ophthalmol Vis Sci2001，42，2： | 1 |
| 14 | Twenty years' research on peer victimization and psychosocial maladjustment:A metaanalytic review of cross-sectional studies显示文摘 | Hawker DS Boulton MJ | 2000 | J Child Psychol Psychiatry2000，41，4： | 1 |
| 15 | The diabetic foot: grand overview, epidemiology and pathogenesis显示文摘 | BOULTON AJM | 2008 | Diabetes Metab Res Rev2008，24，11： | 1 |
| 16 | The diabetic foot: a global view显示文摘 | Boulton AJM | 2000 | Diabetes Metab Res Rev2000，16，1： | 1 |
| 17 | Twenty years' research on peer victimization and psychological maladjustment:a meta-analysis review of cross-sectional studies显示文摘 | Hawker D S Boulton M J | 2000 | Aaaociation for Child Psychology and Psychiatry2000，41，4： | 1 |
| 18 | A role for hepatocyte growth factor in diabetic retinopathy显示文摘 | Boulton M | 1999 | Br J Ophthalmol1999，83，： | 1 |
| 19 | Cellular functions of the BRCA tumour-suppressor proteins显示文摘 | Boulton SJ | 2006 | Bioehem Soe Trans2006，34，5： | 1 |
| 20 | Diabetic neuropathies:a statement by the American Diabetes Association显示文摘 | Boulton AJ Vinik AI Arezzo JC | 2005 | Diabetes Care2005，28，4： | 1 |
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