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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Study on the microbiological degradation of bensulfuronmethyl 显示文摘 | Brusa T Ferrari F Bolzacehini E | 2001 | Annals of Microbiology2001，51，： | 1 |
| 3 | Triamcinoloneassisted pars plana vitrectomy for proliferative vitreoretinopathy显示文摘 | Furino C Micelli Ferrari T Boscia F | | 0，，6： | 1 |
| 4 | Expression of the G2-M checkpoint regulators cyclinB1 and P34CDC2 in breast cancer:a correlation with cellular kinetice显示文摘 | Megha T Lazzi S Ferrari F | 1999 | Anticancer Res1999，19，1： | 1 |
| 5 | Kinetic mechanism and mierostruerure during the formation of Si3N4 matrix in Si3N4 MoSi2 composites显示文摘 | Beruto D T Ferrari A Giordani M Marino F | 2003 | Materials Science and Engineering2003，，355： | 1 |
| 6 | Impact of immune escape mutations on HIV-1fitness in the context of the cognate transmitted/founder genome显示文摘 | Song H Pavlicek J W Cai F Bhattacharya T Li H Iyer S S Bar K J Decker J M Goonetilleke N Liu M K Berg A Hora B Drinker M S Eudailey J Pickeral J Moody M A Ferrari G McMichael A Perelson A S Shaw G M Hahn B H Haynes B F Gao F | 2012 | Retrovirology2012，9，： | 1 |
| 7 | Reactive plasma spraying of titanium in nitrogen containing plasma gas 显示文摘 | Bacci T Bertaminl L Ferrari F | 2000 | Materials Science and Engineering A2000，283，12： | 1 |
| 8 | Numerical simulation of vortex-induced vibration on flexible cylinders 显示文摘 | Yamamoto C T Meneghini J R Saltara F Fregonesi R A Ferrari J A Jr | 2004 | Journal of Fluids and Structures2004，19，： | 1 |
| 9 | 查看详情显示文摘 | Sun Z P Hasan T Torrisi F Popa D Privitera Wang F Q Bonac-corso F Basko D M Ferrari A C | | 0，，： | 1 |
| 10 | 查看详情显示文摘 | Bonaccorso F Sun Z Hasan T Ferrari A C | | 0，，： | 1 |
| 11 | Molecular characterization of synovial sarcoma in children and adolescents: evidence of Akt activation 显示文摘 | Bozzi F Ferrari A Negri T | 2008 | Transl Oncol2008，1，2： | 1 |
| 12 | Reactive plasma spraying of titanium in nitrogen containing plasma gas显示文摘 | ertamini L Ferrari F Galliono F P Galvanetto E | 2000 | Materials Science and Engineering2000，283，： | 1 |
| 13 | Gra- phene photonics and optoelectronics 显示文摘 | Bonaccorso F Sun Z Hasan T Ferrari A C | 2010 | Nature Photon- ics2010，，4： | 1 |
| 14 | Triamcinolone-assisted pars plana vitrectomy for proliferative vitreoretinopathy显示文摘 | Furino C Micelli Ferrari T Boscia F | 2003 | Retina2003，23，6： | 1 |
| 15 | Anaerobic nitrite production by plant cells and tissues : evidence for two nitrate pools显示文摘 | Ferrari T F Yoder O C Filner P | 1973 | Plant Physiol1973，51，： | 1 |
| 16 | Prevalence of intestinal parasites in dogs from So Paulo State, Brazil 显示文摘 | Oliveira-Sequeira T C G Amarante A F T Ferrari T B | 2002 | Veterinary Parasitology2002，103，： | 1 |
| 17 | Fresh concrete: A herschel-bulkley material显示文摘 | LARRARD F D FERRARIS C F SEDRAN T | 1998 | Mater Struct1998，31，： | 1 |
| 18 | Beta-amyloid induces paired helical filament-like tau filaments in tissue culture显示文摘 | HOERNDLI F BAECHI T | 2003 | J Biol Chem2003，278，40： | 1 |
| 19 | Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection显示文摘 | Ferrari C Penna A Bertoletti A Valli A Antoni A D Giuberti T Cavalli A Petit M A Fiaccadori F | 1990 | J Immunol1990，145，10： | 1 |
| 20 | Triameinolone - as- sisted Pars Plana vitreetomy for Proliferati vevitreoretinopathy 显示文摘 | Furino C Mieelli Ferrari T Boseia F | 2003 | Retina2003，23，2： | 1 |
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