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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Impact of immune escape mutations on HIV-1fitness in the context of the cognate transmitted/founder genome显示文摘 | Song H Pavlicek J W Cai F Bhattacharya T Li H Iyer S S Bar K J Decker J M Goonetilleke N Liu M K Berg A Hora B Drinker M S Eudailey J Pickeral J Moody M A Ferrari G McMichael A Perelson A S Shaw G M Hahn B H Haynes B F Gao F | 2012 | Retrovirology2012，9，： | 1 |
| 3 | Characterization of hepatitis B virus(HBV)-specific T-cell dysfunction in chronic HBV infection显示文摘 | Boni C Fisicaro P Valdatta C Amadei B Di Vincenzo P Giuberti T Laccabue D Zerbini A Cavalli A Missale G Bertoletti A Ferrari C | 2007 | J Virol2007，81，8： | 1 |
| 4 | Measuring the objectness o fimage w indows显示文摘 | Alexe B Deselaers T Ferrari V | 2012 | IEEE Transactions on Pattern Analysis andMachine Intelligence2012，34，11： | 1 |
| 5 | Measuring the object- ness of image windows 显示文摘 | ALEXE B DESELAERS T FERRARI V | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，11： | 1 |
| 6 | Prevalence of intestinal parasites in dogs from So Paulo State, Brazil 显示文摘 | Oliveira-Sequeira T C G Amarante A F T Ferrari T B | 2002 | Veterinary Parasitology2002，103，： | 1 |
| 7 | Measuring the object- ness of image windows显示文摘 | Alexe B Deselaers T Ferrari V | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，11： | 1 |
| 8 | Measuring the objectness of image windows显示文摘 | ALEXE B DESELAERS T FERRARI V | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，11： | 1 |
| 9 | Academic procrastination:Personality correlates with Myers-Briggs types,self-efficacy and academic locus of control显示文摘 | Joseph R Ferrari James T Parker & Carolyn B Ware | 1992 | Journal of Social Behavior & Personality1992，7，3： | 1 |
| 10 | Influence of the Urea Content on the YSZ Hydrothermal Synthesis under Dilute Conditions and Its Role as Dis- persant Agent in the Post-reaction Medium显示文摘 | GONZALO-JUAN I FERRARI B COLOMER M T | 2009 | Journal of the European Ceramic Society2009，29，15： | 1 |
| 11 | Weakly supervised localization and learning with generic knowledge显示文摘 | Deselaers T Alexe B Ferrari V | 2012 | International Journal of Computer Vision2012，100，3： | 1 |
| 12 | Measuring the objectness of image Windows显示文摘 | Alexe B Deselaers T Ferrari V | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，11： | 1 |
| 13 | Measuring the objectness of image windows显示文摘 | Alexe B Deselaers T Ferrari V | 2012 | IEEE Trans on Pattern Analysis and Machine Intelligence2012，34，11： | 1 |
| 14 | Measuring the Objectness of Image Windows显示文摘 | ALEXE B DESELAERS T FERRARI V | 2012 | IEEE Transactions on Software Engineering2012，34，11： | 1 |
| 15 | Measuring the objectness of image windows显示文摘 | Alexe B Deselaers T Ferrari V | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，11： | 1 |
| 16 | Measuring the objectness of image windows显示文摘 | Alexe B Deselaers T Ferrari V | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，11： | 1 |
| 17 | Catalytic,enantioselective alkylation of α-imino esters using late transition metal phosphine complexes as catalysts显示文摘 | Ferraris D Young B Dudding T | 1998 | J Am Chem Soc1998，120，： | 1 |
| 18 | Measuring the objeetness of image windows显示文摘 | Alexe B Deselaers T Ferrari V | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，11： | 1 |
| 19 | Prevalence of intestinal parasites in dogs from S?o Paulo State, Brazil显示文摘 | Oliveira-Sequeira T C G Amarante A F T Ferrari T B | 2002 | Veterinary Parasitology2002，103，： | 1 |
| 20 | Catalytic,enantioselective alkylation of α-imino esters:the synthesis of nonnatural α-amino acid derivatives显示文摘 | Ferraris D Young B Lectka T | 2002 | J Am Chem Soc2002，124，1： | 1 |
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