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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Clinical parameters, post- mortem analysis and estimation of lethal dose in victims of a massive intoxication with diethylene glycol显示文摘 | Ferrari LA Giannuzzi L | 2005 | Forensic Sci Int2005，153，1： | 1 |
| 3 | Biomarkers of a native fish species( Cnesterodon decemmaculatus) application to the water toxicity assessment of a peri - urban polluted river of Argentina显示文摘 | de la Torte F R Ferrari L Salibian A | 2005 | Chemosphere2005，59，4： | 1 |
| 4 | Clinical parameters, postmortem analysis and estimation of lethal dose in victims of a massive intoxication with diethylene glycol显示文摘 | Ferrari LA Giannuzzi L | 2005 | Forensic Sci lnt2005，153，1： | 1 |
| 5 | Hospital Volume, Margin Status, and Long-Term Survival after Pancreaticoduodenectomy for Pancreatic Adenocarcinoma显示文摘 | La Torre Marco Nigri Giuseppe Ferrari Linda Cosenza Giulia Ravaioli Matteo Ramacciato Giovanni | 2012 | EN2012，，2： | 1 |
| 6 | Substance abuse relapsein Oxford house recovery homes : A survival analysis evaluation显示文摘 | HARVEY R JASON LA FERRARI JR | 2016 | Subst Abuse2016，37，2： | 1 |
| 7 | Biomarkers of a native fish species (Cnesterodon decemmaculatus) application to the water toxicity assessment of a peri-urban polluted river of Argentina显示文摘 | DE LA TORRE F R FERRARI L SALIBIAN A | 2005 | Chemosphere2005，59，4： | 1 |
| 8 | Clinical proteomics : written in blood显示文摘 | Liotta LA Ferrari M Petricoin E | 2003 | Nature2003，425，： | 1 |
| 9 | Biomarkers Assessment in Juvenile Cyprinus crapio Exposed to Waterborne Cadmium显示文摘 | DE LA TORRE F R SALIBIN A FERRARI L | 2000 | Environmental Pollution2000，109，： | 1 |
| 10 | Promotion of neuronal, survival by GM1 ganglioside显示文摘 | Ferrari G Greene LA | 1998 | Ann N Y Acad Sci1998，19，27： | 1 |
| 11 | Written in blood 显示文摘 | Liotta LA Ferrari M Petricoin EF | 2003 | Nature2003，425，6961： | 1 |
| 12 | Open-Label, Randomized, Placebo-Controlled Evaluation of Intracoronary Adenosine or Nitroprusside After Thrombus Aspiration During Primary Percutaneous Coronary Intervention for the Prevention of Microvascular Obstruction in Acute Myocardial Infarction显示文摘 | Giampaolo Niccoli Stefano Rigattieri Maria Rosaria De Vita Marco Valgimigli Pierfrancesco Corvo Franco Fabbiocchi Enrico Romagnoli Alberto Ranieri De Caterina Giuseppe La Torre Paolo Lo Schiavo Fabio Tarantino Roberto Ferrari Fabrizio Tomai Paolo Olivares | 2013 | JACC: Cardiovascular Interventions2013，，： | 1 |
| 13 | Polymorphisms in the PPAR gamma gene influence bone density in Humans 显示文摘 | Kiel DP Ferrari S Cupples LA | 2005 | J Bone Miner Res2005，20，： | 1 |
| 14 | Extracellular ATP induces a distorted maturation of dendritic cells and inhibits their capacity to initiate Th1 responses显示文摘 | la Sala A Ferrari D Corinti S | 2001 | J Immunol2001，166，3： | 1 |
| 15 | Clinical Proteomiee: Written in blood 显示文摘 | Liotta LA Ferrari M Petricoin E | 2003 | Nature2003，425，6961： | 1 |
| 16 | Freshwater pollution biomarker: response of brain acetylcholinesterase activity in two fish species 显示文摘 | de la Torre F R Ferrari L Salibián A | 2002 | Comp Biochem Physiology Part C2002，131，： | 1 |
| 17 | Development of the digestive tract of milkfish,Chanos chanos (Forsskal):histology and histochemistry显示文摘 | Ferraris R P Tan J D De la Cruz M C | | 0，，3： | 1 |
| 18 | Hibemating myocardium:another piece of the puzzle falls into place 显示文摘 | Rahimtoola SH La Canna G Ferrari R | 2006 | J Am Coll Cardiol2006，47，5： | 1 |
| 19 | Post-mortem analysis of formic acid disposition in acute methanol intoxication显示文摘 | Ferrari LA Arado MG Nardo CA | 2003 | Forensic Sci Int2003，133，12： | 1 |
| 20 | Development of the digestive tract of milkfish,Chanos chanos (Forsskal):histology and histochemistry显示文摘 | FERRARIS R P TAN J D DE LA CRUZ M C | 1987 | Aquaculture1987，61，34： | 1 |
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