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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Electron transfer in a new highly conducting donor-acceptor complex显示文摘 | Ferraris J P Cowan D O Walatka V | 1973 | J Am Chem Soc1973，95，： | 2 |
| 3 | Combined treatment with a β-blocker and intermittent PTH improves bone mass and mieroarehitecture in ovariectomized mice 显示文摘 | Pierroz D D Bouxsein M L Rizzoli R Ferrari S L | 2006 | Bone2006，39，： | 1 |
| 4 | WNT and betacatenin signalling:diseases and therapies显示文摘 | Moon R T Kohn A D De Ferrari G V | 2004 | Nature Reviews Genetics2004，5，9： | 1 |
| 5 | The Ca2 + concentration of the endoplasmic retieulum is a key determinant of ceramide-induced ap- optosis : significance for the molecular mechanism of Bcl - 2 action 显示文摘 | Pinton P Ferrari D Papizzi Z | 2001 | E MBO J2001，20，11： | 1 |
| 6 | A capacitive sen- sor system for the analysis of two-phase flows of oil and conductive water 显示文摘 | Demori M Ferrari V Strazza D | 2010 | Sensors and Actuators A: Physical2010，163，1： | 1 |
| 7 | Chcmokinc (C-X-C motif') ligand (CXCL)10 in autoimmune diseases 显示文摘 | Antonelli A Ferrari SM G-iuggioli D | 2014 | Autoimmun Rev2014，13，3： | 1 |
| 8 | Safety of antitumor necrosis factor-alpha therapy in patients with rheumatoid arthritis and chronic hepatitis C virus infection显示文摘 | FERRI C FERRACCIOLI G FERRARI D | 2008 | J Rheumatol2008，35，10： | 1 |
| 9 | Extraabdominal desmoid tumor 显示文摘 | Pignatti G Barbanti - Brodano G Ferrari D | 2000 | Clin Orthop Res2000，375，： | 1 |
| 10 | VSWS:the variable-interval sampled working set policy显示文摘 | Ferrari D Yih Y | 1983 | IEEE Transactions on Software Engineering1983，9，3： | 1 |
| 11 | 50 Hz magnetic fields of varying flux intensity affect cell shape changes in invertebrate immunocytes: the role of potassium ion channels显示文摘 | Ottaviani E Malagoli D Ferrari A | 2002 | Bioelectromagnetics2002，23，4： | 1 |
| 12 | Interactions of interleukin-6 promoter polymorphisms with dietary and lifestyle factors and their association with bone mass in men and women from the Framingham osteoporosis study显示文摘 | Ferrari SL Karasik D Liu J | 2004 | J Bone Miner Res2004，19，4： | 1 |
| 13 | Thyroid involvement in hepatitis C-associated mixed cryoglobulinemia显示文摘 | Fallahi P Ferrari SM Giuggioli D | 2014 | Hormones(Athens)2014，13，1： | 1 |
| 14 | Caspase-dependent alterations of Ca2+signaling in the induction of apoptosis by hepatitis B virus X protein显示文摘 | Chami M Ferrari D Nicotera P | 2003 | The Journal of Biological Chemistry2003，278，31： | 1 |
| 15 | Nucleotide receptors:an emerging family of regulatory molecules in blood cells显示文摘 | CHIOZZI P FERRARI D | 2001 | Blood2001，97，： | 1 |
| 16 | Ethanol production from eucalyptus wood hemicellulose hydrolysate by Pichia stipitis显示文摘 | Ferrari M D Neirotti E Albornoz C | 1992 | Biotechnology and Biocngineering1992，40，7： | 1 |
| 17 | Calcium and apoptosis: facts and hypotheses显示文摘 | RIZZUTO R PINTON P FERRARI D | 2003 | Oncogene2003，22，： | 1 |
| 18 | Molecular machinery and signaling events in apoptosisi显示文摘 | PINTON P FERRARI D VIRGILIO F D | 2001 | Drug Development Research2001，52，4： | 1 |
| 19 | Muscle regeneration by bone marrow- derived myogenic progenitors显示文摘 | Ferrari G Angelis D Coletta M | 1998 | Science1998，279，5356： | 1 |
| 20 | Purinergic modulation of interleukin-1 beta release from mieroglial cells stimulated with bacterial endotoxin 显示文摘 | Ferrari D Chiozzi P Falzoni S | 1997 | J Exp Med1997，185，： | 1 |
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