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| 1 | Spiral CT in gastric carcinoma:Comparison with barium study,fiberoptic gastroscopy and histopathology显示文摘AIM: To evaluate spiral computed tomography (CT) including virtual gastroscopy for diagnosis of gastric carcinoma in comparison with upper gastrointestinal series (UGI),fiberoptic gastroscopy (FG) and histopathology.METHODS: Sixty patients with histologically proven gastric carcinoma (54 advanced and 6 early) were included in this study. The results of spiral CT were compared with those of UGI and FG. Two observers blindly evaluated images of spiral CT and UGI and video recording of FG with consensus in terms of diagnostic confidence with a five-point scale.Sensitivities of lesion detection, Borrmann′s classification of spiral CT, UGI and FG, as well as the accuracy of TNM staging of spiral CT were determined by comparing them to surgical and histological findings.RESULTS: The lesion detection rate was 98 % (59/60),95 % (57/60) and 98 % (59/60) for spiral CT, UGI and FG,respectively. There were no statistical differences in the detection sensitivity among the three techniques (P>0.05).For the sensitivity in Borrmann′s classification, spiral CT was higher than that of UGI (P=0.025) and similar to that of FG (P>0.05). The accuracy of spiral CT in staging the gastric carcinoma was 76.7 %. Six cases of early gastric carcinoma were all detected by spiral CT as well as FG.CONCLUSION: Spiral CT is equivalent to UGI and FG in the detection of gastric carcinoma, and superior to UGI but similar to FG in the Borrmann′s classification of advanced gastric carcinoma. Spiral CT is more valuable than FG in the staging of gastric carcinoma. | FengChen Yi-ChengNi Kai-ErZheng Sheng-HongJu JunSun Xi-Long Man-HuaXu HaoZhang GuyMarchal | 2003 | World Journal of Gastroenterology2003，9，7： | 22 |
| 2 | 精神活性物质成瘾的行为医学研究显示文摘本课题建立吗啡,甲基苯丙胺以及可卡因诱导的大、小鼠行为敏化模型。探讨了L-型钙通道阻滞剂,情绪稳定剂(锂盐,丙戊酸钠和卡马西平),以及新型μ受体部分激动剂噻吩诺啡对行为敏化形成,转化以及表达的影响。利用行为敏化模型,率先开展了曲马朵和槟榔嚼块提取物多药滥用的精神药理学研究。此外,在条件性位置偏爱和纳洛酮促吗啡戒断动物模型上,发现钙调蛋白抑制剂具有明显的干预作用,钙调蛋白可能是阿片类物质依赖治疗的新的分子靶点。与澳大利亚成瘾神经科学的合作研究发现,GABAB受体正性别构调节剂CGP9730可以抑制嗜酒大鼠的自饮酒行为,具有潜在的治疗酒精依赖与成瘾的临床应用价值。 | 梁建辉 邓艳萍 FengChen AndrewJLawrence | 2006 | 中国药物依赖性杂志2006，15，3： | 13 |
| 3 | Modeling of rotational supercavitating evaporator and the geometrical characteristics of supercavity within显示文摘In this paper,a rotational supercavitating evaporator(RSCE)was at first modeled by means of theoretical analysis approach.The geometrical characteristics of supercavity in the modeled RSCE were then studied through numerical simulations.The current research objectives consist in determination of shape of the supercavitator(which in the plane of rotation generates supercavity occupying the most volume between blades),and location of the area suitable for steam extraction by revealing the inner structure of supercavity.Analytical analysis was performed by solving empirical equations for the shape of RSCE,through which an evaluation of two-dimensional relative position of supercavity trailing edge for different shapes of the supercavitator has been realized.Numerical simulation was then carried out,by numerically solving the unsteady Navier-Stokes equations in their conservation form coupled with the Rayleigh-Plesset cavitation and Shear-Stress Transport turbulence models,for verification of the results obtained from empirical equations.Despite unreliable assumption of applicability of empirical equations we have confirmed similarity of the supercavity shapes obtained by both methods for the same RSCE.Therefore,the shape of supercavitator calculated by using empirical equations is acceptable,which provides a simple but reliable approach for design of RSCE.The inner structure of supercavity obtained by numerical simulation has indicated position and parameters for steam extraction openings for further numerical and experimental studies on the performance of RSCE.Practical application of steam or gas extraction is suggested for solving of some problems associated with cavitating pumping of cryogenic liquid. | LIKHACHEV Dmitriy S. LI FengChen | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，3： | 9 |
| 4 | Theoretical analysis of flamelet model for supersonic turbulent combustion显示文摘Being physically intuitionistic and computationally efficient,the flamelet model has obtained increasing attention and becomes popular in numerical simulations of supersonic combustion.However,the flamelet model was firstly built for simulations of the low-speed flows.Therefore it is still unclear whether the assumption of the flamelet model is reasonable in supersonic combustion.This paper tries to identify the existence of the flamelet mode in supersonic combustion.Firstly,the interaction of the turbulent fluctuation and the flame is discussed,based on which the combustion regime is distinguished.Then the charac-teristic length scale of the turbulent flows and the combustion inside the scramjet combustor are calculated and compared,which are used to identify whether the assumption of the flamelet model is reasonable in supersonic flows.The results show that for premixed combustion,due to the low fluctuation velocity in the recirculation zone and the shear layer,the assumption of the flamelet model is established for all the flight Mach numbers,while for non-premixed combustion the assumption is also established for most of the flight Mach numbers except for very high Mach number under which the slow reaction mode dominates the combustion.In order to quantitatively examine the combustion mode,numerical calculations are performed to simulate the strut-injection supersonic combustion which has been experimentally investigated in German Aerospace Center.The results show that the supersonic combustion occurs in the fully-developed turbulent regions and the assumption of the flamelet model is established in the whole flow field. | FAN ZhouQin LIU WeuDong SUN MingBo WANG ZhenGuo ZHUANG FengChen LUO WenLei | 2012 | Science China(Technological Sciences)2012，55，1： | 7 |
| 5 | Accuracy of triage strategies for human papillomavirus DNA-positive women in low-resource settings:A cross-sectional study in China显示文摘Objective: Care HPV is a human papillomavirus(HPV) DNA test for low-resource settings(LRS).This study assesses optimum triage strategies for care HPV-positive women in LRS.Methods: A total of 2,530 Chinese women were concurrently screened for cervical cancer with visual inspection with acetic acid(VIA),liquid-based cytology and HPV testing by physician-and self-collected care HPV,and physician-collected Hybrid Capture 2(HC2).Screen-positive women were referred to colposcopy with biopsy and endocervical curettage as necessary.HPV-positivity was defined as ≥1.0 relative light units/cutoff(RLU/CO) for both care HPV and HC2.Primary physician-HC2,physician-care HPV and self-care HPV and in sequential screening with cytology,VIA,or increased HPV test-positivity performance,stratified by age,were assessed for cervical intraepithelial neoplasia(CIN) grade 2/3 or worse(CIN2/3+) detection.Results: The sensitivities and specificities of primary HPV testing for CIN2+ were: 83.8%,88.1% for physiciancare HPV; 72.1%,88.2% for self-care HPV; and 97.1%,86.0% for HC2.Physician-care HPV test-positive women with VIA triage had a sensitivity of 30.9% for CIN2+ versus 80.9% with cytology triage.Self-care HPV testpositive women with VIA triage was 26.5% versus 66.2% with cytology triage.The sensitivity of HC2 test-positive women with VIA triage was 38.2% versus 92.6% with cytology triage.The sensitivity of physician-care HPV testing for CIN2+ decreased from 83.8% at ≥1.0 RLU/CO to 72.1% at ≥10.00 RLU/CO,while the sensitivity of selfcare HPV testing decreased from 72.1% at ≥1.0 RLU/CO to 32.4% at ≥10.00 RLU/CO; similar trends were seen with age-stratification.Conclusions: VIA and cytology triage improved specificity for CIN2/3 than no triage.Sensitivity with VIA triage was unsuitable for a mass-screening program.VIA provider training might improve this strategy.Cytology triage could be feasible where a high-quality cytology program exists.Triage of HPV test-positive women by increased test positivity cutoff adds another LRS triage option. | Margaret Wang Shangying Hu Shuang Zha o Wenhua Zhang Qinjing Pan Xun Zhang FengChen Jinxiu Han Junfei Ma Jennifer S.Smith Youlin Qiao Caihong Zhou Fanghui Zhao | 2017 | Chinese Journal of Cancer Research2017，29，6： | 6 |
| 6 | Experimental study on the performance of a rotational supercavitating evaporator for desalination显示文摘Efforts have been made on experimental research of a supercavitation device for desalination,which is named rotational supercavitating evaporator(RSCE).The RSCE is characterised by the simple construction and responsive capacity control,and only requires rough filtration of the source water for scaling-and fouling-free operations.The present study has been conducted for the water flow at temperature of around 22–30°C and atmospheric pressure as the first step for investigation of the performance characteristics of RSCE.The multiply factor extremal experiments conducted with the Box-Wilson’s method have revealed the salinity of the condensate,the temperature of steam inside the supercavity,and dependence of the shape of supercavity on the rate of steam extraction and rotation speed of impeller.The shape of impeller and the expected supercavitating effects it generates have been confirmed by experimental results at the rotation speed of 5430 rpm(round per minute).The design of the steam extraction openings has been approved during the evacuation of steam.The experimental dependencies have been obtained in form of statistically valid regression equations,which can be used for engineering design of RSCE. | LIKHACHEV Dmitriy S LI FengChen KULAGIN Vladimir A | 2014 | Science China(Technological Sciences)2014，57，11： | 6 |
| 7 | Analysis of coherent structures in drag-reducing polymer solution flow based on proper orthogonal decomposition显示文摘Direct numerical simulation(DNS) of forcing homogeneous isotropic turbulence with polymers was performed.In order to understand the polymers effect on turbulent coherent structures,proper orthogonal decomposition was performed to identify coherent structures based on DNS data,so as to analyze the remarkable difference due to the addition of polymers.The results showed that the numbers for eigenmodes required for capturing coherent structures were 32 and 24 for the Newtonian fluid and polymer solution flows,respectively,which means the decrease of the complexity in polymer solution flow.Through the POD energy spectrum,it was found that the turbulent kinetic energy is distributed onto a large number of eigenmodes whether in the Newtonian fluid flow or polymer solution flow,suggesting that polymer solution flow is still turbulent in one aspect.Besides,the POD eigenmodes were investigated,which found that the small-scale structures are inhibited in polymer solution flow. | CAI WeiHua LI FengChen ZHANG HongNa WANG Yue WANG Lu | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，5： | 5 |
| 8 | Investigation on reversible pump turbine flow structures and associated pressure field characteristics under different guide vane openings显示文摘The use of reversible pump turbines(RPT) within pumped storage power plants goes with prolonged periods of off-design operating conditions, which leads to the onset of operating mode-dependent instabilities. In order to decrease the gravity of RPT flow instabilities and associated damages or even completely eliminate them, a deep understanding of its onset and development mechanism is needed. In line with this, the present study seeks to numerically investigate the onset and development mechanism of RPT unsteady flow structures as well as the evolutional characteristics of associated pressure pulsations throughout the RPT complete flow passage, under off-design conditions for three GVOs namely 17, 21, and 25 mm. The study results showed that low torque operating conditions and associated vaneless space back flow structures were the trigger of flow unsteadiness onset within the RPT vaneless space, the instabilities which grew to cause the S-shape characteristics appearance. Moreover, the runner flow unsteadiness was found to decrease with the GVO increase. On the other hand, the GVO increase worsened the pressure pulsation levels within RPT flow zones, where pressure pulsations within the vaneless space and flow zones in its vicinities were found to be the most sensitive to GVO changes. | BINAMA Maxime SU WenTao CAI WeiHua LI FengChen WEI XianZhu MUHIRWA Alex GONG RuZhi WEKESA David W | 2019 | Science China(Technological Sciences)2019，62，11： | 5 |
| 9 | Prevention of diet-induced obesity by safflower oil: insights at the levels of PPARα, Orexin, and Ghrelin gene expression of adipocytes in mice显示文摘这研究的目的是在老鼠由一本高红花油食谱和 adipocytic 基因表示调查导致食谱的肥胖的预防。四十只 3-week-old C57BL/6 老鼠随机被划分成三个组:控制组(反对, 5% 猪油 +5% 红花油) ,高猪油组(LAR, 45% 猪油 +5% 红花油) ,并且高红花油组(SAF, 45% 红花油 +5% 猪油) 。在 10 个星期以后, LAR 组的 10 只老鼠高被换到红花油饮食(LARSAF ) 。十个星期以后,葡萄糖忍耐测试被葡萄糖的 intraperitoneal 注射执行。类脂化合物和胰岛素的传播层次被测量,白脂肪质的纸巾为基因薄片和反向的 transcriptasepolymerase 链反应分析被拿。LAR 组比 CON 组显示出更高的身体重量,脂肪过多索引,胰岛素,和类脂化合物(P < 0.05 ) 。在 LARSAF 组的身体重量在饮食的颠倒以后减少了。血浆生物化学的侧面在 LARSAF 和 SAF 组减少了(P < 0.05 ) 与那些相比 LAR 组。LARSAF 组的血葡萄糖水平与 LAR 组的相比在 intraperitoneal 葡萄糖忍耐测试期间被减少。LARSAF 组有 Orexin 和 Ghrelin 基因表示的底层,而 PPAR 基因表示的水平显著地与 LAR 组的相比被提高。那么, SAF 食谱能改变 adipocytic 在导致食谱的肥胖的有效改善的脂肪过多相关的基因表示和结果。 | Zhong Zhang Qiang Li Fengchen Liu Yuqian Sun Jinchao Zhang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，3： | 3 |
| 10 | Numerical study on the characteristics of natural supercavitation by planar symmetric wedge-shaped cavitators for rotational supercavitating evaporator显示文摘With the application of supercavitation effect, a novel device named rotational supercavitating evaporator(RSCE) was recently designed for desalination. In order to improve the blade shape of rotational cavitator in RSCE for performance optimization and then design three-dimensional blades, numerical simulations are conducted on the supercavitating flows(with cavitation number ranging from 0.055 to 0.315) around two-dimensional planar symmetric wedge-shaped cavitators with different wedge angles varied from 10 to 180 degrees. Proper numerical method for simulating supercavitating flows around planar symmetric cavitator is established, and assessment of k-ε-v2 -f turbulence model in simulating cavitating flows is conducted. It shows that the size of computational domain would affect the simulation result. Empirical formulae for supercavity dimensions about cavitation number at different wedge angles are obtained, which are of significant importance in the subsequent design of three-dimensional blade. The characteristics of resistance at different wedge angles are discussed, which, together with the characteristics of supercavity dimensions, play important roles in the optimal design of RSCE. | ZHENG ZhiYing LI FengChen LI Qian KULAGIN Vladimir A | 2015 | Science China(Technological Sciences)2015，58，6： | 3 |
| 11 | Occurrence and a screening‐level risk assessment of human pharmaceuticals in the Pearl River system, South China显示文摘 | Jian‐LiangZhao Guang‐GuoYing You‐ShengLiu FengChen Ji‐FengYang LiWang Xiao‐BingYang Jenny L.Stauber Michael St. J.Warne | 2010 | Environmental Toxicology and Chemistry2010，，6： | 2 |
| 12 | Experimental Study on the Ride Comfort of a Crawler Power Chassis Scale Model Based on the Similitude Theory显示文摘The ride comfort experimental assessment of crawler off-road vehicle is relatively overlooked, and is expensive and difficult to execute with higher and higher ride comfort performance requirements. To trade off between precise and cost, an experimental method based on the similitude theory is proposed. Under the guidance of the similitude theory, a 1:5 crawler power chassis scale model equipped with a kind of variable stiffness suspension system is used. The power spectrum density(PSD), the root mean square(RMS) of weighed acceleration, peak factor, average absorbed power(AAP) and vibration dose value(VDV) are selected as ride comfort evaluation indexes, and tests results are transformed via similarity indexes to predict the performance of full-scale power chassis. PSD shows that the low-order natural frequency of the vertical natural frequency(z axis) is 1.1 Hz, and the RMS, AAP and VDV values indicate the ride comfort performance of this kind of power chassis is between the 'A little uncomfortable' and 'Rather uncomfortable'. From the results, low-order vertical natural frequency, obtained by PSD, validates that the similarity relationship between two models is satisfied, and 1:5 scale model used in experiment meets the similarity relationship with the full-scale model; consequently, the ride comfort prophase evaluation with the 1:5 scale model is feasible. The attempt of applying the similitude theory to crawler vehicle ride comfort test study decreases the cost and improves the test feasibility with sufficient test precise. | ZHAO Jianzhu WANG Fengchen YU Bin TONG Pengcheng CHEN Kuifu | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 2 |
| 13 | Experimental study on the characteristics of ventilated cavitation around an underwater navigating body influenced by turbulent drag-reducing additives显示文摘In this study, a new control strategy for turbulent drag reduction involving ventilated cavitation is proposed. The configurational and hydrodynamic characteristics of ventilated cavities influenced by turbulent drag-reducing additives were experimentally studied in water tunnel. The test model was fixed in the water tunnel by a strut in the aft-part. Aqueous solutions of CTAC/Na Sal(cetyltrimethyl ammonium chloride/sodium salicylate) with weight concentrations of 100, 200, 400 and 600 ppm(part per million), respectively, were injected into the ventilated air cavity from the edge of the cavitator with accurate control by an injection pump. The cavity configurations were recorded by a high-speed CCD camera. The hydrodynamic characteristics of the test model were measured by a six-component balance. Experimental results show that, within the presently tested cases, the lengths of cavity influenced by drag-reducing solution are smaller than normal condition(ventilated cavity) in water, but the asymmetry of the cavity is improved. The drag resisted by the test model is reduced dramatically(the maximum drag reduction can reach to 80%) and the re-entrant jet is more complex after the CTAC solution is injected into the cavity. Turbulent drag-reducing additives have the potential in enhancement of supercavitating asymmetry and further drag reduction. | JIANG ChenXing LI FengChen | 2015 | Science China(Physics,Mechanics & Astronomy)2015，58，9： | 2 |
| 14 | Analysis of heat transfer performance for turbulent viscoelastic fluid-based nanofluid using field synergy principle显示文摘In this paper,the field synergy principle is firstly performed on the viscoelastic fluid-based nanofluid and other relevant fluid in channel at turbulent flow state to scrutinize their heat transfer performance based on our direct numerical simulation database.The cosine values of intersection angle between velocity vector and temperature gradient vector are calculated for different simulated cases with varying nanoparticle volume fraction,nanoparticle diameter,Reynolds number and Weissenberg number.It is found that the filed synergy effect is enhanced when the nanoparticle volume fraction is increased,nanoparticle diameter is decreased and Weissenberg number is decreased,i.e.the heat transfer is also enhanced.However,the filed synergy effect is weakened with the increase of Reynolds number which may be the possible reason for the power function relationship in empirical correlation of heat transfer between heat transfer performance and Reynolds number with the constant power exponent lower than 1.Finally,it is also observed that the field synergy principle can be used to analyze the heat transfer process of viscoelastic fluid-based nanofluid at the turbulent flow state even if some negative cosine values of intersection angle exist in the flow field. | YANG JuanCheng LI FengChen NI MingJiu YU Bo | 2015 | Science China(Technological Sciences)2015，58，7： | 2 |
| 15 | Experimental study on the characteristics of heat transfer and flow resistance in turbulent pipe flows of viscoelastic-fluid-based Cu nanofluid 显示文摘 | Yang Juancheng Li Fengchen He Yurong Huang Yimin Jiang Baocheng | 2013 | International Journal of Heat and Mass Transfer2013，62，： | 1 |
| 16 | Assessment of les Performance in Simulating Complex 3d flows in Turbo-machines 显示文摘 | SU Wentao LI Fengchen LI Xiaobin | 2012 | Engineering Applications of Computational Fluid Mechan- ics2012，6，3： | 1 |
| 17 | Multifunctional Mesoporous Nanoellipsoids for Biological Bimodal Imaging and Magnetically Targeted Delivery of Anticancer Drugs显示文摘 | YuChen HangrongChen ShengjianZhang FengChen LingxiaZhang JiaminZhang MinZhu HuixiaWu LiminGuo JingweiFeng JianlinShi | 2010 | Adv Funct Mater2010，，2： | 1 |
| 18 | Experimental study on symmetry breaking in a swirling free-surface cylinder flow influenced by viscoelasticity 显示文摘 | LI Fengchen OISHI M KAWAGUCHI Y | 2007 | Exp Thermal Fluid Sci2007，31，3： | 1 |
| 19 | Investigation of turbulence structures in a drag-reduced turbulent channel flow with surfactant additive using stereoscopic particle image velocimetry 显示文摘 | LI Fengchen KAWAGUCHI Y HISHIDA K | 2006 | Exp Fluids2006，40，： | 1 |
| 20 | Reynolds-number dependence of turbulence structures in a drag-reducing surfactant solution channel flow investigated by PIV 显示文摘 | LI Fengchen KAWAGUCHI Y SEGAWA T | 2005 | Phys Fluids2005，17，7： | 1 |
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