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| 1 | Advances in research on the carrot,an important root vegetable in the Apiaceae family显示文摘Carrots(Daucus carota L.),among the most important root vegetables in the Apiaceae family,are cultivated worldwide.The storage root is widely utilized due to its richness in carotenoids,anthocyanins,dietary fiber,vitamins and other nutrients.Carrot extracts,which serve as sources of antioxidants,have important functions in preventing many diseases.The biosynthesis,metabolism,and medicinal properties of carotenoids in carrots have been widely studied.Research on hormone regulation in the growth and development of carrots has also been widely performed.Recently,with the development of high-throughput sequencing technology,many efficient tools have been adopted in carrot research.A large amount of sequence data has been produced and applied to improve carrot breeding.A genome editing system based on CRISPR/Cas9 was also constructed for carrot research.In this review,we will briefly summarize the origins,genetic breeding,resistance breeding,genome editing,omics research,hormone regulation,and nutritional composition of carrots.Perspectives about future research work on carrots are also briefly provided. | Feng Que Xi-Lin Hou Guang-Long Wang Zhi-Sheng Xu Guo-Fei Tan Tong Li Ya-Hui Wang Ahmed Khadr Ai-Sheng Xiong | 2019 | Horticulture Research2019，6，1： | 11 |
| 2 | Delivery room resuscitation and short-term outcomes of extremely preterm and extremely low birth weight infants: a multicenter survey in North China显示文摘Background:Delivery room resuscitation assists preterm infants,especially extremely preterm infants(EPI)and extremely low birth weight infants(ELBWI),in breathing support,while it potentially exerts a negative impact on the lungs and outcomes of preterm infants.This study aimed to assess delivery room resuscitation and discharge outcomes of EPI and ELBWI in China.Methods:The clinical data of EPI(gestational age[GA]<28 weeks)and ELBWI(birth weight[BW]<1000 g),admitted within 72 h of birth in 33 neonatal intensive care units from five provinces and cities in North China between 2017 and 2018,were analyzed.The primary outcomes were delivery room resuscitation and risk factors for delivery room intubation(DRI).The secondary outcomes were survival rates,incidence of bronchopulmonary dysplasia(BPD),and risk factors for BPD.Results:A cohort of 952 preterm infants were enrolled.The incidence of DRI,chest compressions,and administration of epinephrine was 55.9%(532/952),12.5%(119/952),and 7.0%(67/952),respectively.Multivariate analysis revealed that the risk factors for DRI were GA<28 weeks(odds ratio[OR],3.147;95%confidence interval[CI],2.082–4.755),BW<1000 g(OR,2.240;95%CI,1.606–3.125),and antepartum infection(OR,1.429;95%CI,1.044–1.956).The survival rate was 65.9%(627/952)and was dependent on GA.The rate of BPD was 29.3%(181/627).Multivariate analysis showed that the risk factors for BPD were male(OR,1.603;95% CI,1.061–2.424),DRI(OR,2.094;95% CI,1.328–3.303),respiratory distress syndrome exposed to≥2 doses of pulmonary surfactants(PS;OR,2.700;95%CI,1.679–4.343),and mechanical ventilation≥7 days(OR,4.358;95% CI,2.777–6.837).However,a larger BW(OR,0.998;95% CI,0.996–0.999),antenatal steroid(OR,0.577;95%CI,0.379–0.880),and PS use in the delivery room(OR,0.273;95%CI,0.160–0.467)were preventive factors for BPD(all P<0.05).Conclusion:Improving delivery room resuscitation and management of respiratory complications are imperative during early management of the health of EPI and ELBWI. | Shuai-Jun Li Qi Feng Xiu-Ying Tian Ying Zhou Yong Ji Yue-Mei Li Shu-Fen Zhai Wei Guo Fang Zhang Rong-Xiu Zheng Hai-Ying He Xia Liu Jun-Yi Wang Hua Mei Hong-Yun Wang Hua Xie Chao-Mei Zeng Li Ma Ping-Ping Zhang Jin-Yu Li Xiao-Ying Wang Li-Hua Li Hong Cui Shu-Lan Yang Lu Chen Xiao-Hong Gu Yan-Ju Hu Sheng-Shun Que Li-Xia Sun Ming Yang Wen-Li Zhao Qiu-Yan Ma Hai-Juan Wang Jiu-Ye Guo | 2021 | Chinese Medical Journal2021，，13： | 7 |
| 3 | Morphological characteristics, anatomical structure, and gene expression: novel insights into gibberellin biosynthesis and perception during carrot growth and development显示文摘Gibberellins(GAs)are considered potentially important regulators of cell elongation and expansion in plants.Carrot undergoes significant alteration in organ size during its growth and development.However,the molecular mechanisms underlying gibberellin accumulation and perception during carrot growth and development remain unclear.In this study,five stages of carrot growth and development were investigated using morphological and anatomical structural techniques.Gibberellin levels in leaf,petiole,and taproot tissues were also investigated for all five stages.Gibberellin levels in the roots initially increased and then decreased,but these levels were lower than those in the petioles and leaves.Genes involved in gibberellin biosynthesis and signaling were identified from the carrotDB,and their expression was analyzed.All of the genes were evidently responsive to carrot growth and development,and some of them showed tissue-specific expression.The results suggested that gibberellin level may play a vital role in carrot elongation and expansion.The relative transcription levels of gibberellin pathway-related genes may be the main cause of the different bioactive GAs levels,thus exerting influences on gibberellin perception and signals.Carrot growth and development may be regulated by modification of the genes involved in gibberellin biosynthesis,catabolism,and perception. | Guang-Long Wang Fei Xiong Feng Que Zhi-Sheng Xu Feng Wang Ai-Sheng Xiong | 2015 | Horticulture Research2015，2，1： | 6 |
| 4 | 中国1960-2016年风能资源的时空分布特征显示文摘基于462个气象观测站1960–2016年共57年的近地面风速日资料,利用克里格空间内插,最小二乘法,相关系数检验和经验正交函数分解(EOF)等方法分析了年均和各个季节中国区域风速及有效风能密度的时空变化特征。研究结果表明:在中国北部和部分沿海地区年平均风速在3 m s-1以上,有效风能密度在75 W m-2以上,而在中国南部地区平均风速和有效风能密度均较小。近五十多年以来,中国区域年均和季节平均风速呈明显下降趋势,北部地区春季递减率最大,沿海地区冬季递减率最大。广东部分地区年平均风速有增大的趋势,西南,华南和华中西部地区年平均风速变化不大。平均风速大的区域,递减率也大。年平均风速和年有效风能密度的主要空间分布模态表现出高度的一致性,均呈现逐年减小趋势。中国风速及风能资源的减小趋势,主要与全球变暖及土地利用变化有关。 | FENG Yucheng QUE Linjing FENG Jinming | 2020 | Atmospheric and Oceanic Science Letters2020，13，2： | 5 |
| 5 | Controllable synthesis of nanorod/nanodisk TiO_2 from titanium-containing electric furnace molten slag显示文摘Nanostructured TiO2 with different morphologies and crystal phases was successfully synthesized from titanium-containing electric furnace molten slag by using a hydrothermal method followed by reflux process in acid solution. The effects of acid concentration, reflux time, and acid type on the formation of TiO2 were systematically investigated by scanning electron microscopy, X-ray diffraction(XRD), transmission electron microscopy(TEM),high-resolution transmission electron microscopy(HRTEM),and X-ray fluorescence(XRF). It is indicated that TiO2 nanorod with rutile phase is achieved in nitric or hydrochloric acid, while anatase TiO2 nanodisk is formed in sulfuric acid.With the increase of the concentration of hydrochloric acid from 0.3 to 1.5 mol L-1, the dispersibility and crystallinity of the final product can be improved. With prolonging the reflux time from 6 to 14 h, the rutile TiO2 nanorod with uniform crystal size and high crystallinity is obtained. The growth mechanism of TiO2 nanorod and nanodisk prepared under different conditions was also discussed. | Zai-Qing Que Yang Li Hai-Yang Yu Feng Zheng Mei Zhang Min Guo | 2015 | Rare Metals2015，34，4： | 2 |
| 6 | Exogenous abscisic acid suppresses the lignification and changes the growth, root anatomical structure and related gene profiles of carrot显示文摘Plant hormones are essential elements that control a great num ber of cellular processes that occur during plant growth.Abscisic acid(ABA)is a plant hormone known for its roles in regulating growth/development and response to biotic/abiotic stresses of the plant.It modulates plant growth and development in many aspects,such as seed dormancy,stomata movement,and xylem fiber differ entiation[1],Furthermore,ABA can inhibit stem elongation and shoot growth,as well as reduce shoot weight,which results in the repression of the overall growth of the plant.It has been postu lated that ABA inhibits shoot growth by restricting the synthesis of gibberellin[2]. | Ahmed Khadr Yahui Wang Feng Que Tong Li Zhisheng Xu Aisheng Xiong | 2020 | Acta Biochimica et Biophysica Sinica2020，52，1： | 2 |
| 7 | Intercomparison of different physics schemes in the WRF model over the Asian summer monsoon region显示文摘WRF模式对包含西太平洋、东印度洋和中国大陆的大区域气候模拟能力的提高对东亚夏季风气候的预测非常重要。本文的研究目的是找出合理的物理方案组合来模拟中国大陆、东印度洋和西太平洋这一特大区域的降水和温度。通过模拟2008年夏季气候并与观测进行对比分析,主要比较了Mellor–Yamada–Janjic(MYJ)和Yonsei University(YSU)边界层方案、WSM3和WSM5微物理过程方案、Betts–Miller–Janjic(BMJ)和Tiedtke积云参数化方案对这一区域的气候模拟结果。研究表明:各种物理方案的组合对于温度空间分布的模拟与观测类似;边界层方案的选择对降水影响较大,MYJ方案比YSU方案对降水的模拟效果要好;积云方案Tiedtke对雨带分布,特别是赤道辐合带(ITCZ)降水模拟更加合理。 | QUE Lin-Jing QUE Wei-Lun FENG Jin-Ming | 2016 | Atmospheric and Oceanic Science Letters2016，9，3： | 2 |
| 8 | 甲状腺癌骨转移的诊疗措施的个例报道及其文献回顾(英文)显示文摘研究目的:探究甲状腺癌骨转移的规范诊疗措施,为提高甲状腺癌骨转移的生存期提供指导。创新要点:本例病人通过普外科、骨科联合手术,内分泌激素替代治疗,I131治疗等多学科联合治疗,取得较好的疗效,对探究甲状腺癌骨转移的规范化诊疗措施有重要的指导意义。研究方法:本文分析本科室一例甲状腺癌骨转移病人,同时搜集了1996年至2013年中文文献报道的甲状腺癌骨转移患者11例,通过统计其病理类型、手术方式、转移部位、随访资料等,讨论其规范化治疗方式。重要结论:彻底的术前检查对发现甲状腺癌骨转移至关重要。甲状腺癌骨转移需要多学科协同治疗,手术治疗仍为首选,联合手术的激素替代治疗、I131治疗、二膦酸盐治疗是较好的选择。放疗的作用仍需大样本数据的评估。 | Wei-dong ZHANG Da-ren LIU Cheng-cheng FENG Chuan-biao ZHOU Chen-ni ZHAN Ri-sheng QUE Li CHEN | 2014 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2014，15，12： | 2 |
| 9 | Efficacy,safety and immunogenicity of hexavalent rotavirus vaccine in Chinese infants显示文摘A randomized,double-blind,placebo-controlled multicenter trial was conducted in healthy Chinese infants to assess the efficacy and safety of a hexavalent live human-bovine reassortant rotavirus vaccine(HRV)against rotavirus gastroenteritis(RVGE).A total of 6400 participants aged 6-12 weeks were enrolled and randomly assigned to either HRV(n?3200)or placebo(n?3200)group.All the subjects received three oral doses of vaccine four weeks apart.The vaccine efficacy(VE)against RVGE caused by rotavirus serotypes contained in HRV was evaluated from 14 days after three doses of administration up until the end of the second rotavirus season.VE against severe RVGE,VE against RVGE hospitalization caused by serotypes contained in HRV,and VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were also investigated.All adverse events(AEs)were collected for 30 days after each dose.Serious AEs(SAEs)and intussusception cases were collected during the entire study.Our data showed that VE against RVGE caused by serotypes contained in HRV was 69.21%(95%CI:53.31-79.69).VE against severe RVGE and RVGE hospitalization caused by serotypes contained in HRV were 91.36%(95%CI:78.45-96.53)and 89.21%(95%CI:64.51-96.72)respectively.VE against RVGE,severe RVGE,and RVGE hospitalization caused by natural infection of any serotype of rotavirus were 62.88%(95%CI:49.11-72.92),85.51%(95%CI:72.74-92.30)and 83.68%(95%CI:61.34-93.11).Incidences of AEs from the first dose to one month post the third dose in HRV and placebo groups were comparable.There was no significant difference in incidences of SAEs in HRV and placebo groups.This study shows that this hexavalent reassortant rotavirus vaccine is an effective,well-tolerated,and safe vaccine for Chinese infants. | Zhiwei Wu Qingliang Li Yan Liu Huakun Lv Zhaojun Mo Fangjun Li Qingchuan Yu Fei Jin Wei Chen Yong Zhang Teng Huang Xiaosong Hu Wei Xia Jiamei Gao Haisong Zhou Xuan Bai Yueyue Liu Zhenzhen Liang Zhijun Jiang Yingping Chen Jiuwei Zhang Jialiang Du Biao Yang Bo Xing Yantao Xing Ben Dong Qinghai Yang Chen Shi Tingdong Yan Bo Ruan Haiyun Shi Xingliang Fan Dongyang Feng Weigang Lv Dong Zhang Xiangchu Kong Liuyifan Zhou Dinghong Que Hong Chen Zhongbing Chen Xiang Guo Weiwei Zhou Cong Wu Qingrong Zhou Yuqing Liu Jian Qiao Ying Wang Xinguo Li Kai Duan Yuliang Zhao Gelin Xu Xiaoming Yang | 2022 | Virologica Sinica2022，37，5： | 2 |
| 10 | Flexible Subclavian Artery Closure for an Inadvertent Injury to the Internal Mammary Artery During Internal Jugular Vein Catheterization显示文摘Central vein catheter (CVC) placement,which is widely utilized in clinical departments,is also highly important in preoperative preparations for radiofrequency catheter ablation (RFCA).The internal jugular vein or subclavian vein is the routine target.Arterial injury is not uncommon during the procedure but is potentially devastating in spite of the safety and advantages of the Seldinger technique. | Dong-Dong Que Lei Liu Xu-Dong Song Xian-Bao Wang Xiu-Li Zhang Yi-Jun Zhou Li-Yun Feng Wen-Jie Yu Yuan-Qing Li Ping-Zhen Yang | 2016 | Chinese Medical Journal2016，，7： | 1 |
| 11 | The oyster genome reveals stress adaptation and complexity of shell formation显示文摘 | Zhang G Fang X Guo X Li L Luo R Xu F Yang P Zhang L Wang X Qi H Xiong Z Que H Xie Y Holland PW Paps J Zhu Y Wu F Chen Y Wang J Peng C Meng J Yang L Liu J Wen B Zhang N Huang Z Zhu Q Feng Y Mount A Hedgecock D Xu Z Liu Y Domazet-Loso T Du Y Sun X Zhang S L | | 0，，7418： | 1 |
| 12 | Evaluation of Disintegration Time of Rapidly Disintegrating Tablets by a Paddle Method显示文摘 | Li Que Wei Wu Xiao Feng Cheng | 2006 | Pharmaceutical Development and Technology2006，11，： | 1 |
| 13 | Understanding Li roles in chemical reversibility of O2-type Li-rich layered cathode materials显示文摘Traditional O3-type Li-rich layered materials are attractive with ultra-high specific capacities,but suffering from inherent problems of voltage hysteresis and poor cycle performance.As an alternative,O2-type materials show the potential to improve the oxygen redox reversibility and structural stability.However,their structure-performance relationship is still unclear.Here,we investigate the correlation between the Li component and dynamic chemical reversibility of O2-type Li-rich materials.By exploring the formation mechanism of a series of materials prepared by Na/Li exchange,we reveal that insufficient Li leads to an incomplete replacement,and the residual Na in the Li-layer would hinder the fast diffusion of Li^(+).Moreover,excessive Li induces the extraction of interlayer Li during the melting chemical reaction stage,resulting in a reduction in the valence of Mn,which leads to a severe Jahn-Teller effect.Structural detection confirms that the regulation of Li can improve the cycle stability of Li-rich materials and suppress the trend of voltage fading.The reversible phase evolution observed in in-situ X-ray diffraction confirms the excellent structural stability of the optimized material,which is conducive to capacity retention.This work highlights the significance of modulating dynamic electrochemical performance through the intrinsic structure. | Jie Feng Yun-Shan Jiang Fu-Da Yu Wang Ke Lan-Fang Que Jenq-Gong Duh Zhen-Bo Wang | 2022 | Journal of Energy Chemistry2022，31，3： | 1 |
| 14 | Evaluation of Disintegration Time of Rapidly Disintegrating Tablets by a Paddle Method显示文摘 | Li Que Wei Wu Xiao Feng Cheng and Tao Wu | 2006 | Pharmaceutical Development and Technology2006，11，： | 1 |
| 15 | The oyster genome reveals stress adaptation and complexity of shell formation显示文摘 | Zhang G Fang X Guo X Li L Luo R Xu F Yang P Zhang L Wang X Qi H Xiong Z Que H Xie Y Holland PW Paps J Zhu Y Wu F Chen Y Wang J Peng C Meng J Yang L Liu J Wen B Zhang N Huang Z Zhu Q Feng Y Mount A Hedgecock D Xu Z Liu Y Domazet-Loso T Du Y Sun X Zhang S L | | 0，，： | 1 |
| 16 | Controversial protamine in dealing with acute cardiac tamponade during radiofrequency ablation显示文摘To the Editor:During radiofrequency catheter ablation(RFCA),acute cardiac tamponade is a common but life-threatening occurrence in which rapid blood accumulation in the pericardium cavity compresses the heart and causes the systemic circulation to deteriorate.Emergency percutaneous pericardiocentesis and immediate autologous blood transfusion are necessary.The administration of protamine for incessant bleeding is controversial,for pericardial blood clots may form spontaneously despite the neutralizing effects of heparin and may even necessitate thoracotomy.Our aim is to discuss the necessity and optimum time of protamine administration and to explore the means to prevent blood clot formation. | Dong-Dong Que Li-Yun Feng Ya-Shu Yang Xu-Dong Song Ping-Zhen Yang | 2021 | Chinese Medical Journal2021，，20： | 1 |
| 17 | Sulfur-doped graphene nanoribbons with a sequence of distinct band gaps显示文摘不同于 graphene 表, graphene nanoribbons (GNR ) 能展出能被控制杂质做和 GNR 宽度和边结构调节的半导体的乐队差距特征。然而,完成如此的控制是在 GNR 的制造的主要挑战。V 形臂章类型 GNR 最近经由太古或代替 N 的 oligophenylene 单体的帮助表面的聚合被综合。原则上, GNR 异质接面能被混合二不同单体制作。在这份报纸,我们用代替硫的 oligophenylene 单体报导 V 形臂章类型 GNR 的制造和描述第一次生产 GNR 和相关 heterostructures。第一原则的计算证明 GNR 差距能被经由 debromination 和 intramolecular cyclodehydrogenation 从 cyclodehydrogenated 异构体使用不同的硫配置定制。这个特征应该由设计他们的硫配置为多重 GNR 异质接面的创造启用一条新途径。这些预言经由扫描通道显微镜学并且扫描通道光谱学被证实了。例如,我们发现了包含 S GNR 与不同乐队差距包含片断,即,导致量的一个序列的多重异质接面的一个序列点。这个不平常的 intraribbon 异质接面序列可能在使用量点的 nanoscale optoelectronic 应用是有用的。 | Yan-Fang Zhang Yi Zhang Geng Li Jianchen Lu Yande Que Hui Chen Reinhard Berger Xinliang Feng Klaus Müllen Xiao Lin Yu-Yang Zhang Shixuan Du Sokrates T. Pantelides Hong-Jun Gao | 2017 | Nano Research2017，10，10： | 1 |
| 18 | A combination therapy for androgenic alopecia based on quercetin and zinc/copper dual-doped mesoporous silica nanocomposite microneedle patch显示文摘A nanocomposite microneedle(ZCQ/MN)patch containing copper/zinc dual-doped mesoporous silica nanoparticles loaded with quercetin(ZCQ)was developed as a combination therapy for androgenic alopecia(AGA).The degradable microneedle gradually dissolves after penetration into the skin and releases the ZCQ nanoparticles.ZCQ nanoparticles release quercetin(Qu),copper(Cu^(2+))and zinc ions(Zn^(2+))subcutaneously to synergistically promote hair follicle regeneration.The mechanism of promoting hair follicle regeneration mainly includes the regulation of the main pathophysiological phenomena of AGA such as inhibition of dihydrotestosterone,inhibition of inflammation,promotion of angiogenesis and activation of hair follicle stem cells by the combination of Cu^(2+)and Zn^(2+)ions and Qu.This study demonstrates that the systematic intervention targeting different pathophysiological links of AGA by the combination of organic drug and bioactive metal ions is an effective treatment strategy for hair loss,which provides a theoretical basis for development of biomaterial based anti-hair loss therapy. | Zhaowenbin Zhang Wenbo Li Di Chang Ziqin Wei Endian Wang Jing Yu Yuze Xu Yumei Que Yanxin Chen Chen Fan Bing Ma Yanling Zhou Zhiguang Huan Chen Yang Feng Guo Jiang Chang | 2023 | Bioactive Materials2023，，6： | 1 |
| 19 | Overexpression of a sugarcane ScCaM gene negatively regulates salinity and drought stress responses in transgenic Arabidopsis thaliana显示文摘Calmodulin(CaM)proteins play a key role in signal transduction under various stresses.In the present study,the effects of a sugarcane ScCaM gene(NCBI accession number:GQ246454)on drought and salt stress tolerance in transgenic Arabidopsis thaliana and Escherichia coli cells were evaluated.The results demonstrated a significant negative role of ScCaM in the drought and salt stress tolerance of transgenic lines of A.thaliana,as indicated by the phenotypes.In addition,the expression of AtP5CS and AtRD29A,two genes tightly related to stress resistance,was significantly lower in the overexpression lines than in the wild type.The growth of E.coli BL21 cells expressing ScCaM showed weaker tolerance under mannitol and NaCl stress.Taken together,this study revealed that the ScCaM gene plays a negative regulatory role in both mannitol and NaCl stresses,and it possibly exerts protective mechanisms common in both prokaryotes and eukaryotes under stress conditions. | JINXIAN LIU JINGFANG FENG CHANG ZHANG YONGJUAN REN WEIHUA SU GUANGHENG WU XIANYU FU NING HUANG YOUXIONG QUE HUI LING JUN LUO | 2023 | BIOCELL2023，47，1： | 0 |
| 20 | Self-assembled TiO_(2)hole-blocking layers for efficient perovskite solar cells显示文摘The self-assembly process for compatible functional layers of devices is a simple,feasible,and energy-saving strategy.In mesoporous perovskite solar cells(PSCs),compact and scaffold TiO_(2) films generally function as the hole-blocking and electron-transporting layers,respectively.However,both of these layers are usually generated through a high-temperature annealing process.Here,we deposited TiO_(2) compact films through a room-temperature self-assembly process as effective hole-blocking layers for PSCs.The thickness of TiO_(2) compact films can be easily controlled by the deposition time.Through the optimization of TiO_(2) compact films(80 nm),the power conversion efficiency(PCE)of mesoporous PSCs without and with hole conductor layers increases up to 10.66%and 17.95%,respectively.Notably,an all-low-temperature planar PSC with the self-assembled TiO_(2) layer exhibits a PCE of 16.41%. | Zhongbao Que Liang Chu Shuaibo Zhai Yifei Feng Chen Chen Wei Liu Ruiyuan Hu Jing Hu Xing’ao Li | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，6： | 0 |
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