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| 1 | Late Pleistocene glaciation of the Hulifang Massif of Gongwang mountains in Yunnan Province显示文摘Late Pleistocene glaciation was restricted to only a few high mountains in eastern China. The Gongwang mountainsconstitute one ofthe typicalplacesonce glaciated.Geomorphic mapping of the area and the TL dating provides evidence for at least four distinct glaciations. YJT-I glacial advance occurred about100 ka BP and two TL absolute ages(101,100 ±7780 a BP;104,000±8300 a BP)indicate thisadvance happened during the Penultimale Glaciation.The early stage glacialadvance (YJT-II advance) during the last glaciation occurred about 40,920±3400 a BP. The last glacial maximum advance (YJT-IIIadvance)about18-25 ka BP,which sustained by two TL ages(18,230 ± 1420 a BP;25,420 ±2110 a BP).The Penultimale and the early stage glaciationswere more extensive and the lastglacialmaximum (LGM )and the late-glacialperiod (YJT-IV advance,10 ka BP) were progressively less extensive. Correlated with the other mountains in eastern China, these glacial advances in the Gongwang mountains justlike the advances in the western partsuch as Diancang mountains,Yulong mountains ofYunnan Province and the glacierseries are more complete than the adjacent mid-latitude regions such as Taibai mountain and Taiwan mountains and are roughly representativeofclimatechangesduring thelastglacialcyclein Yunnan Province. | ZHANG Wei CUI Zhijiu FENG Jinliag YI Chaolu YA NG Jianqiang | 2005 | Journal of Geographical Sciences2005，15，4： | 13 |
| 2 | A new prognostic histopathologic classification of nasopharyngeal carcinoma显示文摘Background:The current World Health Organization(WHO) classification of nasopharyngeal carcinoma(NPC) con?veys little prognostic information.This study aimed to propose an NPC histopathologic classification that can poten?tially be used to predict prognosis and treatment response.Methods:We initially developed a histopathologic classification based on the morphologic traits and cell differentia?tion of tumors of 2716 NPC patients who were identified at Sun Yat?sen University Cancer Center(SYSUCC)(training cohort).Then,the proposed classification was applied to 1702 patients(retrospective validation cohort) from hospitals outside SYSUCC and 1613 patients(prospective validation cohort) from SYSUCC.The efficacy of radiochemotherapy and radiotherapy modalities was compared between the proposed subtypes.We used Cox proportional hazards models to estimate hazard ratios(HRs) with 95% confidence intervals(CI) for overall survival(OS).Results:The 5?year OS rates for all NPC patients who were diagnosed with epithelial carcinoma(EC;3708 patients),mixed sarcomatoid?epithelial carcinoma(MSEC;1247 patients),sarcomatoid carcinoma(SC;823 patients),and squamous cell carcinoma(SCC;253 patients) were 79.4%,70.5%,59.6%,and 42.6%,respectively(P < 0.001).In mul?tivariate models,patients with MSEC had a shorter OS than patients with EC(HR = 1.44,95% CI = 1.27–1.62),SC(HR = 2.00,95% CI = 1.76–2.28),or SCC(HR = 4.23,95% CI = 3.34–5.38).Radiochemotherapy significantly improved survival compared with radiotherapy alone for patients with EC(HR 49–0.75),and possibly for those with SCC(HR = 0.67,95% CI = 0.56–0.80),MSEC(HR = 0.58,95% CI = 0..74–1.28).= 0.63;95% CI = 0.40–0.98),but not for patients with SC(HR = 0.97,95% CI = 0Conclusions:The proposed classification offers more information for the prediction of NPC prognosis compared with the WHO classification and might be a valuable tool to guide treatment decisions for subtypes that are associ?ated with a poor prognosis. | Hai-Yun Wang Yih-Leong Chang Ka-Fai To Jacqueline S.G.Hwang Hai-Qiang Mai Yan-Fen Feng Ellen T.Chang Chen-Ping Wang Michael Koon Ming Kam Shie-Lee Cheah Ming Lee Li Gao Hui-Zhong Zhang Jie-Hua He Hao Jiang Pei-Qing Ma Xiao-Dong Zhu Liang Zeng Chun-Yan Chen Gang Chen Ma-Yan Huang Sha Fu Qiong Shao An-Jia Han Hai-Gang Li Chun-Kui Shao Pei-Yu Huang Chao-Nan Qian Tai-Xiang Lu Jin-Tian Li Weimin Ye Ingemar Ernberg Ho Keung Ng Joseph T.S.Wee Yi-Xin Zeng Hans-Olov Adami Anthony T.C.Chan Jian-Yong Shao | 2016 | Chinese Journal of Cancer2016，35，6： | 10 |
| 3 | Telomere-dependent and telomereindependent roles of RAP1 in regulating human stem cell homeostasis显示文摘RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclea匚 Here we generated RAP1 -deficient human embryonic stem cells (hESCs) by using CRISPR/Cas9 technique and obtained RAP1-deficient human mesenchymal stem cells (hMSCs) and neural stem cells (hNSCs) via directed differentiation. In both hMSCs and hNSCs, RAP1 not only negatively regulated telomere length but also acted as a transcriptional regulator of RELN by tuning the methylation status of its gene promoter. RAP1 deficiency enhanced self-renewal and delayed senescence in hMSCs, but not in hNSCs, suggesting complicated lineage-specific effects of RAP1 in adult stem cells.Altogether, these results demonstrate for the first time that RAP1 plays both telomeric and nontelomeric roles in regulating human stem cell homeostasis. | Xing Zhang Zunpeng Liu Xiaoqian Liu Si Wang Yiyuan Zhang Xiaojuan He Shuhui Sun Shuai Ma Ng Shyh-Chang Feng Liu Qiang Wang Xiaoqun Wang Lin Liu Weiqi Zhang Moshi Song Guang-Hui Liu Jing Qu | 2019 | Protein & Cell2019，10，9： | 7 |
| 4 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 5 | A NOVEL CAPACITY ANALYZING METHOD FOR MULTIMEDIA CDMA SYSTEMS BASED ON POWER LEVEL ALLOCATION显示文摘A novel method is proposed to analyze the capacity of future Code Division Multiple Access (CDMA) systems carrying multimedia services. The power level allocation is firstly investigated to meet each call’s Bit Error Rate (BER) requirement, then the system capacity is defined from the conditions for the exis-tence of the physical meaning of these power levels. Simulation results have shown that the capacity analyzing methods can be well used in the performance evaluation of the system accommodating heterogeneous services and the spectral efficiency of this scheme is higher than the existing ones. | Pan Su Tung Sang Ng Feng Guangzeng | 2006 | Journal of Electronics(China)2006，23，6： | 5 |
| 6 | Alkali and Silane Treatments towards Exemplary Mechanical Properties of Kenaf and Pineapple Leaf Fibre-reinforced Composites显示文摘Following the contemporary research trend of exploring the potential of eco-friendly natural fibres,this work studies the effects of alkali and silane treatments,with varying concentrations,on the mechanical characterization of composites reinforced with kenaf and pineapple leaf fibre(PALF).Kenaf-and PALF-based composites were fabricated through the heat compression method.Their mechanical characterization was then performed to evaluate the tensile,flexural and impact properties.The findings concluded that chemical treatments indeed enhanced the mechanical properties of composite materials.5%NaOH and 3%silane treatments can respectively provide the optimum mechanical properties to the kenaf fibre and PALF reinforced composites.Chemical treatment results evidenced that silane-treated composites exhibit higher mechanical properties compared to the NaOH-treated composites.When comparing the mechanical properties of kenaf-and PALF-reinforced polypropylene composites,the overall results show that composites based on PALF have superior mechanical properties. | Ng Lin Feng Sivakumar Dhar Malingam Nadlene Razali Sivarao Subramonian | 2020 | Journal of Bionic Engineering2020，17，2： | 3 |
| 7 | 2D materials for conducting holes from grain boundaries in perovskite solar cells显示文摘Grain boundaries in organic-inorganic halide perovskite solar cells(PSCs)have been found to be detrimental to the photovoltaic performance of devices.Here,we develop a unique approach to overcome this problem by modifying the edges of perovskite grain boundaries with flakes of high-mobility two-dimensional(2D)materials via a convenient solution process.A synergistic effect between the 2D flakes and perovskite grain boundaries is observed for the first time,which can significantly enhance the performance of PSCs.We find that the 2D flakes can conduct holes from the grain boundaries to the hole transport layers in PSCs,thereby making hole channels in the grain boundaries of the devices.Hence,2D flakes with high carrier mobilities and short distances to grain boundaries can induce a more pronounced performance enhancement of the devices.This work presents a cost-effective strategy for improving the performance of PSCs by using high-mobility 2D materials. | Peng You Guanqi Tang Jiupeng Cao Dong Shen Tsz-Wai Ng Zafer Hawash Naixiang Wang Chun-Ki Liu Wei Lu Qidong Tai Yabing Qi Chun-Sing Lee Feng Yan | 2021 | Light(Science & Applications)2021，10，4： | 3 |
| 8 | FeCo alloy@N-doped graphitized carbon as an efficient cocatalyst for enhanced photocatalytic H2 evolution by inducing accelerated charge transfer显示文摘Cocatalysts play important roles in improving the activity and stability of most photocatalysts.It is of great significance to develop economical,efficient and stable cocatalysts.Herein,using Na2CoFe(CN)6 complex as precursor,a novel noble-metal-free FeCo@NGC cocatalyst(nano-FeCo alloy@N-doped graphitized carbon) is fabricated by a simple pyrolysis method.Coupling with g-C3 N4, the optimal FeCo@NGC/g-C3N4 receives a boosted visible light driven photocatalytic H2 evolution rate of 42.2 μmol h-1, which is even higher than that of 1.0 wt% Pt modified g-C3N4 photocatalyst.Based on the results of density functional theory(DFT) calculations and practical experiment measurements,such outstanding photocatalytic performance of FeCo@NGC/g-C3N4 is mainly attributed to two aspects.One is the accelerated charge transfer behavior,induced by a photogene rated electrons secondary transfer performance on the surface of FeCo alloy nanoparticles.The other is related to the adjustment of H adsorption energy(approaching the standard hydrogen electrode potential) by the presence of external NGC thin layer.Both factors play key roles in the H2 evolution reaction.Such outstanding performance highlights an enormous potential of developing noble-metal-free bimetallic nano-alloy as inexpensive and efficient cocatalysts for solar applications. | Sibo Chen Yun Hau Ng Jihai Liao Qiongzhi Gao Siyuan Yang Feng Peng Xinhua Zhong Yueping Fang Shengsen Zhang | 2021 | Journal of Energy Chemistry2021，30，1： | 3 |
| 9 | Poststroke DNA immunization against neurite growth inhibitors is beneficial to the recovery from local cerebral ischemia in rats显示文摘BACKGROUND: Inhibitory signals, i.e. neurite growth inhibitors (NGIs), presenting on central nervous system (CNS) myelin have been shown to play a crucial role in inhibiting lesioned axonal sprouting and leading to less functional recovery. Vaccines targeting NGIs may provide multifactorial protection against brain insults by overcoming the inhibitory effects of these NGIs and boosting the body's immune repair mechanisms. OBJECTIVE: To evaluate the effect of poststroke DNA immunization against NGIs on the rehabilitation for sensorimotor function of rat models of local cerebral ischemia. DESIGN: Completely randomized grouping design, and controlled experiment. SETTING: Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, Singapore. MATERIALS: Sixty adult male Sprague-Dawley rats ranging in age from 45 to 120 days and in weight from 180 to 250 grams were provided by Animal Center of Department of Anatomy, Faculty of Medicine, National University of Singapore. pcDNA3.1(+)-neurite growth inhibitors (pcDNA-NGIs) a gift was provided by Dr. Xiao from Department of Clinical Research, Singapore General Hospital, Singapore. METHODS: The experiment was carried out at Brain Injury Research Laboratory, Department of Neurosurgery, National Neuroscience Institute, Singapore from August 2003 to April 2005. ①The involved rats were randomized into 3 groups: pcDNA-NGIs group (group A), pcDNA3.1 (+) group (group B) and model group (group C), with 20 rats in each group. Left focal cerebral ischemia (FCI) was permanently induced through middle cerebral artery occlusion (MCAO) with the assistance of an operating microscope. Successful MCAO was determined by a 20% decrease to baseline in the ipsilateral cerebral blood flow. 100 μg of pcDNA-NGIs eluted in phosphate-buffered saline (PBS) was intramuscularly injected into the tibial muscle once a week after MCAO for 6 weeks in group A. As control, pcDNA3.1 (+) was also administrated in the same way in group B and nothing was administrated in group C. ② The modified neurological severity score (mNSS), a composite of motor, sensory, reflex and balance tests, was used to test the sensorimotor deficit. The mNSS was graded on a scale of 0–18, i.e. normal score was 0, maximal deficit score was 18, and 1 point was warded for the inability to perform the tasks or the lack of a tested reflex. ③ The newly generated axons of corticorubral projection were traced by stereotaxic guided injection of 100 g/L biotinylated dextran amine. Rats were sacrificed two weeks after tracing, and cryostat coronal sections of midbrains (30 μm) were reacted to BDA according to the manufacturer's instruction by the free-floating method. Images were captured on a DM RXA2 LEICA Microscope with a Spot Digital Camera system (Germany), and the numbers of labeled axons on the denervated side in four standard coronal sections including the red nucleus were manually quantified. MAIN OUTCOME MEASURES: ① The number of newly generated axons of corticorubral projection. ②The improvement in sensorimotor deficit. RESULTS: All the involved 60 rats entered the stage of final analysis. ① The number of newly generated axons of corticorubral projection of rats: Only ipsilateral axons of CRP were noted with little evidence of fibers crossing to the contralateral red nucleus in rats of groups B and C. More BDA-positive fibers crossing the midline and terminating in the contralateral red nucleus in appropriate target areas mirroring thenon-differentiated red nucleus were found in rats of group A. Quantitative analysis showed that BDA-labeled axons in the denervated side of rats in group A were more than those in group B (P < 0.05). ② Improvement in sensorimotor deficit of rats: At 2 weeks after immunization, significant improvement in sensorimotor deficit was found in rats of group A. There were significant differences of improvement in sensorimotor deficit of rats between group A and group B or group C at 12 and 14 weeks after immunization (P < 0.05). CONCLUSION: ① Poststroke DNA immunization against NGIs leads to increased sensorimotor recovery following FCI and compensatory newly growth of axons from corticorubral projection. | Xingbao Zhu Jasmine Lee Jill Wong Wan Loo Tan Zhongtang Feng Tinghua Wang Zhicheng Xiao Ivan Ng | 2007 | Neural Regeneration Research2007，2，2： | 3 |
| 10 | Hepatitis B virus X protein promotes hepatocellular carcinoma transformation through interleukin-6 activation of microRNA-21 expression显示文摘 | Chi Han Li Feiyue Xu Sheungching Chow Lu Feng Deling Yin Tzi Bun Ng Yangchao Chen | 2014 | European Journal of Cancer2014，，15： | 2 |
| 11 | In situ kinetic studies of microemulsion polymerizations of styrene and methacrylate by raman spectroscopy 显示文摘 | FENG L NG K Y S | 1990 | Macromolecules1990，23，4： | 1 |
| 12 | A Practical Simple Geometry and Gain/Phase Calibration Technique for An- tenna Array Processing显示文摘 | Ng B P Lie J P Er M H Feng A | 2009 | IEEE Transactions on Anten- nas and Propagation2009，57，7： | 1 |
| 13 | Effects of polymer, organic solvent and mixing strength on integrity of proteins and liposomes encapsulated in polymeric mlcrospheres fabricated by the double emulsion process显示文摘 | RUAN G NG JK FENG SS | 2004 | J Microencapsul2004，21，4： | 1 |
| 14 | Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sj:gren's syndrome 显示文摘 | Xiao L Ng T B Feng Y B | 2011 | Phytomedicine2011，15，18： | 1 |
| 15 | The MADlib analytics library:or MAD skills,the SQL显示文摘 | Hellerstein JM Ré C Schoppmann F Wang DZ Fratkin E Gorajek A Ng KS Welton C Feng X Li K Kumar A | | 0，，12： | 1 |
| 16 | Dendrobium candidum extract increases the expression of aquaporin-5 in labial glands from patients with Sjgren's syndrome显示文摘 | Xiao L Ng TB Feng YB | 2011 | Phytomedicine2011，18，23： | 1 |
| 17 | Tradeoffs Among Free-Flow Speed, Capacity, Cost, and Environmental Footprint in Highway Design显示文摘 | Chen Feng Ng Kenneth A Small | 2012 | Transportation2012，39，6： | 1 |
| 18 | Bis {N - 显示文摘 | Feng Bao Juan Feng and SeikWeng Ng | 2005 | Acta Cryst E2005，，： | 1 |
| 19 | Bis {5 - methyl - 2 - phenyl - 4 - - 1H - pyrazol - 3 (4H) - onatojO} cobalt(Ⅱ) 显示文摘 | Feng Bao Yuan - Hong Jiao SeikWeng Ng | 2006 | Acta Cryst E2006，6，： | 1 |
| 20 | Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain显示文摘 | Feng Q Wang H Ng HH | 2002 | Curr Bioi2002，12，12： | 1 |
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