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| 1 | Cardiovascular autonomic neuropathy in diabetes:Pathophysiology,clinical assessment and implications显示文摘Cardiovascular autonomic neuropathy(CAN)is a debilitating condition that mainly occurs in long-standing type 2 diabetes patients but can manifest earlier,even before diabetes is diagnosed.CAN is a microvascular complication that results from lesions of the sympathetic and parasympathetic nerve fibers,which innervate the heart and blood vessels and promote alterations in cardiovascular autonomic control.The entire mechanism is still not elucidated,but several aspects of the pathophysiology of CAN have already been described,such as the production of advanced glycation end products,reactive oxygen species,nuclear factor kappa B,and pro-inflammatory cytokines.This microvascular complication is an important risk factor for silent myocardial ischemia,chronic kidney disease,myocardial dysfunction,major cardiovascular events,cardiac arrhythmias,and sudden death.It has also been suggested that,compared to other traditional cardiovascular risk factors,CAN progression may have a greater impact on cardiovascular disease development.However,CAN might be subclinical for several years,and a late diagnosis increases the mortality risk.The duration of the transition period from the subclinical to clinical stage remains unknown,but the progression of CAN is associated with a poor prognosis.Several tests can be used for CAN diagnosis,such as heart rate variability(HRV),cardiovascular autonomic reflex tests,and myocardial scintigraphy.Currently,it has already been described that CAN could be detected even during the subclinical stage through a reduction in HRV,which is a non-invasive test with a lower operating cost.Therefore,considering that diabetes mellitus is a global epidemic and that diabetic neuropathy is the most common chronic complication of diabetes,the early identification and treatment of CAN could be a key point to mitigate the morbidity and mortality associated with this long-lasting condition. | Alice Duque Mauro Felippe Felix Mediano Andrea De Lorenzo Luiz Fernando Rodrigues Jr | 2021 | World Journal of Diabetes2021，12，6： | 14 |
| 2 | Reestablishing biologicwidth with forced eruption显示文摘 | Felippe L A Monteiro S Jr Vieira L C | 2003 | Quintessence Int2003，34，10： | 1 |
| 3 | Effect of tempera- ture and storage media on human periodontal ligament fibroblast vi- ability 显示文摘 | Souza BD L0ckemeyer DD Felippe WT | 2010 | Dent Traumatol2010，26，3： | 1 |
| 4 | Negative regulation of anthocyanin biosynthesis in Arabidopsis by a miR156-targeted SPL transcription factor显示文摘 | Gou J Y Felippes F F Liu C J | | 0，，04： | 1 |
| 5 | Mixed formulation of bond-slip problems under cyclic loads显示文摘 | Ayoub A Felippou F C | 1999 | J Struct Eng1999，125，6： | 1 |
| 6 | MIGS:miRNA induced gene silencing显示文摘 | FELIPPES FF WANG JW WEIGEL D | | 0，，03： | 1 |
| 7 | Comparative analysis of non-autonomous effects of tasiRNAs and miRNAs in Arabidopsis thaliana显示文摘 | de Felippes FF Ott F Weigel D | 2011 | Nucleic Acids Research2011，39，： | 1 |
| 8 | The effect of applica- tion time of EDTA and NaOCI on intracanal smear layer re- moval: an SEM analysis 显示文摘 | Teixeira CS Felippe MC Felippe WT | 2005 | Int Endod J2005，38，： | 1 |
| 9 | Surgical site in- fection among women discharged with a drain in situ after breast cancer surgery显示文摘 | Felippe WA Werneck GL Santoro-Lopes G | 2007 | World J Surg2007，31，12： | 1 |
| 10 | Effect of temperature and storage media on human periodontal ligament fibroblast viability显示文摘 | Souza BD Ltickemeyer DD Felippe WT | 2010 | Dent Traumatol2010，26，3： | 1 |
| 11 | Trypanoeidal tet- rahydrofuran lignans from Peperomia blanda 显示文摘 | Felippe L G Baldoqui D C Kato M J | 2008 | Phytochemis- try2008，69，2： | 1 |
| 12 | Stevia re b audiana, a review显示文摘 | GM Felippe | 1978 | Journal of Chromatography1978，161，： | 1 |
| 13 | Administration of a murine diet supplemented with conjugated linoleic acid increases the expression and activity of hepatic uncoupling proteins显示文摘 | Amanda Pereira Larissa Sá Felippe Reis Fernanda Cardoso Rosana Alberici Ieda Prado Marcos Eberlin Sergio Uyemura Carlos Curti Luciane Alberici | 2012 | Journal of Bioenergetics and Biomembranes2012，，5： | 1 |
| 14 | Interfacial evaluation of experimentally weakened roots restored with adhesive materials and fibre posts:An SEM analysis显示文摘 | da Silveira Teixeira C Santos Felippe MC Silva-Sousa YT | 2008 | J Dent2008，36，9： | 1 |
| 15 | Effect of tempera- ture and storage media on human periodontal ligament fibroblast vi- ability 显示文摘 | Souza BD Luckemeyer DD Felippe WT | 2010 | Dent Traumatol2010，26，3： | 1 |
| 16 | The effect of the renewal of calcium hydroxide paste on the apexification and periapical healing of teeth with incomplete root formation显示文摘 | Felippe MC Felippe WT Marques MM | 2005 | Int Endod J2005，38，7： | 1 |
| 17 | Natural compounds isolated from Brazilian plants are potent inhibitors of hepatitis C virus replication in vitro显示文摘 | A.C.G. Jardim Z. Igloi J.F. Shimizu V.A.F.F.M. Santos L.G. Felippe B.F. Mazzeu Y. Amako M. Furlan M. Harris P. Rahal | 2015 | Antiviral Research2015，，： | 1 |
| 18 | Negative regulation of an-thocyanin biosynthesis in arabidopsis by a mirl56-targeted spltranscription factor显示文摘 | Gou JY Felippes FF Liu CJ | 2011 | The Plant Cell2011，23，4： | 1 |
| 19 | Evolution of Arabidopsis thaliana micro RNAs from random sequences显示文摘 | Felippes F F Schneeberger K Dezulian T | 2008 | Rna2008，14，12： | 1 |
| 20 | Interfacial evaluation of experi-mentally weakened roots restored with adhesive materialsand fibre posts :an SEM analysis 显示文摘 | DA SILVEIRA TEIXEIRA C SANTOS FELIPPE M C SILVA-SOUSA Y T | 2008 | Journal of dentist-ry2008，36，9： | 1 |
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