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| 1 | Naringenin reduces lung metastasis in a breast cancer resection model显示文摘Metastasis is the main cause of death in cancer patients. To improve the outcomes of patients undergoing a surgery, new adjuvant therapies that can effectively inhibit metastases have to be developed. Studies have shown that flavonoid naringenin, a natural product that is mainly present in grapes and citrus, may contribute to cancer prevention. It has many advantages compared to traditional chemotherapeutic drugs, such as low toxicity. To determine whether naringenin can also inhibit metastases, a breast cancer resection model that mimics clinical situations was established. We found that orally administered naringenin significantly decreased the number of metastatic tumor cells in the lung and extended the life span of tumor resected mice. Flow cytometry analysis revealed that T cells displayed enhanced antitumor activity in naringenin treated mice, with an increased proportion of IFN-γ and IL-2 expressing T cells. In vitro studies further demonstrated that relief of immunosuppression caused by regulatory T cells might be the fundamental mechanism of metastasis inhibition by naringenin. These results indicate that orally administered naringenin can inhibit the outgrowth of metastases after surgery via regulating host immunity. Thus, naringenin can be an ideal surgical adjuvant therapy for breast cancer patients. | Lei Qin Lingtao Jin Linlin Lu Xiaoyan Lu Chunling Zhang Fayun Zhang Wei Liang | 2011 | Protein & Cell2011，2，6： | 12 |
| 2 | Chrysin promotes osteogenic differentiation via ERK/MAPK activation显示文摘T he effect of the anti-infl ammatory fl avonoid chrysin on osteogenesis was determined in preosteoblast MC3T3-E1 cells.Results demonstrated that chrysin could induce osteogenic differentiation in the absence of other osteo-genic agents.Chrysin treatment promoted the expres-sion of transcription factors(Runx2 and Osx)and bone formation marker genes(Col1A1,OCN,and OPN)as well as enhanced the formation of mineralized nodules.During osteogenic differentiation,chrysin preferentially activated ERK1/2,but not JNK nor the p38 MAPKs.Further experi-ments with inhibitors revealed the co-treatment of U0126,PD98059,or ICI182780(a general ER antagonist)with chrysin effectively abrogated the chrysin-induced osteo-genesis and ERK1/2 activation.Thus,the effect of chrysin on osteogenesis is ERK1/2-dependent and involves ER.Therefore,chrysin has the signifi cant potential to enhance osteogenesis for osteoporosis prevention and treatment. | Wenfeng Zeng Yan Yan Fayun Zhang Chunling Zhang Wei Liang | 2013 | Protein & Cell2013，4，7： | 8 |
| 3 | Accuracy of three-dimensional seismic ground response analysis in time domain using nonlinear numerical simulations显示文摘To provide appropriate uses of nonlinear ground response analysis for engineering practice, a three-dimensional soil column with a distributed mass system and a time domain numerical analysis were implemented on the Open Sees simulation platform. The standard mesh of a three-dimensional soil column was suggested to be satisfied with the specified maximum frequency. The layered soil column was divided into multiple sub-soils with a different viscous damping matrix according to the shear velocities as the soil properties were significantly different. It was necessary to use a combination of other one-dimensional or three-dimensional nonlinear seismic ground analysis programs to confirm the applicability of nonlinear seismic ground motion response analysis procedures in soft soil or for strong earthquakes. The accuracy of the three-dimensional soil column finite element method was verified by dynamic centrifuge model testing under different peak accelerations of the earthquake. As a result, nonlinear seismic ground motion response analysis procedures were improved in this study. The accuracy and efficiency of the three-dimensional seismic ground response analysis can be adapted to the requirements of engineering practice. | Liang Fayun Chen Haibing Huang Maosong | 2017 | Earthquake Engineering and Engineering Vibration2017，16，3： | 6 |
| 4 | Vitamin C induces periodontal ligament progenitor cell differentiation via activation of ERK pathway mediated by PELP1显示文摘The differentiation of periodontal ligament(PDL)progenitor cells is important for maintaining the homeostasis of PDL tissue and alveolar bone.Vitamin C(VC),a water-soluble nutrient that cannot be biosynthesized by humans,is vital for mesenchymal stem cells differentiation and plays an important role in bone remodeling.Therefore,the objective of this study was to determine the function and mechanism of VC in PDL progenitor cells osteogenic differentiation at the molecular level.We demonstrated that VC could induce the osteogenic differentiation and maturation of PDL progenitor cell without other osteogenic agents.During the process,VC preferentially activated ERK1/2 but did not affect JNK or p38.Co-treatment with ERK inhibitor effectively decreased the Vitamin C-induced expression of Runx2.ERK inhibitor also abrogated Vitamin C-induced the minimized nodules formation.PELP1,a nuclear receptor co-regulator,was up-regulated under VC treatment.PELP1 knockdown inhibited ERK phosphorylation.The overexpression of PELP1 had a positive relationship with Runx2 expression.Taken together,we could make a conclude that VC induces the osteogenic differentiation of PDL progenitor cells via PELP1-ERK axis.Our fi nding implies that VC may have a potential in the regeneration medicine and application to periodontitis treatment. | Yan Yan Wenfeng Zeng Shujun Song Fayun Zhang Wenxi He Wei Liang Zhongying Niu | 2013 | Protein & Cell2013，4，8： | 6 |
| 5 | Carrier dynamic overlapping switching frequency optimal pulse width modulation method for modular multilevel converters显示文摘Modular multilevel converters(MMCs) operate in the low modulation index region in many applications.However, when utilized at the low modulation index region, large harmonics appear in the output voltage, which degrade the performance of the MMC. To improve the harmonic characteristic in the low modulation index, the carrier dynamic overlapping switching frequency optimal pulse width modulation(CDOSFOPWM) method is proposed for the MMC here. The whole modulation index region is divided into three regions: high modulation index region, middle modulation index region, and low modulation index region. The carrier amplitude, carrier overlap ratio, and frequency of triangular carriers are chosen dynamically according to the modulation index region of the modulation signals, to achieve the optimal harmonic characteristic in the whole modulation index region and maintain the switching loss. The number of on-state submodules(SMs) can be calculated by CDOSFOPWM, and the selection of SMs is performed by a reducing switching frequency voltage balancing algorithm. Finally, the proposed method is verified by simulation and experimental results. | Fayun ZHOU Qianming XU An LUO Zhixing HE Yan LI Ning XIE Yichao WANG | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，6： | 5 |
| 6 | 3D macropore carbon-vacancy g-C_(3)N_(4) constructed using polymethylmethacrylate spheres for enhanced photocatalytic H_(2) evolution and CO_(2) reduction显示文摘Metal-free g-C_3N_4 is widely used in photocatalytic reactions owing to its suitable band structure.However, it has low specific surface area and insufficient absorbance for visible light, and its photoexcited carriers have high recombination rates. In this study, the 3 D macropore C-vacancy g-C_3N_4 was prepared through a facile one-step route. Polymethylmethacrylate is used as a template to increase the surface reaction sites of g-C_3N_4 and extend its visible-light range. Compared to unmodified g-C_3N_4, the H2 production and CO_2 reduction rates of the fabricated g-C_3N_4 significantly improved. The special pore structure significantly improved the light utilization efficiency of g-C_3N_4 and increased the number of surface-active sites. The introduction of C-vacancy extended the absorption band of visible-light and suppressed the carrier recombination. The newly developed synthesis strategy can improve solar energy conversion efficiency and potentially modifies g-C_3N_4. | Xuewen Wang Qjuchan Li Lei Gan Xinfei Ji Fayun Chen Xinke Peng Rongbin Zhang | 2021 | Journal of Energy Chemistry2021，30，2： | 3 |
| 7 | Influences of Thermal Martensites and Grain Orientations on Strain-induced Martensites in High Manganese TRIP/TWIP Steels显示文摘Strain-induced martensites in high manganese TRIP/TWIP steels were investigated in the presence of thermal martensites and under the influence of austenitic grain orientation by X-ray diffraction(XRD),scanning electron microscopy(SEM) and electron backscattered diffraction(EBSD).Before deformation,the morphology of α'-M depended mainly on the number of variants and growing period.Regardless of martensite morphologies and deformation,the Kurdjumov-Sachs(K-S) orientation relationships always maintained.The 6 α-M variants formed from a plate of ε-M were of 3 pairs of twins with a common axis <110> α' parallel to the normal of {111} γ habit plane to minimize transformation strain.When α'-M could be formed only by deformation,it nucleated at the intersection of ε-M variants and grew mainly in thick ε-M plates.Thick ε plates promoted significantly the α'-M and weakened the influence of grain orientations.During tension,the transformation in <100>-oriented grains was observed to be slower than that in <111>-oriented grains.Deformation twins promoted ε-M formation slightly and had no apparent effect on α'-M.Deformation increased the number of ε-M variants,but reduced that of α'-M variants. | Fayun Lu Ping Yang Li Meng Fenge Cui Hua Ding | 2011 | Journal of Materials Science & Technology2011，27，3： | 3 |
| 8 | Contamination, chemical speciation and vertical distribution of heavy metals in soils of an old and large industrial zone in Northeast China显示文摘 | Fayun Li Zhiping Fan Pengfei Xiao Kokyo Oh Xiping Ma Wei Hou | 2009 | Environmental Geology2009，，8： | 2 |
| 9 | Simplified Boundary Element Method for Kinematic Response of Single Piles in Two-Layer Soil显示文摘 | Fayun Liang Haibing Chen Wei Dong Guo Ga Zhang | 2013 | Journal of Applied Mathematics2013，，： | 1 |
| 10 | Group interaction on vertically loaded piles in saturated poroelastic soil显示文摘 | Fayun Liang Zhu Song Wei Dong Guo | 2014 | Computers and Geotechnics2014，，： | 1 |
| 11 | Integral equation method for analysis of piled rafts with dissimilar piles under vertical loading显示文摘 | Fayun Liang Longzhu Chen Jie Han | 2008 | Computers and Geotechnics2008，，3： | 1 |
| 12 | Entropy-Based Global and Local Weight Adaptive Image Segmentation Models显示文摘This paper proposes a parameter adaptive hybrid model for image segmentation. The hybrid model combines the global and local information in an image, and provides an automated solution for adjusting the selection of the two weight parameters. Firstly, it combines an improved local model with the global Chan-Vese(CV) model, while the image’s local entropy is used to establish the index for measuring the image’s gray-level information. Parameter adjustment is then performed by the real-time acquisition of the ratio of the different functional energy in a self-adapting model responsive to gray-scale distribution in the image segmentation process.Compared with the traditional linear adjustment model, which is based on trial-and-error, this paper presents a more quantitative and intelligent method for achieving the dynamic nonlinear adjustment of global and local terms.Experiments show that the proposed model achieves fast and accurate segmentation for different types of noisy and non-uniform grayscale images and noise images. Moreover, the method demonstrates high stability and is insensitive to the position of the initial contour. | Gang Li Yi Zhao Ling Zhang Xingwei Wang Yueqin Zhang Fayun Guo | 2020 | Tsinghua Science and Technology2020，25，1： | 1 |
| 13 | Numerical analysis of composite piled raft with cushion subjected to vertical load显示文摘 | Liang Fayun Chen Longzhu Shi Xuguang | 2003 | Computers and Geotechnics2003，30，： | 1 |
| 14 | Methodologies for the establishment of an orthotopic transplantation model of ovarian cancer in mice显示文摘这研究使用了不同方法建立 orthotopic 移植的一个动物模型让卵巢的癌症提供肿瘤在人的身体由发生并且发展的机制的精确模拟。我们由使用 orthotopic 移植方法论的三种类型与酶植入 4T1 乳癌房间 stably-transfected 进 BALB/c 老鼠:(1 ) 有教养的房间直接被注入老鼠卵巢;(2 ) 房间暂停开始在老鼠颈的皮肤下面被植入;在形成的肿瘤质量以后,肿瘤被移开并且磨擦了进房间暂停,它然后被注入老鼠卵巢;并且(3 ) 一个下的肿瘤团是首先产生了,移开,并且切了进小片,它直接被植入进老鼠卵巢。在这些模型被建立以后,在 vivo,光成像被执行。结果和数据在组之中被比较。与下的肿瘤片培植建立的 Orthotopic 移植模型在老鼠显示出肿瘤开发和侵略的更好的模拟。这个模型也显示了可以忽略的反应到人工的因素。这研究成功地由使用下的肿瘤片与肿瘤形成和转移的高率建立了卵巢的癌症的一个 orthotopic 移植模型。这研究也在人为卵巢的癌症的一个动物模型的未来建立提供了一个方法学的基础。 | Cunjian Yi Lei Zhang Fayun Zhang Li Li Shengrong Ling Xiaowen Wang Xiangqiong Liu Wei Liang | 2014 | Frontiers of Medicine2014，8，1： | 1 |
| 15 | Gd_(2)O_(3) nanoparticles modified g-C_(3)N_(4) with enhanced photocatalysis activity for degradation of organic pollutants显示文摘Gd_(2) O_(3) nanoparticles modified g-C_(3) N_(4) photocatalytic composites were synthesized by a simple one-step hydrothermal method.The structure,morphology,optical properties of the prepared photocatalyst were characterized by X-ray diffraction(XRD),field emission scanning electron microscopy(FESEM),field emission transmission electron microscopy(FETEM) and X-ray photoelectron spectroscopy(XPS).The result demonstrates that gadolinium is mainly dispersed on the surface of g-C_(3) N_(4) in the form of Gd_(2) O_(3),and does not destroy the lattice structure of g-C_(3) N_(4).Besides,the gadolinium can cause the red shift of the absorption edge of light,narrow the band gap,and increase the separation efficiency of the photogenerated electron and hole of g-C_(3) N_(4).Especially,the specific surface area of g-C_(3) N_(4) can be significantly increased.Furthermore,g-C_(3) N_(4)/Gd-0.05 displays the highest photodegradation performance when it is used for degradation of methyl orange(MO),methylene blue(MB) and Rhodamine B(RhB).The photodegradation rate of g-C_(3) N_(4)/Gd-0.05 composites is 72.4% for MO,95.5% for RhB,100% for MB after120 min under visible light(λ> 420 nm) irradiation.Narrow band gap promotes the separation of photogenerated electron and hole,which enhances the photocatalytic activity of g-C_(3) N_(4).It is noted that g-C_(3) N_(4)/Gd-0.05 exhibits excellent photocatalytic stability by the photocurrent and the cyclic photodegradation of MO. | Yipeng Zhou Fanshan Zeng Chaoyang Sun Jun Wu Yu Xie Fayun Zhang Senlin Rao Fahui Wang Jinbing Zhang Jinsheng Zhao Shiqian Li | 2021 | Journal of Rare Earths2021，39，11： | 1 |
| 16 | Hydroxyl radical generation and oxidative stress in Carassius auratus liver as affected by 2,4,6-trichlorophenol显示文摘 | LI Fayun JI Lianliang LUO Yi | 2007 | Chemosphere2007，67，： | 1 |
| 17 | Hydroxyl radical generation and oxidative stress in Carassius auratus liver as affected by 2,4,6-trichlorophenol显示文摘 | Li Fayun JI Lianliang Luo Yi | 2007 | Chemosphere2007，67，： | 1 |
| 18 | Contamination, chemical speciation and vertical distribution of heavy metals in soils of an old and large industrial zone in Northeast China显示文摘 | Fayun Li Zhiping Fan Pengfei Xiao Kokyo Oh Xiping Ma Wei Hou | 2009 | Environmental Geology2009，，8： | 1 |
| 19 | Group interaction on vertically loaded piles in saturated poroelastic soil显示文摘 | Fayun Liang Zhu Song Wei Dong Guo | 2014 | Computers and Geotechnics2014，，： | 1 |
| 20 | Polymeric micelles for enhanced lymphatic drug delivery to treat metastatic tumors显示文摘 | Qin Lei Zhang Fayun Lu Xiaoyan | | 0，，02： | 1 |
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