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| 1 | Synergistically Enhanced Mucoadhesive and Penetrable Polypeptide Nanogel for Efficient Drug Delivery to Orthotopic Bladder Cancer显示文摘Intravesical chemotherapy has been recommended after the gold standard of transurethral resection of the bladder tumor to prevent bladder cancer(BC)from local recurrence in the clinic.However,due to rapid urine excretion and barrier protection of the bladder wall,the clinical performances of chemotherapeutic drugs are severely compromised.In the present work,a smart positively charged disulfide-crosslinked nanogel of oligoarginine-poly(ethylene glycol)-poly(L-phenylalanine-co-L-cystine)(R_(9)-PEG-P(LP-co-LC))was prepared to prolong the retention period and enhance the penetration capability of chemotherapeutic agent toward the bladder wall.PEG significantly improved the aqueous dispersibility of the 10-hydroxycamptothecin(HCPT)-loaded R_(9)-PEG-P(LP-co-LC)(i.e.,R_(9)NG/HCPT)and enhanced the mucoadhesive capability by the nonspecific interaction between PEG chain and the bladder mucosa accompanied with the electrostatic interaction between the cationic R_(9)and negatively charged bladder mucosa.Besides,R_(9),as a cell-penetrating peptide,efficiently penetrated through the cell membrane and delivered carried cargo.The disulfide bond endowed the selective release behavior of HCPT triggered by the intracellular reductive microenvironment.As an advanced chemotherapeutic nanoformulation,the smart R_(9)NG/HCPT demonstrated superior cytotoxicity against human BC 5637 cells in vitro and remarkably enhanced tumor suppression activity toward orthotopic BC models of mouse and rat in vivo,indicating its great potential in the clinical intravesical BC chemotherapy. | Hui Guo Faping Li Heping Qiu Weiguo Xu Pengqiang Li Yuchuan Hou Jianxun Ding Xuesi Chen | 2020 | Research2020，，1： | 7 |
| 2 | Microstructure and strengthening mechanism of hot-extruded ultralight Mg-Li-Al-Sn alloys with high strength显示文摘Duplex-structured Mg-7Li-2Al-1.5Sn alloys with high strength were fabricated and their strengthening mechanism was investigated.The Mg-7Li-2Al-1.5Sn alloys were prepared by casting and extruded at the temperature of 533 K with an extrusion ratio of 25:1.The microstructure and mechanical properties of Mg-7Li-2Al-1.5Sn alloys were systematically investigated by OM,XRD,SEM,TEM,and tensile tests.The results show that Mg-7Li-2Al-1.5Sn alloys are mainly composed ofα-Mg,β-Li,LiMgAl_(2),Mg_(2)Sn and Li_(2)MgSn phases.The yield strength(YS),ultimate tensile strength(UTS)and elongation(EL)of the extruded alloy at room temperature reach 250 MPa,324 MPa and 11.9%,respectively.A lot of Sn-rich precipitates(Mg_(2)Sn and Li_(2)MgSn)are precipitated during extrusion with an average size of∼14 nm,which is beneficial to the grain refinement.Dynamic recrystallization occurs during hot deformation and the nanoprecipitates effectively refine the dynamic recrystallized(DRXed)grains.Besides,the residual dislocations existed in DRXed and un-DRXed grains result in the dislocation strengthening in the extruded alloy.Mg7Li-2Al-1.5Sn alloys possess excellent high-temperature mechanical properties with the YS,UTS and EL of 200 MPa,237 MPa and 26.7%at 423 K,respectively.Sn-rich precipitates with good thermal stability can effectively prevent grain growth,which is good for the improvement of the high-temperature performance of Mg-Li-Al-Sn alloy. | Gang Zhou Yan Yang Hanzhu Zhang Faping Hu Xueping Zhang Chen Wen Weidong Xie Bin Jiang Xiaodong Peng Fusheng Pan | 2022 | Journal of Materials Science & Technology2022，，8： | 7 |
| 3 | Understanding of the sodium storage mechanism in hard carbon anodes显示文摘Hard carbon has been regarded as the most promising anode material for sodiumion batteries(SIBs)due to its low cost,high reversible capacity,and low working potential.However,the uncertain sodium storage mechanism hinders the rational design and synthesis of high-performance hard carbon anode materials for practical SIBs.During the past decades,tremendous efforts have been put to stimulate the development of hard carbon materials.In this review,we discuss the recent progress of the study on the sodium storage mechanism of hard carbon anodes,and the effective strategies to improve their sodium storage performance have been summarized.It is anticipated that hard carbon anodes with high electrochemical properties will be inspired and fabricated for large-scale energy storage applications. | Xiaoyang Chen Changyu Liu Yongjin Fang Xinping Ai Faping Zhong Hanxi Yang Yuliang Cao | 2022 | Carbon Energy2022，4，6： | 3 |
| 4 | Peeling behavior and spalling resistance of CFRP sheets bonded to bent concrete surfaces显示文摘在这份报纸,脱皮的行为和碳纤维的 spalling 抵抗效果增强了聚合物(CFRP ) 表外部地结合了到偏好水泥表面第一试验性地被调查。 21 个弄弯的标本和七个飞机标本在纸,有结合的 CFRP 表的弄弯的标本能在隧道在模仿具体 spalling 被学习,水道电缆,拱门桥等等,而有结合的 CFRP 表的飞机标本能在横梁模仿具体 spalling ,衔接,平板桥牌和步行桥牌。有弯曲的不同半径的三种弄弯的标本被指实际隧道结构选择,并且飞机标本与弄弯的被用于比较。脱皮的负担被装载从弄弯的具体表面放进横梁的中央槽口到 debond CFRP 表的一个圆形的钢试管在 FRP 表上使用,同时完整范围的负担鈥揹e 弯曲曲线被记录由一山 831.10 弹性体测试系统。基于试验性的结果,理论分析也为标本被进行。理论、试验性的结果显示出那二个仅仅材料参数, CFRP 具体的接口的界面的破裂精力和 CFRP 表的张力的僵硬,为描述界面的 spalling 行为被需要。弯曲的半径在剥负担鈥揹e 弯曲曲线上有显著影响,这被发现。在纸给的测试方法和测试结果对隧道加强的设计者的参考有用、可得到。关键词 FRP 表 - 界面的破裂精力 - Debonding - Spalling 抵抗 - 偏好水泥表面工程被广东省的科技的计划支持,中国(2005B32801002 ) 。 | Hong Yuan Faping Li | 2010 | Acta Mechanica Sinica2010，26，2： | 3 |
| 5 | Efficacy and safety of benralizumab in patients with eosinophilic asthma: a meta-analysis of randomized placebo-controlled trials显示文摘 | Ting Liu Faping Wang Geng Wang Hui Mao | 2018 | Frontiers of Medicine2018，12，3： | 2 |
| 6 | Locating Error Considering Dimensional Errors Modeling for Multistation Manufacturing System显示文摘Multistation machining process is widely applied in contemporary manufacturing environment.Modeling of variation propagation in multistation machining process is one of the most important research scenarios.Due to the existence of multiple variation streams,it is challenging to model and analyze variation propagation in a multi-station system.Current approaches to error modeling for multistation machining process are not explicit enough for error control and ensuring final product quality.In this paper,a mathematic model to depict the part dimensional variation of the complex multistation manufacturing process is formulated.A linear state space dimensional error propagation equation is established through kinematics analysis of the influence of locating parameter variations and locating datum variations on dimensional errors,so the dimensional error accumulation and transformation within the multistation process are quantitatively described.A systematic procedure to build the model is presented,which enhances the way to determine the variation sources in complex machining systems.A simple two-dimensional example is used to illustrate the proposed procedures.Finally,an industrial case of multistation machining part in a manufacturing shop is given to testify the validation and practicability of the method.The proposed analytical model is essential to quality control and improvement for multistation systems in machining quality forecasting and design optimization. | ZHANG Faping LU Jiping TANG Shuiyuan SUN Houfang JIAO Li | 2010 | Chinese Journal of Mechanical Engineering2010，23，6： | 2 |
| 7 | A polyethylene microsphere-coated separator with rapid thermal shutdown function for lithium-ion batteries显示文摘Thermal runaway is the main factor contributing to the unsafe behaviors of lithium-ion batteries(LIBs)in practical applications.The application of separators for the thermal shutdown has been proven as an effective approach to protecting LIBs from thermal runaway.In this work,we developed a thermal shutdown separator by coating a thin layer of low-density polyethylene microspheres(PM)onto a commercial porous polypropylene(PP)membrane and investigated the thermal response behaviors of the as-prepared PM/PP separator in LIBs.The structural and thermal analysis results revealed that the coated PM layer had a porous structure,which facilitated the occurrence of normal charge-discharge reactions at ambient temperature,although it could melt completely and fuse together within very short time periods:3 s at 110℃and 1 s at 120℃,to block off the pores of the PP substrate,thereby cutting off the ion transportation between the electrodes and interrupting the battery reaction.Consequently,the PM/PP separator exhibits very similar electrochemical performance to that of a conventional separator at ambient temperature.However,it performs a rapid thermal shutdown at an elevated temperature of^110℃,thus controlling the temperature rise and maintaining the cell in a safe status.Due to its synthetic simplicity and low cost,this separator shows promise for possible application in building safe LIBs. | Chongrong Zhang Hui Li Shixuan Wang Yuliang Cao Hanxi Yang Xinping Ai Faping Zhong | 2020 | Journal of Energy Chemistry2020，29，5： | 2 |
| 8 | Regulation of proto-oncogenic Dbl by chaperone-controlled, ubiquitin-mediated degradation显示文摘 | Elena K Krista K Faping D | 2007 | Mol Cell Biol2007，27，5： | 1 |
| 9 | Improved Initial Charging Capacity of Na-poor Na0.44MnO2 via Chemical Presodiation Strategy for Low-cost Sodium-ion Batteries显示文摘Sodium-ion batteries(SIBs)are promising for grid-scale energy storage applications due to the natural abundance and low cost of sodium.Among various Na insertion cathode materials,Na0.44MnO2 has attracted the most attention because of its cost effectiveness and structural stability.However,the low initial charge capacity for Na-poor Na0.44MnO2 hinders its practical applications.Herein,we developed a facile chemical presodiated method using sodiated biphenly to transform Na-poor Na0.44MnO2 into Na-rich Na0.66MnO2.After presodiation,the initial charge capacity of Na0.44MnO2 is greatly enhanced from 56.5 mA·h/g to 115.7 mA·h/g at 0.1 C(1 C=121 mA/g)and the excellent cycling stability(the capacity retention of 94.1%over 200 cycles at 2 C)is achieved.This presodiation strategy would open a new avenue for promoting the practical applications of Na-poor cathode materials in sodium-ion batteries. | ZHOU Xi LAI Yangyang WU Xiangjiang CHEN Zhongxue ZHONG Faping Al Xinping YANG Hanxi CAO Yuliang | 2021 | Chemical Research in Chinese Universities2021，37，2： | 1 |
| 10 | Evaluation of antioxidant and immune activity of Phellinus ribis glucan in mice显示文摘 | Chengfu Yuan Xiuning Huang Li Cheng Youquan Bu Geli Liu Faping Yi Zhengmei Yang Fangzhou Song | 2008 | Food Chemistry2008，，2： | 1 |
| 11 | Antioxidative and immunoprotective effects of Pyracantha fortuneana (Maxim.) Li polysaccharides in mice显示文摘 | Chengfu Yuan Changdong Wang Youquan Bu Tingxiu Xiang Xiuning Huang Zhiwei Wang Faping Yi Guosheng Ren Geli Liu Fangzhou Song | 2010 | Immunology Letters2010，，1： | 1 |
| 12 | Antioxidative and immunoprotective effects of Pyracantha fortuneana (Maxim.) Li polysaccharides in mice显示文摘 | Chengfu Yuan Changdong Wang Youquan Bu Tingxiu Xiang Xiuning Huang Zhiwei Wang Faping Yi Guosheng Ren Geli Liu Fangzhou Song | 2010 | Immunology Letters2010，，1： | 1 |
| 13 | Modeling and matc- hing technology of manufacturing resources based on se- mantic 显示文摘 | GAO Bo YAN Yan ZHANG Faping | 2012 | Advanced Materials Research2012，，586： | 1 |
| 14 | Journal of Magnesium and Alloys显示文摘 | Hu Faping Pan Jia Ma Xin | 2013 | (1): 2632013，，1： | 1 |
| 15 | Planted floating bed performance in treatment of eutrophic river water显示文摘 | BU Faping XU Xiaoyi | 2013 | Environmental Monitoring and Assessment2013，185，： | 1 |
| 16 | Aplication of AVO Technique to Gas Exploration in Liaohe Oil Field显示文摘AplicationofAVOTechniquetoGasExplorationinLiaoheOilFieldYuChangqing(SeniorEngineer,BeijingComputerCenter,MGMR)ZhouFaping(Rese... | Yu Changqing(Senior Engineer, Beijing Computer Center, MGMR)Zhou Faping(Research Institute of Liaohe Oilfield) | 1996 | China Oil & Gas1996，3，4： | 0 |
| 17 | A New Aim-Points-Choosing Model for Attacking Mobile Missile Systems显示文摘A new aim-points-choosing model for attacking mobile missile systems in sector region is presented and realized in this paper. The model has the generality for attacking mobile target andis also useful for making an operational decision. | Wu Faping Bi Yiding & Li Jingwen(Xi’an Research Inst. of Hi-Tech., HongQing Town, 710025, P. R. China) | 1999 | Journal of Systems Engineering and Electronics1999，10，4： | 0 |
| 18 | Transcriptional factor RUNX1:A potential therapeutic target for fibrotic pulmonary disease显示文摘Runt-related transcription factor-1(RUNX1),also known as the core-binding factor alpha 2 subunit,is closely related to human leukemia.The functions of RUNX1 in modulating cell proliferation,differentiation,and survival in multiple systems have been gradually discovered with the emergence of transgenic mice.RUNX1 is a powerful transcription factor implicated in diverse signaling pathways and cellular mechanisms that participate in lung development and pulmonary diseases.RUNX1 has recently been identified as a target regulator of fibrotic remodeling diseases,particularly in the kidney.However,the role of RUNX1 in pulmonary fibrosis is unclear.Pulmonary fibrosis is characterized by obscure nosogenesis,limited therapy,and poor prognosis.Moreover,the population of patients with pulmonary fibrosis is gradually increasing.Thus,there is an unmet need for therapeutic targets.In this review,we retrospectively discuss the alteration in RUNX1 mRNA expression in the RNA sequencing data of human fibrotic lungs and the protein levels in mouse pulmonary fibrosis.Subsequently,we focused on the interaction between RUNX1 and several signaling pathways involved in pulmonary fibrosis.Finally,this review highlights the therapeutic potential of RUNX1 as a target for slowing the progression of fibrotic lung disease. | JIA LIU FAPING WANG BO YUAN FENGMING LUO | 2023 | BIOCELL2023，47，4： | 0 |
| 19 | Research on the Shaping and Structuring of the Chinese Labor Market显示文摘The shaping of the Chinese labor market is the core of the structural transformation of the Chinese economy and society since 1978.Based on the labor market segmentation theory,this paper tries to analyze the transformational process of changing from the employment structure under the planned economy system to the labor market,the result of which shows that the Chinese labor market presents obvious structuralization(or segmentation),forming a three-part labor market—peasant-worker labor market,talent labor market and the labor market inside the state-owned enterprise,each owning a respective function.The development of the present Chinese labor market faces serious problems of employment and re-structuring. | He Faping | 2013 | 学术界2013，，10： | 0 |
| 20 | Degraded Characteristics of Absorption Solution of Lampblack Waste Gas by Biological Contact Oxidation Process显示文摘We got the sludge from secondary sedimentation tank of wastewater treatment plant. After cultivation by simulating aerobic biological reactor for 30 days,the biofilm system that could degrade the oleaginous materials of absorption solution spraying lampblack waste gas was successfully obtained. From different influent concentration and temperature experiments,it was shown that the degradation efficiency of the oleaginous materials was the most,when the influent concentration and the temperature of the biological contact oxidation reactor were 300 mg/L and35 ℃,especially the effluent concentration and the degradation efficiency of the oleaginous materials was 51 mg/L and 83%. The modified Michaelis-Menten equation was used to analyze the data,and the kinetics parameters were obtained: K_m=( 164. 867 ± 0. 001) mg/L; vmax=( 0. 595 ±0. 001) mg/( L·min). | Yan Ming Zhao Weixing Yue Jianxiong Yin Faping Sun Junzhao Tu Jiacai Sun Chuangqi | 2018 | Meteorological and Environmental Research2018，9，1： | 0 |
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